{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:12:33Z","timestamp":1760425953186,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s13365-021-00944-6","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T18:59:40Z","timestamp":1612292380000},"page":"810-819","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV-1-infected individuals"],"prefix":"10.1007","volume":"27","author":[{"given":"Rosangela Souza","family":"Kalil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Vasconcellos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Rosadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Cony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulcino P.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassia C. Alves","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everton","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Galv\u00e3o-Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"P.Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6007-9142","authenticated-orcid":false,"given":"Marzia","family":"Puccioni-Sohler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"944_CR1","doi-asserted-by":"publisher","unstructured":"Aglioti S (1997) The role of the thalamus and basal ganglia in human cognition, J Neurolinguistcs 10:255\u2212265. https:\/\/doi.org\/10.1016\/S0911-6044(97)00020-1","DOI":"10.1016\/S0911-6044(97)00020-1"},{"key":"944_CR2","volume-title":"Association Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)","author":"A Psychiatric","year":"2013","unstructured":"Psychiatric A (2013) Association Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). Americ Psyc Assoc, Arlington, VA"},{"key":"944_CR3","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000832","author":"A Ara\u00fajo","year":"2020","unstructured":"Ara\u00fajo A, Bangham CRM, Casseb J, Gotuzzo E, Jacobson S, Martin F, Penalva de Oliveira A, Puccioni-Sohler M, Taylor GP, Yamano Y (2020) Management of HAM\/TSP Systematic review and consensus-based recommendations 2019. Neurol Clin Pract. https:\/\/doi.org\/10.1212\/CPJ.0000000000000832","journal-title":"Neurol Clin Pract"},{"key":"944_CR4","doi-asserted-by":"publisher","unstructured":"Bagnato F, Butman JA, Mora CA, Gupta S,. Yamano Y, Tasciyan TA, Solomon M, Santos WJ, Stone RD, MC Farland HT, Jacobson S (2005) Coventional magnetic resonance imaging features in patient with tropical spastic paraparesis, J Neurovirol 11:525\u2212534. https:\/\/doi.org\/10.1080\/13550280500385039","DOI":"10.1080\/13550280500385039"},{"key":"944_CR5","unstructured":"Cartier L, Gomaz A. (1999) Subcortical dementia in HTLV-1 tropical spastic paraparesis. Study of 43 cases Rev Med Chil1 127:444\u2212450"},{"key":"944_CR6","doi-asserted-by":"publisher","unstructured":"Cartier L, Araya F, Castillo JL, Ruix F, Gomaz A, Tajima K (1992) Progressive spastic paraparesis associated with Human T-Cell Leukemia Virus Type I (HTLV-I). Inter Med 3:1257\u221261. https:\/\/doi.org\/10.2169\/internationalmedicine.31.1257","DOI":"10.2169\/internationalmedicine.31.1257"},{"key":"944_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ijid.2019.05.010","volume":"84","author":"APS Champs","year":"2019","unstructured":"Champs APS, de Azeredo Passos VM, Carvalho G, Barreto SM, Meirelles C, Camarelli P (2019) Cognitive impairment in HTLV-1-associated myelopathy, proviral load and inflammatory markers. Int J Infect Dis 84:121\u2013126","journal-title":"Int J Infect Dis"},{"key":"944_CR8","doi-asserted-by":"publisher","unstructured":"Cummings JK, Benson DF (1984) Subcortical dementia. Review of an emerging concept. Arch Neurol 41:874\u2212879. https:\/\/doi.org\/10.1093\/brain\/112.4.1057","DOI":"10.1093\/brain\/112.4.1057"},{"key":"944_CR9","doi-asserted-by":"publisher","unstructured":"Cummings JK (1993) Frontal-subcortical and human behavior. Arch Neurol 50:873\u2212880. https:\/\/doi.org\/10.1001\/archneur.1993.100540080076020","DOI":"10.1001\/archneur.1993.100540080076020"},{"key":"944_CR10","unstructured":"Diniz LMF, Da Cruz VM, Torres RM, Cosenza RM (2000) Rey\u2019s verbal auditory learning test: norms for the Brazilian population. Rev Bras Neurol"},{"key":"944_CR11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, Paul RM (1975) Minimental state: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr. Res. 12:189\u2013198. https:\/\/doi.org\/10.1016\/0022-3956(75)90026-6","journal-title":"J Psychiatr. Res."