{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:16:51Z","timestamp":1782523011202,"version":"3.54.5"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:00:00Z","timestamp":1360800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s13365-013-0152-3","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T09:16:30Z","timestamp":1360746990000},"page":"150-156","source":"Crossref","is-referenced-by-count":55,"title":["Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders"],"prefix":"10.1007","volume":"19","author":[{"name":"The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. E.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Letendre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bloss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Goate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. B.","family":"Gelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"McArthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Morgello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"McCutchan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gamst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fennema-Notestine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Vaida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. B.","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,14]]},"reference":[{"key":"152_CR1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11481-009-9152-8","volume":"4","author":"CL Achim","year":"2009","unstructured":"Achim CL, Adame A, Dumaop W, Everall IP, Masliah E (2009) Increased accumulation of intraneuronal amyloid beta in HIV-infected patients. J Neuroimmune Pharmacol 4:190\u2013199","journal-title":"J Neuroimmune Pharmacol"},{"key":"152_CR2","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1212\/01.WNL.0000287431.88658.8b","volume":"69","author":"A Antinori","year":"2007","unstructured":"Antinori A, Arendt G, Becker JT et al (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69:1789\u20131799","journal-title":"Neurology"},{"issue":"Suppl 1","key":"152_CR3","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/00002030-200401001-00003","volume":"18","author":"JT Becker","year":"2004","unstructured":"Becker JT, Lopez OL, Dew MA, Aizenstein HJ (2004) Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS 18(Suppl 1):S11\u2013S18","journal-title":"AIDS"},{"key":"152_CR4","volume-title":"Brief visuospatial memory test\u2014revised","author":"RH Benedict","year":"1997","unstructured":"Benedict RH (1997) Brief visuospatial memory test\u2014revised. Psychological Assessment Resources, Odessa"},{"key":"152_CR5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1076\/clin.12.1.43.1726","volume":"12","author":"RH Benedict","year":"1998","unstructured":"Benedict RH, Schretlen D, Groninger L, Brandt J (1998) Hopkins verbal learning test\u2014revised: normative data and analysis of inter-form and test\u2013retest reliability. Clin Neuropsychol 12:43\u201355","journal-title":"Clin Neuropsychol"},{"key":"152_CR6","volume-title":"Multilingual aphasia examination","author":"AL Benton","year":"1983","unstructured":"Benton AL, Hamsher K, Sivan AB (1983) Multilingual aphasia examination. AJA Associates, Iowa City"},{"key":"152_CR7","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1073\/pnas.0803526105","volume":"105","author":"TD Burt","year":"2008","unstructured":"Burt TD, Agan BK, Marconi VC et al (2008) Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4\/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A 105:8718\u20138723","journal-title":"Proc Natl Acad Sci U S A"},{"key":"152_CR8","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1212\/WNL.0b013e3181c5b445","volume":"73","author":"DB Clifford","year":"2009","unstructured":"Clifford DB, Fagan AM, Holtzman DM et al (2009) CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease. Neurology 73:1982\u20131987","journal-title":"Neurology"},{"key":"152_CR9","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/2677","volume":"4","author":"EH Corder","year":"1998","unstructured":"Corder EH, Robertson K, Lannfelt L et al (1998) HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nat Med 4:1182\u20131184","journal-title":"Nat Med"},{"key":"152_CR10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/107319119800500407","volume":"5","author":"MC Diehr","year":"1998","unstructured":"Diehr MC, Heaton RK, Miller W, Grant I (1998) The Paced Auditory Serial Addition Task (PASAT): norms for age, education, and ethnicity. Assessment 5:375\u2013387","journal-title":"Assessment"},{"key":"152_CR11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1600-0404.1997.tb00217.x","volume":"95","author":"O Dunlop","year":"1997","unstructured":"Dunlop O, Goplen AK, Liestol K et al (1997) HIV dementia and apolipoprotein E. Acta Neurol Scand 95:315\u2013318","journal-title":"Acta Neurol Scand"},{"key":"152_CR12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1359786806066041","volume":"20","author":"MA Enoch","year":"2006","unstructured":"Enoch MA, Shen PH, Xu