{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:53:39Z","timestamp":1790679219894,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["148361"],"award-info":[{"award-number":["148361"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s13365-018-0666-9","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T09:31:56Z","timestamp":1533807116000},"page":"761-768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis"],"prefix":"10.1007","volume":"24","author":[{"given":"Coraline","family":"Canivet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Rh\u00e9aume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Piret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gosselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"666_CR1","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1084\/jem.20142274","volume":"212","author":"LL Andersen","year":"2015","unstructured":"Andersen LL, Mork N, Reinert LS, Kofod-Olsen E, Narita R, Jorgensen SE, Skipper KA, Honing K, Gad HH, Ostergaard L, Orntoft TF, Hornung V, Paludan SR, Mikkelsen JG, Fujita T, Christiansen M, Hartmann R, Mogensen TH (2015) Functional IRF3 deficiency in a patient with herpes simplex encephalitis. J Exp Med 212:1371\u20131379. \n                    https:\/\/doi.org\/10.1084\/jem.20142274","journal-title":"J Exp Med"},{"key":"666_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1089\/107999002753452665","volume":"22","author":"B Barnes","year":"2002","unstructured":"Barnes B, Lubyova B, Pitha PM (2002) On the role of IRF in host defense. J Interf Cytokine Res 22:59\u201371. \n                    https:\/\/doi.org\/10.1089\/107999002753452665","journal-title":"J Interf Cytokine Res"},{"key":"666_CR3","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.antiviral.2013.10.007","volume":"100","author":"N Boivin","year":"2013","unstructured":"Boivin N, Menasria R, Piret J, Rivest S, Boivin G (2013) The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis. Antivir Res 100:649\u2013653. \n                    https:\/\/doi.org\/10.1016\/j.antiviral.2013.10.007","journal-title":"Antivir Res"},{"key":"666_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.mib.2010.05.007","volume":"13","author":"K Brennan","year":"2010","unstructured":"Brennan K, Bowie AG (2010) Activation of host pattern recognition receptors by viruses. Curr Opin Microbiol 13:503\u2013507. \n                    https:\/\/doi.org\/10.1016\/j.mib.2010.05.007","journal-title":"Curr Opin Microbiol"},{"key":"666_CR5","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/j.ajpath.2013.06.014","volume":"183","author":"KM Bryant-Hudson","year":"2013","unstructured":"Bryant-Hudson KM, Chucair-Elliott AJ, Conrady CD, Cohen A, Zheng M, Carr DJJ (2013) HSV-1 targets lymphatic vessels in the eye and draining lymph node of mice leading to edema in the absence of a functional type I interferon response. Am J Pathol 183:1233\u20131242. \n                    https:\/\/doi.org\/10.1016\/j.ajpath.2013.06.014","journal-title":"Am J Pathol"},{"key":"666_CR6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.antiviral.2015.09.007","volume":"123","author":"C Canivet","year":"2015","unstructured":"Canivet C, Menasria R, Rheaume C, Piret J, Boivin G (2015) Valacyclovir combined with artesunate or rapamycin improves the outcome of herpes simplex virus encephalitis in mice compared to antiviral therapy alone. Antivir Res 123:105\u2013113. \n                    https:\/\/doi.org\/10.1016\/j.antiviral.2015.09.007","journal-title":"Antivir Res"},{"key":"666_CR7","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molimm.2008.10.010","volume":"46","author":"T Chew","year":"2009","unstructured":"Chew T, Noyce R, Collins SE, Hancock MH, Mossman KL (2009) Characterization of the interferon regulatory factor 3-mediated antiviral response in a cell line deficient for IFN production. Mol Immunol 46:393\u2013399. \n                    https:\/\/doi.org\/10.1016\/j.molimm.2008.10.010","journal-title":"Mol Immunol"},{"key":"666_CR8","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S1074-7613(00)80146-6","volume":"11","author":"WM