{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:47:51Z","timestamp":1790898471880,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s13365-023-01135-1","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T14:54:16Z","timestamp":1684853656000},"page":"297-307","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Brain opportunistic infections and tumors in people living with HIV \u2014 still a challenge in efficient antiretroviral therapy era"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-2527","authenticated-orcid":false,"given":"Cristiana","family":"Oprea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-0187","authenticated-orcid":false,"given":"Irina","family":"Ianache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina","family":"Vasile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Costescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gratiela","family":"Tardei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya","family":"Umlauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Achim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"issue":"1","key":"1135_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s11910-015-0603-8","volume":"16","author":"F Albarillo","year":"2016","unstructured":"Albarillo F, O\u2019Keefe P (2016) Opportunistic Neurologic Infections in Patients with Acquired Immunodeficiency Syndrome (AIDS). Curr Neurol Neurosci Rep 16(1):10","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"1135_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1468-1293.2010.00857.x","volume":"12","author":"A Antinori","year":"2011","unstructured":"Antinori A, Coenen T, Costagiola D, Dedes N, Ellefson M, Gatell J et al (2011) Late presentation of HIV infection: a consensus definition. HIV Med 12(1):61\u201364","journal-title":"HIV Med"},{"issue":"9","key":"1135_CR3","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1097\/00002030-199809000-00016","volume":"12","author":"C Apetrei","year":"1998","unstructured":"Apetrei C, Necula A, Holm-Hansen C, Loussert-Ajaka I, Pandrea I, Cozmei C et al (1998) HIV-1 diversity in Romania. AIDS 12(9):1079\u20131085","journal-title":"AIDS"},{"issue":"2","key":"1135_CR4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s11060-010-0252-3","volume":"101","author":"S Bayraktar","year":"2011","unstructured":"Bayraktar S, Bayraktar UD, Ramos JC, Stefanovic A, Lossos IS (2011) Primary CNS lymphoma in HIV positive and negative patients: comparison of clinical characteristics, outcome and prognostic factors. J Neurooncol 101(2):257\u2013265","journal-title":"J Neurooncol"},{"issue":"11","key":"1135_CR5","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/nrneurol.2016.149","volume":"12","author":"LN Bowen","year":"2016","unstructured":"Bowen LN, Smith B, Reich D, Quezado M, Nath A (2016) HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment. Nat Rev Neurol 12(11):662\u2013674","journal-title":"Nat Rev Neurol"},{"key":"1135_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/B978-0-444-63849-6.00014-1","volume":"152","author":"D Brandsma","year":"2018","unstructured":"Brandsma D, Bromberg JEC (2018) Primary CNS lymphoma in HIV infection. Handb Clin Neurol 152:177\u2013186","journal-title":"Handb Clin Neurol"},{"key":"1135_CR7","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12879-016-1462-x","volume":"16","author":"LE Coelho","year":"2016","unstructured":"Coelho LE, Cardoso SW, Amancio RT, Moreira RI, Ribeiro SR, Coelho AB et al (2016) Predictors of opportunistic illnesses incidence in post combination antiretroviral therapy era in an urban cohort from Rio de Janeiro. Brazil BMC Infectious Diseases 16:134","journal-title":"Brazil BMC Infectious Diseases"},{"key":"1135_CR8","unstructured":"CNLAS (2021) Evolutia HIV in Romania 31 decembrie&nbsp;2021 [cited 2021 31 decembrie 2021]. Available from: https:\/\/www.cnlas.ro\/images\/doc\/31122021.pdf"},{"key":"1135_CR9","doi-asserted-by":"crossref","unstructured":"Committee UKCHCSS, Garvey L, Winston A, Walsh J, Post F, Porter K et al (2011) HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era. Euro J Neurol 18(3):527\u201334","DOI":"10.1111\/j.1468-1331.2010.03291.x"},{"key":"1135_CR10","unstructured":"CNLAS (2016) Evolutia infectiei HIV\/SIDA in Romania 31 Decembrie 2016.