{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:13:22Z","timestamp":1787742802530,"version":"build-2784847793"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s13365-024-01238-3","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T14:52:04Z","timestamp":1733237524000},"page":"84-94","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High glucose potentiates Zika virus induced-astroglial dysfunctions"],"prefix":"10.1007","volume":"31","author":[{"given":"Natalie Katherine","family":"Thomaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Daniele","family":"Bobermin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Sesterheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Muterle","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Fumaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Seady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belisa","family":"Parmeggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Concli","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilhian","family":"Leipnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00e9lia","family":"Santi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter O.","family":"Beys-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Almeida","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo M.","family":"Roehe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos-Alberto","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Onofre","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Quincozes-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"1238_CR1","doi-asserted-by":"publisher","first-page":"198084","DOI":"10.1016\/j.virusres.2020.198084","volume":"286","author":"LT Almeida","year":"2020","unstructured":"Almeida LT, Ferraz AC, da Silva Caetano CC et al (2020) Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo. Virus Res 286:198084. https:\/\/doi.org\/10.1016\/j.virusres.2020.198084","journal-title":"Virus Res"},{"key":"1238_CR2","doi-asserted-by":"publisher","first-page":"108719","DOI":"10.1016\/j.neuropharm.2021.108719","volume":"196","author":"JV Andersen","year":"2021","unstructured":"Andersen JV, Markussen KH, Jakobsen E et al (2021) Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration. Neuropharmacology 196:108719. https:\/\/doi.org\/10.1016\/j.neuropharm.2021.108719","journal-title":"Neuropharmacology"},{"key":"1238_CR3","doi-asserted-by":"publisher","first-page":"eaaw6284","DOI":"10.1126\/sciadv.aaw6284","volume":"6","author":"J Barbeito-Andr\u00e9s","year":"2020","unstructured":"Barbeito-Andr\u00e9s J, Pezzuto P, Higa LM et al (2020) Congenital Zika syndrome is associated with maternal protein malnutrition. Sci Adv 6:eaaw6284. https:\/\/doi.org\/10.1126\/sciadv.aaw6284","journal-title":"Sci Adv"},{"key":"1238_CR4","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1212\/01.wnl.0000286385.59836.e2","volume":"69","author":"EE Benarroch","year":"2007","unstructured":"Benarroch EE (2007) Aquaporin-4, homeostasis, and neurologic disease. Neurology 69:2266\u20132268. https:\/\/doi.org\/10.1212\/01.wnl.0000286385.59836.e2","journal-title":"Neurology"},{"key":"1238_CR5","doi-asserted-by":"publisher","first-page":"4708","DOI":"10.1007\/s12035-018-1417-x","volume":"56","author":"WO Beys-da-Silva","year":"2019","unstructured":"Beys-da-Silva WO, Rosa RL, Santi L et al (2019) Zika Virus infection of human mesenchymal stem cells promotes Differential expression of proteins linked to several neurological diseases. Mol Neurobiol 56:4708\u20134717. https:\/\/doi.org\/10.1007\/s12035-018-1417-x","journal-title":"Mol Neurobiol"},{"key":"1238_CR6","doi-asserted-by":"publisher","first-page":"e52164","DOI":"10.1371\/journal.pone.0052164","volume":"7","author":"LD Bobermin","year":"2012","unstructured":"Bobermin LD, Quincozes-Santos A, Guerra MC et al (2012) Resveratrol prevents ammonia toxicity in astroglial cells. PLoS ONE 7:e52164. https:\/\/doi.org\/10.1371\/journal.pone.0052164","journal-title":"PLoS ONE"},{"key":"1238_CR7","doi-asserted-by":"publisher","first-page":"21604","DOI":"10.1038\/s41598-020-78735-y","volume":"10","author":"LD Bobermin","year":"2020","unstructured":"Bobermin LD, Quincozes-Santos A, Santos CL et al (2020) Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats. Sci