{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:30:20Z","timestamp":1761863420878},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T00:00:00Z","timestamp":1422662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s13365-015-0318-2","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T14:58:01Z","timestamp":1422629881000},"page":"186-198","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Investigating the role of ankyrin-rich membrane spanning protein in human immunodeficiency virus type-1 Tat-induced microglia activation"],"prefix":"10.1007","volume":"21","author":[{"given":"Vir B.","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia K.","family":"Wooten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph W.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay B.","family":"Maggirwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Kiebala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,31]]},"reference":[{"key":"318_CR1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-V","volume":"27","author":"E Blasi","year":"1990","unstructured":"Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F (1990) Immortalization of murine microglial cells by a v-raf\/v-myc carrying retrovirus. J Neuroimmunol 27:229\u2013237","journal-title":"J Neuroimmunol"},{"key":"318_CR2","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1038\/sj.onc.1204868","volume":"20","author":"GD Bren","year":"2001","unstructured":"Bren GD, Solan NJ, Miyoshi H, Pennington KN, Pobst LJ, Paya CV (2001) Transcription of the RelB gene is regulated by NF-kappaB. Oncogene 20:7722\u20137733","journal-title":"Oncogene"},{"key":"318_CR3","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1038\/cddis.2011.108","volume":"2","author":"F Cesca","year":"2011","unstructured":"Cesca F, Yabe A, Spencer-Dene B, Arrigoni A, Al-Qatari M, Henderson D, Phillips H, Koltzenburg M, Benfenati F, Schiavo G (2011) Kidins220\/ARMS is an essential modulator of cardiovascular and nervous system development. Cell Death Dis 2:e226","journal-title":"Cell Death Dis"},{"key":"318_CR4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/cdd.2011.141","volume":"19","author":"F Cesca","year":"2012","unstructured":"Cesca F, Yabe A, Spencer-Dene B, Scholz-Starke J, Medrihan L, Maden CH, Gerhardt H, Orriss IR, Baldelli P, Al-Qatari M, Koltzenburg M, Adams RH, Benfenati F, Schiavo G (2012) Kidins220\/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ 19:194\u2013208","journal-title":"Cell Death Differ"},{"key":"318_CR5","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1097\/00002030-199712000-00006","volume":"11","author":"HC Chang","year":"1997","unstructured":"Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B (1997) HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. Aids 11:1421\u20131431","journal-title":"Aids"},{"key":"318_CR6","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1523\/JNEUROSCI.1264-12.2012","volume":"32","author":"Y Chen","year":"2012","unstructured":"Chen Y, Fu WY, Ip JP, Ye T, Fu AK, Chao MV, Ip NY (2012) Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development. J Neurosci 32:8263\u20138269","journal-title":"J Neurosci"},{"key":"318_CR7","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S1473-3099(13)70269-X","volume":"13","author":"DB Clifford","year":"2013","unstructured":"Clifford DB, Ances BM (2013) HIV-associated neurocognitive disorder. Lancet Infect Dis 13:976\u2013986","journal-title":"Lancet Infect Dis"},{"key":"318_CR8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/13550280490279807","volume":"10","author":"TG D\u2019Aversa","year":"2004","unstructured":"D\u2019Aversa TG, Yu KO, Berman JW (2004) Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat. J Neurovirol 10:86\u201397","journal-title":"J Neurovirol"},{"key":"318_CR9","doi-asserted-by":"crossref","first-page":"e51793","DOI":"10.1371\/journal.pone.0051793","volume":"7","author":"DC Davidson","year":"2012","unstructured":"Davidson DC, Hirschman MP, Sun A, Singh