{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:48:33Z","timestamp":1759160913619},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Medison Pharma SRL, Israel","award":["8343-10-SNC"],"award-info":[{"award-number":["8343-10-SNC"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s13365-016-0445-4","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T13:21:58Z","timestamp":1462972918000},"page":"736-746","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Host cell virus entry mechanisms enhance anti-JCV-antibody switch in natalizumab-treated multiple sclerosis patients"],"prefix":"10.1007","volume":"22","author":[{"given":"Anat","family":"Achiron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gadi","family":"Miron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Zilkha-Falb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Magalashvili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Dolev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gurevich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"445_CR1","doi-asserted-by":"crossref","first-page":"839719","DOI":"10.1155\/2013\/839719","volume":"2013","author":"A Bellizzi","year":"2013","unstructured":"Bellizzi A, Anzivino E, Rodio DM, Palamara AT, Nencioni L, Pietropaolo V (2013) New insights on human polyomavirus JC and pathogenesis of progressive multifocal leukoencephalopathy. Clin Dev Immunol 2013:839719","journal-title":"Clin Dev Immunol"},{"key":"445_CR2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1056\/NEJMe058122","volume":"353","author":"JR Berger","year":"2005","unstructured":"Berger JR, Koralnik IJ (2005) Progressive multifocal leukoencephalopathy and natalizumab\u2014unforeseen consequences. N Engl J Med 353:414\u2013416","journal-title":"N Engl J Med"},{"key":"445_CR3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/ana.23893","volume":"74","author":"JR Berger","year":"2013","unstructured":"Berger JR, Houff SA, Gurwell J, Vega N, Miller CS, Danaher RJ (2013) JC virus antibody status underestimates infection rates. Ann Neurol 74:84\u201390","journal-title":"Ann Neurol"},{"key":"445_CR4","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1056\/NEJMoa1107829","volume":"366","author":"G Bloomgren","year":"2012","unstructured":"Bloomgren G, Richman S, Hotermans C, Subramanyam M, Goelz S, Natarajan A, Lee S, Plavina T, Scanlon JV, Sandrock A, Bozic C (2012) Risk of natalizumab-associated progressive multifocal leukoencephalopathy. N Engl J Med 366:1870\u20131880","journal-title":"N Engl J Med"},{"key":"445_CR5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0733-8619(18)31105-8","volume":"2","author":"BR Brooks","year":"1984","unstructured":"Brooks BR, Walker DL (1984) Progressive multifocal leukoencephalopathy. Neurol Clin 2:299\u2013313","journal-title":"Neurol Clin"},{"key":"445_CR6","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1099\/vir.0.19369-0","volume":"84","author":"M Caruso","year":"2003","unstructured":"Caruso M, Cavaldesi M, Gentile M, Sthandier O, Amati P, Garcia MI (2003) Role of sialic acid-containing molecules and the alpha4beta1 integrin receptor in the early steps of polyomavirus infection. J Gen Virol 84:2927\u20132936","journal-title":"J Gen Virol"},{"key":"445_CR7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/infdis\/147.4.676","volume":"147","author":"PM Chesters","year":"1983","unstructured":"Chesters PM, Heritage J, McCance DJ (1983) Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues. J Infect Dis 147:676\u2013684","journal-title":"J Infect Dis"},{"key":"445_CR8","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1103492","volume":"306","author":"GF Elphick","year":"2004","unstructured":"Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ (2004) The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science 306:1380\u20131383","journal-title":"Science"},{"key":"445_CR9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1128\/CMR.05031-11","volume":"25","author":"MW Ferenczy","year":"2012","unstructured":"Ferenczy MW, Marshall LJ, Nelson CD, Atwood WJ, Nath A, Khalili K, Major EO (2012) Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev 25:471\u2013506","journal-title":"Clin Microbiol Rev"},{"key":"445_CR10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ana.22128","volume":"68","author":"L Gorelik","year":"2010","unstructured":"Gorelik L, Lerner M, Bixler S, Crossman M, Schlain B, Simon K, Pace A, Cheung A, Chen LL, Berman M, Zein F, Wilson E, Yednock T, Sandrock A, Goelz SE, Subramanyam M (2010) Anti-JC virus antibodies: implications