{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:49:17Z","timestamp":1789674557877,"version":"4.0.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s13365-013-0167-9","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T15:16:48Z","timestamp":1369754208000},"page":"274-279","source":"Crossref","is-referenced-by-count":18,"title":["HIV-associated progressive multifocal leukoencephalopathy: longitudinal study of JC virus non-coding control region rearrangements and host immunity"],"prefix":"10.1007","volume":"19","author":[{"given":"Marco","family":"Iannetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bellizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lo Menzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Anzivino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"D\u2019Abramo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"d\u2019Ettorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Pietropaolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Vullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa","family":"Ciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"167_CR1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1099\/0022-1317-82-5-1221","volume":"82","author":"HT Agostini","year":"2001","unstructured":"Agostini HT, Deckhut A, Jobes DV, Girones R, Schlunck G, Prost MG, Frias C, P\u00e9rez-Trallero E, Ryschkewitsch CF, Stoner GL (2001) Genotypes of JC virus in East, Central and Southwest Europe. J Gen Virol 82:1221\u20131231","journal-title":"J Gen Virol"},{"key":"167_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13365-012-0080-7","volume":"18","author":"A Bellizzi","year":"2012","unstructured":"Bellizzi A, Nardis C, Anzivino E, Rod\u00eco D, Fioriti D, Mischitelli M, Chiarini F, Pietropaolo V (2012) Human polyomavirus JC reactivation and pathogenetic mechanisms of progressive multifocal leukoencephalopathy and cancer in the era of monoclonal antibody therapies. J Neurovirol 18:1\u201311","journal-title":"J Neurovirol"},{"key":"167_CR3","unstructured":"Biogen Idec (2012) Study to explore the effect of mefloquine in subjects with progressive multifocal leukoencephalopathy (PML). ClinicalTrials.gov website. Available: http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00746941 . Accessed 04 Aug 2012"},{"key":"167_CR4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/QAI.0b013e31822ccfcc","volume":"58","author":"SL Butler","year":"2011","unstructured":"Butler SL, Valdez H, Westby M, Perros M, June CH, Jacobson JM, Levy Y, Cooper DA, Douek D, Lederman MM, Tebas P (2011) Disease-modifying therapeutic concepts for HIV in the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 58:297\u2013303","journal-title":"J Acquir Immune Defic Syndr"},{"key":"167_CR5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1473-3099(09)70226-9","volume":"9","author":"P Cinque","year":"2009","unstructured":"Cinque P, Koralnik IJ, Gerevini S, Miro JM, Price RW (2009) Progressive multifocal leukoencephalopathy complicating HIV-1 infection. Lancet Infect Dis 9:625\u2013636","journal-title":"Lancet Infect Dis"},{"key":"167_CR6","doi-asserted-by":"crossref","first-page":"e35793","DOI":"10.1371\/journal.pone.0035793","volume":"7","author":"X Dang","year":"2012","unstructured":"Dang X, W\u00fcthrich C, Gordon J, Sawa H, Koralnik IJ (2012) JC virus encephalopathy is associated with a novel agnoprotein-deletion JCV variant. PLoS One 7:e35793. doi: 10.1371\/journal.pone.0035793","journal-title":"PLoS One"},{"key":"167_CR7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/QAI.0b013e31817bec64","volume":"49","author":"V Falc\u00f2","year":"2008","unstructured":"Falc\u00f2 V, Olmo M, Villar del Saz S, Guelar A, Santos JR, Guti\u00e9rrez M, Colomer D, Deig E, Mateo G, Montero M, Pedrol E, Podzamczer D, Domingo P, Llibre JM (2008) Influence of HAART on the clinical course of HIV-1-infected patients with progressive multifocal leukoencephalopathy: results of an observational multicenter study. J Acquir Immune Defic Syndr 49:26\u201331","journal-title":"J Acquir Immune Defic Syndr"},{"key":"167_CR8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/13550280390241188","volume":"9","author":"CG Fedele","year":"2003","unstructured":"Fedele CG, Ciardi MR, Delia S, Contreras G, Perez JL, De O\u00f1a M, Vidal E, Tenorio A (2003) Identical rearranged forms of JC polyomavirus transcriptional control region in plasma and cerebrospinal fluid of acquired immunodeficiency syndrome patients with progressive multifocal leukoencephalopathy. J Neurovirol 9:551\u2013558","journal-title":"J Neurovirol"},{"key":"167_CR9","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1212\/WNL.0b013e318268465b","volume":"79","author":"S Gheuens","year":"2012","unstructured":"Gheuens S, Ngo L, Wang X, Alsop DC, Lenkinski RE, Koralnik IJ (2012) Metabolic profile of PML lesions in patients with and without IRIS: an observational study. Neurology 79:1041\u20131048","journal-title":"Neurology"},{"key":"167_CR10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00126334-200204010-00004","volume":"29","author":"JV Giorgi","year":"2002","unstructured":"Giorgi JV, Lyles RH, Matud JL, Yamashita TE, Mellors JW, Hultin LE, Jamieson BD, Margolick JB, Rinaldo CR Jr, Phair JP, Detels R, Multicenter AIDS Cohort Study (2002) Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection. J Acquir Immune Defic Syndr 29:346\u2013355","journal-title":"J Acquir Immune Defic Syndr"},{"key":"167_CR11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneuroim.2011.07.003","volume":"238","author":"SD Harrison","year":"2011","unstructured":"Harrison SD, Newsome RL, Skolasky JC, McArthur AN, Daniel M (2011) Immune reconstitution is not a prognostic factor in progressive multifocal leukoencephalopathy. J Neuroimmunol 