{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:59:01Z","timestamp":1767142741241,"version":"build-2238731810"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2017\/25\/B\/NZ2\/00414"],"award-info":[{"award-number":["2017\/25\/B\/NZ2\/00414"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005033","name":"Politechnika Bialostocka","doi-asserted-by":"publisher","award":["WZ\/WI-IIT\/3\/2020"],"award-info":[{"award-number":["WZ\/WI-IIT\/3\/2020"]}],"id":[{"id":"10.13039\/501100005033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Appl Genetics"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s13353-022-00691-2","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T06:25:43Z","timestamp":1648189543000},"page":"361-368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Separating gene clustering in the rare mucopolysaccharidosis disease"],"prefix":"10.1007","volume":"63","author":[{"given":"Leon","family":"Bobrowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"\u0141ukaszuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Gaffke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzanna","family":"Cyske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Ferenc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Pierzynowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"W\u0119grzyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"691_CR1","unstructured":"Bobrowski L (2019) Data exploration and linear separability. Lambert Academic Publishing, Chisinau,  Moldova"},{"key":"691_CR2","doi-asserted-by":"crossref","unstructured":"Bobrowski L (2020) Small samples of multidimensional feature vectors. In: Hernes M, Wojtkiweicz K, Szczerbicki E (eds) Advances in computational collective intelligence - 12th International Conference ICCCI 2020 Proceedings. Springer Nature Switzerland AG, Cham, Switzerland, pp. 87\u201398","DOI":"10.1007\/978-3-030-63119-2_8"},{"key":"691_CR3","doi-asserted-by":"crossref","unstructured":"Bobrowski L (2021) Complexes of low dimensional linear classifiers with L1 margins. In: Nguyen NT, Chittayasothorn S, Niyato D, Trawinski B (eds) Intelligent information and database systems - 13th Asian Conference, ACIIDS 2021 Proceedings, Springer Nature Switzerland AG, Cham, Switzerland, pp. 29\u201340","DOI":"10.1007\/978-3-030-73280-6_3"},{"key":"691_CR4","doi-asserted-by":"crossref","unstructured":"Bobrowski, L, \u0141ukaszuk T (2011) Relaxed linear separability (RLS) approach to feature (gene) subset selection. In: Xia X (ed) Selected works in bioinformatics, IntechOpen Ltd, London, UK, pp. 103\u2013118","DOI":"10.5772\/22572"},{"key":"691_CR5","doi-asserted-by":"crossref","unstructured":"Bobrowski L, \u0141ukaszuk T (2020) Linear classifiers with the L1 margin from a small number of high-dimensional vectors. In: Nguyen NT, Jearanaitanakij K, Selamat S, Trawinski B, Chittayasothorn S (eds) Intelligent information and database systems - 12th Asian Conference, ACIIDS 2021 Proceedings, Springer Nature Switzerland AG, Cham, Switzerland, pp. 79\u201389","DOI":"10.1007\/978-3-030-42058-1_7"},{"key":"691_CR6","doi-asserted-by":"crossref","unstructured":"Boser BE, Guyon I, Vapnik VN (1992) A training algorithm for optimal margin classifiers. In: Proceedings of the Fifth Annual Workshop of Computational Learning Theory, ACM Pittsburgh, vol 5, pp 144\u2013152","DOI":"10.1145\/130385.130401"},{"key":"691_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12881-020-01051-9","volume":"21","author":"L Chkioua","year":"2020","unstructured":"Chkioua L, Grissa O, Leban N, Gribaa M, Boudabous H, Turkia HB, Ferchichi S, Tebib N, Laradi S (2020) The mutational spectrum of Hunter syndrome reveals correlation between biochemical and clinical profiles in Tunisian patients. BMC Med Genet 21:111. https:\/\/doi.org\/10.1186\/s12881-020-01051-9","journal-title":"BMC Med Genet"},{"key":"691_CR8","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/cge.13583","volume":"96","author":"LA Clarke","year":"2019","unstructured":"Clarke LA, Giugliani R, Guffon N, Jones SA, Keenan HA, Munoz-Rojas MV, Okuyama T, Viskochil D, Whitley CB, Wijburg FA, Muenzer J (2019) Genotype-phenotype relationships in mucopolysaccharidosis type I (MPS I): Insights from the International MPS I Registry. Clin Genet 96:281\u2013289. https:\/\/doi.org\/10.1111\/cge.13583","journal-title":"Clin Genet"},{"key":"691_CR9","unstructured":"Duda OR, Hart PE, Stork DG (2001) Pattern classification. J. Wiley, New York, USA"},{"key":"691_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgmr.2020.100692","volume":"25","author":"Y Fukuhara","year":"2020","unstructured":"Fukuhara Y, Miura A, Yamazaki N, So T, Kosuga M, Yanagi