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These properties make it a promising treatment for various neurological conditions. This study aimed to examine the effects of CBD on hypothalamic neurons at the transcriptome level using the adult-derived mHypoA-2\/12 mouse cell line. The cells were exposed to four different CBD concentrations (ranging from 0.325 to 3\u00a0\u00b5M) for 6 and 24\u00a0h. Apart from the transcriptome analysis, apoptosis (caspase 3\/7 activity) and viability (MTT) assays were performed. The obtained results showed that CBD enhanced cell viability, especially after 24\u00a0h of treatment and at lower or intermediate concentrations, and reduced apoptosis, with significant effects at the highest concentration. CBD caused moderate transcriptome profile changes (13 to 69 genes per treatment), with more genes affected at higher concentrations and shorter exposure times, indicating a stronger initial cellular response. Further analysis revealed that CBD affects several biological processes, including: intrinsic apoptosis suppression via p53 modulation, impacting genes like\n                    <jats:italic>Bbc3<\/jats:italic>\n                    ,\n                    <jats:italic>Mdm2<\/jats:italic>\n                    ,\n                    <jats:italic>Cdkn1a<\/jats:italic>\n                    , and\n                    <jats:italic>Smad3<\/jats:italic>\n                    . Additionally, CBD influenced genes involved in extracellular matrix organization, including metalloproteinases (\n                    <jats:italic>Mmp-3<\/jats:italic>\n                    ,\n                    <jats:italic>Mmp-13<\/jats:italic>\n                    ) and their inhibitors (\n                    <jats:italic>Timp1<\/jats:italic>\n                    ), as well as collagen components (\n                    <jats:italic>Col11a1<\/jats:italic>\n                    ) and mitochondrial respiratory chain complexes (\n                    <jats:italic>mt-Nd5<\/jats:italic>\n                    ,\n                    <jats:italic>mt-Nd4<\/jats:italic>\n                    ). Genes related to serotonin and dopamine biosynthesis, as well as\n                    <jats:italic>Aldh2<\/jats:italic>\n                    , were also impacted, linking CBD\u2019s effects in hypothalamic neurons to potential benefits in managing alcohol use disorders. These findings suggest the hypothalamus is a significant target for CBD, warranting further investigation.\n                  <\/jats:p>","DOI":"10.1007\/s13353-025-00970-8","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T22:40:05Z","timestamp":1746657605000},"page":"1029-1051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elucidating the transcriptomic response of adult-derived mHypoA-2\/12 mouse hypothalamic neuron cell line to cannabidiol (CBD) exposure"],"prefix":"10.1007","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5979-144X","authenticated-orcid":false,"given":"A.","family":"Gurgul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Jasielczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Szmato\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Semik-Gurgul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kucharski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mizera-Szpilka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Oc\u0142o\u0144","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"970_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.5863\/1551-6776-25.1.75","volume":"25","author":"R Abu-Sawwa","year":"2020","unstructured":"Abu-Sawwa R, Stehling C (2020) Epidiolex (cannabidiol) primer: frequently asked questions for patients and caregivers. 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