{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:16:41Z","timestamp":1793654201206,"version":"4.5.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005857","name":"Uniwersytet Przyrodniczy w Poznaniu","doi-asserted-by":"crossref","award":["Statutory fund No. 506.534.05.00"],"award-info":[{"award-number":["Statutory fund No. 506.534.05.00"]}],"id":[{"id":"10.13039\/501100005857","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Appl Genetics"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rapid progress in knowledge of the organization of the dog genome has facilitated the identification of the mutations responsible for numerous monogenic diseases, which usually present a breed-specific distribution. The majority of these diseases have clinical and molecular counterparts in humans. The affected dogs have thus become valuable models for preclinical studies of gene therapy for problems such as eye diseases, immunodeficiency, lysosomal storage diseases, hemophilia, and muscular dystrophy. Successful gene therapies in dogs have significantly contributed to decisions to run clinical trials for several human diseases, such as Leber\u2019s congenital amaurosis 2\u2014LCA2 (caused by a mutation of <jats:italic>RPE65<\/jats:italic>), X-linked retinitis pigmentosa\u2014XLRP (caused by mutation <jats:italic>RPGR<\/jats:italic>), and achromatopsia (caused by mutation of <jats:italic>CNGB3<\/jats:italic>). Promising results were also obtained for canine as follows: hemophilia (A and B), mucopolysaccharidoses (MPS I, MPS IIIB, MPS VII), leukocyte adhesion deficiency (CLAD), and muscular dystrophy (a counterpart of human Duchenne dystrophy). Present knowledge on molecular background of canine monogenic diseases and their successful gene therapies prove that dogs have an important contribution to preclinical studies.<\/jats:p>","DOI":"10.1007\/s13353-020-00554-8","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T11:56:39Z","timestamp":1584532599000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of gene therapy for canine monogenic diseases on the progress of preclinical studies"],"prefix":"10.1007","volume":"61","author":[{"given":"Marek","family":"Switonski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"issue":"1","key":"554_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/ng0501-92","volume":"28","author":"GM Acland","year":"2001","unstructured":"Acland GM, Aguirre GD, Ray J, Zhang Q, Aleman TS, Cideciyan AV, Pearce-Kelling SE, Anand V, Zeng Y, Maguire AM, Jacobson SG, Hauswirth WW, Bennett J (2001) Gene therapy restores vision in a canine model of childhood blindness. Nat Genet 28(1):92\u201395. https:\/\/doi.org\/10.1038\/ng0501-92","journal-title":"Nat Genet"},{"issue":"6","key":"554_CR2","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.ymthe.2005.08.008","volume":"12","author":"GM Acland","year":"2005","unstructured":"Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG (2005) Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther 12(6):1072\u20131082. https:\/\/doi.org\/10.1016\/j.ymthe.2005.08.008","journal-title":"Mol Ther"},{"key":"554_CR3","first-page":"23","volume":"4","author":"GD Aguirre","year":"1998","unstructured":"Aguirre GD, Baldwin V, Pearce-Kelling S, Narfstr\u00f6m K, Ray K, Acland GM (1998) Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. Mol Vis 4:23","journal-title":"Mol Vis"},{"issue":"4","key":"554_CR4","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1016\/j.jaip.2017.12.008","volume":"6","author":"E Almarza Novoa","year":"2018","unstructured":"Almarza Novoa E, Kasbekar S, Thrasher AJ, Kohn DB, Sevilla J, Nguyen T, Schwartz JD, Bueren JA (2018) Leukocyte adhesion deficiency-I: a comprehensive review of all published cases. J Allergy Clin Immunol Pract 6(4):1418\u20131420.e10. https:\/\/doi.org\/10.1016\/j.jaip.2017.12.008","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"6410","key":"554_CR5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1126\/science.aau1549","volume":"362","author":"L Amoasii","year":"2018","unstructured":"Amoasii L, Hildyard JCW, Li H, Sanchez-Ortiz E, Mireault A, Caballero D, Harron R, Stathopoulou TR, Massey C, Shelton JM, Bassel-Duby R, Piercy RJ, Olson EN (2018) Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science 362(6410):86\u201391. https:\/\/doi.org\/10.1126\/science.aau1549","journal-title":"Science"},{"key":"554_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.10.002","volume":"62","author":"D Athanasiou","year":"2018","unstructured":"Athanasiou D, Aguila M, Bellingham J, Li W, McCulley C, Reeves PJ, Cheetham ME (2018) The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy. Prog