MV, Kasischke K, Maggirwar SB (2012) Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders. PLoS One 7:e51793","journal-title":"PLoS One"},{"key":"318_CR10","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(13)61809-7","volume":"382","author":"SG Deeks","year":"2013","unstructured":"Deeks SG, Lewin SR, Havlir DV (2013a) The end of AIDS: HIV infection as a chronic disease. Lancet 382:1525\u20131533","journal-title":"Lancet"},{"key":"318_CR11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.10.001","volume":"39","author":"SG Deeks","year":"2013","unstructured":"Deeks SG, Tracy R, Douek DC (2013b) Systemic effects of inflammation on health during chronic HIV infection. Immunity 39:633\u2013645","journal-title":"Immunity"},{"key":"318_CR12","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.4049\/jimmunol.1200653","volume":"190","author":"S Deswal","year":"2013","unstructured":"Deswal S, Meyer A, Fiala GJ, Eisenhardt AE, Schmitt LC, Salek M, Brummer T, Acuto O, Schamel WW (2013) Kidins220\/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells. J Immunol 190:1927\u20131935","journal-title":"J Immunol"},{"issue":"Suppl","key":"318_CR13","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0092-8674(02)00703-1","volume":"109","author":"S Ghosh","year":"2002","unstructured":"Ghosh S, Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl):S81\u2013S96","journal-title":"Cell"},{"key":"318_CR14","doi-asserted-by":"crossref","unstructured":"Gill AJ, Kolson DL (2014) Chronic Inflammation and the Role for Cofactors (Hepatitis C, Drug Abuse, Antiretroviral Drug Toxicity, Aging) in HAND Persistence. Curr HIV\/AIDS Rep","DOI":"10.1007\/s11904-014-0210-3"},{"key":"318_CR15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2174\/1570162033485122","volume":"1","author":"PR Gorry","year":"2003","unstructured":"Gorry PR, Ong C, Thorpe J, Bannwarth S, Thompson KA, Gatignol A, Vesselingh SL, Purcell DF (2003) Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia. Curr HIV Res 1:463\u2013473","journal-title":"Curr HIV Res"},{"key":"318_CR16","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1212\/WNL.0000000000000492","volume":"82","author":"I Grant","year":"2014","unstructured":"Grant I, Franklin DR Jr, Deutsch R, Woods SP, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Heaton RK (2014) Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology 82:2055\u20132062","journal-title":"Neurology"},{"key":"318_CR17","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/sj.jcbfm.9600254","volume":"26","author":"K Hayashi","year":"2006","unstructured":"Hayashi K, Pu H, Andras IE, Eum SY, Yamauchi A, Hennig B, Toborek M (2006) HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier. J Cereb Blood Flow Metab 26:1052\u20131065","journal-title":"J Cereb Blood Flow Metab"},{"key":"318_CR18","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","volume":"75","author":"RK Heaton","year":"2010","unstructured":"Heaton RK, Clifford DB, Franklin DR Jr, Woods SP, Ake C, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Rivera-Mindt M, Vigil OR, Taylor MJ, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I (2010) HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 75:2087\u20132096","journal-title":"Neurology"},{"issue":"Suppl 3","key":"318_CR19","doi-asserted-by":"crossref","first-page":"S375","DOI":"10.1093\/infdis\/jis200","volume":"205","author":"PY Hsue","year":"2012","unstructured":"Hsue PY, Deeks SG, Hunt PW (2012) Immunologic basis of cardiovascular disease in HIV-infected adults. J Infect Dis 205(Suppl 3):S375\u2013S382","journal-title":"J Infect Dis"},{"key":"318_CR20","doi-asserted-by":"crossref","first-page":"40048","DOI":"10.1074\/jbc.M005261200","volume":"275","author":"T Iglesias","year":"2000","unstructured":"Iglesias T, Cabrera-Poch N, Mitchell MP, Naven TJ, Rozengurt E, Schiavo G (2000) Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D. J Biol Chem 275:40048\u201340056","journal-title":"J Biol