{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:11:10Z","timestamp":1762809070357,"version":"3.37.3"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s13365-021-00955-3","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T16:06:26Z","timestamp":1614614786000},"page":"279-301","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Altered expression of fractalkine in HIV-1-infected astrocytes and consequences for the virus-related neurotoxicity"],"prefix":"10.1007","volume":"27","author":[{"given":"Vincent","family":"S\u00e9n\u00e9cal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Barat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Vanasse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Leboeuf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gosselin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6919-7847","authenticated-orcid":false,"given":"Michel J.","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"955_CR1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s13365-016-0505-9","volume":"23","author":"M Abassi","year":"2017","unstructured":"Abassi M, Morawski BM, Nakigozi G, Nakasujja N, Kong X, Meya DB, Robertson K, Gray R, Wawer MJ, Sacktor N, Boulware DR (2017) \u2019Cerebrospinal fluid biomarkers and HIV-associated neurocognitive disorders in HIV-infected individuals in Rakai. Uganda\u2019, J Neurovirol 23:369\u2013375","journal-title":"Uganda', J Neurovirol"},{"key":"955_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.imbio.2004.04.001","volume":"209","author":"P Ancuta","year":"2004","unstructured":"Ancuta P, Moses A, Gabuzda D (2004) Transendothelial migration of CD16+ monocytes in response to fractalkine under constitutive and inflammatory conditions. Immunobiology 209:11\u201320","journal-title":"Immunobiology"},{"key":"955_CR3","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1189\/jlb.0206125","volume":"80","author":"P Ancuta","year":"2006","unstructured":"Ancuta P, Wang J, Gabuzda D (2006) CD16+ monocytes produce IL-6, CCL2, and matrix metalloproteinase-9 upon interaction with CX3CL1-expressing endothelial cells. J Leukoc Biol 80:1156\u20131164","journal-title":"J Leukoc Biol"},{"key":"955_CR4","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1089\/aid.2016.0273","volume":"33","author":"KS Appelberg","year":"2017","unstructured":"Appelberg KS, Wallet MA, Taylor JP, Cash MN, Sleasman JW, Goodenow MM (2017) HIV-1 infection primes macrophages through STAT signaling to promote enhanced inflammation and viral replication. AIDS Res Hum Retroviruses 33:690\u2013702","journal-title":"AIDS Res Hum Retroviruses"},{"key":"955_CR5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/ar.23728","volume":"301","author":"J Bahney","year":"2018","unstructured":"Bahney J, von Bartheld CS (2018) The cellular composition and glia-neuron ratio in the spinal cord of a human and a nonhuman primate: comparison with other species and brain regions. Anat Rec (Hoboken) 301:697\u2013710","journal-title":"Anat Rec (Hoboken)"},{"key":"955_CR6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/glia.440140404","volume":"14","author":"ME Ballestas","year":"1995","unstructured":"Ballestas ME, Benveniste EN (1995) Interleukin 1-beta- and tumor necrosis factor-alpha-mediated regulation of ICAM-1 gene expression in astrocytes requires protein kinase C activity. Glia 14:267\u2013278","journal-title":"Glia"},{"key":"955_CR7","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3109\/08923970009026002","volume":"22","author":"AA Baqui","year":"2000","unstructured":"Baqui AA, Jabra-Rizk MA, Kelley JI, Zhang M, Falkler WA Jr, Meiller TF (2000) Enhanced interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha production by LPS stimulated human monocytes isolated from HIV+ patients. Immunopharmacol Immunotoxicol 22:401\u2013421","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"955_CR8","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1002\/glia.23310","volume":"66","author":"C Barat","year":"2018","unstructured":"Barat C, Proust A, Deshiere A, Leboeuf M, Drouin J, Tremblay MJ (2018) Astrocytes sustain long-term productive HIV-1 infection without establishment of reactivable viral latency. Glia 66:1363\u20131381","journal-title":"Glia"},{"key":"955_CR9","doi-asserted-by":"publisher","first-page":"e12686","DOI":"10.7554\/eLife.12686","volume":"5","author":"M Barboric","year":"2016","unstructured":"Barboric M, Fujinaga K (2016) The two sides of Tat. Elife 5:e12686","journal-title":"Elife"},{"key":"955_CR10","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/385640a0","volume":"385","author":"JF Bazan","year":"1997","unstructured":"Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385:640\u2013644","journal-title":"Nature"},{"key":"955_CR11","first-page":"816","volume":"154","author":"JE Bell","year":"1998","unstructured":"Bell JE (1998) The neuropathology of adult HIV infection. Rev Neurol (Paris) 154:816\u2013829","journal-title":"Rev Neurol (Paris)"},{"key":"955_CR12","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1086\/314662","volume":"179","author":"A Bergamini","year":"1999","unstructured":"Bergamini A, Faggioli E, Bolacchi F, Gessani S, Cappannoli L, Uccella I, Demin F, Capozzi M, Cicconi R, Placido R, Vendetti S, Colizzi GM, Rocchi G (1999) Enhanced production of tumor necrosis factor-alpha and interleukin-6 due to prolonged response to lipopolysaccharide in human macrophages infected in vitro with human immunodeficiency virus type 1. J Infect Dis 179:832\u2013842","journal-title":"J Infect