Retin Eye Res 62:1\u201323. https:\/\/doi.org\/10.1016\/j.preteyeres.2017.10.002","journal-title":"Prog Retin Eye Res"},{"issue":"R1","key":"554_CR7","doi-asserted-by":"publisher","first-page":"R95","DOI":"10.1093\/hmg\/ddz157","volume":"28","author":"P Batty","year":"2019","unstructured":"Batty P, Lillicrap D (2019) Advances and challenges for hemophilia gene therapy. Hum Mol Genet 28(R1):R95\u2013R101. https:\/\/doi.org\/10.1093\/hmg\/ddz157","journal-title":"Hum Mol Genet"},{"key":"554_CR8","doi-asserted-by":"publisher","unstructured":"Bauer TR Jr, Allen JM, Hai M, Tuschong LM, Khan IF, Olson EM, Adler RL, Burkholder TH, Gu Y-C, Russell DW, Hickstein DD (2008) Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors. Nat Med 14(1):93\u201397. https:\/\/doi.org\/10.1038\/nm1695","DOI":"10.1038\/nm1695"},{"issue":"5","key":"554_CR9","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/mt.2013.34","volume":"21","author":"TR Bauer Jr","year":"2013","unstructured":"Bauer TR Jr, Tuschong LM, Calvo KR, Shive HR, Burkholder TH, Karlsson EK, West RR, Russell DW, Hickstein DD (2013) Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency. Mol Ther 21(5):964\u2013972. https:\/\/doi.org\/10.1038\/mt.2013.34","journal-title":"Mol Ther"},{"issue":"6","key":"554_CR10","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1073\/pnas.1118847109","volume":"109","author":"WA Beltran","year":"2012","unstructured":"Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Rom\u00e1n AJ, Deng WT, Swider M, Alem\u00e1n TS, Boye SL, Genini S, Swaroop A, Hauswirth WW, Jacobson SG, Aguirre GD (2012) Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A 109(6):2132\u20132137. https:\/\/doi.org\/10.1073\/pnas.1118847109","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"554_CR11","first-page":"4031","volume":"60","author":"WA Beltran","year":"2019","unstructured":"Beltran WA, Dufour VL, Ainsworth SM, Roszak K, Aguirre GD (2019) Long-term longitudinal assessment of functional rescue in mutant XLRP dogs after RPGR gene augmentation therapy. Invest Ophthalmol Vis Sci 60(9), meeting abstract):4031","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"554_CR12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.ymgme.2013.06.015","volume":"110","author":"PW Bigg","year":"2013","unstructured":"Bigg PW, Sleeper MM, O'Donnell PA, Liu Y, Wu S, Casal ML, Haskins ME, Ponder KP (2013) The effect of neonatal gene therapy with a gamma retroviral vector on cardiac valve disease in mucopolysaccharidosis VII dogs after a decade. Mol Genet Metab 110(3):311\u2013318. https:\/\/doi.org\/10.1016\/j.ymgme.2013.06.015","journal-title":"Mol Genet Metab"},{"issue":"1","key":"554_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1089\/humc.2015.002","volume":"26","author":"AM Bradbury","year":"2015","unstructured":"Bradbury AM, Gurda BL, Casal ML, Ponder KP, Vite CH, Haskins ME (2015) A review of gene therapy in canine and feline models of lysosomal storage disorders. Hum Gene Ther Clin Dev 26(1):27\u201337. https:\/\/doi.org\/10.1089\/humc.2015.002","journal-title":"Hum Gene Ther Clin Dev"},{"issue":"43","key":"554_CR14","doi-asserted-by":"publisher","first-page":"11476","DOI":"10.1073\/pnas.1709082114","volume":"114","author":"EA Brown","year":"2017","unstructured":"Brown EA, Dickinson PJ, Mansour T, Sturges BK, Aguilar M, Young AE, Korff C, Lind J, Ettinger CL, Varon S, Pollard R, Brown CT, Raudsepp T, Bannasch DL (2017) FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs. Proc Natl Acad Sci U S A 114(43):11476\u201311481. https:\/\/doi.org\/10.1073\/pnas.1709082114","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"554_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s00439-019-01999-6","volume":"138","author":"M Bunel","year":"2019","unstructured":"Bunel M, Chaudieu G, Hamel C, Lagoutte L, Manes G, Botherel N, Brabet P, Pilorge P, Andr\u00e9 C, Quignon P (2019) Natural models for retinitis pigmentosa: progressive retinal atrophy in dog breeds. Hum Genet 138(5):441\u2013453. https:\/\/doi.org\/10.1007\/s00439-019-01999-6","journal-title":"Hum Genet"},{"issue":"9","key":"554_CR16","doi-asserted-by":"publisher","first-page":"E674","DOI":"10.3390\/genes10090674","volume":"10","author":"J Cehajic Kapetanovic","year":"2019","unstructured":"Cehajic Kapetanovic J, McClements ME, Martinez-Fernandez de la Camara C, MacLaren RE (2019) Molecular strategies for RPGR gene therapy. Genes (Basel) 10(9):E674. https:\/\/doi.org\/10.3390\/genes10090674","journal-title":"Genes (Basel)"},{"issue":"36","key":"554_CR17","doi-asserted-by":"publisher","first-page":"E8547","DOI":"10.1073\/pnas.1805055115","volume":"115","author":"AV