{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:46:26Z","timestamp":1788057986768,"version":"build-2784847793"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["NS003130"],"award-info":[{"award-number":["NS003130"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s13365-019-00736-z","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T14:04:01Z","timestamp":1556028241000},"page":"648-660","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["HIV and Alzheimer\u2019s disease: complex interactions of HIV-Tat with amyloid \u03b2 peptide and Tau protein"],"prefix":"10.1007","volume":"25","author":[{"given":"Alina","family":"Hategan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer","family":"Masliah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-5855","authenticated-orcid":false,"given":"Avindra","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"issue":"2","key":"736_CR1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s11481-009-9152-8","volume":"4","author":"CL Achim","year":"2009","unstructured":"Achim CL, Adame A, Dumaop W, Everall IP, Masliah E, Neurobehavioral Research Center (2009) Increased accumulation of intraneuronal amyloid beta in HIV-infected patients. J NeuroImmune Pharmacol 4(2):190\u2013199","journal-title":"J NeuroImmune Pharmacol"},{"issue":"5","key":"736_CR2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nsmb.1799","volume":"17","author":"M Ahmed","year":"2010","unstructured":"Ahmed M, Davis J, Aucoin D, Sato T, Ahuja S, Aimoto S, Elliott JI, Van Nostrand WE, Smith SO (2010) Structural conversion of neurotoxic amyloid-beta (1-42) oligomers to fibrils. Nat Struct Mol Biol 17(5):561\u2013567","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"736_CR3","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.expneurol.2009.07.005","volume":"219","author":"MY Aksenov","year":"2009","unstructured":"Aksenov MY, Aksenova MV, Mactutus CF, Booze RM (2009) Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures. Exp Neurol 219(2):586\u2013590","journal-title":"Exp Neurol"},{"issue":"3","key":"736_CR4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neulet.2010.03.073","volume":"475","author":"MY Aksenov","year":"2010","unstructured":"Aksenov MY, Aksenova MV, Mactutus CF, Booze RM (2010) HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures. Neurosci Lett 475(3):174\u2013178","journal-title":"Neurosci Lett"},{"issue":"12","key":"736_CR5","doi-asserted-by":"publisher","first-page":"6923","DOI":"10.1073\/pnas.121119298","volume":"98","author":"A Alonso","year":"2001","unstructured":"Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K (2001) Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments\/straight filaments. Proc Natl Acad Sci U S A 98(12):6923\u20136928","journal-title":"Proc Natl Acad Sci U S A"},{"key":"736_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/978-1-61779-185-7_26","volume":"762","author":"IE Andr\u00e1s","year":"2011","unstructured":"Andr\u00e1s IE, Toborek M (2011) HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level. Methods Mol Biol 762:355\u2013370","journal-title":"Methods Mol Biol"},{"issue":"1","key":"736_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/iub.1106","volume":"65","author":"IE Andr\u00e1s","year":"2013","unstructured":"Andr\u00e1s IE, Toborek M (2013) Amyloid beta accumulation in HIV-1-infected brain: the role of the blood brain barrier. IUBMB Life 65(1):43\u201349","journal-title":"IUBMB Life"},{"issue":"2","key":"736_CR8","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/jnr.10762","volume":"74","author":"IE Andr\u00e1s","year":"2003","unstructured":"Andr\u00e1s IE, Pu H, Deli MA, Nath A, Hennig B, Toborek M (2003) HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells. J Neurosci Res 74(2):255\u2013265","journal-title":"J Neurosci Res"},{"issue":"9","key":"736_CR9","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/sj.jcbfm.9600115","volume":"25","author":"IE Andr\u00e1s","year":"2005","unstructured":"Andr\u00e1s IE, Pu H, Tian J, Deli MA, Andr\u00e1s IE, Pu H, Tian J, Deli MA, Nath A, Hennig B, Toborek M (2005) Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J Cereb Blood Flow Metab 25(9):1159\u20131170","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"736_CR10","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1124\/mol.107.042028","volume":"73","author":"IE Andr\u00e1s","year":"2008","unstructured":"Andr\u00e1s IE, Rha G, Huang W, Eum S, Couraud PO, Romero IA, Hennig B, Toborek M (2008) Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells. Mol Pharmacol 73(5):1424\u20131433","journal-title":"Mol Pharmacol"},{"issue":"2","key":"736_CR11","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.mcn.2009.11.004","volume":"43","author":"IE Andr\u00e1s","year":"2010","unstructured":"Andr\u00e1s IE, Eum SY, Huang W, Zhong Y, Hennig B, Toborek M (2010) HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin. Mol Cell Neurosci 43(2):232\u2013243","journal-title":"Mol Cell Neurosci"},{"key":"736_CR12","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.4049\/jimmunol.173.10.6228","volume":"173","author":"HK Avraham","year":"2004","unstructured":"Avraham HK, Jiang S, Lee TH, Prakash O, Avraham S (2004) HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells. J Immunol 173:6228\u20136233","journal-title":"J Immunol"},{"key":"736_CR13","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1186\/1743-422X-10-358","volume":"10","author":"A Bagashev","year":"2013","unstructured":"Bagashev A, Sawaya BE (2013) Roles and functions of HIV-1 Tat protein in the CNS: an overview. Virol J 10:358\u2013378","journal-title":"Virol J"},{"key":"736_CR14","doi-asserted-by":"publisher","first-page":"6405","DOI":"10.1021\/jp410275y","volume":"118","author":"KA Ball","year":"2014","unstructured":"Ball KA, Wemmer DE, Head-Gordon T (2014) Comparison of structure determination methods for intrinsically disordered amyloid-\u03b2 peptides. J Phys Chem B 118:6405\u20136416","journal-title":"J Phys Chem