Dis"},{"key":"955_CR13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.virol.2014.02.007","volume":"454\u2013455","author":"J Bertin","year":"2014","unstructured":"Bertin J, Jalaguier P, Barat C, Roy MA, Tremblay MJ (2014) Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1\/fractalkine-mediated transmigration of HIV-1-infected CD4(+) T cells across an in vitro blood-brain barrier model. Virology 454\u2013455:128\u2013138","journal-title":"Virology"},{"key":"955_CR14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fimmu.2014.00071","volume":"5","author":"D Bhatt","year":"2014","unstructured":"Bhatt D, Ghosh S (2014) Regulation of the NF-kappaB-mediated transcription of inflammatory genes. Front Immunol 5:71","journal-title":"Front Immunol"},{"key":"955_CR15","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1096\/fj.07-094235","volume":"22","author":"PK Bhavsar","year":"2008","unstructured":"Bhavsar PK, Sukkar MB, Khorasani N, Lee KY, Chung KF (2008) Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB. FASEB J 22:1807\u20131816","journal-title":"FASEB J"},{"key":"955_CR16","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1128\/JVI.76.3.1004-1014.2002","volume":"76","author":"S Bounou","year":"2002","unstructured":"Bounou S, Leclerc JE, Tremblay MJ (2002) Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivo. J Virol 76:1004\u20131014","journal-title":"J Virol"},{"key":"955_CR17","doi-asserted-by":"publisher","first-page":"e3664","DOI":"10.1371\/journal.pone.0003664","volume":"3","author":"JN Brown","year":"2008","unstructured":"Brown JN, Kohler JJ, Coberley CR, Sleasman JW, Goodenow MM (2008) HIV-1 activates macrophages independent of Toll-like receptors. PLoS ONE 3:e3664","journal-title":"PLoS ONE"},{"key":"955_CR18","doi-asserted-by":"publisher","first-page":"7925","DOI":"10.1128\/JVI.75.17.7925-7933.2001","volume":"75","author":"M Canki","year":"2001","unstructured":"Canki M, Thai JN, Chao W, Ghorpade A, Potash MJ, Volsky DJ (2001) Highly productive infection with pseudotyped human immunodeficiency virus type 1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes. J Virol 75:7925\u20137933","journal-title":"J Virol"},{"key":"955_CR19","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1182\/blood.V90.3.1091.1091_1091_1100","volume":"90","author":"R Cantin","year":"1997","unstructured":"Cantin R, Fortin JF, Lamontagne G, Tremblay M (1997) The acquisition of host-derived major histocompatibility complex class II glycoproteins by human immunodeficiency virus type 1 accelerates the process of virus entry and infection in human T-lymphoid cells. Blood 90:1091\u20131100","journal-title":"Blood"},{"key":"955_CR20","doi-asserted-by":"publisher","first-page":"8006","DOI":"10.1038\/s41598-019-44463-1","volume":"9","author":"YM Cantres-Rosario","year":"2019","unstructured":"Cantres-Rosario YM, Ortiz-Rodriguez SC, Santos-Figueroa AG, Plaud M, Negron K, Cotto B, Langford D, Melendez LM (2019) HIV infection induces extracellular cathepsin B uptake and damage to neurons. Sci Rep 9:8006","journal-title":"Sci Rep"},{"key":"955_CR21","doi-asserted-by":"publisher","first-page":"41125","DOI":"10.1074\/jbc.M111.268466","volume":"286","author":"JR Chang","year":"2011","unstructured":"Chang JR, Mukerjee R, Bagashev A, Del Valle L, Chabrashvili T, Hawkins BJ, He JJ, Sawaya BE (2011) HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs. J Biol Chem 286:41125\u201341134","journal-title":"J Biol Chem"},{"key":"955_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2014.03.002","volume":"456\u2013457","author":"A Chauhan","year":"2014","unstructured":"Chauhan A, Mehla R, Vijayakumar TS, Handy I (2014) Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes. Virology 456\u2013457:1\u201319","journal-title":"Virology"},{"key":"955_CR23","doi-asserted-by":"publisher","first-page":"e92325","DOI":"10.1371\/journal.pone.0092325","volume":"9","author":"SS Choi","year":"2014","unstructured":"Choi SS, Lee HJ, Lim I, Satoh J, Kim SU (2014) Human astrocytes: secretome profiles of cytokines and chemokines. PLoS One 9:e92325","journal-title":"PLoS One"},{"key":"955_CR24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1080\/13550280600748946","volume":"12","author":"MJ Churchill","year":"2006","unstructured":"Churchill MJ, Gorry PR, Cowley D, Lal L, Sonza S, Purcell DF, Thompson KA, Gabuzda D, McArthur JC, Pardo CA, Wesselingh SL (2006) Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues. J Neurovirol 12:146\u2013152","journal-title":"J Neurovirol"},{"key":"955_CR25","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/ana.21697","volume":"66","author":"MJ Churchill","year":"2009","unstructured":"Churchill MJ, Wesselingh SL, Cowley D, Pardo CA, McArthur JC, Brew BJ, Gorry PR (2009) Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia. Ann Neurol 66:253\u2013258","journal-title":"Ann Neurol"},{"key":"955_CR26","doi-asserted-by":"publisher","first-page":"27569","DOI":"10.18632\/oncotarget.15174","volume":"8","author":"E Clark","year":"2017","unstructured":"Clark E, Nava B, Caputi M (2017) Tat is a multifunctional viral protein that modulates cellular gene expression and functions. Oncotarget 8:27569\u201327581","journal-title":"Oncotarget"},{"key":"955_CR27","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/S1473-3099(13)70269-X","volume":"13","author":"DB Clifford","year":"2013","unstructured":"Clifford DB, Ances BM (2013) HIV-associated neurocognitive disorder. Lancet Infect Dis 13:976\u2013986","journal-title":"Lancet Infect Dis"},{"key":"955_CR28","doi-asserted-by":"publisher","first-page":"23799","DOI":"10.1074\/jbc.273.37.23799","volume":"273","author":"C