Cideciyan","year":"2018","unstructured":"Cideciyan AV, Sudharsan R, Dufour VL, Massengill MT, Iwabe S, Swider M, Lisi B, Sumaroka A, Marinho LF, Appelbaum T, Rossmiller B, Hauswirth WW, Jacobson SG, Lewin AS, Aguirre GD, Beltran WA (2018) Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proc Natl Acad Sci U S A 115(36):E8547\u2013E8556. https:\/\/doi.org\/10.1073\/pnas.1805055115","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"554_CR18","doi-asserted-by":"publisher","first-page":"3846","DOI":"10.1182\/blood.V88.10.3846.bloodjournal88103846","volume":"88","author":"S Connelly","year":"1996","unstructured":"Connelly S, Mount J, Mauser A, Gardner JM, Kaleko M, McClelland A, Lothrop CD Jr (1996) Complete short-term correction of canine hemophilia A by in vivo gene therapy. Blood 88(10):3846\u20133853","journal-title":"Blood"},{"issue":"1","key":"554_CR19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/vop.12265","volume":"19","author":"CJ Dixon","year":"2016","unstructured":"Dixon CJ (2016) Achromatopsia in three sibling Labrador Retrievers in the UK. Vet Ophthalmol 19(1):68\u201372. https:\/\/doi.org\/10.1111\/vop.12265","journal-title":"Vet Ophthalmol"},{"key":"554_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/jhered\/90.1.3","volume":"90","author":"G Dolf","year":"1999","unstructured":"Dolf G, Batt R, Baumle E, Binns M, Brenig B, Bull B, Dunner S, Fredholm M, Gaillard C, Gerlach J, Giger U, Goldspink G, Graphodatsky AS, Holmes N, Judd S, Juneja K, Kelly EP, Kent MG, King WA, Lingaas F, Long S, Lubas G, Mariat D, Marki U, Mattews M, Mellersh C, Mohan-Ram V, Molyneux K, Morris B, Niini T, Panthier J-J, Pascal O, Patterson D, Pihkanen S, Randi E, Reimann N, Rothuizen J, Sampson J, Sanchez A, Sargan DR, Schelling C, Schook LB, Stranzinger G, Switonski M, Troyer D, Van de Weghe A, Ward OG, Wilton A, Wintero AK, Zhang P (1999) DogMap: an international collaboration toward a low-resolution canine genetic marker map. J Hered 90:3\u20136. https:\/\/doi.org\/10.1093\/jhered\/90.1.3","journal-title":"J Hered"},{"issue":"1","key":"554_CR21","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1089\/humc.2015.004","volume":"26","author":"PJ Felsburg","year":"2015","unstructured":"Felsburg PJ, De Ravin SS, Malech HL, Sorrentino BP, Burtner C, Kiem HP (2015) Gene therapy studies in a canine model of X-linked severe combined immunodeficiency. Hum Gene Ther Clin Dev 26(1):50\u201356. https:\/\/doi.org\/10.1089\/humc.2015.004","journal-title":"Hum Gene Ther Clin Dev"},{"issue":"1","key":"554_CR22","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13023-018-0807-5","volume":"13","author":"AM Flinn","year":"2018","unstructured":"Flinn AM, Gennery AR (2018) Adenosine deaminase deficiency: a review. Orphanet J Rare Dis 13(1):65. https:\/\/doi.org\/10.1186\/s13023-018-0807-5","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"554_CR23","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ymthe.2019.08.013","volume":"28","author":"KL Gardiner","year":"2020","unstructured":"Gardiner KL, Cideciyan AV, Swider M, Dufour VL, Sumaroka A, Kom\u00e1romy AM, Hauswirth WW, Iwabe S, Jacobson SG, Beltran WA, Aguirre GD (2020) Long-term structural outcomes of late-stage RPE65 gene therapy. Mol Ther 28(1):266\u2013278. https:\/\/doi.org\/10.1016\/j.ymthe.2019.08.013","journal-title":"Mol Ther"},{"issue":"5","key":"554_CR24","doi-asserted-by":"publisher","first-page":"e3015","DOI":"10.1002\/jgm.3015","volume":"20","author":"SL Ginn","year":"2018","unstructured":"Ginn SL, Amaya AK, Alexander IE, Edelstein M, Abedi MR (2018) Gene therapy clinical trials worldwide to 2017: an update. J Gene Med 20(5):e3015. https:\/\/doi.org\/10.1002\/jgm.3015","journal-title":"J Gene Med"},{"issue":"4","key":"554_CR25","first-page":"363","volume":"54","author":"YC Gu","year":"2004","unstructured":"Gu YC, Bauer TR Jr, Ackermann MR, Smith CW, Kehrli ME Jr, Starost MF, Hickstein DD (2004) The genetic immunodeficiency disease, leukocyte adhesion deficiency, in humans, dogs, cattle, and mice. Comp Med 54(4):363\u2013372","journal-title":"Comp Med"},{"issue":"2","key":"554_CR26","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/mt.2015.189","volume":"24","author":"BL Gurda","year":"2016","unstructured":"Gurda BL, De Guilhem De Lataillade A, Bell P, Zhu Y, Yu H, Wang P, Bagel J, Vite CH, Sikora T, Hinderer C, Calcedo R, Yox AD, Steet RA, Ruane T, O'Donnell P, Gao G, Wilson JM, Casal M, Ponder KP, Haskins ME (2016) Evaluation of AAV-mediated gene therapy for central nervous system disease in canine mucopolysaccharidosis VII. Mol Ther 24(2):206\u2013216. https:\/\/doi.org\/10.1038\/mt.2015.189","journal-title":"Mol