&nbsp;[cited 2017 July]. Available from: http:\/\/www.cnlas.ro\/images\/doc\/31122016_rom.pdf"},{"key":"1135_CR11","unstructured":"CNLAS (2017) HIV\/AIDS infection in Romania 30 June 2017.&nbsp;[cited 2017 30 June 2017]. Available from: http:\/\/www.cnlas.ro\/images\/doc\/30062017_eng.pdf"},{"key":"1135_CR12","unstructured":"CNLAS (2018) Infectia HIV\/SIDA in Romania - Update 2017 [cited 2018 January]. Available from: http:\/\/www.cnlas.ro\/images\/doc\/01122017_rom.pdf"},{"key":"1135_CR13","unstructured":"CNLAS (2015) 30 years of HIV experience in Romania.&nbsp;[cited 2015 30 September 2015]. Available from: http:\/\/www.cnlas.ro\/images\/doc\/24112015_eng.pdf"},{"key":"1135_CR14","unstructured":"CNLAS (2022) Infectia HIV\/SIDA in Romania, Update 30 iunie&nbsp;2022. Available from: https:\/\/www.cnlas.ro\/images\/doc\/30062022.pdf"},{"key":"1135_CR15","unstructured":"DHHS (2016) Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents.&nbsp;[updated July 2016]. Available from: https:\/\/aidsinfo.nih.gov\/contentfiles\/lvguidelines\/adultandadolescentgl.pdf"},{"issue":"1","key":"1135_CR16","first-page":"10","volume":"62","author":"C Didilescu","year":"2013","unstructured":"Didilescu C, Cioran N, Chiotan D, Popescu G (2013) Tuberculosis in children in Romania. Pneumologia 62(1):10\u201314","journal-title":"Pneumologia"},{"issue":"3","key":"1135_CR17","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2174\/157016206777709500","volume":"4","author":"R Dunfee","year":"2006","unstructured":"Dunfee R, Thomas ER, Gorry PR, Wang J, Ancuta P, Gabuzda D (2006) Mechanisms of HIV-1 neurotropism. Curr HIV Res 4(3):267\u2013278","journal-title":"Curr HIV Res"},{"key":"1135_CR18","unstructured":"EACS (2015) Guidelines Version 8.0.&nbsp;[updated January 2017]. Available from: http:\/\/www.eacsociety.org\/files\/guidelines_8.0-english-revised_20160610.pdf"},{"key":"1135_CR19","unstructured":"ECDC (2014) From Dublin to Rome: ten years of responding to HIV in Europe and Central Asia Stockholm: ECDC. Available from: https:\/\/ecdc.europa.eu\/sites\/portal\/files\/media\/en\/publications\/Publications\/dublin-rome-10-years-hiv-europe-central-asia.pdf"},{"key":"1135_CR20","unstructured":"EMCDDA (2016) Drog Ana Raportul national privind situatia drogurilor 2016; Romania \u2013 noi tendinte si evolutii.&nbsp;[cited 2017 July]. Available from: http:\/\/www.ana.gov.ro\/rapoarte%20nationale\/RN_2016.pdf"},{"issue":"5","key":"1135_CR21","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1007\/s13365-014-0275-1","volume":"20","author":"L Ene","year":"2014","unstructured":"Ene L, Franklin DR, Burlacu R, Luca AE, Blaglosov AG, Ellis RJ et al (2014) Neurocognitive functioning in a Romanian cohort of young adults with parenterally acquired HIV-infection during childhood. J Neurovirol 20(5):496\u2013504","journal-title":"J Neurovirol"},{"issue":"5","key":"1135_CR22","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/jnen\/62.5.429","volume":"62","author":"F Gray","year":"2003","unstructured":"Gray F, Chretien F, Vallat-Decouvelaere AV, Scaravilli F (2003) The changing pattern of HIV neuropathology in the HAART era. J Neuropathol Exp Neurol 62(5):429\u2013440","journal-title":"J Neuropathol Exp Neurol"},{"key":"1135_CR23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1742-4690-6-39","volume":"6","author":"ML Guimaraes","year":"2009","unstructured":"Guimaraes ML, Vicente AC, Otsuki K, da Silva RF, Francisco M, da Silva FG et al (2009) Close phylogenetic relationship between Angolan and Romanian HIV-1 subtype F1 isolates. Retrovirology 6:39","journal-title":"Retrovirology"},{"key":"1135_CR24","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.936257","volume":"23","author":"F