Chem"},{"key":"318_CR21","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/eji.201040513","volume":"41","author":"RM Jean-Mairet","year":"2011","unstructured":"Jean-Mairet RM, Lopez-Menendez C, Sanchez-Ruiloba L, Sacristan S, Rodriguez-Martinez M, Riol-Blanco L, Sanchez-Mateos P, Sanchez-Madrid F, Rodriguez-Fernandez JL, Campanero MR, Iglesias T (2011) The neuronal protein Kidins220\/ARMS associates with ICAM-3 and other uropod components and regulates T-cell motility. Eur J Immunol 41:1035\u20131046","journal-title":"Eur J Immunol"},{"key":"318_CR22","doi-asserted-by":"crossref","first-page":"28837","DOI":"10.1074\/jbc.274.41.28837","volume":"274","author":"KT Jeang","year":"1999","unstructured":"Jeang KT, Xiao H, Rich EA (1999) Multifaceted activities of the HIV-1 transactivator of transcription, Tat. J Biol Chem 274:28837\u201328840","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"318_CR23","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/sj.cdd.4401623","volume":"12","author":"M Kaul","year":"2005","unstructured":"Kaul M, Zheng J, Okamoto S, Gendelman HE, Lipton SA (2005) HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ 12(Suppl 1):878\u2013892","journal-title":"Cell Death Differ"},{"key":"318_CR24","doi-asserted-by":"crossref","first-page":"e18633","DOI":"10.1371\/journal.pone.0018633","volume":"6","author":"M Kiebala","year":"2011","unstructured":"Kiebala M, Maggirwar SB (2011) Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PLoS One 6:e18633","journal-title":"PLoS One"},{"key":"318_CR25","doi-asserted-by":"crossref","first-page":"e11875","DOI":"10.1371\/journal.pone.0011875","volume":"5","author":"M Kiebala","year":"2010","unstructured":"Kiebala M, Polesskaya O, Yao Z, Perry SW, Maggirwar SB (2010) Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production. PLoS One 5:e11875","journal-title":"PLoS One"},{"key":"318_CR26","doi-asserted-by":"crossref","first-page":"12604","DOI":"10.1523\/JNEUROSCI.2958-08.2008","volume":"28","author":"HJ Kim","year":"2008","unstructured":"Kim HJ, Martemyanov KA, Thayer SA (2008) Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death. J Neurosci 28:12604\u201312613","journal-title":"J Neurosci"},{"key":"318_CR27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1523\/JNEUROSCI.21-01-00176.2001","volume":"21","author":"H Kong","year":"2001","unstructured":"Kong H, Boulter J, Weber JL, Lai C, Chao MV (2001) An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors. J Neurosci 21:176\u2013185","journal-title":"J Neurosci"},{"key":"318_CR28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.molcel.2006.05.002","volume":"22","author":"A Kovalenko","year":"2006","unstructured":"Kovalenko A, Wallach D (2006) If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation. Mol Cell 22:433\u2013436","journal-title":"Mol Cell"},{"key":"318_CR29","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3892\/mmr.2013.1727","volume":"8","author":"N Li","year":"2013","unstructured":"Li N, Dong X, Yang C, Liu Y, Ni X (2013) Expression of neuronal protein Kidins220\/ARMS in the spleen and peripheral blood of mice following airway allergen challenge. Mol Med Rep 8:1871\u20131875","journal-title":"Mol Med Rep"},{"key":"318_CR30","doi-asserted-by":"crossref","first-page":"11547","DOI":"10.1158\/0008-5472.CAN-07-1930","volume":"67","author":"YH Liao","year":"2007","unstructured":"Liao YH, Hsu SM, Huang PH (2007) ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma. Cancer Res 67:11547\u201311556","journal-title":"Cancer Res"},{"key":"318_CR31","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/82199","volume":"6","author":"Y Liu","year":"2000","unstructured":"Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ (2000) Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med 6:1380\u20131387","journal-title":"Nat Med"},{"key":"318_CR32","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s11481-013-9504-2","volume":"8","author":"TD Marcotte","year":"2013","unstructured":"Marcotte TD, Deutsch R, Michael BD, Franklin