Ther"},{"issue":"4","key":"554_CR27","first-page":"543","volume":"90","author":"MM Hassall","year":"2017","unstructured":"Hassall MM, Barnard AR, MacLaren RE (2017) Gene therapy for color blindness. Yale J Biol Med 90(4):543\u2013551","journal-title":"Yale J Biol Med"},{"issue":"5","key":"554_CR28","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1089\/hum.1998.9.5-629","volume":"9","author":"JM Howell","year":"1998","unstructured":"Howell JM, Lochm\u00fcller H, O'Hara A, Fletcher S, Kakulas BA, Massie B, Nalbantoglu J, Karpati G (1998) High-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscle of dystrophic dogs: prolongation of expression with immunosuppression. Hum Gene Ther 9(5):629\u2013634","journal-title":"Hum Gene Ther"},{"issue":"8","key":"554_CR29","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/avj.12206","volume":"92","author":"TB Hugo","year":"2014","unstructured":"Hugo TB, Heading KL (2014) Leucocyte adhesion deficiency III in a mixed-breed dog. Aust Vet J 92(8):299\u2013302. https:\/\/doi.org\/10.1111\/avj.12206","journal-title":"Aust Vet J"},{"key":"554_CR30","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.nbd.2017.08.017","volume":"108","author":"ML Katz","year":"2017","unstructured":"Katz ML, Rustad E, Robinson GO, Whiting REH, Student JT, Coates JR, Narfstrom K (2017) Canine neuronal ceroid lipofuscinoses: promising models for preclinical testing of therapeutic interventions. Neurobiol Dis 108:277\u2013287. https:\/\/doi.org\/10.1016\/j.nbd.2017.08.017","journal-title":"Neurobiol Dis"},{"issue":"5130","key":"554_CR31","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1126\/science.8211118","volume":"262","author":"MA Kay","year":"1993","unstructured":"Kay MA, Rothenberg S, Landen CN, Bellinger DA, Leland F, Toman C, Finegold M, Thompson AR, Read MS, Brinkhous KM et al (1993) In vivo gene therapy of hemophilia B: sustained partial correction in factor IX-deficient dogs. Science 262(5130):117\u2013119","journal-title":"Science"},{"key":"554_CR32","doi-asserted-by":"publisher","first-page":"363","DOI":"10.2147\/CLEP.S48890","volume":"5","author":"BT Kelly","year":"2013","unstructured":"Kelly BT, Tam JS, Verbsky JW, Routes JM (2013) Screening for severe combined immunodeficiency in neonates. Clin Epidemiol 5:363\u2013369. https:\/\/doi.org\/10.2147\/CLEP.S48890","journal-title":"Clin Epidemiol"},{"issue":"3","key":"554_CR33","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.ymgme.2017.05.016","volume":"121","author":"SA Khan","year":"2017","unstructured":"Khan SA, Peracha H, Ballhausen D, Wiesbauer A, Rohrbach M, Gautschi M, Mason RW, Giugliani R, Suzuki Y, Orii KE, Orii T, Tomatsu S (2017) Epidemiology of mucopolysaccharidoses. Mol Genet Metab 121(3):227\u2013240. https:\/\/doi.org\/10.1016\/j.ymgme.2017.05.016","journal-title":"Mol Genet Metab"},{"issue":"9","key":"554_CR34","doi-asserted-by":"publisher","first-page":"6328","DOI":"10.1073\/pnas.082714499","volume":"99","author":"JW Kijas","year":"2002","unstructured":"Kijas JW, Cideciyan AV, Aleman TS, Pianta MJ, Pearce-Kelling SE, Miller BJ, Jacobson SG, Aguirre GD, Acland GM (2002) Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa. Proc Natl Acad Sci U S A 99(9):6328\u20136333. https:\/\/doi.org\/10.1073\/pnas.082714499","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5641","key":"554_CR35","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1126\/science.1086432","volume":"301","author":"EF Kirkness","year":"2003","unstructured":"Kirkness EF, Bafna V, Halpern AL, Levy S, Remington K, Rusch DB, Delcher AL, Pop M, Wang W, Fraser CM, Venter JC (2003) The dog genome: survey sequencing and comparative analysis. Science 301(5641):1898\u20131903. https:\/\/doi.org\/10.1126\/science.1086432","journal-title":"Science"},{"issue":"13","key":"554_CR36","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1093\/hmg\/ddq136","volume":"19","author":"AM Kom\u00e1romy","year":"2010","unstructured":"Kom\u00e1romy AM, Alexander JJ, Rowlan JS, Garcia MM, Chiodo VA, Kaya A, Tanaka JC, Acland GM, Hauswirth WW, Aguirre GD (2010) Gene therapy rescues cone function in congenital achromatopsia. Hum Mol Genet 19(13):2581\u20132593. https:\/\/doi.org\/10.1093\/hmg\/ddq136","journal-title":"Hum Mol Genet"},{"key":"554_CR37","doi-asserted-by":"publisher","first-page":"107834","DOI":"10.1016\/j.exer.2019.107834","volume":"189","author":"AA Kondkar","year":"2019","unstructured":"Kondkar AA, Abu-Amero KK (2019) Leber congenital amaurosis: current genetic basis, scope for genetic testing and personalized medicine. Exp Eye Res 189:107834. https:\/\/doi.org\/10.1016\/j.exer.2019.107834","journal-title":"Exp