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Many factors during in vitro fertilization and embryo transfer procedures may affect placental gene expression and fetus development. The present study aimed to identify differences in angiogenesis-related gene (\n                    <jats:italic>VEGFA<\/jats:italic>\n                    ,\n                    <jats:italic>FGF2<\/jats:italic>\n                    ,\n                    <jats:italic>FLT1<\/jats:italic>\n                    , and\n                    <jats:italic>KDR<\/jats:italic>\n                    ) expression profiles in placentas after assisted reproductive technology fertilization and natural conception in healthy women. In a case-control study, term placentas were collected from Caucasian women after assisted reproductive technology fertilization (\n                    <jats:italic>N<\/jats:italic>\n                    = 20) and after natural conception in women with uncomplicated pregnancy (\n                    <jats:italic>N<\/jats:italic>\n                    = 9). The mRNA expression in placentas was examined for\n                    <jats:italic>VEGFA<\/jats:italic>\n                    ,\n                    <jats:italic>FGF2<\/jats:italic>\n                    ,\n                    <jats:italic>FLT1<\/jats:italic>\n                    , and\n                    <jats:italic>KDR<\/jats:italic>\n                    genes by real-time quantitative polymerase chain reaction (RT-qPCR). Group stratification was performed for comparison of investigated genes between the type of embryo transferred (fresh\/frozen), place of tissue donation (center\/margin), and newborns\u2019 gender (male\/female). In the ART placentas, significant down-regulation of\n                    <jats:italic>VEGFA<\/jats:italic>\n                    gene (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.016) and up-regulation of\n                    <jats:italic>FLT1<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.026) and\n                    <jats:italic>KDR<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) gene receptors were observed. Genes encoding\n                    <jats:italic>VEGFA<\/jats:italic>\n                    receptors were up-regulated in both fresh (ET) and frozen (FET) embryo transfer groups compared to controls. For the\n                    <jats:italic>FLT1<\/jats:italic>\n                    gene, a statistically significant difference was observed between the frozen embryo transfer group and the controls (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.032). Relative expression of\n                    <jats:italic>KDR<\/jats:italic>\n                    was significantly higher for both embryo transfer groups compared to controls (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and between ET and FET (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). No statistically significant differences were observed between placental expression in different places of tissue donation and newborns\u2019 gender. We observed differences in the placental expression of\n                    <jats:italic>VEGFA<\/jats:italic>\n                    and its receptors\n                    <jats:italic>FLT1<\/jats:italic>\n                    and\n                    <jats:italic>KDR<\/jats:italic>\n                    in pregnancies after assisted reproductive technology compared to naturally conceived pregnancies. More research is needed to clarify these alterations that may affect placental development and fetal health.\n                  <\/jats:p>","DOI":"10.1007\/s13353-023-00823-2","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:02:52Z","timestamp":1705579372000},"page":"531-540","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Up-regulated mRNA expression of VEGFA receptors (FLT1 and KDR) in placentas after assisted reproductive technology fertilization"],"prefix":"10.1007","volume":"65","author":[{"given":"Aleksandra E.","family":"Mrozikiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Kurzawi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Walczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Skrzypczak-Zieli\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"O\u017carowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"J\u0119drzejczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"issue":"Suppl A","key":"823_CR1","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1053\/plac.1999.0524","volume":"21","author":"A Ahmed","year":"2000","unstructured":"Ahmed A, Dunk C, Ahmad S, Khaliq A (2000) Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review. 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Approval was granted by the Ethics Committee of the Poznan University of Medical Sciences (no. 1159\/19, date: 5 December 2019). Research involving human participants, their data, or biological material.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Prior to delivery, women provided written informed consent for the research studies conducted on their placental tissue collected after delivery. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}