B"},{"issue":"6","key":"736_CR15","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/sj.mp.4000552","volume":"4","author":"TA Bayer","year":"1999","unstructured":"Bayer TA, Cappai R, Masters CL, Beyreuther K, Multhaup G (1999) It all sticks together- -the APP-related family of proteins and Alzheimer\u2019s disease. Mol Psychiatry 4(6):524\u2013528","journal-title":"Mol Psychiatry"},{"key":"736_CR16","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1097\/00002030-200401001-00003","volume":"18","author":"JT Becker","year":"2004","unstructured":"Becker JT, Lopez OL, Dew MA, Aizenstein HJ (2004) Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS 18:S11\u2013S18","journal-title":"AIDS"},{"issue":"3","key":"736_CR17","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.bbamem.2014.12.015","volume":"1848","author":"N Ben-Dov","year":"2015","unstructured":"Ben-Dov N, Korenstein R (2015) The uptake of HIV Tat peptide proceeds via two pathways which differ from macropinocytosis. Biochim Biophys Acta 1848(3):869\u2013877","journal-title":"Biochim Biophys Acta"},{"issue":"17","key":"736_CR18","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1016\/j.cub.2016.06.046","volume":"26","author":"NA Bright","year":"2016","unstructured":"Bright NA, Davis LJ, Luzio JP (2016) Endolysosomes are the principal intracellular sites of acid hydrolase activity. Curr Biol 26(17):2233\u20132245","journal-title":"Curr Biol"},{"issue":"4","key":"736_CR19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.addr.2004.12.001","volume":"57","author":"H Brooks","year":"2005","unstructured":"Brooks H, Lebleu B, Viv\u00e8s E (2005) Tat peptide-mediated cellular delivery: back to basics. Adv Drug Deliv Rev 57(4):559\u2013577","journal-title":"Adv Drug Deliv Rev"},{"key":"736_CR20","first-page":"1","volume":"9","author":"XL Bu","year":"2018","unstructured":"Bu XL, Xiang Y, Jin WS, Wang J, Shen LL, Huang ZL, Zhang K, Liu YH, Zeng F, Liu JH, Sun HL, Zhuang ZQ, Chen SH, Yao XQ, Giunta B, Shan YC, Tan J, Chen XW, Dong ZF, Zhou HD, Zhou XF, Song W, Wang YJ (2018) Blood-derived amyloid-\u03b2 protein induces Alzheimer\u2019s disease pathologies. Mol Psychiatry 9:1\u20139","journal-title":"Mol Psychiatry"},{"issue":"1","key":"736_CR21","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0002-9440(10)64538-5","volume":"157","author":"AM Cataldo","year":"2000","unstructured":"Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA (2000) Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer\u2019s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 157(1):277\u2013286","journal-title":"Am J Pathol"},{"issue":"8","key":"736_CR22","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.neurobiolaging.2011.06.004","volume":"33","author":"L Chen","year":"2012","unstructured":"Chen L, Choi JJ, Choi YJ, Hennig B, Toborek M (2012) HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits. Neurobiol Aging 33(8):1579\u20131590","journal-title":"Neurobiol Aging"},{"issue":"10","key":"736_CR23","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1016\/j.neurobiolaging.2013.04.015","volume":"34","author":"X Chen","year":"2013","unstructured":"Chen X, Hui L, Geiger NH, Haughey NJ, Geiger JD (2013) Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production. Neurobiol Aging 34(10):2370\u20132378","journal-title":"Neurobiol Aging"},{"key":"736_CR24","first-page":"4196572","volume":"2016","author":"Y Chen","year":"2016","unstructured":"Chen Y, Huang W, Jiang W, Wu X, Ye B, Zhou X (2016) HIV-1 Tat regulates occludin and A\u03b2 transfer receptor expression in brain endothelial cells via Rho\/ROCK signaling pathway. Oxidative Med Cell Longev 2016:4196572","journal-title":"Oxidative Med Cell Longev"},{"issue":"7","key":"736_CR25","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1073\/pnas.96.7.3590","volume":"96","author":"F Chiti","year":"1999","unstructured":"Chiti F, Webster P, Taddei N, Clark A, Stefani M, Ramponi G, Dobson CM (1999) Designing conditions for in vitro formation of amyloid protofilaments and fibrils. Proc Natl Acad Sci U S A 96(7):3590\u20133594","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"30","key":"736_CR26","doi-asserted-by":"publisher","first-page":"9663","DOI":"10.1021\/jacs.6b05129","volume":"138","author":"MT Colvin","year":"2016","unstructured":"Colvin MT, Silvers R, Ni QZ, Can TV, Sergeyev I, Rosay M, Donovan KJ, Michael B, Wall J, Linse S, Griffin RG (2016) Atomic resolution structure of monomorphic A\u03b2 42 amyloid fibrils. J Am Chem Soc 138(30):9663\u20139674","journal-title":"J Am Chem Soc"},{"key":"736_CR27","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1471-2105-8-65","volume":"8","author":"O Conchillo-Sol\u00e9","year":"2007","unstructured":"Conchillo-Sol\u00e9 O, de Groot NS, Avil\u00e9s FX, Vendrell J, Daura X, Ventura S (2007) AGGRESCAN: a server for the prediction and evaluation of \u201chot spots\u201d of aggregation in polypeptides. BMC Bioinformatics 8:65","journal-title":"BMC Bioinformatics"},{"key":"736_CR28","first-page":"153","volume":"12","author":"A Daily","year":"2006","unstructured":"Daily A, Nath A, Hersh L (2006) Tat peptides inhibit neprilysin. J Neuro-Oncol 12:153\u2013160","journal-title":"J Neuro-Oncol"},{"issue":"1","key":"736_CR29","first-page":"28","volume":"24","author":"SM de Almeida","year":"2018","unstructured":"de Almeida SM, Ribeiro CE, Rotta I, Piovesan M, Tang B, Vaida F, Raboni SM, Letendre S, Potter M, Batistela Fernandes MS, Ellis RJ, HIV Neurobehavioral Research Center (HNRC) Group (2018) Biomarkers of neuronal injury and amyloid metabolism in the cerebrospinal fluid of patients infected with HIV-1 subtypes B and C. J Neuro-Oncol 24(1):28\u201340","journal-title":"J Neuro-Oncol"},{"key":"736_CR30","volume-title":"Computational drug discovery and design. Methods in molecular biology (methods and protocols)","author":"NS de Groot","year":"2012","unstructured":"de Groot NS, Castillo V, Gra\u00f1a-Montes R, Ventura S (2012) AGGRESCAN: method, application, and perspectives for drug design. In: Baron R (ed) Computational drug discovery and design. Methods in