Eye Res"},{"issue":"1\u20132","key":"554_CR38","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00335-011-9382-y","volume":"23","author":"JN Kornegay","year":"2012","unstructured":"Kornegay JN, Bogan JR, Bogan DJ, Childers MK, Li J, Nghiem P, Detwiler DA, Larsen CA, Grange RW, Bhavaraju-Sanka RK, Tou S, Keene BP, Howard JF Jr, Wang J, Fan Z, Schatzberg SJ, Styner MA, Flanigan KM, Xiao X, Hoffman EP (2012) Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies. Mamm Genome 23(1\u20132):85\u2013108. https:\/\/doi.org\/10.1007\/s00335-011-9382-y","journal-title":"Mamm Genome"},{"key":"554_CR39","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nature04338","volume":"438","author":"K Lindblad-Toh","year":"2005","unstructured":"Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ 3rd, Zody MC, Mauceli E, Xie X, Breen M, Wayne RK, Ostrander EA, Ponting CP, Galibert F, Smith DR, PJ DJ, Kirkness E, Alvarez P, Biagi T, Brockman W, Butler J, Chin CW, Cook A, Cuff J, Daly MJ, DeCaprio D, Gnerre S, Grabherr M, Kellis M, Kleber M, Bardeleben C, Goodstadt L, Heger A, Hitte C, Kim L, Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R, Webber C, Baldwin J, Abebe A, Abouelleil A, Aftuck L, Ait-Zahra M, Aldredge T, Allen N, An P, Anderson S, Antoine C, Arachchi H, Aslam A, Ayotte L, Bachantsang P, Barry A, Bayul T, Benamara M, Berlin A, Bessette D, Blitshteyn B, Bloom T, Blye J, Boguslavskiy L, Bonnet C, Boukhgalter B, Brown A, Cahill P, Calixte N, Camarata J, Cheshatsang Y, Chu J, Citroen M, Collymore A, Cooke P, Dawoe T, Daza R, Decktor K, DeGray S, Dhargay N, Dooley K, Dooley K, Dorje P, Dorjee K, Dorris L, Duffey N, Dupes A, Egbiremolen O, Elong R, Falk J, Farina A, Faro S, Ferguson D, Ferreira P, Fisher S, FitzGerald M, Foley K, Foley C, Franke A, Friedrich D, Gage D, Garber M, Gearin G, Giannoukos G, Goode T, Goyette A, Graham J, Grandbois E, Gyaltsen K, Hafez N, Hagopian D, Hagos B, Hall J, Healy C, Hegarty R, Honan T, Horn A, Houde N, Hughes L, Hunnicutt L, Husby M, Jester B, Jones C, Kamat A, Kanga B, Kells C, Khazanovich D, Kieu AC, Kisner P, Kumar M, Lance K, Landers T, Lara M, Lee W, Leger JP, Lennon N, Leuper L, LeVine S, Liu J, Liu X, Lokyitsang Y, Lokyitsang T, Lui A, Macdonald J, Major J, Marabella R, Maru K, Matthews C, McDonough S, Mehta T, Meldrim J, Melnikov A, Meneus L, Mihalev A, Mihova T, Miller K, Mittelman R, Mlenga V, Mulrain L, Munson G, Navidi A, Naylor J, Nguyen T, Nguyen N, Nguyen C, Nguyen T, Nicol R, Norbu N, Norbu C, Novod N, Nyima T, Olandt P, O\u2019Neill B, O\u2019Neill K, Osman S, Oyono L, Patti C, Perrin D, Phunkhang P, Pierre F, Priest M, Rachupka A, Raghuraman S, Rameau R, Ray V, Raymond C, Rege F, Rise C, Rogers J, Rogov P, Sahalie J, Settipalli S, Sharpe T, Shea T, Sheehan M, Sherpa N, Shi J, Shih D, Sloan J, Smith C, Sparrow T, Stalker J, Stange-Thomann N, Stavropoulos S, Stone C, Stone S, Sykes S, Tchuinga P, Tenzing P, Tesfaye S, Thoulutsang D, Thoulutsang Y, Topham K, Topping I, Tsamla T, Vassiliev H, Venkataraman V, Vo A, Wangchuk T, Wangdi T, Weiand M, Wilkinson J, Wilson A, Yadav S, Yang S, Yang X, Young G, Yu Q, Zainoun J, Zembek L, Zimmer A, Lander ES (2005) Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438:803\u2013819. https:\/\/doi.org\/10.1038\/nature04338","journal-title":"Nature"},{"issue":"2","key":"554_CR40","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1053\/j.seminhematol.2013.03.023","volume":"50","author":"JN Lozier","year":"2013","unstructured":"Lozier JN, Nichols TC (2013) Animal models of hemophilia and related bleeding disorders. Semin Hematol 50(2):1751\u20131784. https:\/\/doi.org\/10.1053\/j.seminhematol.2013.03.023","journal-title":"Semin Hematol"},{"issue":"21","key":"554_CR41","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1056\/NEJMoa0802315","volume":"358","author":"AM Maguire","year":"2008","unstructured":"Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, Rossi S, Lyubarsky A, Arruda VR, Konkle B, Stone E, Sun J, Jacobs J, Dell'Osso L, Hertle R, Ma JX, Redmond TM, Zhu X, Hauck B, Zelenaia O, Shindler KS, Maguire MG, Wright JF, Volpe NJ, McDonnell JW, Auricchio A, High KA, Bennett J (2008) Safety and efficacy of gene transfer for Leber\u2019s congenital amaurosis. N Engl J Med 358(21):2240\u20132248. https:\/\/doi.org\/10.1056\/NEJMoa0802315","journal-title":"N Engl J Med"},{"issue":"11","key":"554_CR42","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1016\/j.cub.2017.04.057","volume":"27","author":"TW Marchant","year":"2017","unstructured":"Marchant TW, Johnson EJ, McTeir L, Johnson CI, Gow A, Liuti T, Kuehn D, Svenson K, Bermingham ML, Dr\u00f6gem\u00fcller