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Neurovirol."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>About 40% of the Guillain-Barr\u00e9 syndrome (GBS)\u00a0cases are associated with prodromal infections; occasionally, it has been associated to chronic hepatitis C or its reactivation. A 38-year-old man came to our attention after transaminase elevation occurred during recovery from GBS. All the possible causes of acute hepatitis were excluded except for\u00a0the positivity of HCVRNA, and a diagnosis of new onset hepatitis C was made. Recalling patient history, we observed that (i) anti-HCV antibodies were negative and liver enzymes were normal 7\u00a0weeks before GBS onset; (ii) in the early stages of ICU admission, liver enzymes started to rise, but the elevation remained mild under steroid treatment; (iii) serum aminotransferase peak occurred 11\u00a0weeks after GBS onset; and (iv) HCV RNA was already significantly high when anti-HCV antibodies became positive, consistent with an acute hepatitis. Furthermore, anti-HCV seroconversion was likely delayed or blurred by steroids and immunoglobulin infusions. The interval of time between GBS onset and transaminase elevation compared with the patient clinical history allows us to establish a cause-effect relationship between the two diseases. All patients with GBS should be tested for hepatitis C, or its reactivation if already present, and followed up for an early diagnosis and treatment.<\/jats:p>","DOI":"10.1007\/s13365-023-01167-7","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T15:11:18Z","timestamp":1693408278000},"page":"640-643","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Guillain-Barr\u00e9 syndrome as clinical presentation of a recently acquired hepatitis C"],"prefix":"10.1007","volume":"29","author":[{"given":"Filomena","family":"Boccia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia Lucia","family":"Florio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-3537","authenticated-orcid":false,"given":"Emanuele","family":"Durante-Mangoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Zampino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"issue":"5","key":"1167_CR1","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.4103\/1319-2442.243969","volume":"29","author":"M Balwani","year":"2018","unstructured":"Balwani M, Bawankule C, Ramteke V, Hepatitis Pasari A, C, (2018) virus directly acting antivirals and Guillain-Barr\u00e9 syndrome. 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None of these competing interests affected the present study.\u00a0FB, RZ, and LLF declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}