Rep 10:21604. https:\/\/doi.org\/10.1038\/s41598-020-78735-y","journal-title":"Sci Rep"},{"key":"1238_CR8","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1016\/j.cmet.2021.07.006","volume":"33","author":"G Bonvento","year":"2021","unstructured":"Bonvento G, Bola\u00f1os JP (2021) Astrocyte-neuron metabolic cooperation shapes brain activity. Cell Metabol 33:1546\u20131564. https:\/\/doi.org\/10.1016\/j.cmet.2021.07.006","journal-title":"Cell Metabol"},{"key":"1238_CR9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1385\/0-89603-472-0:347","volume":"108","author":"RW Browne","year":"1998","unstructured":"Browne RW, Armstrong D (1998) Reduced glutathione and glutathione disulfide. Methods Mol Biol 108:347\u2013352. https:\/\/doi.org\/10.1385\/0-89603-472-0:347","journal-title":"Methods Mol Biol"},{"key":"1238_CR10","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/s0076-6879(85)13062-4","volume":"113","author":"I Carlberg","year":"1985","unstructured":"Carlberg I, Mannervik B (1985) Glutathione reductase. Methods Enzymol 113:484\u2013490. https:\/\/doi.org\/10.1016\/s0076-6879(85)13062-4","journal-title":"Methods Enzymol"},{"key":"1238_CR11","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","volume":"37","author":"E Colombo","year":"2016","unstructured":"Colombo E, Farina C (2016) Astrocytes: key regulators of Neuroinflammation. Trends Immunol 37:608\u2013620. https:\/\/doi.org\/10.1016\/j.it.2016.06.006","journal-title":"Trends Immunol"},{"key":"1238_CR12","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/s41583-018-0080-6","volume":"19","author":"G Dall\u00e9rac","year":"2018","unstructured":"Dall\u00e9rac G, Zapata J, Rouach N (2018) Versatile control of synaptic circuits by astrocytes: where, when and how? Nat Rev Neurosci 19:729\u2013743. https:\/\/doi.org\/10.1038\/s41583-018-0080-6","journal-title":"Nat Rev Neurosci"},{"key":"1238_CR13","doi-asserted-by":"publisher","unstructured":"Das S, Mukherjee T, Mohanty S et al (2024) Impact of NF-\u03baB signaling and Sirtuin-1 protein for TargetedInflammatory intervention. Curr Pharm Biotechnol 25. https:\/\/doi.org\/10.2174\/0113892010301469240409082212","DOI":"10.2174\/0113892010301469240409082212"},{"key":"1238_CR14","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.abb.2006.06.025","volume":"453","author":"AQ dos Santos","year":"2006","unstructured":"dos Santos AQ, Nardin P, Funchal C et al (2006) Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells. Arch Biochem Biophys 453:161\u2013167. https:\/\/doi.org\/10.1016\/j.abb.2006.06.025","journal-title":"Arch Biochem Biophys"},{"key":"1238_CR15","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1007\/s11064-014-1481-1","volume":"40","author":"R Dringen","year":"2015","unstructured":"Dringen R, Brandmann M, Hohnholt MC, Blumrich E-M (2015) Glutathione-dependent detoxification processes in astrocytes. Neurochem Res 40:2570\u20132582. https:\/\/doi.org\/10.1007\/s11064-014-1481-1","journal-title":"Neurochem Res"},{"key":"1238_CR16","doi-asserted-by":"publisher","first-page":"3890","DOI":"10.1038\/s41467-019-11866-7","volume":"10","author":"CP Figueiredo","year":"2019","unstructured":"Figueiredo CP, Barros-Arag\u00e3o FGQ, Neris RLS et al (2019) Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Nat Commun 10:3890. https:\/\/doi.org\/10.1038\/s41467-019-11866-7","journal-title":"Nat Commun"},{"key":"1238_CR17","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41583-018-0070-8","volume":"19","author":"JV Forrester","year":"2018","unstructured":"Forrester JV, McMenamin PG, Dando SJ (2018) CNS infection and immune privilege. Nat Rev Neurosci 19:655\u2013671. https:\/\/doi.org\/10.1038\/s41583-018-0070-8","journal-title":"Nat Rev Neurosci"},{"key":"1238_CR18","doi-asserted-by":"publisher","first-page":"104538","DOI":"10.1016\/j.neuint.2019.104538","volume":"131","author":"F Galland","year":"2019","unstructured":"Galland F, Seady M, Taday J et al (2019) Astrocyte culture models: Molecular and function characterization of primary culture, immortalized astrocytes and C6 glioma cells. Neurochem Int 131:104538. https:\/\/doi.org\/10.1016\/j.neuint.2019.104538","journal-title":"Neurochem Int"},{"key":"1238_CR19","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/joa.12959","volume":"235","author":"J