for PML risk stratification. Ann Neurol 68:295\u2013303","journal-title":"Ann Neurol"},{"key":"445_CR11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/acn3.174","volume":"2","author":"M Gurevich","year":"2015","unstructured":"Gurevich M, Miron G, Achiron A (2015) Optimizing multiple sclerosis diagnosis: gene expression and genomic association. Ann Clin Transl Neurol 2:271\u2013277","journal-title":"Ann Clin Transl Neurol"},{"key":"445_CR12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jneuroim.2011.03.001","volume":"234","author":"A Harrer","year":"2011","unstructured":"Harrer A, Wipfler P, Einhaeupl M, Pilz G, Oppermann K, Hitzl W, Afazel S, Haschke-Becher E, Strasser P, Trinka E, Kraus J (2011) Natalizumab therapy decreases surface expression of both VLA-heterodimer subunits on peripheral blood mononuclear cells. J Neuroimmunol 234:148\u2013154","journal-title":"J Neuroimmunol"},{"key":"445_CR13","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/bmt.2009.381","volume":"45","author":"D Jing","year":"2010","unstructured":"Jing D, Oelschlaegel U, Ordemann R, H\u00f6lig K, Ehninger G, Reichmann H, Ziemssen T, Bornh\u00e4user M (2010) CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and function. Bone Marrow Transplant 45:1489\u20131496","journal-title":"Bone Marrow Transplant"},{"key":"445_CR14","doi-asserted-by":"crossref","first-page":"12992","DOI":"10.1128\/JVI.76.24.12992-13000.2002","volume":"76","author":"R Komagome","year":"2002","unstructured":"Komagome R, Sawa H, Suzuki T, Suzuki Y, Tanaka S, Atwood WJ, Nagashima K (2002) Oligosaccharides as receptors for JC virus. J Virol 76:12992\u201313000","journal-title":"J Virol"},{"key":"445_CR15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jcv.2013.02.002","volume":"57","author":"P Lee","year":"2013","unstructured":"Lee P, Plavina T, Castro A, Berman M, Jaiswal D, Rivas S, Schlain B, Subramanyam M (2013) A second-generation ELISA (STRATIFY JCV\u2122 DxSelect\u2122) for detection of JC virus antibodies in human serum and plasma to support progressive multifocal leukoencephalopathy risk stratification. J Clin Virol 57:141\u2013146","journal-title":"J Clin Virol"},{"key":"445_CR16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jneuroim.2007.11.007","volume":"194","author":"RL Lindberg","year":"2008","unstructured":"Lindberg RL, Achtnichts L, Hoffmann F, Kuhle J, Kappos L (2008) Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients. J Neuroimmunol 194:153\u2013164","journal-title":"J Neuroimmunol"},{"key":"445_CR17","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1056\/NEJMc1214233","volume":"368","author":"EO Major","year":"2013","unstructured":"Major EO, Frohman E, Douek D (2013) JC viremia in natalizumab-treated patients with multiple sclerosis. N Engl J Med 368:2240\u20132241","journal-title":"N Engl J Med"},{"key":"445_CR18","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1099\/vir.0.023184-0","volume":"91","author":"LJ Marshall","year":"2010","unstructured":"Marshall LJ, Dunham L, Major EO (2010) Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter\/enhancer of JC virus and supports viral activity. J Gen Virol 91:3042\u20133052","journal-title":"J Gen Virol"},{"key":"445_CR19","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1128\/JVI.70.10.7004-7012.1996","volume":"70","author":"MC Monaco","year":"1996","unstructured":"Monaco MC, Atwood WJ, Gravell M, Tornatore CS, Major EO (1996) JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency. J Virol 70:7004\u20137012","journal-title":"J Virol"},{"key":"445_CR20","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1007\/s00415-012-6487-5","volume":"259","author":"O Outteryck","year":"2012","unstructured":"Outteryck O, Ongagna JC, Duhamel A, Z\u00e9phir H, Collongues N, Lacour A, Fleury MC, Berteloot AS, Blanc F, Giroux M, Vermersch P, de S\u00e8ze J (2012) Anti-JCV antibody prevalence in a French cohort of MS patients under natalizumab therapy. J Neurol 259:2293\u20132298","journal-title":"J Neurol"},{"issue":"7","key":"445_CR21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1177\/1352458513505353","volume":"20","author":"O Outteryck","year":"2013","unstructured":"Outteryck O, Z\u00e9phir H, Salleron J, Ongagna JC, Etxeberria A, Collongues N, Lacour A, Fleury MC, Blanc F, Giroux M, de Seze J, Vermersch P (2013) JC-virus seroconversion in multiple sclerosis patients receiving natalizumab. Mult Scler 20(7):822\u2013829","journal-title":"Mult Scler"},{"key":"445_CR22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ygeno.2012.08.003","volume":"100","author":"SR