Chu","year":"1999","unstructured":"Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M (1999) JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity 11:721\u2013731","journal-title":"Immunity"},{"key":"666_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2009.09.013","volume":"220","author":"CD Conrady","year":"2010","unstructured":"Conrady CD, Drevets DA, Carr DJ (2010) Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing? J Neuroimmunol 220:1\u20139. \n                    https:\/\/doi.org\/10.1016\/j.jneuroim.2009.09.013","journal-title":"J Neuroimmunol"},{"key":"666_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.cytogfr.2012.01.001","volume":"23","author":"C Fritz-French","year":"2012","unstructured":"Fritz-French C, Tyor W (2012) Interferon-\u03b1 (IFN\u03b1) neurotoxicity. Cytokine Growth Factor Rev 23:7\u201314. \n                    https:\/\/doi.org\/10.1016\/j.cytogfr.2012.01.001","journal-title":"Cytokine Growth Factor Rev"},{"key":"666_CR11","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/337270a0","volume":"337","author":"T Fujita","year":"1989","unstructured":"Fujita T, Kimura Y, Miyamoto M, Barsoumian EL, Taniguchi T (1989) Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1. Nature 337:270\u2013272. \n                    https:\/\/doi.org\/10.1038\/337270a0","journal-title":"Nature"},{"key":"666_CR12","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nature03464","volume":"434","author":"K Honda","year":"2005","unstructured":"Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434:772\u2013777. \n                    https:\/\/doi.org\/10.1038\/nature03464","journal-title":"Nature"},{"key":"666_CR13","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1128\/MCB.20.2.617-627.2000","volume":"20","author":"MS Iordanov","year":"2000","unstructured":"Iordanov MS, Paranjape JM, Zhou A, Wong J, Williams BR, Meurs EF, Silverman RH, Magun BE (2000) Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways. Mol Cell Biol 20:617\u2013627","journal-title":"Mol Cell Biol"},{"key":"666_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1006\/smim.2000.0210","volume":"12","author":"M Karin","year":"2000","unstructured":"Karin M, Delhase M (2000) The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 12:85\u201398. \n                    https:\/\/doi.org\/10.1006\/smim.2000.0210","journal-title":"Semin Immunol"},{"key":"666_CR15","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s13365-013-0178-6","volume":"19","author":"PG Kennedy","year":"2013","unstructured":"Kennedy PG, Steiner I (2013) Recent issues in herpes simplex encephalitis. J Neuro-Oncol 19:346\u2013350. \n                    https:\/\/doi.org\/10.1007\/s13365-013-0178-6","journal-title":"J Neuro-Oncol"},{"key":"666_CR16","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1073\/pnas.0308057100","volume":"101","author":"EA Kurt-Jones","year":"2004","unstructured":"Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW (2004) Herpes simplex virus 1 interaction with toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A 101:1315\u20131320. \n                    https:\/\/doi.org\/10.1073\/pnas.0308057100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"666_CR17","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1084\/jem.189.4.663","volume":"189","author":"DA Leib","year":"1999","unstructured":"Leib DA, Harrison TE, Laslo KM, Machalek MA, Moorman NJ, Virgin HW (1999) Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo. J Exp Med 189:663\u2013672","journal-title":"J Exp Med"},{"key":"666_CR18","doi-asserted-by":"publisher","first-page":"34320","DOI":"10.1074\/jbc.M002814200","volume":"275","author":"R Lin","year":"2000","unstructured":"Lin R, Mamane Y, Hiscott J (2000) Multiple regulatory domains control IRF-7 activity in response to virus infection. J Biol Chem 275:34320\u201334327. \n                    https:\/\/doi.org\/10.1074\/jbc.M002814200","journal-title":"J Biol