D, Cookson DR, Bharti AR, Grant I, Letendre SL (2013) A concise panel of biomarkers identifies neurocognitive functioning changes in HIV-infected individuals. J Neuroimmune Pharmacol 8:1123\u20131135","journal-title":"J Neuroimmune Pharmacol"},{"key":"318_CR33","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1023\/B:NERE.0000021241.90133.89","volume":"29","author":"L Minghetti","year":"2004","unstructured":"Minghetti L, Visentin S, Patrizio M, Franchini L, Ajmone-Cat MA, Levi G (2004) Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions. Neurochem Res 29:965\u2013978","journal-title":"Neurochem Res"},{"key":"318_CR34","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.addr.2007.10.006","volume":"60","author":"I Nakase","year":"2008","unstructured":"Nakase I, Takeuchi T, Tanaka G, Futaki S (2008) Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides. Adv Drug Deliv Rev 60:598\u2013607","journal-title":"Adv Drug Deliv Rev"},{"key":"318_CR35","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/1531-8249(200002)47:2<186::AID-ANA8>3.0.CO;2-3","volume":"47","author":"A Nath","year":"2000","unstructured":"Nath A, Haughey NJ, Jones M, Anderson C, Bell JE, Geiger JD (2000) Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Ann Neurol 47:186\u2013194","journal-title":"Ann Neurol"},{"key":"318_CR36","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/jcs.102764","volume":"125","author":"VE Neubrand","year":"2012","unstructured":"Neubrand VE, Cesca F, Benfenati F, Schiavo G (2012) Kidins220\/ARMS as a functional mediator of multiple receptor signalling pathways. J Cell Sci 125:1845\u20131854","journal-title":"J Cell Sci"},{"key":"318_CR37","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1086\/652749","volume":"201","author":"J Neuhaus","year":"2010","unstructured":"Neuhaus J, Jacobs DR Jr, Baker JV, Calmy A, Duprez D, La Rosa A, Kuller LH, Pett SL, Ristola M, Ross MJ, Shlipak MG, Tracy R, Neaton JD (2010) Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. J Infect Dis 201:1788\u20131795","journal-title":"J Infect Dis"},{"key":"318_CR38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.resp.2010.09.012","volume":"175","author":"X Ni","year":"2011","unstructured":"Ni X, Li X, Fang X, Li N, Cui W, Zhang B, Liu Y (2011) Kidins220\/ARMS contributes to airway inflammation and hyper-responsiveness in OVA-sensitized mice. Respir Physiol Neurobiol 175:97\u2013103","journal-title":"Respir Physiol Neurobiol"},{"key":"318_CR39","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1471-4159.2001.00568.x","volume":"79","author":"A Nicolini","year":"2001","unstructured":"Nicolini A, Ajmone-Cat MA, Bernardo A, Levi G, Minghetti L (2001) Human immunodeficiency virus type-1 Tat protein induces nuclear factor (NF)-kappaB activation and oxidative stress in microglial cultures by independent mechanisms. J Neurochem 79:713\u2013716","journal-title":"J Neurochem"},{"key":"318_CR40","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","volume":"1","author":"A Oeckinghaus","year":"2009","unstructured":"Oeckinghaus A, Ghosh S (2009) The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1:a000034","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"318_CR41","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.2065","volume":"12","author":"A Oeckinghaus","year":"2011","unstructured":"Oeckinghaus A, Hayden MS, Ghosh S (2011) Crosstalk in NF-kappaB signaling pathways. Nat Immunol 12:695\u2013708","journal-title":"Nat Immunol"},{"key":"318_CR42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1073\/pnas.232688199","volume":"100","author":"XF Qin","year":"2003","unstructured":"Qin XF, An DS, Chen IS, Baltimore D (2003) Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A 100:183\u2013188","journal-title":"Proc Natl Acad Sci U S A"},{"key":"318_CR43","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/eji.200324640","volume":"34","author":"L Riol-Blanco","year":"2004","unstructured":"Riol-Blanco L, Iglesias T, Sanchez-Sanchez N, de la