Hanif","year":"2022","unstructured":"Hanif F, Satiti S, Subagya S, Retnowulan H, Subronto YW, Mulya DP et al (2022) Progressive Worsening of Neurological Manifestations in HIV-Associated Opportunistic Central Nervous System (CNS) Infection Patients After COVID-19 Vaccinations: A Possible Co-Incidence Causality. The American Journal of Case Reports 23:e936257","journal-title":"The American Journal of Case Reports"},{"key":"1135_CR25","unstructured":"Ianache I, Calistru PI, Tardei G, Ruta S, Oprea C (2016) Late presentation in HIV-infected injecting drug users - a huge challenge for the Romanian health-care system. Roman J Leg Med 24(2):122\u2013127"},{"issue":"4 Pt 1","key":"1135_CR26","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.lpm.2014.09.020","volume":"44","author":"L Karila","year":"2015","unstructured":"Karila L, Megarbane B, Chevillard L, Benturquia N, Laplanche JL, Lejoyeux M (2015) Novel psychoactive substances: a review. Presse Medicale 44(4 Pt 1):383\u2013391","journal-title":"Presse Medicale"},{"issue":"3","key":"1135_CR27","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1517\/17425255.2015.996546","volume":"11","author":"S Kumar","year":"2015","unstructured":"Kumar S, Rao PS, Earla R, Kumar A (2015) Drug-drug interactions between anti-retroviral therapies and drugs of abuse in HIV systems. Expert Opin Drug Metab Toxicol 11(3):343\u2013355","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"Suppl 3","key":"1135_CR28","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1080\/13550280500513846","volume":"11","author":"C Manzardo","year":"2005","unstructured":"Manzardo C, Del Mar OM, Sued O, Garcia F, Moreno A, Miro JM (2005) Central nervous system opportunistic infections in developed countries in the highly active antiretroviral therapy era. J Neurovirol 11(Suppl 3):72\u201382","journal-title":"J Neurovirol"},{"key":"1135_CR29","doi-asserted-by":"publisher","first-page":"305","DOI":"10.54044\/RAMI.2021.04.01","volume":"80","author":"M M\u0103rd\u0103rescu","year":"2021","unstructured":"M\u0103rd\u0103rescu M, Popa MI, Streinu-Cercel A (2021) HIV\/AIDS IN ROMANIA \u2013 A SHORT HISTORY AND UPDATE, 2021. Romanian Archives of Microbiology and Immunology 80:305\u2013311","journal-title":"Romanian Archives of Microbiology and Immunology"},{"issue":"5","key":"1135_CR30","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/s00415-015-7713-8","volume":"262","author":"A Matinella","year":"2015","unstructured":"Matinella A, Lanzafame M, Bonometti MA, Gajofatto A, Concia E, Vento S et al (2015) Neurological complications of HIV infection in pre-HAART and HAART era: a retrospective study. J Neurol 262(5):1317\u20131327","journal-title":"J Neurol"},{"key":"1135_CR31","doi-asserted-by":"crossref","unstructured":"McNamara PH, Coen R, Redmond J, Doherty CP, Bergin C (2017) A High Prevalence Rate of a Positive Screen for Cognitive Impairment in Patients With Human Immunodeficiency Virus Attending an Irish Clinic. Open For Infect Dis 4(1):ofw242","DOI":"10.1093\/ofid\/ofw242"},{"key":"1135_CR32","doi-asserted-by":"crossref","unstructured":"Mhatre R, Govekar S, Bn N, Lakshman LP, Banda RPS et al (2020) Ocular pathology in NeuroAIDS - An autopsy study. Exper Eye Res 198:108148","DOI":"10.1016\/j.exer.2020.108148"},{"key":"1135_CR33","doi-asserted-by":"crossref","unstructured":"Mulherkar TH, Gomez DJ, Sandel G, Jain P (2022) Co-Infection and Cancer: Host-Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses. Viruses 14(9)","DOI":"10.3390\/v14092037"},{"issue":"2","key":"1135_CR34","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/ajcp\/aqv087","volume":"145","author":"A Nael","year":"2016","unstructured":"Nael A, Walavalkar V, Wu W (2016) CD4-Positive T-cell primary central nervous system lymphoma in an HIV positive patient. Am J Clin Pathol 145(2):258\u2013265","journal-title":"Am J Clin Pathol"},{"key":"1135_CR35","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/j.1749-6632.2009.05277.x","volume":"1187","author":"A