molecular biology (methods and protocols), vol 819. Springer, New York"},{"issue":"11 Suppl 1","key":"736_CR31","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1161\/01.STR.0000143452.85382.d1","volume":"35","author":"R Deane","year":"2004","unstructured":"Deane R, Wu Z, Zlokovic BV (2004) RAGE (yin) versus LRP (yang) balance regulates Alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke 35(11 Suppl 1):2628\u20132631","journal-title":"Stroke"},{"key":"736_CR32","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1600-0854.2011.01286.x","volume":"13","author":"S Debaisieux","year":"2012","unstructured":"Debaisieux S, Rayne F, Yezid H, Beaumelle B (2012) The ins and outs of HIV-1 Tat. Traffic 13:355\u2013363","journal-title":"Traffic"},{"key":"736_CR33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S1093-3263(00)00138-8","volume":"19","author":"AK Dunker","year":"2001","unstructured":"Dunker AK, Lawson JD, Brown CJ, Williams RM, Romero P, Oh JS, Oldfield CJ, Campen AM, Ratliff CM, Hipps KW, Aussio J, Nissen MS, Reeves R, Kang C, Kissinger CR, Bailey RW, Griswold MD, Chiu W, Garner EC, Obradovic Z (2001) Intrinsically disordered protein. J Mol Graph Model 19:26\u201359","journal-title":"J Mol Graph Model"},{"key":"736_CR34","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1083\/jcb.200207113","volume":"160","author":"R Ehehalt","year":"2003","unstructured":"Ehehalt R, Keller P, Haass C, Thiele C, Simons K (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160:113\u2013123","journal-title":"J Cell Biol"},{"key":"736_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/jnnp.65.1.29","volume":"65","author":"MM Esiri","year":"1998","unstructured":"Esiri MM, Biddolph SC, Morris CS (1998) Prevalence of Alzheimer plaques in AIDS. J Neurol Neurosurg Psychiatry 65:29\u201333","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"736_CR36","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1750-3639.1999.tb00219.x","volume":"9","author":"IP Everall","year":"1999","unstructured":"Everall IP, Heaton RK, Marcotte TD, Ellis RJ, McCutchan JA, Atkinson JH, Grant I, Mallory M, Masliah E (1999) Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center. Brain Pathol 9:209\u2013217","journal-title":"Brain Pathol"},{"issue":"2","key":"736_CR37","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S1525-0016(03)00122-9","volume":"8","author":"A Ferrari","year":"2003","unstructured":"Ferrari A, Pellegrini V, Arcangeli C, Fittipaldi A, Giacca M, Beltram F (2003) Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time. Mol Ther 8(2):284\u2013294","journal-title":"Mol Ther"},{"issue":"22","key":"736_CR38","doi-asserted-by":"publisher","first-page":"4387","DOI":"10.1007\/s00018-014-1702-4","volume":"71","author":"D Ferrell","year":"2014","unstructured":"Ferrell D, Giunta B (2014) The impact of HIV-1 on neurogenesis: implications for HAND. Cell Mol Life Sci 71(22):4387\u20134392","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"736_CR39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2174\/1570162X13666150311164201","volume":"13","author":"JA Fields","year":"2015","unstructured":"Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E (2015a) Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res 13(1):43\u201354","journal-title":"Curr HIV Res"},{"issue":"5","key":"736_CR40","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1523\/JNEUROSCI.3207-14.2015","volume":"35","author":"J Fields","year":"2015","unstructured":"Fields J, Dumaop W, Eleuteri S, Campos S, Serger E, Trejo M, Kosberg K, Adame A, Spencer B, Rockenstein E, He JJ, Masliah E (2015b) HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci 35(5):1921\u20131938","journal-title":"J Neurosci"},{"issue":"36","key":"736_CR41","doi-asserted-by":"publisher","first-page":"34141","DOI":"10.1074\/jbc.M303045200","volume":"278","author":"A Fittipaldi","year":"2003","unstructured":"Fittipaldi A, Ferrari A, Zopp\u00e9 M, Arcangeli C, Pellegrini V, Beltram F, Giacca M (2003) Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins. J Biol Chem 278(36):34141\u201334149","journal-title":"J Biol Chem"},{"issue":"7662","key":"736_CR42","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature23002","volume":"547","author":"AWP Fitzpatrick","year":"2017","unstructured":"Fitzpatrick AWP, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SHW (2017) Cryo-EM structures of tau filaments from Alzheimer\u2019s disease. Nature 547(7662):185\u2013190","journal-title":"Nature"},{"issue":"6","key":"736_CR43","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/0092-8674(88)90263-2","volume":"55","author":"AD Frankel","year":"1988","unstructured":"Frankel AD, Pabo CO (1988) Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55(6):1189\u20131193","journal-title":"Cell"},{"issue":"44","key":"736_CR44","doi-asserted-by":"publisher","first-page":"10716","DOI":"10.1021\/bi00159a011","volume":"31","author":"PE Fraser","year":"1992","unstructured":"Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, Podlisny MB, Kirschner DA (1992) Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry 31(44):10716\u201310723","journal-title":"Biochemistry"},{"key":"736_CR45","first-page":"41","volume":"10","author":"E Garner","year":"1999","unstructured":"Garner E, Romero P, Dunker AK, Brown C, Obradovic Z (1999) Predicting binding regions within disordered proteins. Genome Inform 10:41\u201350","journal-title":"Genome Inform"},{"key":"736_CR46","first-page":"260","volume":"1","author":"B Giunta","year":"2008","unstructured":"Giunta B, Zhou Y, Hou H, Rrapo E, Fernandez F et al (2008) HIV-1 Tat inhibits microglial phagocytosis of Abeta peptide. Int J Clin Exp Pathol 1:260\u2013275","journal-title":"Int J Clin Exp Pathol"},{"key":"736_CR47","first-page":"433","volume":"2","author":"B Giunta","year":"2009","unstructured":"Giunta B, Hou H, Zhu Y, Rrapo E, Tian J et al (2009) HIV-1 Tat contributes to Alzheimer\u2019s disease-like pathology in PSAPP mice. Int J Clin Exp Pathol 