Combadiere","year":"1998","unstructured":"Combadiere C, Salzwedel K, Smith ED, Tiffany HL, Berger EA, Murphy PM (1998) Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. J Biol Chem 273:23799\u201323804","journal-title":"J Biol Chem"},{"key":"955_CR29","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1073\/pnas.95.6.3117","volume":"95","author":"K Conant","year":"1998","unstructured":"Conant K, Garzino-Demo A, Nath A, McArthur JC, Halliday W, Power C, Gallo RC, Major EO (1998) Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci U S A 95:3117\u20133121","journal-title":"Proc Natl Acad Sci U S A"},{"key":"955_CR30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3109\/13550280009006384","volume":"6","author":"M Cota","year":"2000","unstructured":"Cota M, Kleinschmidt A, Ceccherini-Silberstein F, Aloisi F, Mengozzi M, Mantovani A, Brack-Werner R, Poli G (2000) Upregulated expression of interleukin-8, RANTES and chemokine receptors in human astrocytic cells infected with HIV-1. J Neurovirol 6:75\u201383","journal-title":"J Neurovirol"},{"key":"955_CR31","doi-asserted-by":"publisher","first-page":"4716","DOI":"10.1128\/JVI.03478-12","volume":"87","author":"MS Dahabieh","year":"2013","unstructured":"Dahabieh MS, Ooms M, Simon V, Sadowski I (2013) A doubly fluorescent HIV-1 reporter shows that the majority of integrated HIV-1 is latent shortly after infection. J Virol 87:4716\u20134727","journal-title":"J Virol"},{"key":"955_CR32","doi-asserted-by":"publisher","first-page":"3222","DOI":"10.1111\/j.1460-9568.2004.03800.x","volume":"20","author":"K Deiva","year":"2004","unstructured":"Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, Freyssinet JM, Tardieu M (2004) Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci 20:3222\u20133232","journal-title":"Eur J Neurosci"},{"key":"955_CR33","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/febs.13168","volume":"282","author":"N Dhamija","year":"2015","unstructured":"Dhamija N, Choudhary D, Ladha JS, Pillai B, Mitra D (2015) Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel. FEBS J 282:595\u2013610","journal-title":"FEBS J"},{"key":"955_CR34","first-page":"54","volume":"17","author":"D Elbirt","year":"2015","unstructured":"Elbirt D, Mahlab-Guri K, Bezalel-Rosenberg S, Gill H, Attali M, Asher I (2015) HIV-associated neurocognitive disorders (HAND). Isr Med Assoc J 17:54\u201359","journal-title":"Isr Med Assoc J"},{"key":"955_CR35","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.virol.2014.02.006","volume":"454\u2013455","author":"MA Endsley","year":"2014","unstructured":"Endsley MA, Somasunderam AD, Li G, Oezguen N, Thiviyanathan V, Murray JL, Rubin DH, Hodge TW, O\u2019Brien WA, Lewis B, Ferguson MR (2014) Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain. Virology 454\u2013455:60\u201366","journal-title":"Virology"},{"key":"955_CR36","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S0165-5728(03)00117-6","volume":"138","author":"D Erichsen","year":"2003","unstructured":"Erichsen D, Lopez AL, Peng H, Niemann D, Williams C, Bauer M, Morgello S, Cotter RL, Ryan LA, Ghorpade A, Gendelman HE, Zheng J (2003) Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia. J Neuroimmunol 138:144\u2013155","journal-title":"J Neuroimmunol"},{"key":"955_CR37","doi-asserted-by":"publisher","first-page":"4752","DOI":"10.1182\/blood.V91.12.4752","volume":"91","author":"R Esser","year":"1998","unstructured":"Esser R, Glienke W, Andreesen R, Unger RE, Kreutz M, Rubsamen-Waigmann H, von Briesen H (1998) Individual cell analysis of the cytokine repertoire in human immunodeficiency virus-1-infected monocytes\/macrophages by a combination of immunocytochemistry and in situ hybridization. Blood 91:4752\u20134760","journal-title":"Blood"},{"key":"955_CR38","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1523\/JNEUROSCI.3863-05.2006","volume":"26","author":"EA Eugenin","year":"2006","unstructured":"Eugenin EA, Osiecki K, Lopez L, Goldstein H, Calderon TM, Berman JW (2006) CCL2\/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS. J Neurosci 26:1098\u20131106","journal-title":"J Neurosci"},{"key":"955_CR39","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1126\/science.287.5461.2274","volume":"287","author":"S Faure","year":"2000","unstructured":"Faure S, Meyer L, Costagliola D, Vaneensberghe C, Genin E, Autran B, Delfraissy JF, McDermott DH, Murphy PM, Debre P, Theodorou I, Combadiere C (2000) Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1. Science 287:2274\u20132277","journal-title":"Science"},{"key":"955_CR40","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1742-4690-8-32","volume":"8","author":"BM Friedrich","year":"2011","unstructured":"Friedrich BM, Murray JL, Li G, Sheng J, Hodge TW, Rubin DH, O\u2019Brien WA, Ferguson MR (2011) A functional role for ADAM10 in human immunodeficiency virus type-1 replication. Retrovirology 8:32","journal-title":"Retrovirology"},{"key":"955_CR41","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1111\/febs.12921","volume":"281","author":"AM Gan","year":"2014","unstructured":"Gan AM, Butoi E, Manea A, Pirvulescu MM, Stan D, Simion V, Calin M, Simionescu M, Manduteanu I (2014) Functional analysis of the fractalkine gene promoter in human aortic smooth muscle cells exposed to proinflammatory conditions. FEBS J 281:3869\u20133881","journal-title":"FEBS J"},{"key":"955_CR42","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1089\/aid.1991.7.671","volume":"7","author":"HX Gan","year":"1991","unstructured":"Gan HX, Ruef C, Hall BF, Tobin E, Remold HG, Mellors JW (1991) Interleukin-6 