Gilbert-Jaramillo","year":"2019","unstructured":"Gilbert-Jaramillo J, Garcez P, James W et al (2019) The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome. J Anat 235:468\u2013480. https:\/\/doi.org\/10.1111\/joa.12959","journal-title":"J Anat"},{"key":"1238_CR20","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3389\/fnins.2018.01035","volume":"12","author":"C-A Gon\u00e7alves","year":"2019","unstructured":"Gon\u00e7alves C-A, Rodrigues L, Bobermin LD et al (2019) Glycolysis-derived compounds from astrocytes that modulate synaptic communication. Front Neurosci 12:1035. https:\/\/doi.org\/10.3389\/fnins.2018.01035","journal-title":"Front Neurosci"},{"key":"1238_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","volume":"20","author":"T Gong","year":"2020","unstructured":"Gong T, Liu L, Jiang W, Zhou R (2020) DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat Rev Immunol 20:95\u2013112. https:\/\/doi.org\/10.1038\/s41577-019-0215-7","journal-title":"Nat Rev Immunol"},{"key":"1238_CR22","doi-asserted-by":"publisher","first-page":"135885","DOI":"10.1016\/j.neulet.2021.135885","volume":"754","author":"Y-Z Guo","year":"2021","unstructured":"Guo Y-Z, Ma Y-M, Zhang X-P et al (2021) Region-specific changes in aquaporin 4 induced by hyperglycemia underlie the differences in cell swelling in the cortex and striatum after cerebral ischemia-reperfusion. Neurosci Lett 754:135885. https:\/\/doi.org\/10.1016\/j.neulet.2021.135885","journal-title":"Neurosci Lett"},{"key":"1238_CR23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","volume":"39","author":"JD Hayes","year":"2014","unstructured":"Hayes JD, Dinkova-Kostova AT (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 39:199\u2013218. https:\/\/doi.org\/10.1016\/j.tibs.2014.02.002","journal-title":"Trends Biochem Sci"},{"key":"1238_CR24","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.arr.2017.10.001","volume":"40","author":"S Hekmatimoghaddam","year":"2017","unstructured":"Hekmatimoghaddam S, Dehghani Firoozabadi A, Zare-Khormizi MR, Pourrajab F (2017) Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging. Ageing Res Rev 40:120\u2013141. https:\/\/doi.org\/10.1016\/j.arr.2017.10.001","journal-title":"Ageing Res Rev"},{"key":"1238_CR25","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/nan.12475","volume":"44","author":"A Hoshi","year":"2018","unstructured":"Hoshi A, Tsunoda A, Yamamoto T et al (2018) Altered expression of glutamate transporter-1 and water channel protein aquaporin\u20104 in human temporal cortex with Alzheimer\u2019s disease. Neuropathology Appl Neurobio 44:628\u2013638. https:\/\/doi.org\/10.1111\/nan.12475","journal-title":"Neuropathology Appl Neurobio"},{"issue":"8","key":"1238_CR26","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.3390\/ijms17081306","volume":"17","author":"H Ikeshima-Kataoka","year":"2016","unstructured":"Ikeshima-Kataoka H (2016) Neuroimmunological implications of AQP4 in astrocytes. Int J Mol Sci 17(8):1306. https:\/\/doi.org\/10.3390\/ijms17081306","journal-title":"Int J Mol Sci"},{"key":"1238_CR27","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3201\/eid1408.080287","volume":"14","author":"RS Lanciotti","year":"2008","unstructured":"Lanciotti RS, Kosoy OL, Laven JJ et al (2008) Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 14:1232\u20131239. https:\/\/doi.org\/10.3201\/eid1408.080287","journal-title":"Emerg Infect Dis"},{"key":"1238_CR28","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1038\/s41598-020-57914-x","volume":"10","author":"PF Ledur","year":"2020","unstructured":"Ledur PF, Karmirian K, Pedrosa C da SG, et al (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218. https:\/\/doi.org\/10.1038\/s41598-020-57914-x","journal-title":"Sci Rep"},{"key":"1238_CR29","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.bbadis.2013.05.017","volume":"1842","author":"B-C Lee","year":"2014","unstructured":"Lee B-C, Lee J (2014) Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochimica et Biophysica Acta (BBA) -. Mol Basis Disease 1842:446\u2013462. https:\/\/doi.org\/10.1016\/j.bbadis.2013.05.017","journal-title":"Mol Basis