K, Hodgkinson C, Goldman D (2006) Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol 20:19\u201326","journal-title":"J Psychopharmacol"},{"key":"152_CR13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/107319119900600204","volume":"6","author":"JA Gladsjo","year":"1999","unstructured":"Gladsjo JA, Schuman CC, Evans JD, Peavy GM, Miller SW, Heaton RK (1999) Norms for letter and category fluency: demographic corrections for age, education, and ethnicity. Assessment 6:147\u2013178","journal-title":"Assessment"},{"key":"152_CR14","volume-title":"Stroop Color and Word Test","author":"CJ Golden","year":"1998","unstructured":"Golden CJ (1998) Stroop Color and Word Test. Stoelting, Chicago"},{"key":"152_CR15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2466\/pms.1977.44.2.367","volume":"44","author":"DM Gronwall","year":"1977","unstructured":"Gronwall DM (1977) Paced auditory serial-addition task: a measure of recovery from concussion. Percept Mot Skills 44:367\u2013373","journal-title":"Percept Mot Skills"},{"key":"152_CR16","first-page":"183","volume-title":"Clinical interpretation of the WAIS-III and WMS-III","author":"RK Heaton","year":"2002","unstructured":"Heaton RK, Taylor M, Manly JJ (2002) Demographic effects and use of demographically corrected norms with the WAIS-III and WMS-III. In: Tulsky D, Saklofske D, Heaton RK, Chelune G, Ivnik R, Bornstein RA, Prifitera A, Ledbetter M (eds) Clinical interpretation of the WAIS-III and WMS-III. Academic, San Diego, pp 183\u2013210"},{"key":"152_CR17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1017\/S1355617704102130","volume":"10","author":"RK Heaton","year":"2004","unstructured":"Heaton RK, Marcotte TD, Mindt MR et al (2004a) The impact of HIV-associated neuropsychological impairment on everyday functioning. J Int Neuropsychol Soc 10:317\u2013331","journal-title":"J Int Neuropsychol Soc"},{"key":"152_CR18","volume-title":"Revised comprehensive norms for an expanded Halstead\u2013Reitan Battery: demographically adjusted neuropsychological norms for African American and Caucasian adults","author":"RK Heaton","year":"2004","unstructured":"Heaton RK, Miller SW, Taylor MJ, Grant I (2004b) Revised comprehensive norms for an expanded Halstead\u2013Reitan Battery: demographically adjusted neuropsychological norms for African American and Caucasian adults. Psychological Assessment Resources, Lutz"},{"key":"152_CR19","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","volume":"75","author":"RK Heaton","year":"2010","unstructured":"Heaton RK, Clifford DB, Franklin DR Jr et al (2010) HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 75:2087\u20132096","journal-title":"Neurology"},{"key":"152_CR20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13365-010-0006-1","volume":"17","author":"RK Heaton","year":"2011","unstructured":"Heaton RK, Franklin DR, Ellis RJ et al (2011) HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol 17:3\u201316","journal-title":"J Neurovirol"},{"key":"152_CR21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/13550284.2010.513365","volume":"16","author":"JA Joska","year":"2010","unstructured":"Joska JA, Combrinck M, Valcour VG et al (2010) Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa. J Neurovirol 16:377\u2013383","journal-title":"J Neurovirol"},{"key":"152_CR22","volume-title":"Grooved pegboard","author":"H Kl\u00f8ve","year":"1963","unstructured":"Kl\u00f8ve H (1963) Grooved pegboard. Lafayette Instruments, Lafayette"},{"key":"152_CR23","volume-title":"Wisconsin Card Sorting Test\u201464 Card Computerized Version","author":"SK Kongs","year":"2000","unstructured":"Kongs SK, Thompson LL, Iverson GL, Heaton RK (2000) Wisconsin Card Sorting Test\u201464 Card Computerized Version. Psychological Assessment Resources, Odessa"},{"key":"152_CR24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-511X-9-8","volume":"9","author":"I Kuhlmann","year":"2010","unstructured":"Kuhlmann I, Minihane AM, Huebbe P, Nebel A, Rimbach G (2010) Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review. Lipids Health Dis 9:8","journal-title":"Lipids Health Dis"},{"key":"152_CR25","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.14219\/jada.archive.2007.0083","volume":"138","author":"MG Magalhaes","year":"2007","unstructured":"Magalhaes MG, Greenberg B, Hansen H, Glick M (2007) Comorbidities in older patients with HIV: a retrospective study. J Am Dent Assoc 138:1468\u20131475","journal-title":"J Am Dent Assoc"},{"key":"152_CR26","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1080\/13803395.2011.559157","volume":"33","author":"MA Norman","year":"2011","unstructured":"Norman MA, Moore DJ, Taylor M et al (2011) Demographically corrected norms for African Americans and Caucasians on the Hopkins Verbal Learning Test\u2014Revised, Brief Visuospatial Memory Test\u2014Revised, Stroop Color and Word Test, and Wisconsin Card Sorting Test 64\u2014Card Version. J Clin Exp Neuropsychol 33:793\u2013804","journal-title":"J Clin Exp