Nath","year":"2010","unstructured":"Nath A (2010) Human immunodeficiency virus-associated neurocognitive disorder: pathophysiology in relation to drug addiction. Ann N Y Acad Sci 1187:122\u2013128","journal-title":"Ann N Y Acad Sci"},{"key":"1135_CR36","doi-asserted-by":"crossref","unstructured":"Nils von H (2016) Potential Drug Interactions Between cART and New Psychoactive Substances. J Antivir Antiretro 8(1948\u20135964):1\u20135","DOI":"10.4172\/jaa.1000e131"},{"issue":"8","key":"1135_CR37","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/myc.13122","volume":"63","author":"S Okurut","year":"2020","unstructured":"Okurut S, Boulware DR, Olobo J, Meya DB (2020) Landmark clinical observations and immunopathogenesis pathways linked to HIV and Cryptococcus fatal central nervous system co-infection. Mycoses 63(8):840\u2013853","journal-title":"Mycoses"},{"issue":"2","key":"1135_CR38","doi-asserted-by":"publisher","first-page":"603","DOI":"10.4314\/ahs.v16i2.31","volume":"16","author":"M Ondounda","year":"2016","unstructured":"Ondounda M, Ilozue C, Magne C (2016) Cerebro-meningeal infections in HIV-infected patients: a study of 116 cases in Libreville. Gabon African Health Sciences 16(2):603\u2013610","journal-title":"Gabon African Health Sciences"},{"issue":"2","key":"1135_CR39","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4323\/rjlm.2017.227","volume":"25","author":"C Oprea","year":"2017","unstructured":"Oprea C, Ianache I, Ionescu P, Ceausu E, Calistru P (2017) Malignancies in HIV-infected patients \u2013 incidence and predictors of survival in a Romanian health care facility. Romanian Journal of Legal Medicine 25(2):227\u2013234","journal-title":"Romanian Journal of Legal Medicine"},{"issue":"5","key":"1135_CR40","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/hiv.12576","volume":"19","author":"C Oprea","year":"2018","unstructured":"Oprea C, Ianache I, Calistru PI, Nica M, Ruta S, Smith C et al (2018) Increasing incidence of HIV- associated tuberculosis in Romanian injecting drug users. HIV Med 19(5):316\u2013323","journal-title":"HIV Med"},{"key":"1135_CR41","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1097\/01.aids.0000238404.16121.47","volume":"20","author":"TD Parsons","year":"2006","unstructured":"Parsons TD, Tucker KA, Hall CD, Robertson WT, Eron JJ, Fried MW et al (2006) Neurocognitive functioning and HAART in HIV and hepatitis C virus co-infection. AIDS 20:1591\u20131595","journal-title":"AIDS"},{"issue":"7","key":"1135_CR42","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.3174\/ajnr.A3183","volume":"34","author":"MJ Post","year":"2013","unstructured":"Post MJ, Thurnher MM, Clifford DB, Nath A, Gonzalez RG, Gupta RK et al (2013a) CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 1: overview and discussion of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome and cryptococcal-immune reconstitution inflammatory syndrome. AJNR Am J Neuroradiol 34(7):1297\u20131307","journal-title":"AJNR Am J Neuroradiol"},{"issue":"7","key":"1135_CR43","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.3174\/ajnr.A3184","volume":"34","author":"MJ Post","year":"2013","unstructured":"Post MJ, Thurnher MM, Clifford DB, Nath A, Gonzalez RG, Gupta RK et al (2013b) CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 2: discussion of neuro-immune reconstitution inflammatory syndrome with and without other pathogens. AJNR Am J Neuroradiol 34(7):1308\u20131318","journal-title":"AJNR Am J Neuroradiol"},{"key":"1135_CR44","unstructured":"Proceedings of The 8th Romanian National HIV\/AIDS Congress and The 3rd Central European HIV Forum : Sibiu, Romania. (2016) BMC Infect Dis 16 Suppl 3:290"},{"issue":"1","key":"1135_CR45","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1128\/AAC.01632-15","volume":"60","author":"AB Sanchez","year":"2015","unstructured":"Sanchez AB, Varano GP, de Rozieres CM, Maung R, Catalan IC, Dowling CC et al (2015) Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage. Antimicrob