{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:07:00Z","timestamp":1789063620090,"version":"build-2803163510"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Appl Genetics"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s13353-024-00843-6","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T10:02:56Z","timestamp":1707991376000},"page":"839-851","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Uncovering the role of aquaporin and chromobox family members as potential biomarkers in head and neck squamous cell carcinoma via integrative multiomics and in silico approach"],"prefix":"10.1007","volume":"65","author":[{"given":"Rishabh","family":"Gurung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Masood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithvi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Ajmeriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milin","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravins","family":"Dohare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahfuzul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"843_CR1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201910149","volume":"219","author":"C Baumann","year":"2020","unstructured":"Baumann C, Zhang X, De La Fuente R (2020) Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements. J Cell Biol 219:e201910149. https:\/\/doi.org\/10.1083\/jcb.201910149","journal-title":"J Cell Biol"},{"key":"843_CR2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"HM Berman","year":"2000","unstructured":"Berman HM, Westbrook J, Feng Z et al (2000) The protein data bank. Nucleic Acids Res 28:235\u2013242. https:\/\/doi.org\/10.1093\/nar\/28.1.235","journal-title":"Nucleic Acids Res"},{"key":"843_CR3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/bs.acr.2021.05.002","volume":"152","author":"GR Bhat","year":"2021","unstructured":"Bhat GR, Hyole RG, Li J (2021) Head and neck cancer: current challenges and future perspectives. Adv Cancer Res 152:67\u2013102. https:\/\/doi.org\/10.1016\/bs.acr.2021.05.002","journal-title":"Adv Cancer Res"},{"key":"843_CR4","doi-asserted-by":"publisher","unstructured":"Bornstein S, White R, Malkoski S et al (2009) Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest JCI38854. https:\/\/doi.org\/10.1172\/JCI38854","DOI":"10.1172\/JCI38854"},{"key":"843_CR5","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3390\/cancers13040781","volume":"13","author":"D Borsetto","year":"2021","unstructured":"Borsetto D, Tomasoni M, Payne K et al (2021) Prognostic significance of CD4+ and CD8+ tumor-infiltrating lymphocytes in head and neck squamous cell carcinoma: a meta-analysis. Cancers 13:781. https:\/\/doi.org\/10.3390\/cancers13040781","journal-title":"Cancers"},{"key":"843_CR6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.stem.2011.12.011","volume":"10","author":"R Camahort","year":"2012","unstructured":"Camahort R, Cowan CA (2012) Cbx proteins help ESCs walk the line between self-renewal and differentiation. Cell Stem Cell 10:4\u20136. https:\/\/doi.org\/10.1016\/j.stem.2011.12.011","journal-title":"Cell Stem Cell"},{"key":"843_CR7","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U et al (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401\u2013404. https:\/\/doi.org\/10.1158\/2159-8290.CD-12-0095","journal-title":"Cancer Discov"},{"key":"843_CR8","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","volume":"19","author":"DS Chandrashekar","year":"2017","unstructured":"Chandrashekar DS, Bashel B, Balasubramanya SAH et al (2017) UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia N Y N 19:649\u2013658. https:\/\/doi.org\/10.1016\/j.neo.2017.05.002","journal-title":"Neoplasia N Y N"},{"key":"843_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","volume":"25","author":"DS Chandrashekar","year":"2022","unstructured":"Chandrashekar DS, Karthikeyan SK, Korla PK et al (2022) UALCAN: an update to the integrated cancer data analysis platform. Neoplasia N Y N 25:18\u201327. https:\/\/doi.org\/10.1016\/j.neo.2022.01.001","journal-title":"Neoplasia