{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:35:10Z","timestamp":1772120110321,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307291\/2017-0"],"award-info":[{"award-number":["307291\/2017-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s13365-020-00883-8","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T10:03:07Z","timestamp":1595930587000},"page":"764-768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intracerebral transfection of anti-rabies virus antibodies is an effective therapy for rabies"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8576-842X","authenticated-orcid":false,"given":"Washington C.","family":"Agostinho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo E.","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"issue":"6","key":"883_CR1","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1001\/archneur.62.6.873","volume":"62","author":"EC Burton","year":"2005","unstructured":"Burton EC, Burns DK, Opatowsky MJ, el-Feky WH, Fischbach B, Melton L, Sanchez E, Randall H, Watkins DL, Chang J, Klintmalm G (2005) Rabies encephalomyelitis: E clinical, neuroradiological, and pathological findings in 4 transplant recipients. Arch Neurol 62(6):873\u2013882. https:\/\/doi.org\/10.1001\/archneur.62.6.873","journal-title":"Arch Neurol"},{"issue":"1","key":"883_CR2","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev-virology-100114-055157","volume":"2","author":"BM Davis","year":"2015","unstructured":"Davis BM, Rall GF, Schnell MJ (2015) Everything you always wanted to know about rabies virus (but were afraid to ask). Annu Rev Virol 2(1):451\u2013471. https:\/\/doi.org\/10.1146\/annurev-virology-100114-055157","journal-title":"Annu Rev Virol"},{"key":"883_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.antiviral.2017.11.003","volume":"49","author":"NL Fuoco","year":"2018","unstructured":"Fuoco NL, Dos Ramos SS, Fernandes ER, Luiz FG, Ribeiro OG, Katz ISS (2018) Infection of neuroblastoma cells by rabies virus is modulated by the virus titer. Antivir Res 49:89\u201394. https:\/\/doi.org\/10.1016\/j.antiviral.2017.11.003","journal-title":"Antivir Res"},{"issue":"4","key":"883_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003709","volume":"9","author":"K Hampson","year":"2015","unstructured":"Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, Barrat J, Blanton JD, Briggs DJ, Cleaveland S, Costa P, Freuling CM, Hiby E, Knopf L, Leanes F, Meslin FX, Metlin A, Miranda ME, M\u00fcller T, Nel LH, Recuenco S, Rupprecht CE, Schumacher C, Taylor L, Vigilato MAN, Zinsstag J, Dushoff J, on behalf of the Global Alliance for Rabies Control Partners for Rabies Prevention (2015) Estimating the global burden of endemic canine rabies. PLoS Negl Trop Dis 9(4):e0003709. https:\/\/doi.org\/10.1371\/journal.pntd.0003709","journal-title":"PLoS Negl Trop Dis"},{"key":"883_CR5","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.omtn.2018.05.025","volume":"12","author":"JK Ho","year":"2018","unstructured":"Ho JK, White PJ, Pouton CW (2018) Self-crosslinking lipopeptide\/DNA\/PEGylated particles: a new platform for DNA vaccination designed for assembly in aqueous solution. Mol Ther Nucleic Acids 12:891\u2013892. https:\/\/doi.org\/10.1016\/j.omtn.2018.05.025","journal-title":"Mol Ther Nucleic Acids"},{"issue":"10","key":"883_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0000535","volume":"3","author":"DC Hooper","year":"2009","unstructured":"Hooper DC, Phares TW, Fabis MJ, Roy A (2009) The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system. PLoS Negl Trop Dis 3(10):1\u20138. https:\/\/doi.org\/10.1371\/journal.pntd.0000535","journal-title":"PLoS Negl Trop Dis"},{"key":"883_CR7","volume-title":"Rabies","author":"AC Jackson","year":"2007","unstructured":"Jackson AC, Wunner WH (2007) Rabies. Academic Press, London"},{"key":"883_CR8","unstructured":"Kawai JGC (2012) Transfection of anti-rabies antibodies into n2a lineage cells (mouse neuroblastoma) and intracellular neutralization for use as an antiviral. Postdoctoral, University of S\u00e3o Paulo"},{"issue":"95","key":"883_CR9","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<720::AID-MUS9>3.0.CO;2-5","volume":"23","author":"P Lewis","year":"2000","unstructured":"Lewis