M, Nussbaumer M, Davey MG, Argyle DJ, Powell RM, Guilherme S, Lang J, Ter Haar G, Leeb T, Schwarz T, Mellanby RJ, Clements DN, Schoenebeck JJ (2017) Canine Brachycephaly is associated with a retrotransposon-mediated missplicing of SMOC2. Curr Biol 27(11):1573\u20131584.e6. https:\/\/doi.org\/10.1016\/j.cub.2017.04.057","journal-title":"Curr Biol"},{"key":"554_CR43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2052-6687-1-3","volume":"1","author":"CS Mellersh","year":"2014","unstructured":"Mellersh CS (2014) The genetics of eye disorders in the dog. Canine Genet Epidemiol 1:3. https:\/\/doi.org\/10.1186\/2052-6687-1-3","journal-title":"Canine Genet Epidemiol"},{"key":"554_CR44","doi-asserted-by":"publisher","unstructured":"Michalakis S, Sch\u00f6n C, Becirovic E, Biel M (2017) Gene therapy for achromatopsia. J Gene Med 19(3). https:\/\/doi.org\/10.1002\/jgm.2944","DOI":"10.1002\/jgm.2944"},{"key":"554_CR45","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1080\/14712598.2019.1607837","volume":"19","author":"MS Nagree","year":"2019","unstructured":"Nagree MS, Scalia S, McKillop WM, Medin JA (2019) An update on gene therapy for lysosomal storage disorders. Expert Opin Biol Ther 19:655\u2013670. https:\/\/doi.org\/10.1080\/14712598.2019.1607837","journal-title":"Expert Opin Biol Ther"},{"issue":"5","key":"554_CR46","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00439-019-01976-z","volume":"138","author":"PP Nghiem","year":"2019","unstructured":"Nghiem PP, Kornegay JN (2019) Gene therapies in canine models for Duchenne muscular dystrophy. Hum Genet 138(5):483\u2013489. https:\/\/doi.org\/10.1007\/s00439-019-01976-z","journal-title":"Hum Genet"},{"issue":"5","key":"554_CR47","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1111\/jth.13301","volume":"14","author":"TC Nichols","year":"2016","unstructured":"Nichols TC, Hough C, Agers\u00f8 H, Ezban M, Lillicrap D (2016) Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies. J Thromb Haemost 14(5):894\u2013905. https:\/\/doi.org\/10.1111\/jth.13301","journal-title":"J Thromb Haemost"},{"issue":"S2","key":"554_CR48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1684\/epd.2016.0844","volume":"18","author":"DA Nita","year":"2016","unstructured":"Nita DA, Mole SE, Minassian BA (2016) Neuronal ceroid lipofuscinoses. Epileptic Disord 18(S2):73\u201388. https:\/\/doi.org\/10.1684\/epd.2016.0844","journal-title":"Epileptic Disord"},{"issue":"12","key":"554_CR49","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/nrg.2017.67","volume":"18","author":"EA Ostrander","year":"2017","unstructured":"Ostrander EA, Wayne RK, Freedman AH, Davis BW (2017) Demographic history, selection and functional diversity of the canine genome. Nat Rev Genet 18(12):705\u2013720. https:\/\/doi.org\/10.1038\/nrg.2017.67","journal-title":"Nat Rev Genet"},{"issue":"4","key":"554_CR50","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1093\/nsr\/nwz049","volume":"6","author":"EA Ostrander","year":"2019","unstructured":"Ostrander EA, Wang GD, Larson G, vonHoldt BM, Davis BW, Jagannathan V, Hitte C, Wayne RK, Zhang YP, Dog10K Consortium (2019) Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health. Natl Sci Rev 6(4):810\u2013824. https:\/\/doi.org\/10.1093\/nsr\/nwz049","journal-title":"Natl Sci Rev"},{"issue":"5943","key":"554_CR51","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1126\/science.1173275","volume":"325","author":"HG Parker","year":"2009","unstructured":"Parker HG, VonHoldt BM, Quignon P, Margulies EH, Shao S, Mosher DS, Spady TC, Elkahloun A, Cargill M, Jones PG, Maslen CL, Acland GM, Sutter NB, Kuroki K, Bustamante CD, Wayne RK, Ostrander EA (2009) An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs. Science 325(5943):995\u2013998. https:\/\/doi.org\/10.1126\/science.1173275","journal-title":"Science"},{"issue":"2","key":"554_CR52","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1354\/vp.41-2-95","volume":"41","author":"LE Perryman","year":"2004","unstructured":"Perryman LE (2004) Molecular pathology of severe combined immunodeficiency in mice, horses, and dogs. Vet Pathol 41(2):95\u2013100. https:\/\/doi.org\/10.1354\/vp.41-2-95","journal-title":"Vet Pathol"},{"issue":"1","key":"554_CR53","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1089\/humc.2014.155","volume":"26","author":"SM Petersen-Jones","year":"2015","unstructured":"Petersen-Jones SM, Kom\u00e1romy AM (2015) Dog models for blinding inherited retinal dystrophies. Hum Gene Ther Clin Dev 26(1):15\u201326. https:\/\/doi.org\/10.1089\/humc.2014.155","journal-title":"Hum Gene Ther Clin Dev"},{"issue":"5","key":"554_CR54","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/hae.13816","volume":"25","author":"F Peyvandi","year":"2019","unstructured":"Peyvandi F, Garagiola I (2019) Clinical advances in gene therapy updates on clinical trials of gene therapy in haemophilia. Haemophilia. 