K, Kaname T, Yamagata T, Sakuraba H, Okuyama T (2020) A cDNA analysis disclosed the discordance of genotype-phenotype correlation in a patient with attenuated MPS II and a 76-base deletion in the gene for iduronate-2-sulfatase. Mol Genet Metab Rep 25:100692. https:\/\/doi.org\/10.1016\/j.ymgmr.2020.100692","journal-title":"Mol Genet Metab Rep"},{"key":"691_CR11","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.3390\/ijms21041204","volume":"21","author":"L Gaffke","year":"2020","unstructured":"Gaffke L, Pierzynowska K, Podlacha M, Hoinkis D, Rintz E, Brokowska J, Cyske Z, W\u0119grzyn G (2020) Underestimated aspect of mucopolysaccharidosis pathogenesis: global changes in cellular processes revealed by transcriptomic studies. Int J Mol Sci 21:1204. https:\/\/doi.org\/10.3390\/ijms21041204","journal-title":"Int J Mol Sci"},{"key":"691_CR12","doi-asserted-by":"publisher","unstructured":"Josahkian JA, Brusius-Facchin AC, Netto ABO, Leistner-Segal S, M\u00e1laga DR, Burin MG, Michelin-Tirelli K, Trapp FB, Cardoso-Dos-Santos AC, Ribeiro EM, Kim CA, de Siqueira ACM, Santos ML, do Valle DA, da Silva RTB, Horovitz DDG, de Medeiros PFV, de Souza CFM, Giuliani LR, Miguel DSCG, Santana-da-Silva LC, Galera MF, Giugliani R (2021) Genotype-phenotype studies in a large cohort of Brazilian patients with Hunter syndrome. Am J Med Genet C Semin Med Genet 187:349-356.\u00a0https:\/\/doi.org\/10.1002\/ajmg.c.31915","DOI":"10.1002\/ajmg.c.31915"},{"key":"691_CR13","doi-asserted-by":"publisher","unstructured":"Knottnerus SJG, Nijmeijer SCM, IJlst L, Te Brinke H, van Vlies N, Wijburg FA (2017) Prediction of phenotypic severity in mucopolysaccharidosis type IIIA. Ann Neurol 82:686-696.\u00a0https:\/\/doi.org\/10.1002\/ana.25069","DOI":"10.1002\/ana.25069"},{"key":"691_CR14","doi-asserted-by":"publisher","unstructured":"Pierzynowska K, Ma\u0144ski A, Liman\u00f3wka M, Wierzba J, Gaffke L, Anikiej P, W\u0119grzyn G (2020) Untypically mild phenotype of a patient suffering from Sanfilippo syndrome B with the c.638C>T\/c.889C>T (p.Pro213Leu\/p.Arg297Ter) mutations in the NAGLU gene. Mol Genet Genomic Med 8:e1356.\u00a0\u00a0https:\/\/doi.org\/10.1002\/mgg3.1356","DOI":"10.1002\/mgg3.1356"},{"key":"691_CR15","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1651-2227.2008.01153.x","volume":"98","author":"E Piotrowska","year":"2009","unstructured":"Piotrowska E, Jak\u00f3bkiewicz-Banecka J, Tylki-Szyma\u0144ska A, Czartoryska B, Wegrzyn A, Wegrzyn G (2009) Correlation between severity of mucopolysaccharidoses and combination of the residual enzyme activity and efficiency of glycosaminoglycan synthesis. Acta Paediatr 98:743\u2013749. https:\/\/doi.org\/10.1111\/j.1651-2227.2008.01153.x","journal-title":"Acta Paediatr"},{"key":"691_CR16","unstructured":"Simonnard M (1966) Linear programming. Prentice - Hall, New York, USA"},{"key":"691_CR17","unstructured":"Tomatsu S, Lavery C, Giugliani R, Hermatz P, Scarpa M, W\u0119grzyn G, Orii T (eds) (2018) Mucopolysaccharidoses update. Nova Publishers, Hauppauge, New York, USA"},{"key":"691_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.gene.2019.04.026","volume":"704","author":"B T\u00fcys\u00fcz","year":"2019","unstructured":"T\u00fcys\u00fcz B, Alkaya DU, Toksoy G, G\u00fcne\u015f N, Y\u0131ld\u0131r\u0131m T, Bayhan \u0130A, Uyguner ZO (2019) Mutation spectrum and pivotal features for differential diagnosis of mucopolysaccharidosis IVA patients with severe and attenuated phenotype. Gene 704:59\u201367. https:\/\/doi.org\/10.1016\/j.gene.2019.04.026","journal-title":"Gene"}],"updated-by":[{"DOI":"10.1007\/s13353-022-00700-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000}}],"container-title":["Journal of Applied Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13353-022-00691-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13353-022-00691-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13353-022-00691-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T02:27:43Z","timestamp":1651804063000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13353-022-00691-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,24]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["691"],"URL":"https:\/\/doi.org\/10.1007\/s13353-022-00691-2","relation":{},"ISSN":["1234-1983","2190-3883"],"issn-type":[{"value":"1234-1983","type":"print"},{"value":"2190-3883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,24]]},"assertion":[{"value":"12 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2022","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s13353-022-00700-4","URL":"https:\/\/doi.org\/10.1007\/s13353-022-00700-4","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}