{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:07:11Z","timestamp":1762618031701,"version":"build-2065373602"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2025-35"],"award-info":[{"award-number":["ORF-2025-35"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Appl Genetics"],"DOI":"10.1007\/s13353-025-01025-8","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T04:05:34Z","timestamp":1762574734000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic variations in NFKB1 signaling molecules: implications for acute lymphoblastic leukemia in Saudi Arabia"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-7174","authenticated-orcid":false,"given":"Fadwa M.","family":"Alkhulaifi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamilah","family":"Alshammari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussah M.","family":"Alobaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa A.","family":"Alqarzae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suliman","family":"Alomar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"issue":"11","key":"1025_CR1","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.31557\/APJCP.2019.20.11.3391","volume":"20","author":"AM Ahmed","year":"2019","unstructured":"Ahmed AM, Al-Trabolsi H, Bayoumy M, Abosoudah I, Yassin F (2019) Improved outcomes of childhood acute lymphoblastic leukemia: a retrospective single center study in Saudi Arabia. Asian Pacific J Cancer Prevention: APJCP 20(11):3391","journal-title":"Asian Pacific J Cancer Prevention: APJCP"},{"key":"1025_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-019-5897-5","volume":"19","author":"A Bawazir","year":"2019","unstructured":"Bawazir A, Al-Zamel N, Amen A, Akiel MA, Alhawiti NM, Alshehri A (2019) The burden of leukemia in the Kingdom of Saudi Arabia: 15 years period (1999\u20132013). BMC Cancer 19:1\u201310","journal-title":"BMC Cancer"},{"issue":"14","key":"1025_CR3","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.3390\/cancers14143557","volume":"14","author":"B Di Francesco","year":"2022","unstructured":"Di Francesco B, Verzella D, Capece D, Vecchiotti D, Di Vito Nolfi M, Flati I, Cornice J, Di Padova M, Angelucci A, Alesse E, Zazzeroni F (2022) NF-\u03baB: a druggable target in acute myeloid Leukemia. Cancers (Basel) 14(14):3557","journal-title":"Cancers (Basel)"},{"issue":"3","key":"1025_CR4","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3892\/ijo.2015.3069","volume":"47","author":"T Grimmig","year":"2015","unstructured":"Grimmig T, Matthes N, Hoeland K, Tripathi S, Chandraker A, Grimm M, Moench R, Moll EM, Friess H, Tsaur I, Blaheta RA (2015) TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer. Int J Oncol 47(3):857\u2013866","journal-title":"Int J Oncol"},{"issue":"1","key":"1025_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-023-01668-1","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M, Zeng C, Zhou T, Zhang J (2024) NF-\u03baB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther 9(1):1\u201337","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"1025_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/biomedicines5020027","volume":"5","author":"V Imbert","year":"2017","unstructured":"Imbert V, Peyron JF (2017) NF-\u03baB in hematological malignancies. Biomedicines 5(2):27","journal-title":"Biomedicines"},{"key":"1025_CR7","doi-asserted-by":"publisher","first-page":"101764","DOI":"10.1016\/j.canep.2020.101764","volume":"67","author":"W Jastaniah","year":"2020","unstructured":"Jastaniah W, Essa MF, Ballourah W, Abosoudah I, Al Daama S, Algiraigri AH, Al Ghemlas I, Alshahrani M, Alsultan A (2020) Incidence trends of childhood acute lymphoblastic leukemia in Saudi Arabia: increasing incidence or competing risks? Cancer Epidemiol 67:101764","journal-title":"Cancer Epidemiol"},{"issue":"1","key":"1025_CR8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41392-022-00985-1","volume":"7","author":"Y Lu","year":"2022","unstructured":"Lu Y, Huang R, Ying J, Li X, Jiao T, Guo L, Zhou H, Wang H, Tuersuntuoheti A, Liu J, Chen Q (2022) RING finger 138 deregulation distorts NF-\u043aB signaling and facilities colitis switch to aggressive malignancy. Signal Transduct Target Ther 7(1):185","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"1025_CR9","doi-asserted-by":"publisher","first-page":"e21726","DOI":"10.1371\/journal.pone.0021726","volume":"6","author":"S Song","year":"2011","unstructured":"Song S, Chen D, Lu J, Liao J, Luo Y, Yang Z, Fu X, Fan X, Wei Y, Yang L, Wang L (2011) NF\u03baB1 and NF\u03baBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population. PLoS One 6(6):e21726","journal-title":"PLoS One"},{"issue":"5","key":"1025_CR10","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nri.2017.142","volume":"18","author":"K Taniguchi","year":"2018","unstructured":"Taniguchi K, Karin M (2018) NF-\u03baB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol 18(5):309\u2013324","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"1025_CR11","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.3390\/cancers13092256","volume":"13","author":"CK Tebbi","year":"2021","unstructured":"Tebbi CK (2021) Etiology of acute leukemia: a review. Cancers (Basel) 13(9):2256","journal-title":"Cancers (Basel)"},{"issue":"1","key":"1025_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.gene.2015.04.059","volume":"567","author":"J Yin","year":"2015","unstructured":"Yin J, Yin M, Vogel U, Wu Y, Yao T, Cheng Y, Sun Z, Hou W, Wang C (2015) NFKB1 common variants and PPP1R13L and CD3EAP in relation to lung cancer risk in a Chinese population. Gene 567(1):31\u201335","journal-title":"Gene"},{"issue":"1","key":"1025_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","volume":"5","author":"H Yu","year":"2020","unstructured":"Yu H, Lin L, Zhang Z, Zhang H, Hu H (2020) Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther 5(1):209","journal-title":"Signal Transduct Target Ther"}],"container-title":["Journal of Applied Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13353-025-01025-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13353-025-01025-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13353-025-01025-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:03:11Z","timestamp":1762617791000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13353-025-01025-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,8]]},"references-count":13,"alternative-id":["1025"],"URL":"https:\/\/doi.org\/10.1007\/s13353-025-01025-8","relation":{},"ISSN":["1234-1983","2190-3883"],"issn-type":[{"type":"print","value":"1234-1983"},{"type":"electronic","value":"2190-3883"}],"subject":[],"published":{"date-parts":[[2025,11,8]]},"assertion":[{"value":"1 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}