},{"key":"944_CR12","doi-asserted-by":"publisher","unstructured":"Fukushuma T, Ikeda T, Uyama E, Uchino M, Okabe H, Ando M (1994) Cognitive event related potencials and brain magnetic resonance imaging in HTLV-1 associated myelophaty (HAM). J Neurol Sci 126 (1) 30\u221239. https:\/\/doi.org\/10.1016\/0022-510x(94)90091-4","DOI":"10.1016\/0022-510x(94)90091-4"},{"key":"944_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jns.2017.04.019","volume":"377","author":"MRP Gasc\u00f3n","year":"2017","unstructured":"Gasc\u00f3n MRP, Casseb J, Vidal SJ, JE, Fonseca LAM, Paiva A, Haziot MJ, Penalva de Oliveira AC, (2017) Cognitive impairment is frequent among symptomatic carriers of human T-cell lymphotropic virus type 1 (HTLV-1). regardless of their clinical status. J Neurol Sci 377:185\u2013189. https:\/\/doi.org\/10.1016\/j.jns.2017.04.019","journal-title":"J Neurol Sci"},{"key":"944_CR14","doi-asserted-by":"publisher","unstructured":"Gessain A. & Cassar O (2012) Epidemiological aspects and world distribution of HTLV-1 infection. Front Microbiol. 3:388. https:\/\/doi.org\/10.3389\/fmicb.2012.00388","DOI":"10.3389\/fmicb.2012.00388"},{"key":"944_CR15","unstructured":"Gorestein C, Pang WY, Armagimon IL (2012) BDI-II Beck inventory of depression. 2 th. S\u00e3o Paulo. Casa do Psic\u00f3logo"},{"key":"944_CR16","doi-asserted-by":"publisher","unstructured":"Gon\u00e7alves LR, Barbosa L, Magalh\u00e3es PMR, Sampaio Rocha-Filho PA (2017) Characterization of cognitive performance and evaluation of quality of life among patients with HTLV-1. Clin Neurol Neurosurg 160 (2017) 142\u2013146. https:\/\/doi.org\/10.1016\/j.clineuro.2017.07.008","DOI":"10.1016\/j.clineuro.2017.07.008"},{"key":"944_CR17","doi-asserted-by":"publisher","unstructured":"Kertsz A, Black SE, Toka G, Benk T, Carr T, Nilchonson L. (1998) Periventricular and subcortical hyperintensities on magnetic resonance imaging:'rims, caps, and unidentified bright objects. Arch Neurol 45:404\u2013408.https:\/\/doi.org\/10.1590\/S00024-282X993000300006","DOI":"10.1590\/S00024-282X993000300006"},{"key":"944_CR18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0022-510x(88)90247-x","volume":"87","author":"J Kira","year":"1998","unstructured":"Kira J, Minato S, Itoyama Y, Goto I, Kato M, Hasuo K (1998) Leukoencephalopathy in HTLV-1-associated myelopathy: MRI and EEG data. J Neurol Sci 87:221\u2013232. https:\/\/doi.org\/10.1016\/0022-510x(88)90247-x","journal-title":"J Neurol Sci"},{"key":"944_CR19","unstructured":"Lezak MD (2004) The practice of neuropsychological assessment, In: Neuropsychological Assessment 4th. New York: Oxford University Press"},{"key":"944_CR20","doi-asserted-by":"publisher","unstructured":"Machado TH, Fichman HC, Santos EL, Carvalho VA. Fialho PP, Koening AM, Fernandes CS, Louren\u00e7o RA, Paradela EMP, Camarelli P (2009) Normative data for healthy elderly on phonemic verbal fluency task- FAS, Dement Neuropsychol 3:155\u2013160. https:\/\/doi.org\/10.1590\/51980-57642009DN30100011","DOI":"10.1590\/51980-57642009DN30100011"},{"key":"944_CR21","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1590\/S0004-282X1993000300006","volume":"51","author":"A Melo","year":"1993","unstructured":"Melo A, Moura L, Rios S, Machado M, Costa G (1993) Magnetic resonance imaging in HTLV-I associated myelopathy. Arq Neuropsiquiatry 51:329\u2013332","journal-title":"Arq Neuropsiquiatry"},{"key":"944_CR22","doi-asserted-by":"publisher","unstructured":"Mendes GB, Kalil RS, Rosadas C, Puccioni-Sohler M. (2014) Temporal lesions and widespread involvement of white matter associates with multi-organ inflammatory disease in human T- lymphotropic virus type 1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). Int J Infect Dis 25:1\u22123. https:\/\/doi.org\/10.1016\/j.ijid.2014.03.1374","DOI":"10.1016\/j.ijid.2014.03.1374"},{"key":"944_CR23","doi-asserted-by":"publisher","unstructured":"Morgan DJ, Caskey MF, Abbehusen C, Oliveira-Filho F, Ara\u00fajo C, Santos AF (2007) Brain resonance imaging white matter lesions are frequent in HTLV-1 carriers and do not discriminate from HAM\/TSP. AIDS Res Hum Retroviruses 23:1499\u22121503. https:\/\/doi.org\/10.1089\/aid.2007.0077","DOI":"10.1089\/aid.2007.0077"},{"key":"944_CR24","doi-asserted-by":"publisher","unstructured":"Nakagawa M, Izumo M, Ijichi S, Kubota H, Arimura K, Kawabata M, Osame M (1995) HTLV-I-associated myelopathy: analysis of 213 patients based on clinical features and laboratory findings. J Neurol 1:50\u221261. https:\/\/doi.org\/10.3109\/13550289509111010","DOI":"10.3109\/13550289509111010"},{"key":"944_CR25","doi-asserted-by":"publisher","unstructured":"Nagai