Neuropsychol"},{"key":"152_CR27","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1468-1293.2008.00614.x","volume":"9","author":"LA Pemberton","year":"2008","unstructured":"Pemberton LA, Stone E, Price P, van Bockxmeer F, Brew BJ (2008) The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia. HIV Med 9:677\u2013680","journal-title":"HIV Med"},{"key":"152_CR28","volume-title":"WAIS-III and WMS-III technical manual","author":"Psychological Corporation","year":"1997","unstructured":"Psychological Corporation (1997) WAIS-III and WMS-III technical manual. Psychological Corporation, San Antonio"},{"key":"152_CR29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1155\/2009\/609839","volume":"21","author":"GD Rabinovici","year":"2009","unstructured":"Rabinovici GD, Jagust WJ (2009) Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. Behav Neurol 21:117\u2013128","journal-title":"Behav Neurol"},{"key":"152_CR30","volume-title":"The Halstead-Reitan neuropsychological test battery: theory and clinical interpretation","author":"RM Reitan","year":"1993","unstructured":"Reitan RM, Wolfson D (1993) The Halstead-Reitan neuropsychological test battery: theory and clinical interpretation. Neuropsychology, Tucson"},{"key":"152_CR31","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1097\/QAD.0b013e328339e25c","volume":"24","author":"SA Spector","year":"2010","unstructured":"Spector SA, Singh KK, Gupta S et al (2010) APOE epsilon4 and MBL-2 O\/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors. AIDS 24:1471\u20131479","journal-title":"AIDS"},{"key":"152_CR32","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/jama.279.10.751","volume":"279","author":"MX Tang","year":"1998","unstructured":"Tang MX, Stern Y, Marder K et al (1998) The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA 279:751\u2013755","journal-title":"JAMA"},{"key":"152_CR33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/JAD-2008-13407","volume":"13","author":"N Urosevic","year":"2008","unstructured":"Urosevic N, Martins RN (2008) Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism. J Alzheimers Dis 13:421\u2013435","journal-title":"J Alzheimers Dis"},{"key":"152_CR34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jneuroim.2004.08.029","volume":"157","author":"V Valcour","year":"2004","unstructured":"Valcour V, Shikuma C, Shiramizu B et al (2004) Age, apolipoprotein E4, and the risk of HIV dementia: the Hawaii aging with HIV cohort. J Neuroimmunol 157:197\u2013202","journal-title":"J Neuroimmunol"},{"key":"152_CR35","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.1073\/pnas.0806919105","volume":"105","author":"V Valcour","year":"2008","unstructured":"Valcour V, Shiramizu B, Shikuma C (2008) Frequency of apolipoprotein E4 among older compared with younger HIV patients: support for detrimental effect of E4 on survival. Proc Natl Acad Sci U S A 105:E66, author reply E67\u201368","journal-title":"Proc Natl Acad Sci U S A"},{"key":"152_CR36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1474-4422(10)70325-2","volume":"10","author":"PB Verghese","year":"2011","unstructured":"Verghese PB, Castellano JM, Holtzman DM (2011) Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol 10:241\u2013252","journal-title":"Lancet Neurol"},{"key":"152_CR37","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1212\/WNL.0b013e3181f4d5bb","volume":"75","author":"P Vivithanaporn","year":"2010","unstructured":"Vivithanaporn P, Heo G, Gamble J et al (2010) Neurologic disease burden in treated HIV\/AIDS predicts survival: a population-based study. Neurology 75:1150\u20131158","journal-title":"Neurology"},{"key":"152_CR38","volume-title":"Composite international diagnostic interview","author":"WHO","year":"1998","unstructured":"WHO (1998) Composite international diagnostic interview. World Health Organization, Geneva"},{"key":"152_CR39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/13803390490509565","volume":"26","author":"SP Woods","year":"2004","unstructured":"Woods SP, Rippeth JD, Frol AB et al (2004) Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV. J Clin Exp Neuropsychol 26:759\u2013778","journal-title":"J Clin Exp Neuropsychol"},{"key":"152_CR40","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/13803390903130737","volume":"32","author":"SP Woods","year":"2010","unstructured":"Woods SP, Dawson MS, Weber E, Grant I (2010) The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection. J Clin Exp Neuropsychol 32:398\u2013407","journal-title":"J Clin Exp Neuropsychol"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-013-0152-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13365-013-0152-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-013-0152-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T12:08:28Z","timestamp":1559477308000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13365-013-0152-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,14]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["152"],"URL":"https:\/\/doi.org\/10.1007\/s13365-013-0152-3","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,14]]}}}