Disease"},{"key":"1238_CR30","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1471-4159.1984.tb06684.x","volume":"43","author":"SF Leong","year":"1984","unstructured":"Leong SF, Clark JB (1984) Regional development of glutamate dehydrogenase in the rat brain. J Neurochem 43:106\u2013111. https:\/\/doi.org\/10.1111\/j.1471-4159.1984.tb06684.x","journal-title":"J Neurochem"},{"key":"1238_CR31","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.bbi.2020.10.007","volume":"91","author":"L Li","year":"2021","unstructured":"Li L, Acioglu C, Heary RF, Elkabes S, Brain (2021) Behav Immun 91:740\u2013755. https:\/\/doi.org\/10.1016\/j.bbi.2020.10.007","journal-title":"Behav Immun"},{"key":"1238_CR32","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","volume":"108","author":"M Linnerbauer","year":"2020","unstructured":"Linnerbauer M, Wheeler MA, Quintana FJ (2020) Astrocyte crosstalk in CNS inflammation. Neuron 108:608\u2013622. https:\/\/doi.org\/10.1016\/j.neuron.2020.08.012","journal-title":"Neuron"},{"key":"1238_CR33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"1238_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00018-023-05024-y","volume":"81","author":"M Llori\u00e1n-Salvador","year":"2024","unstructured":"Llori\u00e1n-Salvador M, Cabeza-Fern\u00e1ndez S, Gomez-Sanchez JA, De La Fuente AG (2024) Glial cell alterations in diabetes-induced neurodegeneration. Cell Mol Life Sci 81:47. https:\/\/doi.org\/10.1007\/s00018-023-05024-y","journal-title":"Cell Mol Life Sci"},{"key":"1238_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"1238_CR36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.14348\/molcells.2016.2318","volume":"39","author":"B Luen Tang","year":"2016","unstructured":"Luen Tang B (2016) Sirt1 and the Mitochondria. Mol Cells 39:87\u201395. https:\/\/doi.org\/10.14348\/molcells.2016.2318","journal-title":"Mol Cells"},{"key":"1238_CR37","doi-asserted-by":"publisher","first-page":"101719","DOI":"10.1016\/j.pneurobio.2019.101719","volume":"184","author":"MA Lynch","year":"2020","unstructured":"Lynch MA (2020) Can the emerging field of immunometabolism provide insights into neuroinflammation? Prog Neurobiol 184:101719. https:\/\/doi.org\/10.1016\/j.pneurobio.2019.101719","journal-title":"Prog Neurobiol"},{"key":"1238_CR38","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/s0076-6879(81)77030-7","volume":"77","author":"B Mannervik","year":"1981","unstructured":"Mannervik B, Guthenberg C (1981) Glutathione transferase (human placenta). Methods Enzymol 77:231\u2013235. https:\/\/doi.org\/10.1016\/s0076-6879(81)77030-7","journal-title":"Methods Enzymol"},{"key":"1238_CR39","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1038\/sj.jcbfm.9600479","volume":"27","author":"TJ Moreira","year":"2007","unstructured":"Moreira TJ, Cebere A, Cebers G et al (2007) Reduced HO-1 protein expression is Associated with more severe neurodegeneration after transient Ischemia Induced by Cortical Compression in Diabetic Goto\u2014Kakizaki rats. J Cereb Blood Flow Metab 27:1710\u20131723. https:\/\/doi.org\/10.1038\/sj.jcbfm.9600479","journal-title":"J Cereb Blood Flow Metab"},{"key":"1238_CR40","doi-asserted-by":"publisher","first-page":"102450","DOI":"10.1016\/j.arr.2024.102450","volume":"100","author":"A Nagayach","year":"2024","unstructured":"Nagayach A, Bhaskar R, Ghosh S et al (2024) Advancing the understanding of Diabetic Encephalopathy through Unravelling Pathogenesis and Exploring Future Treatment perspectives. Ageing Res Rev 100:102450. https:\/\/doi.org\/10.1016\/j.arr.2024.102450","journal-title":"Ageing Res Rev"},{"key":"1238_CR41","doi-asserted-by":"publisher","first-page":"e0208543","DOI":"10.1371\/journal.pone.0208543","volume":"14","author":"CR Ojha","year":"2019","unstructured":"Ojha CR, Rodriguez M, Karuppan MKM et al (2019) Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. PLoS ONE 14:e0208543. https:\/\/doi.org\/10.1371\/journal.pone.0208543","journal-title":"PLoS ONE"},{"key":"1238_CR42","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3389\/fimmu.2017.01016","volume":"8","author":"IG Olmo","year":"2017","unstructured":"Olmo IG, Carvalho TG, Costa VV et al (2017) Zika Virus promotes neuronal cell death in a Non-cell Autonomous Manner by triggering the release of neurotoxic factors. Front Immunol 