expression in primary macrophages infected with human immunodeficiency virus-1 (HIV-1). AIDS Res Hum Retroviruses 7:671\u2013679","journal-title":"AIDS Res Hum Retroviruses"},{"key":"955_CR43","doi-asserted-by":"crossref","unstructured":"Ganief T, Gqamana P, Garnett S, Hoare J, Stein DJ, Joska J, Soares N, Blackburn JM\u00a0(2017) 'Quantitative proteomic analysis of HIV-1 Tat-induced dysregulation in SH-SY5Y neuroblastoma cells', Proteomics, 17.","DOI":"10.1002\/pmic.201600236"},{"key":"955_CR44","doi-asserted-by":"publisher","first-page":"5305","DOI":"10.4049\/jimmunol.171.10.5305","volume":"171","author":"A Garin","year":"2003","unstructured":"Garin A, Tarantino N, Faure S, Daoudi M, Lecureuil C, Bourdais A, Debre P, Deterre P, Combadiere C (2003) Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors. J Immunol 171:5305\u20135312","journal-title":"J Immunol"},{"key":"955_CR45","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/jlb.56.3.389","volume":"56","author":"HE Gendelman","year":"1994","unstructured":"Gendelman HE, Lipton SA, Tardieu M, Bukrinsky MI, Nottet HS (1994) The neuropathogenesis of HIV-1 infection. J Leukoc Biol 56:389\u2013398","journal-title":"J Leukoc Biol"},{"key":"955_CR46","doi-asserted-by":"publisher","first-page":"8416","DOI":"10.1073\/pnas.0910627107","volume":"107","author":"SN Giraud","year":"2010","unstructured":"Giraud SN, Caron CM, Pham-Dinh D, Kitabgi P, Nicot AB (2010) Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes. Proc Natl Acad Sci U S A 107:8416\u20138421","journal-title":"Proc Natl Acad Sci U S A"},{"key":"955_CR47","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.cell.2014.11.023","volume":"159","author":"D Gosselin","year":"2014","unstructured":"Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, Spann NJ, Stender JD, Chun HB, Garner H, Geissmann F, Glass CK (2014) Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell 159:1327\u20131340","journal-title":"Cell"},{"key":"955_CR48","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1742-4690-7-30","volume":"7","author":"G Gras","year":"2010","unstructured":"Gras G, Kaul M (2010) Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection. Retrovirology 7:30","journal-title":"Retrovirology"},{"key":"955_CR49","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/S0006-8993(98)01371-7","volume":"823","author":"HN Hao","year":"1999","unstructured":"Hao HN, Lyman WD (1999) HIV infection of fetal human astrocytes: the potential role of a receptor-mediated endocytic pathway. Brain Res 823:24\u201332","journal-title":"Brain Res"},{"key":"955_CR50","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/jnr.10304","volume":"69","author":"K Hatori","year":"2002","unstructured":"Hatori K, Nagai A, Heisel R, Ryu JK, Kim SU (2002) Fractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res 69:418\u2013426","journal-title":"J Neurosci Res"},{"key":"955_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2014.10.008","volume":"45","author":"S Hong","year":"2015","unstructured":"Hong S, Banks WA (2015) Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications. Brain Behav Immun 45:1\u201312","journal-title":"Brain Behav Immun"},{"key":"955_CR52","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.neulet.2012.05.057","volume":"521","author":"LA Hurst","year":"2012","unstructured":"Hurst LA, Bunning RA, Sharrack B, Woodroofe MN (2012) siRNA knockdown of ADAM-10, but not ADAM-17, significantly reduces fractalkine shedding following pro-inflammatory cytokine treatment in a human adult brain endothelial cell line. Neurosci Lett 521:52\u201356","journal-title":"Neurosci Lett"},{"key":"955_CR53","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1620\/tjem.192.127","volume":"192","author":"T Imaizumi","year":"2000","unstructured":"Imaizumi T, Matsumiya T, Fujimoto K, Okamoto K, Cui X, Ohtaki U, Hidemi Y, Satoh K (2000) Interferon-gamma stimulates the expression of CX3CL1\/fractalkine in cultured human endothelial cells. Tohoku J Exp Med 192:127\u2013139","journal-title":"Tohoku J Exp Med"},{"key":"955_CR54","doi-asserted-by":"publisher","first-page":"6513","DOI":"10.1128\/JVI.02484-10","volume":"85","author":"V Janelle","year":"2011","unstructured":"Janelle V, Brassard F, Lapierre P, Lamarre A, Poliquin L (2011) Mutations in the glycoprotein of vesicular stomatitis virus affect cytopathogenicity: potential for oncolytic virotherapy. J Virol 85:6513\u20136520","journal-title":"J Virol"},{"key":"955_CR55","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/35073667","volume":"410","author":"M Kaul","year":"2001","unstructured":"Kaul M, Garden GA, Lipton SA (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410:988\u2013994","journal-title":"Nature"},{"key":"955_CR56","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3109\/13550281003735691","volume":"16","author":"A Khiati","year":"2010","unstructured":"Khiati A, Chaloin O, Muller S, Tardieu M, Horellou P (2010) Induction of monocyte chemoattractant protein-1 (MCP-1\/CCL2) gene expression by human immunodeficiency virus-1 Tat in human astrocytes is CDK9 dependent. J Neurovirol 16:150\u2013167","journal-title":"J Neurovirol"},{"key":"955_CR57","doi-asserted-by":"publisher","first-page":"7284","DOI":"10.4049\/jimmunol.181.10.7284","volume":"181","author":"R Khorooshi","year":"2008","unstructured":"Khorooshi R, Babcock AA, Owens T (2008) NF-kappaB-driven STAT2 and CCL2 expression in astrocytes in response to brain injury. J Immunol 181:7284\u20137291","journal-title":"J Immunol"},{"key":"955_CR58","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.2131\/jts.37.1275","volume":"37","author":"MS