N Y N"},{"key":"843_CR10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s11060-005-9057-1","volume":"80","author":"Y Chen","year":"2006","unstructured":"Chen Y, Tachibana O, Oda M et al (2006) Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation. J Neurooncol 80:219\u2013225. https:\/\/doi.org\/10.1007\/s11060-005-9057-1","journal-title":"J Neurooncol"},{"key":"843_CR11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-2105-14-128","volume":"14","author":"EY Chen","year":"2013","unstructured":"Chen EY, Tan CM, Kou Y et al (2013) Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics 14:128. https:\/\/doi.org\/10.1186\/1471-2105-14-128","journal-title":"BMC Bioinformatics"},{"key":"843_CR12","doi-asserted-by":"publisher","first-page":"4031","DOI":"10.1002\/jcp.29299","volume":"235","author":"D Desai","year":"2020","unstructured":"Desai D, Pethe P (2020) Polycomb repressive complex 1: regulators of neurogenesis from embryonic to adult stage. J Cell Physiol 235:4031\u20134045. https:\/\/doi.org\/10.1002\/jcp.29299","journal-title":"J Cell Physiol"},{"key":"843_CR13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1146\/annurev-immunol-101220-015603","volume":"40","author":"SM Downs-Canner","year":"2022","unstructured":"Downs-Canner SM, Meier J, Vincent BG, Serody JS (2022) B Cell function in the tumor microenvironment. Annu Rev Immunol 40:169\u2013193. https:\/\/doi.org\/10.1146\/annurev-immunol-101220-015603","journal-title":"Annu Rev Immunol"},{"key":"843_CR14","doi-asserted-by":"publisher","unstructured":"Gcp van Z, Jpglm R, M T et al (2016) The HADDOCK2.2 web server: user-friendly integrative modeling of biomolecular complexes. J Mol Biol 428. https:\/\/doi.org\/10.1016\/j.jmb.2015.09.014","DOI":"10.1016\/j.jmb.2015.09.014"},{"key":"843_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/206525","volume":"2013","author":"X Guo","year":"2013","unstructured":"Guo X, Sun T, Yang M et al (2013) Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma. BioMed Res Int 2013:1\u20137. https:\/\/doi.org\/10.1155\/2013\/206525","journal-title":"BioMed Res Int"},{"key":"843_CR16","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","volume":"123","author":"B Gy\u00f6rffy","year":"2010","unstructured":"Gy\u00f6rffy B, Lanczky A, Eklund AC et al (2010) An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat 123:725\u2013731. https:\/\/doi.org\/10.1007\/s10549-009-0674-9","journal-title":"Breast Cancer Res Treat"},{"key":"843_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-00742-4","author":"B Gy\u0151rffy","year":"2023","unstructured":"Gy\u0151rffy B (2023) Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer. GeroScience. https:\/\/doi.org\/10.1007\/s11357-023-00742-4","journal-title":"GeroScience"},{"key":"843_CR18","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.bbamem.2006.01.008","volume":"1758","author":"T Hibuse","year":"2006","unstructured":"Hibuse T, Maeda N, Nagasawa A, Funahashi T (2006) Aquaporins and glycerol metabolism. Biochim Biophys Acta 1758:1004\u20131011. https:\/\/doi.org\/10.1016\/j.bbamem.2006.01.008","journal-title":"Biochim Biophys Acta"},{"key":"843_CR19","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.2353\/ajpath.2006.050596","volume":"168","author":"MO Hoque","year":"2006","unstructured":"Hoque MO, Soria J-C, Woo J et al (2006) Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am J Pathol 168:1345\u20131353. https:\/\/doi.org\/10.2353\/ajpath.2006.050596","journal-title":"Am J Pathol"},{"key":"843_CR20","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1002\/1878-0261.12894","volume":"15","author":"MA Iqbal","year":"2021","unstructured":"Iqbal MA, Siddiqui S, Ur Rehman A et al (2021) Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer. Mol Oncol 15:1450\u20131465. https:\/\/doi.org\/10.1002\/1878-0261.12894","journal-title":"Mol Oncol"},{"key":"843_CR21","first-page":"1826","volume":"13","author":"M Javed","year":"2023","unstructured":"Javed M, Bukhari RS, Rasool R et al (2023) Screening of four signature genes for clinical testing through