2:433\u2013443","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"736_CR48","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1756-6606-4-23","volume":"4","author":"B Giunta","year":"2011","unstructured":"Giunta B, Ehrhart J, Obregon DF, Lam L, Le L, Jin J, Fernandez F, Tan J, Shytle RD (2011) Antiretroviral medications disrupt microglial phagocytosis of \u03b2-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders. Mol Brain 4(1):23","journal-title":"Mol Brain"},{"key":"736_CR49","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/01.aids.0000161770.06158.5c","volume":"19","author":"DA Green","year":"2005","unstructured":"Green DA, Masliah E, Vinters HV, Beizai P, Moore DJ, Achim CL (2005) Brain deposition of \u03b2-amyloid is a common pathologic feature in HIV positive patients. AIDS 19:407\u2013411","journal-title":"AIDS"},{"key":"736_CR50","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0042-6822(02)00068-5","volume":"307","author":"X Guo","year":"2003","unstructured":"Guo X, Kameoka M, Wei X, Roques B, Gotte M, Liang C, Wainberg MA (2003) Suppression of an intrinsic strand transfer activity of HIV-1 Tat protein by its second-exon sequences. Virology 307:154\u2013163","journal-title":"Virology"},{"issue":"11","key":"736_CR51","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1021\/bi00463a003","volume":"29","author":"K Halverson","year":"1990","unstructured":"Halverson K, Fraser PE, Kirschner DA, Lansbury PT Jr (1990) Molecular determinants of amyloid deposition in Alzheimer\u2019s disease: conformational studies of synthetic beta-protein fragments. Biochemistry 29(11):2639\u20132644","journal-title":"Biochemistry"},{"issue":"4","key":"736_CR52","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nsmb.3379","volume":"24","author":"A Hategan","year":"2017","unstructured":"Hategan A, Bianchet MA, Steiner J, Karnaukhova E, Masliah E, Fields A, Lee MH, Dickens AM, Haughey N, Dimitriadis EK, Nath A (2017) HIV Tat protein and amyloid-\u03b2 peptide form multifibrillar structures that cause neurotoxicity. Nat Struct Mol Biol 24(4):379\u2013386","journal-title":"Nat Struct Mol Biol"},{"issue":"5","key":"736_CR53","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1111\/j.1471-4159.2005.03114.x","volume":"93","author":"K Hayashi","year":"2005","unstructured":"Hayashi K, Pu H, Tian J, Andras IE, Lee YW, Hennig B, Toborek M (2005) HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells. J Neurochem 93(5):1231\u20131241","journal-title":"J Neurochem"},{"issue":"8","key":"736_CR54","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/sj.jcbfm.9600254","volume":"26","author":"K Hayashi","year":"2006","unstructured":"Hayashi K, Pu H, Andras IE, Eum SY, Yamauchi A, Hennig B, Toborek M (2006) HIVTAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier. J Cereb Blood Flow Metab 26(8):1052\u20131065","journal-title":"J Cereb Blood Flow Metab"},{"key":"736_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0306-4522(93)90278-N","volume":"53","author":"M Hayman","year":"1993","unstructured":"Hayman M, Arbuthnott G, Harkiss G, Brace H, Filippi P, Philippon V, Thomson D, Vigne R, Wright A (1993) Neurotoxicity of peptide analogues of the transactivating protein Tat from Maedi-Visna virus and human immunodeficiency virus. Neuroscience 53:1\u20136","journal-title":"Neuroscience"},{"issue":"1","key":"736_CR56","first-page":"3","volume":"17","author":"RK Heaton","year":"2011","unstructured":"Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, Corkran SH, Duarte NA, Clifford DB, Woods SP, Collier AC, Marra CM, Morgello S, Mindt MR, Taylor MJ, Marcotte TD, Atkinson JH, Wolfson T, Gelman BB, McArthur JC, Simpson DM, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I, CHARTER Group, HNRC Group (2011) HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neuro-Oncol 17(1):3\u201316","journal-title":"J Neuro-Oncol"},{"key":"736_CR57","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1080\/13554794.2018.1530362","volume":"4","author":"J Hellmuth","year":"2018","unstructured":"Hellmuth J, Milanini B, Masliah E, Tartaglia MC, Dunlop MB, Moore DJ, Javandel S, DeVaughn S, Valcour V (2018) A neuropathologic diagnosis of Alzheimer\u2019s disease in an older adult with HIV-associated neurocognitive disorder. Neurocase 4:213\u2013219","journal-title":"Neurocase"},{"issue":"4","key":"736_CR58","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/jcbfm.2013.240","volume":"34","author":"W Huang","year":"2014","unstructured":"Huang W, Chen L, Zhang B, Park M, Toborek M (2014) PPAR agonist-mediated protection against HIV Tat-induced cerebrovascular toxicity is enhanced in MMP-9-deficient mice. J Cereb Blood Flow Metab 34(4):646\u2013653","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"736_CR59","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1042\/AN20120017","volume":"4","author":"L Hui","year":"2012","unstructured":"Hui L, Chen X, Haughey NJ, Geiger JD (2012) Role of endolysosomes in HIV-1 Tat-induced neurotoxicity. ASN Neuro 4(4):243\u2013252","journal-title":"ASN Neuro"},{"issue":"8","key":"736_CR60","doi-asserted-by":"publisher","first-page":"656","DOI":"10.2174\/156720510793611592","volume":"7","author":"K Iqbal","year":"2010","unstructured":"Iqbal K, Liu F, Gong CX, Grundke-Iqbal I (2010) Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res 7(8):656\u2013664","journal-title":"Curr Alzheimer Res"},{"issue":"5521","key":"736_CR61","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1126\/science.1059946","volume":"292","author":"N Iwata","year":"2001","unstructured":"Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee HJ, Saido TC (2001) Metabolic regulation of brain Abeta by neprilysin. Science 292(5521):1550\u20131552","journal-title":"Science"},{"issue":"3","key":"736_CR62","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3233\/JAD-2009-1074","volume":"17","author":"LB Jaeger","year":"2009","unstructured":"Jaeger LB, Dohgu S, Hwang MC, Farr SA, Murphy MP, Fleegal-DeMotta MA, Lynch JL, Robinson SM, Niehoff ML, Johnson SN, Kumar VB, Banks WA (2009) Testing the neurovascular hypothesis of