Kim","year":"2012","unstructured":"Kim MS, Takahashi T, Lee JY, Hwang GW, Naganuma A (2012) Methylmercury induces CCL2 expression through activation of NF-kappaB in human 1321N1 astrocytes. J Toxicol Sci 37:1275\u20131278","journal-title":"J Toxicol Sci"},{"key":"955_CR59","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/nyas.12805","volume":"1351","author":"C Lauro","year":"2015","unstructured":"Lauro C, Catalano M, Trettel F, Limatola C (2015) Fractalkine in the nervous system: neuroprotective or neurotoxic molecule? Ann N Y Acad Sci 1351:141\u2013148","journal-title":"Ann N Y Acad Sci"},{"key":"955_CR60","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.1242\/jcs.03231","volume":"119","author":"MH Lehmann","year":"2006","unstructured":"Lehmann MH, Masanetz S, Kramer S, Erfle V (2006) HIV-1 Nef upregulates CCL2\/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner. J Cell Sci 119:4520\u20134530","journal-title":"J Cell Sci"},{"key":"955_CR61","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1097\/QAD.0000000000000605","volume":"29","author":"GH Li","year":"2015","unstructured":"Li GH, Anderson C, Jaeger L, Do T, Major EO, Nath A (2015) Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4. AIDS 29:755\u2013766","journal-title":"AIDS"},{"key":"955_CR62","doi-asserted-by":"crossref","unstructured":"Li GH, Maric D, Major EO, Nath A\u00a0(2020) 'Productive HIV infection in astrocytes can be established via a non-classical mechanism', AIDS.","DOI":"10.1097\/QAD.0000000000002512"},{"key":"955_CR63","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s11481-010-9205-z","volume":"5","author":"KA Lindl","year":"2010","unstructured":"Lindl KA, Marks DR, Kolson DL, Jordan-Sciutto KL (2010) HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities. J Neuroimmune Pharmacol 5:294\u2013309","journal-title":"J Neuroimmune Pharmacol"},{"key":"955_CR64","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fnins.2017.00150","volume":"11","author":"Z Liu","year":"2017","unstructured":"Liu Z, Qiao L, Zhang Y, Zang Y, Shi Y, Liu K, Zhang X, Lu X, Yuan L, Su B, Zhang T, Wu H, Chen D (2017) ASPP2 plays a dual role in gp120-induced autophagy and apoptosis of neuroblastoma cells. Front Neurosci 11:150","journal-title":"Front Neurosci"},{"key":"955_CR65","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2174\/1386207053258488","volume":"8","author":"A Ludwig","year":"2005","unstructured":"Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD (2005) Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. Comb Chem High Throughput Screen 8:161\u2013171","journal-title":"Comb Chem High Throughput Screen"},{"key":"955_CR66","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainresbull.2018.11.017","volume":"146","author":"P Luo","year":"2019","unstructured":"Luo P, Chu SF, Zhang Z, Xia CY, Chen NH (2019) Fractalkine\/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases. Brain Res Bull 146:12\u201321","journal-title":"Brain Res Bull"},{"key":"955_CR67","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s13365-014-0304-0","volume":"21","author":"X Luo","year":"2015","unstructured":"Luo X, He JJ (2015) Cell-cell contact viral transfer contributes to HIV infection and persistence in astrocytes. J Neurovirol 21:66\u201380","journal-title":"J Neurovirol"},{"key":"955_CR68","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.4049\/jimmunol.163.3.1628","volume":"163","author":"D Maciejewski-Lenoir","year":"1999","unstructured":"Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB (1999) Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J Immunol 163:1628\u20131635","journal-title":"J Immunol"},{"key":"955_CR69","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s13365-011-0034-5","volume":"17","author":"RB Meeker","year":"2011","unstructured":"Meeker RB, Poulton W, Markovic-Plese S, Hall C, Robertson K (2011) Protein changes in CSF of HIV-infected patients: evidence for loss of neuroprotection. J Neurovirol 17:258\u2013273","journal-title":"J Neurovirol"},{"key":"955_CR70","doi-asserted-by":"publisher","first-page":"14500","DOI":"10.1073\/pnas.95.24.14500","volume":"95","author":"O Meucci","year":"1998","unstructured":"Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ (1998) Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci U S A 95:14500\u201314505","journal-title":"Proc Natl Acad Sci U S A"},{"key":"955_CR71","doi-asserted-by":"publisher","first-page":"8075","DOI":"10.1073\/pnas.090017497","volume":"97","author":"O Meucci","year":"2000","unstructured":"Meucci O, Fatatis A, Simen AA, Miller RJ (2000) Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A 97:8075\u20138080","journal-title":"Proc Natl Acad Sci U S A"},{"key":"955_CR72","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1189\/jlb.3HI0516-242R","volume":"101","author":"A Mosoian","year":"2017","unstructured":"Mosoian A, Zhang L, Hong F, Cunyat F, Rahman A, Bhalla R, Panchal A, Saiman Y, Fiel MI, Florman S, Roayaie S, Schwartz M, Branch A, Stevenson M, Bansal MB (2017) Frontline Science: HIV infection of Kupffer cells results in an amplified proinflammatory response to LPS. J Leukoc Biol 101:1083\u20131090","journal-title":"J Leukoc Biol"},{"key":"955_CR73","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1002\/glia.21059","volume":"58","author":"C Muratori","year":"2010","unstructured":"Muratori C, Mangino G, Affabris E, Federico M (2010) Astrocytes contacting HIV-1-infected macrophages increase the release of CCL2 in response to the HIV-1-dependent enhancement of