bioinformatics and in vitro methods in head and neck squamous cell carcinoma. Am J Cancer Res 13:1826\u20131844","journal-title":"Am J Cancer Res"},{"key":"843_CR22","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","volume":"6","author":"DE Johnson","year":"2020","unstructured":"Johnson DE, Burtness B, Leemans CR et al (2020) Head and neck squamous cell carcinoma. Nat Rev Dis Primer 6:92. https:\/\/doi.org\/10.1038\/s41572-020-00224-3","journal-title":"Nat Rev Dis Primer"},{"key":"843_CR23","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper J, Evans R, Pritzel A et al (2021) Highly accurate protein structure prediction with AlphaFold. Nature 596:583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2","journal-title":"Nature"},{"key":"843_CR24","doi-asserted-by":"publisher","first-page":"W212","DOI":"10.1093\/nar\/gkz446","volume":"47","author":"AB Keenan","year":"2019","unstructured":"Keenan AB, Torre D, Lachmann A et al (2019) ChEA3: transcription factor enrichment analysis by orthogonal omics integration. Nucleic Acids Res 47:W212\u2013W224. https:\/\/doi.org\/10.1093\/nar\/gkz446","journal-title":"Nucleic Acids Res"},{"key":"843_CR25","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov MV, Jones MR, Rouillard AD et al (2016) Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res 44:W90-97. https:\/\/doi.org\/10.1093\/nar\/gkw377","journal-title":"Nucleic Acids Res"},{"key":"843_CR26","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s13277-012-0350-2","volume":"33","author":"SK Kundu","year":"2012","unstructured":"Kundu SK, Nestor M (2012) Targeted therapy in head and neck cancer. Tumour Biol J Int Soc Oncodevelopmental Biol Med 33:707\u2013721. https:\/\/doi.org\/10.1007\/s13277-012-0350-2","journal-title":"Tumour Biol J Int Soc Oncodevelopmental Biol Med"},{"key":"843_CR27","doi-asserted-by":"publisher","DOI":"10.2196\/27633","volume":"23","author":"A L\u00e1nczky","year":"2021","unstructured":"L\u00e1nczky A, Gy\u0151rffy B (2021) Web-based survival analysis tool tailored for medical research (KMplot): development and implementation. J Med Internet Res 23:e27633. https:\/\/doi.org\/10.2196\/27633","journal-title":"J Med Internet Res"},{"key":"843_CR28","doi-asserted-by":"publisher","first-page":"5676","DOI":"10.1038\/sj.onc.1208920","volume":"24","author":"J Larsson","year":"2005","unstructured":"Larsson J, Karlsson S (2005) The role of Smad signaling in hematopoiesis. Oncogene 24:5676\u20135692. https:\/\/doi.org\/10.1038\/sj.onc.1208920","journal-title":"Oncogene"},{"key":"843_CR29","doi-asserted-by":"publisher","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","volume":"48","author":"T Li","year":"2020","unstructured":"Li T, Fu J, Zeng Z et al (2020) TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res 48:W509\u2013W514. https:\/\/doi.org\/10.1093\/nar\/gkaa407","journal-title":"Nucleic Acids Res"},{"key":"843_CR30","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.21037\/jgo-22-549","volume":"13","author":"W Li","year":"2022","unstructured":"Li W, Chen H, Wang Z et al (2022) Chromobox 4 (CBX4) promotes tumor progression and stemness via activating CDC20 in gastric cancer. J Gastrointest Oncol 13:1058\u20131072","journal-title":"J Gastrointest Oncol"},{"key":"843_CR31","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.1073\/pnas.96.9.4844","volume":"96","author":"NT Liberati","year":"1999","unstructured":"Liberati NT, Datto MB, Frederick JP et al (1999) Smads bind directly to the Jun family of AP-1 transcription factors. Proc Natl Acad Sci 96:4844\u20134849. https:\/\/doi.org\/10.1073\/pnas.96.9.4844","journal-title":"Proc Natl Acad Sci"},{"key":"843_CR32","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1007\/s12032-013-0636-2","volume":"30","author":"S Liu","year":"2013","unstructured":"Liu S, Zhang S, Jiang H et al (2013) Co-expression of AQP3 and AQP5 in esophageal squamous cell carcinoma correlates with aggressive tumor progression and poor prognosis. Med Oncol 30:636. https:\/\/doi.org\/10.1007\/s12032-013-0636-2","journal-title":"Med