Alzheimer\u2019s disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. J Alzheimers Dis 17(3):553\u2013570","journal-title":"J Alzheimers Dis"},{"key":"736_CR63","doi-asserted-by":"publisher","first-page":"28837","DOI":"10.1074\/jbc.274.41.28837","volume":"274","author":"KT Jeang","year":"1999","unstructured":"Jeang KT, Xiao H, Rich EA (1999) Multifaceted activities of the HIV-1 transactivator of transcription. Tat J Biol Chem 274:28837\u201328840","journal-title":"Tat J Biol Chem"},{"key":"736_CR64","first-page":"3160360","volume":"2017","author":"W Jiang","year":"2017","unstructured":"Jiang W, Huang W, Chen Y, Zou M, Peng D, Chen D (2017) HIV-1 Transactivator protein induces ZO-1 and neprilysin dysfunction in brain endothelial cells via the Ras signaling pathway. Oxidative Med Cell Longev 2017:3160360","journal-title":"Oxidative Med Cell Longev"},{"issue":"33","key":"736_CR65","doi-asserted-by":"publisher","first-page":"13588","DOI":"10.1073\/pnas.1308673110","volume":"10","author":"TP Johnson","year":"2013","unstructured":"Johnson TP, Patel K, Johnson KR, Maric D, Calabresi PA, Hasbun R, Nath A (2013) Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. Proc Natl Acad Sci U S A 10(33):13588\u201313593","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"52","key":"736_CR66","doi-asserted-by":"publisher","first-page":"30931","DOI":"10.1074\/jbc.M115.675751","volume":"290","author":"F Kadri","year":"2015","unstructured":"Kadri F, Pacifici M, Wilk A, Parker-Struckhoff A, Del Valle L, Hauser KF, Knapp PE, Parsons C, Jeansonne D, Lassak A, Peruzzi F (2015) HIV-1-Tat protein inhibits SC35-mediated Tau exon 10 inclusion through up-regulation of DYRK1A kinase. J Biol Chem 290(52):30931\u201330946","journal-title":"J Biol Chem"},{"key":"736_CR67","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1126\/science.1079469","volume":"300","author":"R Kayed","year":"2003","unstructured":"Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300:486\u2013489","journal-title":"Science"},{"key":"736_CR68","first-page":"179","volume":"2","author":"MB Khan","year":"2016","unstructured":"Khan MB, Lang MJ, Huang MB, Raymond A, Bond VC, Shiramizu B, Powell MD (2016) Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce A\u03b2_(1-42) secretion in SH-SY5Y neural cells. J Neuro-Oncol 2:179\u2013190","journal-title":"J Neuro-Oncol"},{"issue":"11","key":"736_CR69","doi-asserted-by":"publisher","first-page":"e77972","DOI":"10.1371\/journal.pone.0077972","volume":"8","author":"J Kim","year":"2013","unstructured":"Kim J, Yoon JH, Kim YS (2013) HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein. PLoS One 8(11):e77972","journal-title":"PLoS One"},{"key":"736_CR70","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.jmb.2010.06.023","volume":"401","author":"R Kodali","year":"2010","unstructured":"Kodali R, Williams AD, Chemuru S, Wetzel R (2010) Abeta(1-40) forms five distinct amyloid structures whose \u03b2-sheet contents and fibril stabilities are correlated. J Mol Biol 401:503\u2013517","journal-title":"J Mol Biol"},{"key":"736_CR71","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1073\/pnas.87.4.1561","volume":"87","author":"EH Koo","year":"1990","unstructured":"Koo EH, Sisodia SS, Archer DR, Martin LJ, Weidemann A, Beyreuther K, Fischer P, Masters CL, Price DL (1990) Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A 87:1561\u20131565","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"736_CR72","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1073\/pnas.96.7.3342","volume":"96","author":"PT Lansbury Jr","year":"1999","unstructured":"Lansbury PT Jr (1999) Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease. Proc Natl Acad Sci U S A 96(7):3342\u20133344","journal-title":"Proc Natl Acad Sci U S A"},{"key":"736_CR73","doi-asserted-by":"publisher","first-page":"11501","DOI":"10.1074\/jbc.M800642200","volume":"283","author":"J Lee","year":"2008","unstructured":"Lee J, Retamal C, Cuitino L, Caruano-Yzermans A, Shin JE, van Kerkhof P, Marzolo MP, Bu G (2008) Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. J Biol Chem 283:11501\u201311508","journal-title":"J Biol Chem"},{"issue":"3","key":"736_CR74","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s12640-009-9047-8","volume":"16","author":"W Li","year":"2009","unstructured":"Li W, Li G, Steiner J, Nath A (2009) Role of tat protein in HIV neuropathogenesis. Neurotox Res 16(3):205\u2013220","journal-title":"Neurotox Res"},{"key":"736_CR75","doi-asserted-by":"publisher","DOI":"10.1038\/srep11322","volume":"5","author":"S Li","year":"2015","unstructured":"Li S, Hou H, Mori T, Sawmiller D, Smith A, Tian J, Wang Y, Giunta B, Sanberg PR, Zhang S, Tan J (2015) Swedish mutant APP-based BACE1 binding site peptide reduces APP \u03b2-cleavage and cerebral A\u03b2 levels in Alzheimer\u2019s mice. Sci Rep 5:11322","journal-title":"Sci Rep"},{"issue":"12","key":"736_CR76","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/82199","volume":"6","author":"Y Liu","year":"2000","unstructured":"Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ (2000) Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med 6(12):1380\u20131387","journal-title":"Nat Med"},{"issue":"6","key":"736_CR77","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.cell.2013.08.035","volume":"154","author":"JX Lu","year":"2013","unstructured":"Lu JX, Qiang W, Yau WM, Schwieters CD, Meredith SC, Tycko R (2013) Molecular structure of \u03b2-amyloid fibrils in Alzheimer's disease brain tissue. Cell 154(6):1257\u20131268","journal-title":"Cell"},{"issue":"3","key":"736_CR78","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1128\/JVI.71.3.2495-2499.1997","volume":"71","author":"M Ma","year":"1997","unstructured":"Ma M, Nath A (1997) Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J Virol 71(3):2495\u20132499","journal-title":"J Virol"},{"issue":"35","key":"736_CR79","doi-asserted-by":"publisher","first-page":"23910","DOI":"10.1039\/C7CP04320A","volume":"19","author":"S Macchi","year":"2017","unstructured":"Macchi S, Nifos\u00ec R, Signore