25(5):738\u2013746. https:\/\/doi.org\/10.1111\/hae.13816","journal-title":"Haemophilia."},{"issue":"1","key":"554_CR55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41572-018-0025-4","volume":"4","author":"FM Platt","year":"2018","unstructured":"Platt FM, d'Azzo A, Davidson BL, Neufeld EF, Tifft CJ (2018) Lysosomal storage diseases. Nat Rev Dis Primers 4(1):27. https:\/\/doi.org\/10.1038\/s41572-018-0025-4","journal-title":"Nat Rev Dis Primers"},{"key":"554_CR56","doi-asserted-by":"publisher","first-page":"13102","DOI":"10.1073\/pnas.192353499","volume":"99","author":"KP Ponder","year":"2002","unstructured":"Ponder KP, Melniczek JR, Xu L, Weil MA, O'Malley TM, O'Donnell PA, Knox VW, Aguirre GD, Mazrier H, Ellinwood NM, Sleeper M, Maguire AM, Volk SW, Mango RL, Zweigle J, Wolfe JH, Haskins ME (2002) Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs. Proc Natl Acad Sci U S A 99:13102\u201313107. https:\/\/doi.org\/10.1073\/pnas.192353499","journal-title":"Proc Natl Acad Sci U S A"},{"key":"554_CR57","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.1365-2052.1993.tb00351.x","volume":"24","author":"Report from the First International DogMap Meeting","year":"1993","unstructured":"Report from the First International DogMap Meeting (1993) Anim Genet 24:399. https:\/\/doi.org\/10.1111\/j.1365-2052.1993.tb00351.x","journal-title":"Anim Genet"},{"issue":"9","key":"554_CR58","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1080\/00207454.2018.1430694","volume":"128","author":"A Salmaninejad","year":"2018","unstructured":"Salmaninejad A, Valilou SF, Bayat H, Ebadi N, Daraei A, Yousefi M, Nesaei A, Mojarrad M (2018) Duchenne muscular dystrophy: an updated review of common available therapies. Int J Neurosci 128(9):854\u2013864. https:\/\/doi.org\/10.1080\/00207454.2018.1430694","journal-title":"Int J Neurosci"},{"issue":"4","key":"554_CR59","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1089\/humc.2015.29004.sch","volume":"26","author":"J Schimmer","year":"2015","unstructured":"Schimmer J, Breazzano S (2015) Investor outlook: significance of the positive LCA2 gene therapy phase III results. Hum Gene Ther Clin Dev 26(4):208\u2013210. https:\/\/doi.org\/10.1089\/humc.2015.29004.sch","journal-title":"Hum Gene Ther Clin Dev"},{"key":"554_CR60","doi-asserted-by":"publisher","first-page":"868","DOI":"10.3389\/fgene.2019.00868","volume":"10","author":"A Shahryari","year":"2019","unstructured":"Shahryari A, Saghaeian Jazi M, Mohammadi S, Razavi Nikoo H, Nazari Z, Hosseini ES, Burtscher I, Mowla SJ, Lickert H (2019) Development and clinical translation of approved gene therapy products for genetic disorders. Front Genet 10:868. https:\/\/doi.org\/10.3389\/fgene.2019.00868","journal-title":"Front Genet"},{"issue":"1\u20132","key":"554_CR61","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1242\/dmm.004358","volume":"3","author":"AL Shearin","year":"2010","unstructured":"Shearin AL, Ostrander EA (2010) Leading the way: canine models of genomics and disease. Dis Model Mech 3(1\u20132):27\u201334. https:\/\/doi.org\/10.1242\/dmm.004358","journal-title":"Dis Model Mech"},{"issue":"1","key":"554_CR62","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1365-2516.2009.02127.x","volume":"16","author":"JS Stonebraker","year":"2010","unstructured":"Stonebraker JS, Bolton-Maggs PH, Soucie JM, Walker I, Brooker M (2010) A study of variations in the reported haemophilia a prevalence around the world. Haemophilia 16(1):20\u201332. https:\/\/doi.org\/10.1111\/j.1365-2516.2009.02127.x","journal-title":"Haemophilia"},{"issue":"3","key":"554_CR63","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1111\/j.1365-2516.2011.02588.x","volume":"18","author":"JS Stonebraker","year":"2012","unstructured":"Stonebraker JS, Bolton-Maggs PH, Michael Soucie J, Walker I, Brooker M (2012) A study of variations in the reported haemophilia B prevalence around the world. Haemophilia 18(3):e91\u2013e94. https:\/\/doi.org\/10.1111\/j.1365-2516.2011.02588.x","journal-title":"Haemophilia"},{"issue":"1","key":"554_CR64","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.repbio.2013.12.007","volume":"14","author":"M Switonski","year":"2014","unstructured":"Switonski M (2014) Dog as a model in studies on human hereditary diseases and their gene therapy. Reprod Biol 14(1):44\u201350. https:\/\/doi.org\/10.1016\/j.repbio.2013.12.007","journal-title":"Reprod