Oncol"},{"key":"843_CR33","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.3390\/ijms18102106","volume":"18","author":"S Marlar","year":"2017","unstructured":"Marlar S, Jensen HH, Login FH, Nejsum LN (2017) Aquaporin-3 in cancer. Int J Mol Sci 18:2106. https:\/\/doi.org\/10.3390\/ijms18102106","journal-title":"Int J Mol Sci"},{"key":"843_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ijom.2013.05.022","volume":"43","author":"K Matsuo","year":"2014","unstructured":"Matsuo K, Kawano K (2014) Immunohistochemical distribution and morphometric analysis of aquaporin-3 in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 43:13\u201321. https:\/\/doi.org\/10.1016\/j.ijom.2013.05.022","journal-title":"Int J Oral Maxillofac Surg"},{"key":"843_CR35","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1615\/CritRevEukarGeneExpr.v17.i4.30","volume":"17","author":"C Millet","year":"2007","unstructured":"Millet C, Zhang YE (2007) Roles of Smad3 in TGF-\u03b2 signaling during carcinogenesis. Crit Rev Eukaryot Gene Expr 17:281\u2013293. https:\/\/doi.org\/10.1615\/CritRevEukarGeneExpr.v17.i4.30","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"843_CR36","doi-asserted-by":"publisher","first-page":"6699","DOI":"10.1038\/sj.onc.1206762","volume":"22","author":"C Moon","year":"2003","unstructured":"Moon C, Soria J-C, Jang SJ et al (2003) Involvement of aquaporins in colorectal carcinogenesis. Oncogene 22:6699\u20136703. https:\/\/doi.org\/10.1038\/sj.onc.1206762","journal-title":"Oncogene"},{"key":"843_CR37","doi-asserted-by":"publisher","unstructured":"Moon CS, Moon D, Kang SK (2022) Aquaporins in cancer biology. Front Oncol 12:782829.\u00a0https:\/\/doi.org\/10.3389\/fonc.2022.782829","DOI":"10.3389\/fonc.2022.782829"},{"key":"843_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166561","volume":"1869","author":"AAT Naqvi","year":"2023","unstructured":"Naqvi AAT, Rizvi SAM, Hassan MdI (2023) Pan-cancer analysis of chromobox (CBX) genes for prognostic significance and cancer classification. Biochim Biophys Acta BBA - Mol Basis Dis 1869:166561. https:\/\/doi.org\/10.1016\/j.bbadis.2022.166561","journal-title":"Biochim Biophys Acta BBA - Mol Basis Dis"},{"key":"843_CR39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.canlet.2010.02.005","volume":"294","author":"B Nico","year":"2010","unstructured":"Nico B, Ribatti D (2010) Aquaporins in tumor growth and angiogenesis. Cancer Lett 294:135\u2013138. https:\/\/doi.org\/10.1016\/j.canlet.2010.02.005","journal-title":"Cancer Lett"},{"key":"843_CR40","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.bbagen.2013.09.025","volume":"1840","author":"D Ribatti","year":"2014","unstructured":"Ribatti D, Ranieri G, Annese T, Nico B (2014) Aquaporins in cancer. Biochim Biophys Acta BBA - Gen Subj 1840:1550\u20131553. https:\/\/doi.org\/10.1016\/j.bbagen.2013.09.025","journal-title":"Biochim Biophys Acta BBA - Gen Subj"},{"key":"843_CR41","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00345-013-1153-9","volume":"32","author":"PC Rubenwolf","year":"2014","unstructured":"Rubenwolf PC, Otto W, Denzinger S et al (2014) Expression of aquaporin water channels in human urothelial carcinoma: correlation of AQP3 expression with tumour grade and stage. World J Urol 32:991\u2013997. https:\/\/doi.org\/10.1007\/s00345-013-1153-9","journal-title":"World J Urol"},{"key":"843_CR42","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/sj.bjc.6600512","volume":"87","author":"S Saadoun","year":"2002","unstructured":"Saadoun S, Papadopoulos MC, Davies DC et al (2002) Increased aquaporin 1 water channel expression in human brain tumours. Br J Cancer 87:621\u2013623. https:\/\/doi.org\/10.1038\/sj.bjc.6600512","journal-title":"Br J Cancer"},{"key":"843_CR43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s43042-023-00401-5","volume":"24","author":"P Singh","year":"2023","unstructured":"Singh P, Gurung R, Sultan A, Dohare R (2023) Understanding the role of adipokines and adipogenesis family in hepatocellular carcinoma. Egypt J Med Hum Genet 24:17. https:\/\/doi.org\/10.1186\/s43042-023-00401-5","journal-title":"Egypt