{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:58:01Z","timestamp":1740128281041,"version":"3.37.3"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                <jats:title>Abstract\n<\/jats:title>\n                <jats:p>Human T-lymphotropic virus type-1 (HTLV-1) is a neglected infection most often associated with an indolent process. However, a subset of HTLV-1 seropositive patients face the risk to develop life-threatening T-cell lymphoma\/leukemia, or the highly disabling and incurable HTLV1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). Over the years, other complications to HTLV-1 have been proposed and debated intensely. One of these, although rare, associations include cerebellar ataxia occurring most often in Japanese patients with manifest HAM\/TSP. Here we present a HTLV-1 seropositive patient from the Middle East featuring a slowly progressive cerebellar syndrome with cerebellar atrophy but not evidence of spastic paraparesis. In addition, this patient suffered from autoimmune conditions such as Sj\u00f6gren\u2019s syndrome and vitiligo which are putatively associated with HTLV-1.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s13365-020-00932-2","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T16:04:20Z","timestamp":1616429060000},"page":"345-347","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expanding the etiologic spectrum of spastic ataxia syndrome: chronic infection with human T lymphotropic virus type 1"],"prefix":"10.1007","volume":"27","author":[{"given":"Karolina af","family":"Edhom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Lidman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Granberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham P.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-1480","authenticated-orcid":false,"given":"Martin","family":"Paucar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"issue":"4","key":"932_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.24875\/AIDSRev.19000108","volume":"21","author":"AQC Araujo","year":"2019","unstructured":"Araujo AQC, Wedemann D (2019) HTLV-1 Associated Neurological Complex. What is Hidden below the Water?. AIDS Rev 21(4):211\u2013217","journal-title":"AIDS Rev"},{"issue":"1","key":"932_CR2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1136\/jnnp.2008.167155","volume":"9","author":"SA Cooper","year":"2009","unstructured":"Cooper SA, van der Loeff MS, Taylor GP (2009) The neurology of HTLV-1 infection. Pract Neurol 9(1):16\u201326","journal-title":"Pract Neurol"},{"issue":"2","key":"932_CR3","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/00042560-199510020-00013","volume":"10","author":"F Gracia","year":"1995","unstructured":"Gracia F, Castillo LC, Larreategui M et al (1995) Relation between human T-lymphotropic virus type I and neurologic diseases in Panama: 1985\u20131990. 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J Neurol Sci 96(1):103\u2013123","journal-title":"J Neurol Sci"},{"issue":"1","key":"932_CR6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0022-510X(93)90075-A","volume":"115","author":"J Kira","year":"1993","unstructured":"Kira J, Goto I, Otsuka M et al (1993) Chronic progressive spinocerebellar syndrome associated with antibodies to human T-lymphotropic virus type I: clinico-virological and magnetic resonance imaging studies. J Neurol Sci 115(1):111\u2013116","journal-title":"J Neurol Sci"},{"key":"932_CR7","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.3389\/fmicb.2018.01651","volume":"9","author":"T Sato","year":"2018","unstructured":"Sato T, Yagishita N, Tamaki K et al (2018) Proposal of classification criteria for HTLV-1-associated myelopathy\/tropical spastic paraparesis disease activity. 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