membrane-associated TNFalpha in macrophages. Glia 58:1893\u20131904","journal-title":"Glia"},{"issue":"Suppl 2","key":"955_CR74","doi-asserted-by":"publisher","first-page":"S193","DOI":"10.1086\/344528","volume":"186","author":"A Nath","year":"2002","unstructured":"Nath A (2002) Human immunodeficiency virus (HIV) proteins in neuropathogenesis of HIV dementia. J Infect Dis 186(Suppl 2):S193\u2013S198","journal-title":"J Infect Dis"},{"key":"955_CR75","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.canlet.2008.07.029","volume":"273","author":"I Nevo","year":"2009","unstructured":"Nevo I, Sagi-Assif O, Meshel T, Ben-Baruch A, Johrer K, Greil R, Trejo LE, Kharenko O, Feinmesser M, Yron I, Witz IP (2009) The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells. Cancer Lett 273:127\u2013139","journal-title":"Cancer Lett"},{"key":"955_CR76","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/s41467-018-03432-4","volume":"9","author":"J Nikolic","year":"2018","unstructured":"Nikolic J, Belot L, Raux H, Legrand P, GaudinA. Albertini A. Y (2018) Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein. Nat Commun 9:1029","journal-title":"Nat Commun"},{"key":"955_CR77","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/BF03401633","volume":"2","author":"GJ Nuovo","year":"1996","unstructured":"Nuovo GJ, Alfieri ML (1996) AIDS dementia is associated with massive, activated HIV-1 infection and concomitant expression of several cytokines. Mol Med 2:358\u2013366","journal-title":"Mol Med"},{"key":"955_CR78","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12974-016-0659-7","volume":"13","author":"SA O'Sullivan","year":"2016","unstructured":"O\u2019Sullivan SA, Gasparini F, Mir AK, Dev KK (2016) Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes. J Neuroinflammation 13:189","journal-title":"J Neuroinflammation"},{"key":"955_CR79","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3109\/13550289909029749","volume":"5","author":"JW Oh","year":"1999","unstructured":"Oh JW, Schwiebert LM, Benveniste EN (1999) Cytokine regulation of CC and CXC chemokine expression by human astrocytes. J Neurovirol 5:82\u201394","journal-title":"J Neurovirol"},{"key":"955_CR80","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S0165-5728(01)00262-4","volume":"115","author":"CF Pereira","year":"2001","unstructured":"Pereira CF, Middel J, Jansen G, Verhoef J, Nottet HS (2001) Enhanced expression of fractalkine in HIV-1 associated dementia. J Neuroimmunol 115:168\u2013175","journal-title":"J Neuroimmunol"},{"key":"955_CR81","doi-asserted-by":"crossref","unstructured":"Peron R, Vatanabe IP, Manzine PR, Camins A, Cominetti MR\u00a0(2018) 'Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment', Pharmaceuticals (Basel), 11.","DOI":"10.3390\/ph11010012"},{"key":"955_CR82","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12974-017-1019-y","volume":"14","author":"A Proust","year":"2017","unstructured":"Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ (2017) Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion. J Neuroinflammation 14:242","journal-title":"J Neuroinflammation"},{"key":"955_CR83","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1742-6405-11-13","volume":"11","author":"VR Rao","year":"2014","unstructured":"Rao VR, Ruiz AP, Prasad VR (2014) Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND). AIDS Res Ther 11:13","journal-title":"AIDS Res Ther"},{"key":"955_CR84","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1006\/brbi.1995.1034","volume":"9","author":"MB Rho","year":"1995","unstructured":"Rho MB, Wesselingh S, Glass JD, McArthur JC, Choi S, Griffin J, Tyor WR (1995) A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia. Brain Behav Immun 9:366\u2013377","journal-title":"Brain Behav Immun"},{"key":"955_CR85","doi-asserted-by":"publisher","first-page":"e36571","DOI":"10.1371\/journal.pone.0036571","volume":"7","author":"EJ Rodriguez-Franco","year":"2012","unstructured":"Rodriguez-Franco EJ, Cantres-Rosario YM, Plaud-Valentin M, Romeu R, Rodriguez Y, Skolasky R, Melendez V, Cadilla CL, Melendez LM (2012) Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. PLoS ONE 7:e36571","journal-title":"PLoS ONE"},{"key":"955_CR86","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1017\/S1355617717001102","volume":"23","author":"R Saloner","year":"2017","unstructured":"Saloner R, Cysique LA (2017) HIV-associated neurocognitive disorders: a global perspective. J Int Neuropsychol Soc 23:860\u2013869","journal-title":"J Int Neuropsychol Soc"},{"key":"955_CR87","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/2049-9256-2-2","volume":"2","author":"M Sanmarti","year":"2014","unstructured":"Sanmarti M, Ibanez L, Huertas S, Badenes D, Dalmau D, Slevin M, Krupinski J, Popa-Wagner A, Jaen A (2014) HIV-associated neurocognitive disorders. J Mol Psychiatry 2:2","journal-title":"J Mol Psychiatry"},{"key":"955_CR88","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1365-2990.1997.tb01190.x","volume":"23","author":"D Seilhean","year":"1997","unstructured":"Seilhean D, Dzia-Lepfoundzou A, Sazdovitch V, Cannella B, Raine CS, Katlama C, Bricaire F, Duyckaerts C, Hauw JJ (1997) Astrocytic adhesion molecules are increased in HIV-1-associated cognitive\/motor complex. Neuropathol Appl Neurobiol 23:83\u201392","journal-title":"Neuropathol Appl Neurobiol"},{"key":"955_CR89","doi-asserted-by":"publisher","first-page":"130181","DOI":"10.1098\/rsob.130181","volume":"3","author":"GK Sheridan","year":"2013","unstructured":"Sheridan GK, Murphy KJ (2013) Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage. Open