J Med Hum Genet"},{"key":"843_CR44","doi-asserted-by":"publisher","first-page":"eaay5947","DOI":"10.1126\/science.aay5947","volume":"367","author":"E Sj\u00f6stedt","year":"2020","unstructured":"Sj\u00f6stedt E, Zhong W, Fagerberg L et al (2020) An atlas of the protein-coding genes in the human, pig, and mouse brain. Science 367:eaay5947. https:\/\/doi.org\/10.1126\/science.aay5947","journal-title":"Science"},{"key":"843_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206239","volume":"13","author":"C Sticht","year":"2018","unstructured":"Sticht C, De La Torre C, Parveen A, Gretz N (2018) miRWalk: an online resource for prediction of microRNA binding sites. PLoS ONE 13:e0206239. https:\/\/doi.org\/10.1371\/journal.pone.0206239","journal-title":"PLoS ONE"},{"key":"843_CR46","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"843_CR47","first-page":"360","volume":"9","author":"D Surjana","year":"2011","unstructured":"Surjana D, Damian DL (2011) Nicotinamide in dermatology and photoprotection. Skinmed 9:360\u2013365","journal-title":"Skinmed"},{"key":"843_CR48","doi-asserted-by":"publisher","first-page":"9859","DOI":"10.1038\/s41598-023-36842-6","volume":"13","author":"G Tabassum","year":"2023","unstructured":"Tabassum G, Singh P, Gurung R et al (2023) Investigating the role of Kinesin family in lung adenocarcinoma via integrated bioinformatics approach. Sci Rep 13:9859. https:\/\/doi.org\/10.1038\/s41598-023-36842-6","journal-title":"Sci Rep"},{"key":"843_CR49","doi-asserted-by":"publisher","first-page":"14677","DOI":"10.1038\/ncomms14677","volume":"8","author":"PM-K Tang","year":"2017","unstructured":"Tang PM-K, Zhou S, Meng X-M et al (2017a) Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development. Nat Commun 8:14677. https:\/\/doi.org\/10.1038\/ncomms14677","journal-title":"Nat Commun"},{"key":"843_CR50","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B et al (2017b) GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res 45:W98\u2013W102. https:\/\/doi.org\/10.1093\/nar\/gkx247","journal-title":"Nucleic Acids Res"},{"key":"843_CR51","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Z Tang","year":"2019","unstructured":"Tang Z, Kang B, Li C et al (2019) GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res 47:W556\u2013W560. https:\/\/doi.org\/10.1093\/nar\/gkz430","journal-title":"Nucleic Acids Res"},{"key":"843_CR52","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41417-020-0183-x","volume":"28","author":"RE Tay","year":"2021","unstructured":"Tay RE, Richardson EK, Toh HC (2021) Revisiting the role of CD4+ T cells in cancer immunotherapy-new insights into old paradigms. Cancer Gene Ther 28:5\u201317. https:\/\/doi.org\/10.1038\/s41417-020-0183-x","journal-title":"Cancer Gene Ther"},{"key":"843_CR53","doi-asserted-by":"publisher","first-page":"eaal3321","DOI":"10.1126\/science.aal3321","volume":"356","author":"PJ Thul","year":"2017","unstructured":"Thul PJ, \u00c5kesson L, Wiking M et al (2017) A subcellular map of the human proteome. Science 356:eaal3321. https:\/\/doi.org\/10.1126\/science.aal3321","journal-title":"Science"},{"key":"843_CR54","doi-asserted-by":"publisher","first-page":"W363","DOI":"10.1093\/nar\/gky473","volume":"46","author":"W Tian","year":"2018","unstructured":"Tian W, Chen C, Lei X et al (2018) CASTp 3.0: computed atlas of surface topography of proteins. Nucleic Acids Res 46:W363\u2013W367. https:\/\/doi.org\/10.1093\/nar\/gky473","journal-title":"Nucleic Acids Res"},{"key":"843_CR55","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhl\u00e9n","year":"2015","unstructured":"Uhl\u00e9n M, Fagerberg L, Hallstr\u00f6m BM et al (2015) Proteomics. Tissue-based map of the human proteome. Science 347:1260419. https:\/\/doi.org\/10.1126\/science.1260419","journal-title":"Science"},{"key":"843_CR56","doi-asserted-by":"publisher","first-page":"eaan2507","DOI":"10.1126\/science.aan2507","volume":"357","author":"M Uhlen","year":"2017","unstructured":"Uhlen M, Zhang C, Lee S et al (2017) A pathology atlas of the human cancer transcriptome. Science 