G, Di Pietro S, Boccardi C, D'Autilia F, Beltram F, Cardarelli F (2017) Self-aggregation propensity of the Tat peptide revealed by UV-Vis, NMR and MD analyses. Phys Chem Chem Phys 19(35):23910\u201323914","journal-title":"Phys Chem Chem Phys"},{"key":"736_CR80","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0306-4522(02)00713-3","volume":"117","author":"WF Maragos","year":"2003","unstructured":"Maragos WF, Tillman P, Jones M, Bruce-Keller AJ, Roth S, Bell JE, Nath A (2003) Neuronal injury in hippocampus with human immunodeficiency virus transactivating protein, Tat. Neuroscience 117:43\u201353","journal-title":"Neuroscience"},{"key":"736_CR81","doi-asserted-by":"publisher","unstructured":"Mart\u00ednez-Bonet M, Mu\u00f1oz-Fern\u00e1ndez M\u00c1, \u00c1lvarez S (2018) HIV-1 increases extracellular amyloid-beta levels through neprilysin regulation in primary cultures of human astrocytes. J Cell Physiol. \n                    https:\/\/doi.org\/10.1002\/jcp.26462","DOI":"10.1002\/jcp.26462"},{"issue":"1","key":"736_CR82","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0306-4522(96)00553-2","volume":"78","author":"E Masliah","year":"1997","unstructured":"Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L (1997) Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience 78(1):135\u2013146","journal-title":"Neuroscience"},{"key":"736_CR83","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/sj.cdd.4401577","volume":"1","author":"MP Mattson","year":"2005","unstructured":"Mattson MP, Haughey NJ, Nath A (2005) Cell death in HIV dementia. Cell Death Differ Suppl 1:893\u2013904","journal-title":"Cell Death Differ Suppl"},{"issue":"16","key":"736_CR84","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1002\/anie.200704444","volume":"47","author":"A Mishra","year":"2008","unstructured":"Mishra A, Gordon VD, Yang L, Coridan R, Wong GC (2008) HIV TAT forms pores in membranes by inducing saddle-splay curvature: potential role of bidentate hydrogen bonding. Angew Chem Int Ed Engl 47(16):2986\u20132989","journal-title":"Angew Chem Int Ed Engl"},{"key":"736_CR85","doi-asserted-by":"publisher","first-page":"e25954","DOI":"10.1371\/journal.pone.0025954","volume":"6","author":"B Moores","year":"2011","unstructured":"Moores B, Drolle E, Attwood SJ, Simons J, Leonenko Z (2011) Effect of surfaces on amyloid fibril formation. PLoS One 6:e25954","journal-title":"PLoS One"},{"key":"736_CR86","first-page":"629","volume":"5","author":"S Morgello","year":"2018","unstructured":"Morgello S, Jacobs M, Murray J, Byrd D, Neibart E, Mintz L, Meloni G, Chon C, Crary J (2018) Alzheimer\u2019s disease neuropathology may not predict functional impairment in HIV: a report of two individuals. J Neuro-Oncol 5:629\u2013637","journal-title":"J Neuro-Oncol"},{"issue":"1","key":"736_CR87","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jsb.2018.06.004","volume":"204","author":"S Moss","year":"2018","unstructured":"Moss S, Subramanian V, Acharya KR (2018) High resolution crystal structure of substrate-free human neprilysin. J Struct Biol 204(1):19\u201325","journal-title":"J Struct Biol"},{"issue":"2","key":"736_CR88","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/00002030-200501280-00013","volume":"19","author":"A Nath","year":"2005","unstructured":"Nath A, Hersh LB (2005) Tat and amyloid: multiple interactions. AIDS 19(2):203\u2013204","journal-title":"AIDS"},{"key":"736_CR89","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.expneurol.2013.11.004","volume":"251","author":"A Nath","year":"2014","unstructured":"Nath A, Steiner J (2014) Synaptodendritic injury with HIV-Tat protein: what is the therapeutic target? Exp Neurol 251:112\u2013114","journal-title":"Exp Neurol"},{"issue":"3","key":"736_CR90","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1128\/JVI.70.3.1475-1480.1996","volume":"70","author":"A Nath","year":"1996","unstructured":"Nath A, Psooy K, Martin C, Knudsen B, Magnuson DS, Haughey N, Geiger JD (1996) Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 70(3):1475\u20131480","journal-title":"J Virol"},{"issue":"2","key":"736_CR91","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/1531-8249(200002)47:2<186::AID-ANA8>3.0.CO;2-3","volume":"47","author":"A Nath","year":"2000","unstructured":"Nath A, Haughey NJ, Jones M, Anderson C, Bell JE, Geiger JD (2000) Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Ann Neurol 47(2):186\u2013194","journal-title":"Ann Neurol"},{"issue":"46","key":"736_CR92","doi-asserted-by":"publisher","first-page":"16180","DOI":"10.1073\/pnas.0407273101","volume":"101","author":"HD Nguyen","year":"2004","unstructured":"Nguyen HD, Hall CK (2004) Molecular dynamics simulations of spontaneous fibril formation by random-coil peptides. Proc Natl Acad Sci U S A 101(46):16180\u201316185","journal-title":"Proc Natl Acad Sci U S A"},{"key":"736_CR93","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","volume":"34","author":"RJ O'Brien","year":"2011","unstructured":"O'Brien RJ, Wong PC (2011) Amyloid precursor protein processing and Alzheimer\u2019s disease. Annu Rev Neurosci 34:185\u2013204","journal-title":"Annu Rev Neurosci"},{"issue":"1834","key":"736_CR94","first-page":"9","volume":"105","author":"AK Paravastu","year":"2008","unstructured":"Paravastu AK, Leapman RD, Yau WM, Tycko R (2008) Molecular structural basis for polymorphism in Alzheimer\u2019s \u03b2-amyloid fibrils. Proc Natl Acad Sci U S A 105(1834):9\u201318354","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"736_CR95","doi-asserted-by":"publisher","first-page":"e54769","DOI":"10.1371\/journal.pone.0054769","volume":"8","author":"V Parthsarathy","year":"2013","unstructured":"Parthsarathy V, McClean PL, H\u00f6lscher C, Taylor M, Tinker C, Jones G, Kolosov O, Salvati E, Gregori M, Masserini M, Allsop D (2013) A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe\/PS1\u2206E9 mouse model of Alzheimer\u2019s disease. PLoS One 8(1):e54769","journal-title":"PLoS One"},{"key":"736_CR96","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1142\/S0219720005000886","volume":"1","author":"K