Biol"},{"issue":"2","key":"554_CR65","first-page":"195","volume":"45","author":"M Switonski","year":"2004","unstructured":"Switonski M, Szczerbal I, Nowacka J (2004) The dog genome map and its use in mammalian comparative genomics. J Appl Genet 45(2):195\u2013214","journal-title":"J Appl Genet"},{"issue":"6","key":"554_CR66","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.ophtha.2012.11.048","volume":"120","author":"F Testa","year":"2013","unstructured":"Testa F, Maguire AM, Rossi S, Pierce EA, Melillo P, Marshall K, Banfi S, Surace EM, Sun J, Acerra C, Wright JF, Wellman J, High KA, Auricchio A, Bennett J, Simonelli F (2013) Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital amaurosis type 2. Ophthalmology 120(6):1283\u20131291. https:\/\/doi.org\/10.1016\/j.ophtha.2012.11.048","journal-title":"Ophthalmology"},{"issue":"8","key":"554_CR67","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1182\/blood-2005-10-4057","volume":"107","author":"SS Ting-De Ravin","year":"2006","unstructured":"Ting-De Ravin SS, Kennedy DR, Naumann N, Kennedy JS, Choi U, Hartnett BJ, Linton GF, Whiting-Theobald NL, Moore PF, Vernau W, Malech HL, Felsburg PJ (2006) Correction of canine X-linked severe combined immunodeficiency by in vivo retroviral gene therapy. Blood 107(8):3091\u20133097","journal-title":"Blood"},{"issue":"4","key":"554_CR68","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/gene.2011.6","volume":"12","author":"B Verfuurden","year":"2011","unstructured":"Verfuurden B, Wempe F, Reinink P, van Kooten PJS, Martens E, Gerritsen R, Vos JH, Rutten VPMG, Leegwater PA (2011) Severe combined immunodeficiency in Frisian water dogs caused by a RAG1 mutation. Genes Immun 12(4):310\u2013313. https:\/\/doi.org\/10.1038\/gene.2011.6","journal-title":"Genes Immun"},{"issue":"7290","key":"554_CR69","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/nature08837","volume":"464","author":"BM VonHoldt","year":"2010","unstructured":"VonHoldt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A, Reynolds A, Bryc K, Brisbin A, Knowles JC, Mosher DS, Spady TC, Elkahloun A, Geffen E, Pilot M, Jedrzejewski W, Greco C, Randi E, Bannasch D, Wilton A, Shearman J, Musiani M, Cargill M, Jones PG, Qian Z, Huang W, Ding Z-L, Zhang Y-P, Bustamante CD, Ostrander EA, Novembre J, Wayne RK (2010) Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature 464(7290):898\u2013902. https:\/\/doi.org\/10.1038\/nature08837","journal-title":"Nature"},{"issue":"5","key":"554_CR70","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1089\/hum.2018.243","volume":"30","author":"NB Wasala","year":"2019","unstructured":"Wasala NB, Hakim CH, Chen SJ, Yang NN, Duan D (2019) Questions answered and unanswered by the first CRISPR editing study in a canine model of Duchenne muscular dystrophy. Hum Gene Ther 30(5):535\u2013543. https:\/\/doi.org\/10.1089\/hum.2018.243","journal-title":"Hum Gene Ther"},{"issue":"2","key":"554_CR71","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ymgme.2013.03.013","volume":"109","author":"EM Xing","year":"2013","unstructured":"Xing EM, Knox VW, O'Donnell PA, Sikura T, Liu Y, Wu S, Casal ML, Haskins ME, Ponder KP (2013) The effect of neonatal gene therapy on skeletal manifestations in mucopolysaccharidosis VII dogs after a decade. Mol Genet Metab 109(2):183\u2013193. https:\/\/doi.org\/10.1016\/j.ymgme.2013.03.013","journal-title":"Mol Genet Metab"},{"issue":"8","key":"554_CR72","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/jpc.12868","volume":"51","author":"EM Yiu","year":"2015","unstructured":"Yiu EM, Kornberg AJ (2015) Duchenne muscular dystrophy. J Paediatr Child Health 51(8):759\u2013764. https:\/\/doi.org\/10.1111\/jpc.12868","journal-title":"J Paediatr Child Health"}],"container-title":["Journal of Applied Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13353-020-00554-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13353-020-00554-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13353-020-00554-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:31:03Z","timestamp":1616027463000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13353-020-00554-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["554"],"URL":"https:\/\/doi.org\/10.1007\/s13353-020-00554-8","relation":{},"ISSN":["1234-1983","2190-3883"],"issn-type":[{"value":"1234-1983","type":"print"},{"value":"2190-3883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"assertion":[{"value":"29 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This review article does not contain any studies with human participants or animals performed by the author.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}