238:81\u201386","journal-title":"J Neuroimmunol"},{"key":"167_CR12","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1086\/374786","volume":"187","author":"PW Hunt","year":"2003","unstructured":"Hunt PW, Martin JN, Sinclair E, Bredt B, Hagos E, Lampiris H, Deeks SG (2003) T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 187:1534\u20131543","journal-title":"J Infect Dis"},{"key":"167_CR13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1212\/WNL.52.2.253","volume":"52","author":"IJ Koralnik","year":"1999","unstructured":"Koralnik IJ, BodenD MVX, Lord CI, Letvin NL (1999) JC virus DNA load in patients with and without progressive multifocal leukoencephalopathy. Neurology 52:253\u2013260","journal-title":"Neurology"},{"key":"167_CR14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s11481-010-9203-1","volume":"5","author":"LJ Marshall","year":"2010","unstructured":"Marshall LJ, Major EO (2010) Molecular regulation of JC virus tropism: insights into potential therapeutic targets for progressive multifocal leukoencephalopathy. J Neuroimmune Pharmacol 5:404\u2013417","journal-title":"J Neuroimmune Pharmacol"},{"key":"167_CR15","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1212\/WNL.0b013e3181c0d4a1","volume":"73","author":"A Marzocchetti","year":"2009","unstructured":"Marzocchetti A, Tompkins T, Clifford DB, Gandhi RT, Kesari S, Berger JR, Simpson DM, Prosperi M, De Luca A, Koralnik IJ (2009) Determinants of survival in progressive multifocal leukoencephalopathy. Neurology 73:1551\u20131558","journal-title":"Neurology"},{"key":"167_CR16","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s13365-011-0020-y","volume":"17","author":"M Mascarello","year":"2011","unstructured":"Mascarello M, Lanzafame M, Lattuada E, Concia E, Ferrari S (2011) Progressive multifocal leukoencephalopathy in an HIV patient receiving successful long-term HAART. J Neurovirol 17:196\u2013199","journal-title":"J Neurovirol"},{"key":"167_CR17","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0140-6736(71)91777-6","volume":"1","author":"BL Padgett","year":"1971","unstructured":"Padgett BL, Zu Rhein GM, Walker DL, Eckroade RJ, Dessel BH (1971) Cultivation of papova-like virus from human brain with progressive multifocal leukoencephalopathy. Lancet 1:1257\u20131260","journal-title":"Lancet"},{"key":"167_CR18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/714044482","volume":"9","author":"V Pietropaolo","year":"2003","unstructured":"Pietropaolo V, Videtta M, Fioriti D, Mischitelli M, Arancio A, Orsi N, Degener AM (2003) Rearrangement patterns of JC virus noncoding control region from different biological samples. J Neurovirol 9:603\u2013611","journal-title":"J Neurovirol"},{"issue":"Suppl 2","key":"167_CR19","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1086\/344280","volume":"186","author":"BF Sabath","year":"2002","unstructured":"Sabath BF, Major EO (2002) Traffic of JC virus from sites of initial infection to the brain: the path to progressive multifocal leukoencephalopathy. J Infect Dis 186(Suppl 2):S180\u2013S186","journal-title":"J Infect Dis"},{"key":"167_CR20","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1172\/JCI33034","volume":"117","author":"G Silvestri","year":"2007","unstructured":"Silvestri G, Paiardini M, Pandrea I, Lederman MM, Sodora DL (2007) Understanding the benign nature of SIV infection in natural hosts. J Clin Invest 117:3148\u20133154","journal-title":"J Clin Invest"},{"key":"167_CR21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1742-4690-8-52","volume":"8","author":"RD Sloan","year":"2011","unstructured":"Sloan RD, Wainberg MA (2011) The role of unintegrated DNA in HIV infection. Retrovirology 8:52","journal-title":"Retrovirology"},{"key":"167_CR22","doi-asserted-by":"crossref","first-page":"9200","DOI":"10.1128\/JVI.00609-10","volume":"84","author":"CS Tan","year":"2010","unstructured":"Tan CS, Ellis LC, W\u00fcthrich C, Ngo L, Broge TA Jr, Saint-Aubyn J, Miller JS, Koralnik IJ (2010) JC virus latency in the brain and extraneural organs of patients with and without progressive multifocal leukoencephalopathy. J Virol 84:9200\u20139209","journal-title":"J Virol"},{"key":"167_CR23","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1212\/01.wnl.0000343510.08643.74","volume":"72","author":"K Tan","year":"2009","unstructured":"Tan K, Roda R, Ostrow L, McArthur J, Nath A (2009) PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids. Neurology 72:1458\u20131464","journal-title":"Neurology"},{"key":"167_CR24","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/infdis\/jiq097","volume":"203","author":"MK White","year":"2011","unstructured":"White MK, Khalili K (2011) Pathogenesis of progressive multifocal leukoencephalopathy\u2014revisited. J Infect Dis 203:578\u2013586","journal-title":"J Infect Dis"},{"key":"167_CR25","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1128\/JCM.29.10.2130-2138.1991","volume":"29","author":"Y Yogo","year":"1991","unstructured":"Yogo Y, Iida T, Taguchi F, Kitamura T, Aso Y (1991) Typing of human polyomavirus JC virus on the basis of restriction fragment length polymorphisms. J Clin Microbiol 29:2130\u20132138","journal-title":"J Clin Microbiol"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-013-0167-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13365-013-0167-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-013-0167-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T03:07:09Z","timestamp":1595819229000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13365-013-0167-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,29]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["167"],"URL":"https:\/\/doi.org\/10.1007\/s13365-013-0167-9","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,29]]}}}