Chem"},{"key":"666_CR19","doi-asserted-by":"publisher","first-page":"11082","DOI":"10.1128\/JVI.77.20.11082-11093.2003","volume":"77","author":"GD Luker","year":"2003","unstructured":"Luker GD, Prior JL, Song J, Pica CM, Leib DA (2003) Bioluminescence imaging reveals systemic dissemination of herpes simplex virus type 1 in the absence of interferon receptors. J Virol 77:11082\u201311093","journal-title":"J Virol"},{"key":"666_CR20","doi-asserted-by":"publisher","first-page":"7078","DOI":"10.1128\/JVI.00619-08","volume":"82","author":"P Lundberg","year":"2008","unstructured":"Lundberg P, Ramakrishna C, Brown J, Tyszka JM, Hamamura M, Hinton DR, Kovats S, Nalcioglu O, Weinberg K, Openshaw H, Cantin EM (2008) The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol 82:7078\u20137088. \n                    https:\/\/doi.org\/10.1128\/JVI.00619-08","journal-title":"J Virol"},{"key":"666_CR21","doi-asserted-by":"publisher","first-page":"12399","DOI":"10.1128\/JVI.00888-09","volume":"83","author":"VD Menachery","year":"2009","unstructured":"Menachery VD, Leib DA (2009) Control of herpes simplex virus replication is mediated through an interferon regulatory factor 3-dependent pathway. J Virol 83:12399\u201312406. \n                    https:\/\/doi.org\/10.1128\/JVI.00888-09","journal-title":"J Virol"},{"key":"666_CR22","doi-asserted-by":"publisher","first-page":"9685","DOI":"10.1128\/JVI.00706-10","volume":"84","author":"VD Menachery","year":"2010","unstructured":"Menachery VD, Pasieka TJ, Leib DA (2010) Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection. J Virol 84:9685\u20139694. \n                    https:\/\/doi.org\/10.1128\/JVI.00706-10","journal-title":"J Virol"},{"key":"666_CR23","doi-asserted-by":"publisher","first-page":"7301","DOI":"10.1128\/JVI.00591-13","volume":"87","author":"R Menasria","year":"2013","unstructured":"Menasria R, Boivin N, Lebel M, Piret J, Gosselin J, Boivin G (2013) Both TRIF and IPS-1 adaptor proteins contribute to the cerebral innate immune response against herpes simplex virus 1 infection. J Virol 87:7301\u20137308. \n                    https:\/\/doi.org\/10.1128\/JVI.00591-13","journal-title":"J Virol"},{"key":"666_CR24","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.virol.2013.05.034","volume":"444","author":"AA Murphy","year":"2013","unstructured":"Murphy AA, Rosato PC, Parker ZM, Khalenkov A, Leib DA (2013) Synergistic control of herpes simplex virus pathogenesis by IRF-3, and IRF-7 revealed through non-invasive bioluminescence imaging. Virology 444:71\u201379. \n                    https:\/\/doi.org\/10.1016\/j.virol.2013.05.034","journal-title":"Virology"},{"key":"666_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nri2937","volume":"11","author":"SR Paludan","year":"2011","unstructured":"Paludan SR, Bowie AG, Horan KA, Fitzgerald KA (2011) Recognition of herpesviruses by the innate immune system. Nat Rev Immunol 11:143\u2013154. \n                    https:\/\/doi.org\/10.1038\/nri2937","journal-title":"Nat Rev Immunol"},{"key":"666_CR26","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.cell.2007.05.019","volume":"129","author":"D Panne","year":"2007","unstructured":"Panne D, Maniatis T, Harrison SC (2007) An atomic model of the interferon-beta enhanceosome. Cell 129:1111\u20131123. \n                    https:\/\/doi.org\/10.1016\/j.cell.2007.05.019","journal-title":"Cell"},{"key":"666_CR27","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/rmv.1848","volume":"25","author":"J Piret","year":"2015","unstructured":"Piret J, Boivin G (2015) Innate immune response during herpes simplex virus encephalitis and development of immunomodulatory strategies. Rev Med Virol 25:300\u2013319. \n                    https:\/\/doi.org\/10.1002\/rmv.1848","journal-title":"Rev Med Virol"},{"key":"666_CR28","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/j.1460-2075.1992.tb05041.x","volume":"11","author":"LF Reis","year":"1992","unstructured":"Reis LF, Harada H, Wolchok JD, Taniguchi T, Vilcek J (1992) Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes. EMBO J 11:185\u2013193","journal-title":"EMBO