357:eaan2507. https:\/\/doi.org\/10.1126\/science.aan2507","journal-title":"Science"},{"key":"843_CR57","doi-asserted-by":"publisher","first-page":"eaax9198","DOI":"10.1126\/science.aax9198","volume":"366","author":"M Uhlen","year":"2019","unstructured":"Uhlen M, Karlsson MJ, Zhong W et al (2019) A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science 366:eaax9198. https:\/\/doi.org\/10.1126\/science.aax9198","journal-title":"Science"},{"key":"843_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115659","volume":"143","author":"AJ van Wijnen","year":"2021","unstructured":"van Wijnen AJ, Bagheri L, Badreldin AA et al (2021) Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development. Bone 143:115659. https:\/\/doi.org\/10.1016\/j.bone.2020.115659","journal-title":"Bone"},{"key":"843_CR59","doi-asserted-by":"publisher","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","volume":"50","author":"M Varadi","year":"2022","unstructured":"Varadi M, Anyango S, Deshpande M et al (2022) AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucleic Acids Res 50:D439\u2013D444. https:\/\/doi.org\/10.1093\/nar\/gkab1061","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 3","key":"843_CR60","doi-asserted-by":"publisher","first-page":"S684","DOI":"10.1245\/s10434-013-3171-7","volume":"20","author":"B Wang","year":"2013","unstructured":"Wang B, Tang J, Liao D et al (2013) Chromobox homolog 4 is correlated with prognosis and tumor cell growth in hepatocellular carcinoma. Ann Surg Oncol 20(Suppl 3):S684-692. https:\/\/doi.org\/10.1245\/s10434-013-3171-7","journal-title":"Ann Surg Oncol"},{"key":"843_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijo.2023.5484","volume":"62","author":"J Wang","year":"2023","unstructured":"Wang J, Yang B, Zhang X et al (2023) Chromobox proteins in cancer: multifaceted functions and strategies for modulation (Review). Int J Oncol 62:1\u201325. https:\/\/doi.org\/10.3892\/ijo.2023.5484","journal-title":"Int J Oncol"},{"key":"843_CR62","first-page":"4817","volume":"7","author":"W Xiao","year":"2014","unstructured":"Xiao W, Ou C, Qin J et al (2014) CBX8, a novel DNA repair protein, promotes tumorigenesis in human esophageal carcinoma. Int J Clin Exp Pathol 7:4817\u20134826","journal-title":"Int J Clin Exp Pathol"},{"key":"843_CR63","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3389\/fcell.2020.00653","volume":"8","author":"J Yang","year":"2020","unstructured":"Yang J, Jiang W (2020) The role of SMAD2\/3 in human embryonic stem cells. Front Cell Dev Biol 8:653. https:\/\/doi.org\/10.3389\/fcell.2020.00653","journal-title":"Front Cell Dev Biol"},{"key":"843_CR64","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.omtn.2020.08.030","volume":"22","author":"X Zhang","year":"2020","unstructured":"Zhang X, Shi M, Chen T, Zhang B (2020) Characterization of the immune cell infiltration landscape in head and neck squamous cell carcinoma to aid immunotherapy. Mol Ther Nucleic Acids 22:298\u2013309. https:\/\/doi.org\/10.1016\/j.omtn.2020.08.030","journal-title":"Mol Ther Nucleic Acids"}],"container-title":["Journal of Applied Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13353-024-00843-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13353-024-00843-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13353-024-00843-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:11:47Z","timestamp":1731456707000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13353-024-00843-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["843"],"URL":"https:\/\/doi.org\/10.1007\/s13353-024-00843-6","relation":{},"ISSN":["1234-1983","2190-3883"],"issn-type":[{"value":"1234-1983","type":"print"},{"value":"2190-3883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,15]]},"assertion":[{"value":"16 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal ethics"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Data sharing is not applicable to this article as no new data were created or analyzed in this study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data sharing agreement"}}]}}