Piccolo","year":"2012","unstructured":"Piccolo SR, Sun Y, Campbell JD, Lenburg ME, Bild AH, Johnson WE (2012) A single-sample microarray normalization method to facilitate personalized-medicine workflows. Genomics 100:337\u2013344","journal-title":"Genomics"},{"key":"445_CR23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1056\/NEJMoa044397","volume":"354","author":"CH Polman","year":"2006","unstructured":"Polman CH, O\u2019Connor PW, Havrdova E, Hutchinson M, Kappos L, Miller DH, Phillips JT, Lublin FD, Giovannoni G, Wajgt A, Toal M, Lynn F, Panzara MA, Sandrock AW, Investigators A (2006) A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 354:899\u2013910","journal-title":"N Engl J Med"},{"key":"445_CR24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000302687","volume":"63","author":"N Putzki","year":"2010","unstructured":"Putzki N, Baranwal MK, Tettenborn B, Limmroth V, Kreuzfelder E (2010) Effects of natalizumab on circulating B cells, T regulatory cells and natural killer cells. Eur Neurol 63:311\u2013317","journal-title":"Eur Neurol"},{"key":"445_CR25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/JVI.78.1.250-256.2004","volume":"78","author":"W Querbes","year":"2004","unstructured":"Querbes W, Benmerah A, Tosoni D, Di Fiore PP, Atwood WJ (2004) A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway. J Virol 78:250\u2013256","journal-title":"J Virol"},{"key":"445_CR26","volume-title":"R: a language and environment for statistical computing","author":"R development Core Team","year":"2013","unstructured":"R development Core Team (2013) R: a language and environment for statistical computing. R foundation for Statistical Computing, Vienna"},{"key":"445_CR27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1091\/mbc.11.1.325","volume":"11","author":"M Stahlhut","year":"2000","unstructured":"Stahlhut M, van Deurs B (2000) Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton. Mol Biol Cell 11:325\u2013337","journal-title":"Mol Biol Cell"},{"key":"445_CR28","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.20858","volume":"59","author":"O St\u00fcve","year":"2006","unstructured":"St\u00fcve O, Marra CM, Jerome KR, Cook L, Cravens PD, Cepok S, Frohman EM, Phillips JT, Arendt G, Hemmer B, Monson NL, Racke MK (2006) Immune surveillance in multiple sclerosis patients treated with natalizumab. Ann Neurol 59:743\u2013747","journal-title":"Ann Neurol"},{"key":"445_CR29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1084\/jem.184.1.203","volume":"184","author":"GH Su","year":"1996","unstructured":"Su GH, Ip HS, Cobb BS, Lu MM, Chen HM, Simon MC (1996) The Ets protein Spi-B is expressed exclusively in B cells and T cells during development. J Exp Med 184:203\u2013214","journal-title":"J Exp Med"},{"key":"445_CR30","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1212\/WNL.0b013e3182583022","volume":"78","author":"AK Trampe","year":"2012","unstructured":"Trampe AK, Hemmelmann C, Stroet A, Haghikia A, Hellwig K, Wiendl H, Goelz S, Ziegler A, Gold R, Chan A (2012) Anti-JC virus antibodies in a large German natalizumab-treated multiple sclerosis cohort. Neurology 78:1736\u20131742","journal-title":"Neurology"},{"key":"445_CR31","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1093\/hmg\/10.17.1807","volume":"10","author":"S Waelter","year":"2001","unstructured":"Waelter S, Scherzinger E, Hasenbank R, Nordhoff E, Lurz R, Goehler H, Gauss C, Sathasivam K, Bates GP, Lehrach H, Wanker EE (2001) The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. Hum Mol Genet 10:1807\u20131817","journal-title":"Hum Mol Genet"},{"key":"445_CR32","doi-asserted-by":"crossref","first-page":"Article 17","DOI":"10.2202\/1544-6115.1128","volume":"4","author":"B Zhang","year":"2005","unstructured":"Zhang B, Horvath S (2005) A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol 4:Article 17","journal-title":"Stat Appl Genet Mol Biol"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-016-0445-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13365-016-0445-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-016-0445-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-016-0445-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T18:04:45Z","timestamp":1600538685000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13365-016-0445-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,11]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["445"],"URL":"https:\/\/doi.org\/10.1007\/s13365-016-0445-4","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,11]]}}}