Agents Chemother 60(1):168\u2013179","journal-title":"Antimicrob Agents Chemother"},{"key":"1135_CR46","doi-asserted-by":"crossref","unstructured":"Sheybani F, van de Beek D, Brouwer MC (2021) Suspected Central Nervous System Infections in HIV-Infected Adults. Frontiers in Neurology 12","DOI":"10.3389\/fneur.2021.741884"},{"issue":"17","key":"1135_CR47","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1212\/01.wnl.0000343510.08643.74","volume":"72","author":"K Tan","year":"2009","unstructured":"Tan K, Roda R, Ostrow L, McArthur J, Nath A (2009) PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids. Neurology 72(17):1458\u20131464","journal-title":"Neurology"},{"issue":"2","key":"1135_CR48","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1097\/QAI.0b013e318042e1ee","volume":"45","author":"V Tozzi","year":"2007","unstructured":"Tozzi V, Balestra P, Bellagamba R, Corpolongo A, Salvatori MF, Visco-Comandini U et al (2007) Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment: prevalence and risk factors. J Acquir Immune Defic Syndr 45(2):174\u2013182","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"5","key":"1135_CR49","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/13550280600915339","volume":"12","author":"V Valcour","year":"2006","unstructured":"Valcour V, Yee P, Williams AE, Shiramizu B, Watters M, Selnes O et al (2006) Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection\u2013The Hawaii Aging with HIV Cohort. J Neurovirol 12(5):387\u2013391","journal-title":"J Neurovirol"},{"issue":"3","key":"1135_CR50","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1212\/01.wnl.0000227922.22293.93","volume":"67","author":"A Venkataramana","year":"2006","unstructured":"Venkataramana A, Pardo CA, McArthur JC, Kerr DA, Irani DN, Griffin JW et al (2006) Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patients. Neurology 67(3):383\u2013388","journal-title":"Neurology"},{"issue":"10","key":"1135_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077691","volume":"8","author":"V von Wyl","year":"2013","unstructured":"von Wyl V, Klimkait T, Yerly S, Nicca D, Furrer H, Cavassini M et al (2013) Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study. PLoS ONE 8(10):e77691","journal-title":"PLoS ONE"},{"issue":"6","key":"1135_CR52","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1097\/COH.0000000000000109","volume":"9","author":"EJ Wright","year":"2014","unstructured":"Wright EJ (2014) Neuro OIs: developed and developing countries. Curr Opin HIV AIDS 9(6):539\u2013544","journal-title":"Curr Opin HIV AIDS"},{"issue":"29","key":"1135_CR53","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021141","volume":"99","author":"YM Zeng","year":"2020","unstructured":"Zeng YM, Li Y, He XQ, Huang YQ, Liu M, Yuan J et al (2020) A study for precision diagnosing and treatment strategies in difficult-to-treat AIDS cases and HIV-infected patients with highly fatal or highly disabling opportunistic infections: Study protocol for antiretroviral therapy timing in AIDS patients with toxoplasma encephalitis. Medicine 99(29):e21141","journal-title":"Medicine"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-023-01135-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13365-023-01135-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-023-01135-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T15:56:51Z","timestamp":1744214211000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13365-023-01135-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["1135"],"URL":"https:\/\/doi.org\/10.1007\/s13365-023-01135-1","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"23 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approved by the local Ethical committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the patients signed informed consent at admission in the hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Inform consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}