Peng","year":"2005","unstructured":"Peng K, Vucetic S, Radivojac P, Brown CJ, Dunker AK, Obradovic Z (2005) Optimizing long intrinsic disorder predictors with protein evolutionary information. J Bioinforma Comput Biol 1:35\u201360","journal-title":"J Bioinforma Comput Biol"},{"key":"736_CR97","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1126\/science.1105850","volume":"307","author":"AT Petkova","year":"2005","unstructured":"Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R (2005) Self-propagating, molecular-level polymorphism in Alzheimer\u2019s \u03b2-amyloid fibrils. Science 307:262\u2013265","journal-title":"Science"},{"issue":"50","key":"736_CR98","doi-asserted-by":"publisher","first-page":"50188","DOI":"10.1074\/jbc.M308719200","volume":"278","author":"TB Potocky","year":"2003","unstructured":"Potocky TB, Menon AK, Gellman SH (2003) Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. J Biol Chem 278(50):50188\u201350194","journal-title":"J Biol Chem"},{"issue":"10","key":"736_CR99","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1038\/sj.jcbfm.9600125","volume":"25","author":"H Pu","year":"2005","unstructured":"Pu H, Tian J, Andras IE, Hayashi K, Flora G, Hennig B, Toborek M (2005) HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1\/2 activation. J Cereb Blood Flow Metab 25(10):1325\u20131335","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"736_CR100","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11481-009-9151-9","volume":"4","author":"Lynn Pulliam","year":"2009","unstructured":"Pulliam L (2009) HIV regulation of amyloid beta production. J Neuroimmune Pharmacol 4(2):213\u2013217","journal-title":"Journal of Neuroimmune Pharmacology"},{"issue":"1","key":"736_CR101","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11481-006-9053-z","volume":"2","author":"L Pulliam","year":"2007","unstructured":"Pulliam L, Sun B, Rempel H, Martinez PM, Hoekman JD, Rao RJ, Frey WH 2nd, Hanson LR (2007) Intranasal tat alters gene expression in the mouse brain. J NeuroImmune Pharmacol 2(1):87\u201392","journal-title":"J NeuroImmune Pharmacol"},{"key":"736_CR102","doi-asserted-by":"publisher","unstructured":"Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D (2019) Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer\u2019s disease. J Neuro-Oncol. \n                    https:\/\/doi.org\/10.1007\/s13365-018-0695-4","DOI":"10.1007\/s13365-018-0695-4"},{"key":"736_CR103","first-page":"774","volume":"6","author":"P Rahimian","year":"2016","unstructured":"Rahimian P, He JJ (2016) Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein. J Neuro-Oncol 6:774\u2013788","journal-title":"J Neuro-Oncol"},{"issue":"3","key":"736_CR104","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4161\/pri.2.3.7488","volume":"2","author":"RN Rambaran","year":"2008","unstructured":"Rambaran RN, Serpell LC (2008) Amyloid fibrils: abnormal protein assembly. Prion 2(3):112\u2013117","journal-title":"Prion"},{"issue":"2","key":"736_CR105","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00002030-200501280-00004","volume":"19","author":"HC Rempel","year":"2005","unstructured":"Rempel HC, Pulliam L (2005) HIV-1Tat inhibits neprilysin and elevates amyloid beta. AIDS 19(2):127\u2013135","journal-title":"AIDS"},{"issue":"1\u20132","key":"736_CR106","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/S0006-8993(01)02772-X","volume":"914","author":"E Rockenstein","year":"2001","unstructured":"Rockenstein E, Hansen LA, Mallory M, Trojanowski JQ, Galasko D, Masliah E (2001) Altered expression of the synuclein family mRNA in Lewy body and Alzheimer\u2019s disease. Brain Res 914(1\u20132):48\u201356","journal-title":"Brain Res"},{"issue":"5\u20136","key":"736_CR107","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0197-0186(01)00040-7","volume":"39","author":"J Rogers","year":"2001","unstructured":"Rogers J, Lue LF (2001) Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer\u2019s disease. Neurochem Int 39(5\u20136):333\u2013340","journal-title":"Neurochem Int"},{"issue":"2","key":"736_CR108","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/glia.10153","volume":"40","author":"J Rogers","year":"2002","unstructured":"Rogers J, Strohmeyer R, Kovelowski CJ, Li R (2002) Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40(2):260\u2013269","journal-title":"Glia"},{"issue":"2","key":"736_CR109","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1471-4159.2004.02857.x","volume":"92","author":"S Rossner","year":"2005","unstructured":"Rossner S, Lange-Dohna C, Zeitschel U, Perez-Polo JR (2005) Alzheimer\u2019s disease beta-secretase BACE1 is not a neuron-specific enzyme. J Neurochem 92(2):226\u2013234","journal-title":"J Neurochem"},{"issue":"6","key":"736_CR110","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","volume":"8","author":"DJ Selkoe","year":"2016","unstructured":"Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer\u2019s disease at 25 years. EMBO Mol Med 8(6):595\u2013608","journal-title":"EMBO Mol Med"},{"issue":"1","key":"736_CR111","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S0925-4439(00)00029-6","volume":"1502","author":"LC Serpell","year":"2000","unstructured":"Serpell LC (2000) Alzheimer\u2019s amyloid fibrils: structure and assembly. Biochim Biophys Acta 1502(1):16\u201330","journal-title":"Biochim Biophys Acta"},{"issue":"24","key":"736_CR112","doi-asserted-by":"publisher","first-page":"21895","DOI":"10.1074\/jbc.M008511200","volume":"276","author":"K Shirotani","year":"2001","unstructured":"Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC (2001) Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem 276(24):21895\u201321901","journal-title":"J Biol Chem"},{"key":"736_CR113","doi-asserted-by":"publisher","first-page":"8347","DOI":"10.1074\/jbc.M510748200","volume":"281","author":"S Shojania","year":"2006","unstructured":"Shojania S, O\u2019Neil JD (2006) HIV-1 Tat is a natively unfolded protein: the solution conformation and dynamics of reduced HIV-1 Tat-(1-72) by NMR