Rosa G, Sanchez-Ruiloba L, Cabrera-Poch N, Torres A, Longo I, Garcia-Bordas J, Longo N, Tejedor A, Sanchez-Mateos P, Rodriguez-Fernandez JL (2004) The neuronal protein Kidins220 localizes in a raft compartment at the leading edge of motile immature dendritic cells. Eur J Immunol 34:108\u2013118","journal-title":"Eur J Immunol"},{"key":"318_CR44","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/pr.2013.146","volume":"74","author":"DA Rogers","year":"2013","unstructured":"Rogers DA, Schor NF (2013) Kidins220\/ARMS is expressed in neuroblastoma tumors and stabilizes neurotrophic signaling in a human neuroblastoma cell line. Pediatr Res 74:517\u2013524","journal-title":"Pediatr Res"},{"key":"318_CR45","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.mcn.2008.04.001","volume":"38","author":"LF Sniderhan","year":"2008","unstructured":"Sniderhan LF, Stout A, Lu Y, Chao MV, Maggirwar SB (2008) Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signaling. Mol Cell Neurosci 38:404\u2013416","journal-title":"Mol Cell Neurosci"},{"issue":"54\u20135","key":"318_CR46","first-page":"58","volume":"273","author":"WJ Streit","year":"1995","unstructured":"Streit WJ, Kincaid-Colton CA (1995) The brain\u2019s immune system. Sci Am 273(54\u20135):58\u201361","journal-title":"Sci Am"},{"key":"318_CR47","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.4049\/jimmunol.178.5.3226","volume":"178","author":"Z Sui","year":"2007","unstructured":"Sui Z, Sniderhan LF, Schifitto G, Phipps RP, Gelbard HA, Dewhurst S, Maggirwar SB (2007) Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. J Immunol 178:3226\u20133236","journal-title":"J Immunol"},{"key":"318_CR48","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1091\/mbc.E03-12-0921","volume":"15","author":"A Vendeville","year":"2004","unstructured":"Vendeville A, Rayne F, Bonhoure A, Bettache N, Montcourrier P, Beaumelle B (2004) HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses. Mol Biol Cell 15:2347\u20132360","journal-title":"Mol Biol Cell"},{"key":"318_CR49","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/375497a0","volume":"375","author":"MO Westendorp","year":"1995","unstructured":"Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin KM, Krammer PH (1995) Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497\u2013500","journal-title":"Nature"},{"key":"318_CR50","first-page":"435","volume":"8","author":"A Wooten","year":"2013","unstructured":"Wooten A, Jackson JW, Kiebala M, Maggirwar SB (2013) Ankyrin-rich membrane spanning protein (ARMS) plays a crucial role in HIV-1 Tat-induced activation of microglial cells. J Neuroimmune Pharmacol 8:435","journal-title":"J Neuroimmune Pharmacol"},{"key":"318_CR51","doi-asserted-by":"crossref","first-page":"11466","DOI":"10.1073\/pnas.97.21.11466","volume":"97","author":"H Xiao","year":"2000","unstructured":"Xiao H, Neuveut C, Tiffany HL, Benkirane M, Rich EA, Murphy PM, Jeang KT (2000) Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1. Proc Natl Acad Sci U S A 97:11466\u201311471","journal-title":"Proc Natl Acad Sci U S A"},{"key":"318_CR52","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s11481-009-9174-2","volume":"4","author":"A Yadav","year":"2009","unstructured":"Yadav A, Collman RG (2009) CNS inflammation and macrophage\/microglial biology associated with HIV-1 infection. J Neuroimmune Pharmacol 4:430\u2013447","journal-title":"J Neuroimmune Pharmacol"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-015-0318-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13365-015-0318-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-015-0318-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T10:25:41Z","timestamp":1566296741000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13365-015-0318-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,31]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["318"],"URL":"https:\/\/doi.org\/10.1007\/s13365-015-0318-2","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,31]]}}}