J"},{"key":"666_CR29","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2174\/187152611795768088","volume":"11","author":"F Rozenberg","year":"2011","unstructured":"Rozenberg F, Deback C, Agut H (2011) Herpes simplex encephalitis : from virus to therapy. Infect Disord Drug Targets 11:235\u2013250","journal-title":"Infect Disord Drug Targets"},{"key":"666_CR30","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.1523\/JNEUROSCI.5595-08.2009","volume":"29","author":"AR Sas","year":"2009","unstructured":"Sas AR, Bimonte-Nelson H, Smothers CT, Woodward J, Tyor WR (2009) Interferon-alpha causes neuronal dysfunction in encephalitis. J Neurosci 29:3948\u20133955. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.5595-08.2009","journal-title":"J Neurosci"},{"key":"666_CR31","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S0014-5793(98)01514-2","volume":"441","author":"M Sato","year":"1998","unstructured":"Sato M, Hata N, Asagiri M, Nakaya T, Taniguchi T, Tanaka N (1998) Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7. FEBS Lett 441:106\u2013110","journal-title":"FEBS Lett"},{"key":"666_CR32","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","volume":"13","author":"M Sato","year":"2000","unstructured":"Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, Nakaya T, Katsuki M, Noguchi S, Tanaka N, Taniguchi T (2000) Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha\/beta gene induction. Immunity 13:539\u2013548","journal-title":"Immunity"},{"key":"666_CR33","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1086\/511987","volume":"195","author":"Y Sergerie","year":"2007","unstructured":"Sergerie Y, Boivin G, Gosselin D, Rivest S (2007a) Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice. J Infect Dis 195:817\u2013825","journal-title":"J Infect Dis"},{"key":"666_CR34","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1086\/520094","volume":"196","author":"Y Sergerie","year":"2007","unstructured":"Sergerie Y, Rivest S, Boivin G (2007b) Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis. J Infect Dis 196:853\u2013860","journal-title":"J Infect Dis"},{"key":"666_CR35","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3390\/v5030834","volume":"5","author":"F Sorgeloos","year":"2013","unstructured":"Sorgeloos F, Kreit M, Hermant P, Lardinois C, Michiels T (2013) Antiviral type I and type III interferon responses in the central nervous system. Viruses 5:834\u2013857. \n                    https:\/\/doi.org\/10.3390\/v5030834","journal-title":"Viruses"},{"key":"666_CR36","first-page":"169","volume":"1","author":"KL Tyler","year":"2004","unstructured":"Tyler KL (2004) Update on herpes simplex encephalitis. Rev Neurol Dis 1:169\u2013178","journal-title":"Rev Neurol Dis"},{"key":"666_CR37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.coi.2012.11.001","volume":"25","author":"SY Zhang","year":"2013","unstructured":"Zhang SY, Herman M, Ciancanelli MJ, P\u00e9rez de Diego R, Sancho-Shimizu V, Abel L, Casanova JL (2013) TLR3 immunity to infection in mice and humans. Curr Opin Immunol 25:19\u201333. \n                    https:\/\/doi.org\/10.1016\/j.coi.2012.11.001","journal-title":"Curr Opin Immunol"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13365-018-0666-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-018-0666-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-018-0666-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T07:40:17Z","timestamp":1569224417000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13365-018-0666-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["666"],"URL":"https:\/\/doi.org\/10.1007\/s13365-018-0666-9","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]},"assertion":[{"value":"1 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animals were used in accordance with the Canadian Council on Animal Care guidelines, and all procedures were approved by the Animal Care Ethics Committee of Laval University (protocol no. 2013-078).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}