spectroscopy. J Biol Chem 281:8347\u20138356","journal-title":"J Biol Chem"},{"key":"736_CR114","doi-asserted-by":"publisher","first-page":"999","DOI":"10.2174\/092986610791498993","volume":"17","author":"S Shojania","year":"2010","unstructured":"Shojania S, O\u2019Neil JD (2010) Intrinsic disorder and function of the HIV-1 Tat protein. Protein Pept Lett 17:999\u20131011","journal-title":"Protein Pept Lett"},{"key":"736_CR115","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1126\/science.1691865","volume":"248","author":"SS Sisodia","year":"1990","unstructured":"Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL (1990) Evidence that beta \u2013amyloid protein in Alzheimer\u2019s disease is not derived by normal processing. Science 248:492\u2013495","journal-title":"Science"},{"key":"736_CR116","doi-asserted-by":"publisher","first-page":"44816","DOI":"10.1074\/jbc.M307546200","volume":"278","author":"SM Smith","year":"2003","unstructured":"Smith SM, Pentlicky S, Klase Z, Singh M, Neuveut C, Lu CY, Reitz MS Jr, Yarchoan R, Marx PA, Jeang KT (2003) An in vivo replication-important function in the second coding exon of Tat is constrained against mutation despite cytotoxic T lymphocyte selection. J Biol Chem 278:44816\u201344825","journal-title":"J Biol Chem"},{"issue":"1","key":"736_CR117","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s11481-016-9707-4","volume":"12","author":"ML Soliman","year":"2017","unstructured":"Soliman ML, Geiger JD, Chen X (2017) Caffeine blocks HIV-1 Tat-induced amyloid beta production and Tau phosphorylation. J NeuroImmune Pharmacol 12(1):163\u2013170","journal-title":"J NeuroImmune Pharmacol"},{"issue":"7299","key":"736_CR118","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nature09131","volume":"465","author":"TH Tahirov","year":"2010","unstructured":"Tahirov TH, Babayeva ND, Varzavand K, Cooper JJ, Sedore SC, Price DH (2010) Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 465(7299):747\u2013751","journal-title":"Nature"},{"issue":"5","key":"736_CR119","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1074\/jbc.M006701200","volume":"276","author":"M Tyagi","year":"2001","unstructured":"Tyagi M, Rusnati M, Presta M, Giacca M (2001) Internalization of HIV-1 Tat requires cell surface heparan sulfate proteoglycans. J Biol Chem 276(5):3254\u20133261","journal-title":"J Biol Chem"},{"key":"736_CR120","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1110\/ps.4210102","volume":"11","author":"VN Uversky","year":"2002","unstructured":"Uversky VN (2002) Natively unfolded proteins: a point where biology waits for physics. Protein Sci 11:739\u2013756","journal-title":"Protein Sci"},{"key":"736_CR121","doi-asserted-by":"publisher","first-page":"S79","DOI":"10.1097\/00002030-200401001-00012","volume":"18","author":"VG Valcour","year":"2004","unstructured":"Valcour VG, Shikuma CM, Watters MR, Sacktor NC (2004) Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanisms. AIDS 18:S79\u2013S86","journal-title":"AIDS"},{"issue":"5","key":"736_CR122","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1091\/mbc.e03-12-0921","volume":"15","author":"A Vendeville","year":"2004","unstructured":"Vendeville A, Rayne F, Bonhoure A, Bettache N, Montcourrier P, Beaumelle B (2004) HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses. Mol Biol Cell 15(5):2347\u20132360","journal-title":"Mol Biol Cell"},{"issue":"34","key":"736_CR123","doi-asserted-by":"publisher","first-page":"E4976","DOI":"10.1073\/pnas.1600749113","volume":"113","author":"MA W\u00e4lti","year":"2016","unstructured":"W\u00e4lti MA, Ravotti F, Arai H, Glabe CG, Wall JS, B\u00f6ckmann A, G\u00fcntert P, Meier BH, Riek R (2016) Atomic-resolution structure of a disease-relevant A\u03b2 (1-42) amyloid fibril. Proc Natl Acad Sci U S A 113(34):E4976\u2013E4984","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6531","key":"736_CR124","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/375497a0","volume":"375","author":"MO Westendorp","year":"1995","unstructured":"Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin KM, Krammer PH (1995) Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375(6531):497\u2013500","journal-title":"Nature"},{"issue":"34","key":"736_CR125","doi-asserted-by":"publisher","first-page":"22736","DOI":"10.1074\/jbc.M109.023705","volume":"284","author":"H Yezid","year":"2009","unstructured":"Yezid H, Konate K, Debaisieux S, Bonhoure A, Beaumelle B (2009) Mechanism for HIV- 1 Tat insertion into the endosome membrane. J Biol Chem 284(34):22736\u201322746","journal-title":"J Biol Chem"},{"issue":"36","key":"736_CR126","doi-asserted-by":"publisher","first-page":"21976","DOI":"10.1074\/jbc.M115.667097","volume":"290","author":"M Zeitler","year":"2015","unstructured":"Zeitler M, Steringer JP, M\u00fcller HM, Mayer MP, Nickel W (2015) HIV-Tat protein forms phosphoinositide-dependent membrane pores implicated in unconventional protein secretion. J Biol Chem 290(36):21976\u201321984","journal-title":"J Biol Chem"},{"issue":"49","key":"736_CR127","doi-asserted-by":"publisher","first-page":"31407","DOI":"10.1074\/jbc.271.49.31407","volume":"271","author":"J Zhao","year":"1996","unstructured":"Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L (1996) Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes. J Biol Chem 271(49):31407\u201331411","journal-title":"J Biol Chem"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-019-00736-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13365-019-00736-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-019-00736-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T21:59:10Z","timestamp":1589666350000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13365-019-00736-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,23]]},"references-count":127,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["736"],"URL":"https:\/\/doi.org\/10.1007\/s13365-019-00736-z","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,23]]},"assertion":[{"value":"12 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}