Biol 3:130181","journal-title":"Open Biol"},{"key":"955_CR90","doi-asserted-by":"crossref","unstructured":"Shipley MM, Mangold CA, Szpara ML\u00a0(2016) 'Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line'. J Vis Exp 53193.","DOI":"10.3791\/53193-v"},{"key":"955_CR91","first-page":"1307","volume":"156","author":"P Shrikant","year":"1996","unstructured":"Shrikant P, Benos DJ, Tang LP, Benveniste EN (1996) \u2019HIV glycoprotein 120 enhances intercellular adhesion molecule-1 gene expression in glial cells. Involvement of Janus kinase\/signal transducer and activator of transcription and protein kinase C signaling pathways\u2019, J Immunol 156:1307\u20131314","journal-title":"Involvement of Janus kinase\/signal transducer and activator of transcription and protein kinase C signaling pathways', J Immunol"},{"key":"955_CR92","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/B978-0-444-63849-6.00007-4","volume":"152","author":"RC Smail","year":"2018","unstructured":"Smail RC, Brew BJ (2018) HIV-associated neurocognitive disorder. Handb Clin Neurol 152:75\u201397","journal-title":"Handb Clin Neurol"},{"key":"955_CR93","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3389\/fncel.2014.00360","volume":"8","author":"JD Sokolowski","year":"2014","unstructured":"Sokolowski JD, Chabanon-Hicks CN, Han CZ, Heffron DS, Mandell JW (2014) Fractalkine is a \u201cfind-me\u201d signal released by neurons undergoing ethanol-induced apoptosis. Front Cell Neurosci 8:360","journal-title":"Front Cell Neurosci"},{"key":"955_CR94","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1006\/viro.1996.0320","volume":"220","author":"S Sopper","year":"1996","unstructured":"Sopper S, Demuth M, Stahl-Hennig C, Hunsmann G, Plesker R, Coulibaly C, Czub S, Ceska M, Koutsilieri E, Riederer P, Brinkmann R, Katz M, ter Meulen V (1996) The effect of simian immunodeficiency virus infection in vitro and in vivo on the cytokine production of isolated microglia and peripheral macrophages from rhesus monkey. Virology 220:320\u2013329","journal-title":"Virology"},{"key":"955_CR95","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1089\/088922203762688612","volume":"19","author":"B Sporer","year":"2003","unstructured":"Sporer B, Kastenbauer S, Koedel U, Arendt G, Pfister HW (2003) Increased intrathecal release of soluble fractalkine in HIV-infected patients. AIDS Res Hum Retroviruses 19:111\u2013116","journal-title":"AIDS Res Hum Retroviruses"},{"key":"955_CR96","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.3389\/fimmu.2018.01811","volume":"9","author":"H Suarez","year":"2018","unstructured":"Suarez H, Rocha-Perugini V, Alvarez S, Yanez-Mo M (2018) Tetraspanins, another piece in the HIV-1 replication puzzle. Front Immunol 9:1811","journal-title":"Front Immunol"},{"key":"955_CR97","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mcn.2014.01.003","volume":"59","author":"T Sugimoto","year":"2014","unstructured":"Sugimoto T, Morioka N, Zhang FF, Sato K, Abe H, Hisaoka-Nakashima K, Nakata Y (2014) Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-kappaB activation in spinal astrocytes. Mol Cell Neurosci 59:37\u201346","journal-title":"Mol Cell Neurosci"},{"key":"955_CR98","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1750-1326-6-78","volume":"6","author":"M Suzuki","year":"2011","unstructured":"Suzuki M, El-Hage N, Zou S, Hahn YK, Sorrell ME, Sturgill JL, Conrad DH, Knapp PE, Hauser KF (2011) Fractalkine\/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death. Mol Neurodegener 6:78","journal-title":"Mol Neurodegener"},{"key":"955_CR99","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1186\/1471-2334-14-386","volume":"14","author":"ET Tatro","year":"2014","unstructured":"Tatro ET, Soontornniyomkij B, Letendre SL, Achim CL (2014) Cytokine secretion from brain macrophages infected with human immunodeficiency virus in vitro and treated with raltegravir. BMC Infect Dis 14:386","journal-title":"BMC Infect Dis"},{"key":"955_CR100","first-page":"85","volume":"339","author":"M Thali","year":"2009","unstructured":"Thali M (2009) The roles of tetraspanins in HIV-1 replication. Curr Top Microbiol Immunol 339:85\u2013102","journal-title":"Curr Top Microbiol Immunol"},{"key":"955_CR101","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1111\/j.1471-4159.2007.05197.x","volume":"105","author":"C Tian","year":"2008","unstructured":"Tian C, Erdmann N, Zhao J, Cao Z, Peng H, Zheng J (2008) HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase. J Neurochem 105:994\u20131005","journal-title":"J Neurochem"},{"key":"955_CR102","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.4049\/jimmunol.164.3.1333","volume":"164","author":"N Tong","year":"2000","unstructured":"Tong N, Perry SW, Zhang Q, James HJ, Guo H, Brooks A, Bal H, Kinnear SA, Fine S, Epstein LG, Dairaghi D, Schall TJ, Gendelman HE, Dewhurst S, Sharer LR, Gelbard HA (2000) Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. J Immunol 164:1333\u20131339","journal-title":"J Immunol"},{"key":"955_CR103","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1750-3639.2003.tb00014.x","volume":"13","author":"G Trillo-Pazos","year":"2003","unstructured":"Trillo-Pazos G, Diamanturos A, Rislove L, Menza T, Chao W, Belem P, Sadiq S, Morgello S, Sharer L, Volsky DJ (2003) Detection of HIV-1 DNA in microglia\/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection. Brain Pathol 13:144\u2013154","journal-title":"Brain Pathol"},{"key":"955_CR104","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1002\/cne.24040","volume":"524","author":"CS von