P, Fu Y, Lentz TL (2000) Rabies virus entry at the neuromuscular junction in nerve-muscle cocultures. Muscle Nerve 23(95):720\u2013730. https:\/\/doi.org\/10.1002\/(SICI)1097-4598(200005)23:5<720::AID-MUS9>3.0.CO;2-5","journal-title":"Muscle Nerve"},{"key":"883_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s40779-016-0089-y","volume":"3","author":"S Manoj","year":"2016","unstructured":"Manoj S, Mukherjee A, Johri S, Kumar KV (2016) Recovery from rabies, a universally fatal disease. Mil Med Res 3:21. https:\/\/doi.org\/10.1186\/s40779-016-0089-y","journal-title":"Mil Med Res"},{"issue":"33","key":"883_CR11","doi-asserted-by":"publisher","first-page":"4724","DOI":"10.1016\/j.vaccine.2018.05.066","volume":"37","author":"A Marosi","year":"2018","unstructured":"Marosi A, Dufkova L, Forr\u00f3 B, Felde O, Erd\u00e9lyi K, \u0160irmarov\u00e1 J, Palus M, H\u00f6nig V, Sal\u00e1t J, Tikos R, Gyuranecz M, R\u016f\u017eek D, Martina B, Koraka P, Osterhaus ADME, Bakonyi T (2018) Combination therapy of rabies-infected mice with inhibitors of pro-inflammatory host response, antiviral compounds and human rabies immunoglobulin. Vaccine. 37(33):4724\u20134735. https:\/\/doi.org\/10.1016\/j.vaccine.2018.05.066","journal-title":"Vaccine."},{"key":"883_CR12","doi-asserted-by":"publisher","unstructured":"Prasad S, Lokensgard JR (2019) Brain-resident t cells following viral infection. 32(1):48\u201354. https:\/\/doi.org\/10.1089\/vim.2018.0084","DOI":"10.1089\/vim.2018.0084"},{"key":"883_CR13","unstructured":"PROMED (2009) Rabies, human survival, bat-Brazil. https:\/\/www.promedmail.org\/post\/20090919.3292"},{"issue":"7","key":"883_CR14","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1371\/journal.pntd.0000428","volume":"3","author":"PP van Thiel","year":"2009","unstructured":"van Thiel PP, de Bie RM, Eftimov F et al (2009) Fatal human rabies due to Duvenhage virus from a bat in Kenya: failure of treatment with coma-induction, ketamine, and antiviral drugs. PLoS Negl. Trop. Dis. 3(7):e428. https:\/\/doi.org\/10.1371\/journal.pntd.0000428","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"7","key":"883_CR15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2144\/000112832","volume":"44","author":"CO Weill","year":"2008","unstructured":"Weill CO, Biri S, Erbacher P (2008) Cationic lipid-mediated intracellular delivery of antibodies into live cells. Biotechniques. 44(7):7\u201311. https:\/\/doi.org\/10.2144\/000112832","journal-title":"Biotechniques."},{"key":"883_CR16","volume-title":"Expert consultation on rabies: second Report","author":"WHO","year":"2013","unstructured":"WHO (2013) Expert consultation on rabies: second Report. World Health Organization, Geneva"},{"issue":"24","key":"883_CR17","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1056\/NEJMoa050382","volume":"352","author":"RE Willoughby","year":"2005","unstructured":"Willoughby RE, Tieves KS, Hoffman GM et al (2005) Survival after treatment of rabies with induction of coma. N Engl J Med 352(24):2508\u20132514. https:\/\/doi.org\/10.1056\/NEJMoa050382","journal-title":"N Engl J Med"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-020-00883-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13365-020-00883-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-020-00883-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T19:30:01Z","timestamp":1627414201000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13365-020-00883-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,28]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["883"],"URL":"https:\/\/doi.org\/10.1007\/s13365-020-00883-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/667949","asserted-by":"object"}]},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,28]]},"assertion":[{"value":"21 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This experiment was approved by the Ethics Committee on Animal Use (CEUA) of the School of Veterinary Medicine and Animal Science - University of S\u00e3o Paulo (FMVZ-USP), under protocol no. 9658071016. All mice were used for the experiments; prior to any procedure, mice were anesthetized with isofluoran.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}