M, Usuku K, Matsumoto W, Kodama D, Takenouchi N, Mariotoyo T (1998) Analysis of HTLV-I proviral load in 202 HAM\/TSP patients and 243 asymptomatics HTLV-1 carriers. High proviral load strongly predisposes to HAM\/TSP, J Neurovirology 4:586\u2212593. https:\/\/doi.org\/10.1097\/00042560-199904010-00238","DOI":"10.1097\/00042560-199904010-00238"},{"key":"944_CR26","unstructured":"Osame M, Review of WHO Kagoshima Meeting and Diagnostic Guidelines for HAM, TSP, (1990) In: Blattner WA (ed) Hum Retrovirology: HTLV. Raven Press, New York, pp 191\u2013197"},{"key":"944_CR27","doi-asserted-by":"publisher","unstructured":"Poiesz BJ, Ruscetti FW, Gasdar AF, Bunn PA, Minna JD, Gallo RC (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77:7415\u20137419. https:\/\/doi.org\/10.1073\/pnas.77.12.7415","DOI":"10.1073\/pnas.77.12.7415"},{"key":"944_CR28","doi-asserted-by":"publisher","unstructured":"Puccioni-Sohler M, Gasparetto E, Cabral-Castro MJ, Jorge M, Slatter C, Vidal CM, Cortes RD, Rosen BR, Maianero C (2012) HAM\/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings. Arq Neuropsiquatr 70:246\u2212251. https:\/\/doi.org\/10.1590\/S0004-282X20120000400004","DOI":"10.1590\/S0004-282X20120000400004"},{"key":"944_CR29","doi-asserted-by":"publisher","unstructured":"Rosadas C, Cabral-Castro MJ, Vicente AC, Peralta JM, Puccioni-Sohler M (2013) Validation of a quantitative real-time PCR assay for HTLV-1 proviral load in peripheral blood mononuclear cells. J Virol Methods 193:536\u2212541. https:\/\/doi.org\/10.1016\/j.j.viromet.2013.07.040","DOI":"10.1016\/j.j.viromet.2013.07.040"},{"key":"944_CR30","volume-title":"Rey\u2019s complex figures: test of copying and memory reproduction of complex geometric figure","author":"A Rey","year":"1999","unstructured":"Rey A (1999) Rey\u2019s complex figures: test of copying and memory reproduction of complex geometric figure. Casa do Psic\u00f3logo, S\u00e3o Paulo"},{"key":"944_CR31","doi-asserted-by":"publisher","unstructured":"Silva MT, Mattos P, Alfano A. (2003) Neuropsychological assessment in HTLV-1 infection: a comparative study among HAM\/TSP, asymptomatic, carriers, and healthy controls. J Neurol, Neurosurg Psychiatry 7:1085\u20131089. https:\/\/doi.org\/10.1136\/jnnp.74.8.1085","DOI":"10.1136\/jnnp.74.8.1085"},{"key":"944_CR32","unstructured":"Strauss E, Sherman EMS, Spreen O (2006) A Compendium of Neuropsychological Tests, 3th New York: Oxford University Press"},{"key":"944_CR33","doi-asserted-by":"publisher","unstructured":"Turken U, Whifield-Gabrieli S, Brammer R, Baldo JV, Dronkers NF, Gabrieli JDE (2008) Cognitive processing speed and the structure of white matter pathways: conventional evidence from normal variation and lesion studies. Neuroimage 42:1032\u22121044. https:\/\/doi.org\/10.1016\/j.neuroimage.2008.03.057","DOI":"10.1016\/j.neuroimage.2008.03.057"},{"key":"944_CR34","unstructured":"Wechsler D (2004) Wechsler Intelligence Scale for Adults (WAIS-III): Technical manual. 3th. S\u00e3o Paulo: Casa do Psic\u00f3logo"},{"key":"944_CR35","volume-title":"The Wechsler Memory Scale \u2013 Revised (WMS-R)","author":"D Wechsler","year":"1997","unstructured":"Wechsler D (1997) The Wechsler Memory Scale \u2013 Revised (WMS-R). Psychological Corporation, Santo Antonio, Texas"},{"key":"944_CR36","doi-asserted-by":"publisher","unstructured":"Van den Heuvel DM, ten Dam VH,. de Craen AJM, Admiral-Behloul F, Olofsen H, Bollen EEEM, Jolles J, Murray HM, Blauw GJ, Westendorp RGJ, Van Buchen MA (2006) Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population, J Neurol, Neurosurg Psychiatry 77:149\u2212153. https:\/\/doi.org\/10.1136\/jnnp.2005.070193","DOI":"10.1136\/jnnp.2005.070193"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-021-00944-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13365-021-00944-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-021-00944-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T15:39:26Z","timestamp":1646667566000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13365-021-00944-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["944"],"URL":"https:\/\/doi.org\/10.1007\/s13365-021-00944-6","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"type":"print","value":"1355-0284"},{"type":"electronic","value":"1538-2443"}],"subject":[],"published":{"date-parts":[[2021,2,2]]},"assertion":[{"value":"7 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}