Bartheld","year":"2016","unstructured":"von Bartheld CS, Bahney J, Herculano-Houzel S (2016) The search for true numbers of neurons and glial cells in the human brain: a review of 150 years of cell counting. J Comp Neurol 524:3865\u20133895","journal-title":"J Comp Neurol"},{"key":"955_CR105","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2174\/1570162X12666140526114526","volume":"12","author":"DW Williams","year":"2014","unstructured":"Williams DW, Veenstra M, Gaskill PJ, Morgello S, Calderon TM, Berman JW (2014) Monocytes mediate HIV neuropathogenesis: mechanisms that contribute to HIV associated neurocognitive disorders. Curr HIV Res 12:85\u201396","journal-title":"Curr HIV Res"},{"key":"955_CR106","doi-asserted-by":"publisher","first-page":"678","DOI":"10.3109\/13550289909021296","volume":"5","author":"SE Woodman","year":"1999","unstructured":"Woodman SE, Benveniste EN, Nath A, Berman JW (1999) Human immunodeficiency virus type 1 TAT protein induces adhesion molecule expression in astrocytes. J Neurovirol 5:678\u2013684","journal-title":"J Neurovirol"},{"key":"955_CR107","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1440-1789.2008.00996.x","volume":"29","author":"HQ Xing","year":"2009","unstructured":"Xing HQ, Hayakawa H, Izumo K, Kubota R, Gelpi E, Budka H, Izumo S (2009) In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases. Neuropathology 29:433\u2013442","journal-title":"Neuropathology"},{"key":"955_CR108","doi-asserted-by":"publisher","first-page":"7070","DOI":"10.1073\/pnas.0304859101","volume":"101","author":"Y Xu","year":"2004","unstructured":"Xu Y, Kulkosky J, Acheampong E, Nunnari G, Sullivan J, Pomerantz RJ (2004) HIV-1-mediated apoptosis of neuronal cells: proximal molecular mechanisms of HIV-1-induced encephalopathy. Proc Natl Acad Sci U S A 101:7070\u20137075","journal-title":"Proc Natl Acad Sci U S A"},{"key":"955_CR109","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/S0304-3940(01)01699-8","volume":"303","author":"H Yoshida","year":"2001","unstructured":"Yoshida H, Imaizumi T, Fujimoto K, Matsuo N, Kimura K, Cui X, Matsumiya T, Tanji K, Shibata T, Tamo W, Kumagai M, Satoh K (2001) Synergistic stimulation, by tumor necrosis factor-alpha and interferon-gamma, of fractalkine expression in human astrocytes. Neurosci Lett 303:132\u2013136","journal-title":"Neurosci Lett"},{"key":"955_CR110","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1111\/acel.12593","volume":"16","author":"C Yu","year":"2017","unstructured":"Yu C, Narasipura SD, Richards MH, Hu XT, Yamamoto B, Al-Harthi L (2017) HIV and drug abuse mediate astrocyte senescence in a beta-catenin-dependent manner leading to neuronal toxicity. Aging Cell 16:956\u2013965","journal-title":"Aging Cell"},{"key":"955_CR111","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s13365-012-0109-y","volume":"18","author":"V Zanin","year":"2012","unstructured":"Zanin V, Delbue S, Marcuzzi A, Tavazzi E, Del Savio R, Crovella S, Marchioni E, Ferrante P, Comar M (2012) Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders. J Neurovirol 18:416\u2013422","journal-title":"J Neurovirol"},{"key":"955_CR112","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11904-014-0255-3","volume":"12","author":"Z Zayyad","year":"2015","unstructured":"Zayyad Z, Spudich S (2015) Neuropathogenesis of HIV: from initial neuroinvasion to HIV-associated neurocognitive disorder (HAND). Curr HIV\/AIDS Rep 12:16\u201324","journal-title":"Curr HIV\/AIDS Rep"},{"key":"955_CR113","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jneuroim.2008.06.015","volume":"200","author":"JC Zheng","year":"2008","unstructured":"Zheng JC, Huang Y, Tang K, Cui M, Niemann D, Lopez A, Morgello S, Chen S (2008) HIV-1-infected and\/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1beta and TNF-alpha: involvement of mitogen-activated protein kinases and protein kinase R. J Neuroimmunol 200:100\u2013110","journal-title":"J Neuroimmunol"},{"key":"955_CR114","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1086\/323478","volume":"184","author":"MC Zink","year":"2001","unstructured":"Zink MC, Coleman GD, Mankowski JL, Adams RJ, Tarwater PM, Fox K, Clements JE (2001) Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis. J Infect Dis 184:1015\u20131021","journal-title":"J Infect Dis"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-021-00955-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13365-021-00955-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-021-00955-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T18:38:24Z","timestamp":1675017504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13365-021-00955-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":114,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["955"],"URL":"https:\/\/doi.org\/10.1007\/s13365-021-00955-3","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"type":"print","value":"1355-0284"},{"type":"electronic","value":"1538-2443"}],"subject":[],"published":{"date-parts":[[2021,3,1]]},"assertion":[{"value":"27 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Bioethics Committee at the Centre Hospitalier Universitaire de Qu\u00e9bec-Universit\u00e9 Laval, CHUL building (#B14-04-1973). Human fetal brain tissues from 16 to 22\u00a0weeks aborted fetuses were directly obtained from H\u00f4pital Saint-Fran\u00e7ois d\u2019Assise or the CHUL with the written informed consent of the adult patient. Human blood samples from anonymous healthy volunteers were obtained from the CHUL with the written informed consent of each participant.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}