8:1016. https:\/\/doi.org\/10.3389\/fimmu.2017.01016","journal-title":"Front Immunol"},{"key":"1238_CR43","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s11302-013-9377-0","volume":"9","author":"A Quincozes-Santos","year":"2013","unstructured":"Quincozes-Santos A, Bobermin LD, de Souza DG et al (2013) Gliopreventive effects of guanosine against glucose deprivation in vitro. Purinergic Signal 9:643\u2013654. https:\/\/doi.org\/10.1007\/s11302-013-9377-0","journal-title":"Purinergic Signal"},{"key":"1238_CR44","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/jnc.12694","volume":"130","author":"A Quincozes-Santos","year":"2014","unstructured":"Quincozes-Santos A, Bobermin LD, Souza DG et al (2014) Guanosine protects C6 astroglial cells against azide\u2010induced oxidative damage: a putative role of heme oxygenase 1. J Neurochem 130:61\u201374. https:\/\/doi.org\/10.1111\/jnc.12694","journal-title":"J Neurochem"},{"key":"1238_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbadis.2016.09.013","volume":"1863","author":"A Quincozes-Santos","year":"2017","unstructured":"Quincozes-Santos A, Bobermin LD, de Assis AM et al (2017) Fluctuations in glucose levels induce glial toxicity with glutamatergic, oxidative and inflammatory implications. Biochim Biophys Acta Mol Basis Dis 1863:1\u201314. https:\/\/doi.org\/10.1016\/j.bbadis.2016.09.013","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1238_CR46","doi-asserted-by":"publisher","first-page":"6577","DOI":"10.1007\/s12035-021-02574-9","volume":"58","author":"A Quincozes-Santos","year":"2021","unstructured":"Quincozes-Santos A, Santos CL, de Souza Almeida RR et al (2021) Gliotoxicity and glioprotection: the dual role of glial cells. Mol Neurobiol 58:6577\u20136592. https:\/\/doi.org\/10.1007\/s12035-021-02574-9","journal-title":"Mol Neurobiol"},{"key":"1238_CR47","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1002\/glia.24353","volume":"71","author":"A Quincozes-Santos","year":"2023","unstructured":"Quincozes-Santos A, Bobermin LD, Costa NLF et al (2023) The role of glial cells in Zika virus-induced neurodegeneration. Glia 71:1791\u20131803. https:\/\/doi.org\/10.1002\/glia.24353","journal-title":"Glia"},{"key":"1238_CR48","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000516560","volume":"28","author":"L Santi","year":"2021","unstructured":"Santi L, Riesgo RS, Quincozes-Santos A et al (2021) Zika Virus Infection Associated with Autism Spectrum disorder: a Case Report. Neuroimmunomodulation 28:229\u2013232. https:\/\/doi.org\/10.1159\/000516560","journal-title":"Neuroimmunomodulation"},{"key":"1238_CR49","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.bbamcr.2010.09.019","volume":"1813","author":"RC Scarpulla","year":"2011","unstructured":"Scarpulla RC (2011) Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochimica et Biophysica Acta (BBA) -. Mol Cell Res 1813:1269\u20131278. https:\/\/doi.org\/10.1016\/j.bbamcr.2010.09.019","journal-title":"Mol Cell Res"},{"key":"1238_CR50","doi-asserted-by":"publisher","first-page":"758715","DOI":"10.3389\/fgene.2022.758715","volume":"13","author":"L Schuler-Faccini","year":"2022","unstructured":"Schuler-Faccini L, del Campo M, Garc\u00eda-Alix A et al (2022) Neurodevelopment in children exposed to Zika in utero: clinical and molecular aspects. Front Genet 13:758715. https:\/\/doi.org\/10.3389\/fgene.2022.758715","journal-title":"Front Genet"},{"key":"1238_CR51","doi-asserted-by":"publisher","first-page":"114206","DOI":"10.1016\/j.biopha.2022.114206","volume":"158","author":"Z Shen","year":"2023","unstructured":"Shen Z, Li Z-Y, Yu M-T et al (2023) Metabolic perspective of astrocyte dysfunction in Alzheimer\u2019s disease and type 2 diabetes brains. Biomed Pharmacother 158:114206. https:\/\/doi.org\/10.1016\/j.biopha.2022.114206","journal-title":"Biomed Pharmacother"},{"key":"1238_CR52","doi-asserted-by":"publisher","first-page":"114519","DOI":"10.1016\/j.bbr.2023.114519","volume":"451","author":"INO Souza","year":"2023","unstructured":"Souza INO, Andrade BS, Frost PS et al (2023) Different outcomes of neonatal and adult Zika virus infection on startle reflex and prepulse inhibition in mice. Behav Brain Res 451:114519. https:\/\/doi.org\/10.1016\/j.bbr.2023.114519","journal-title":"Behav Brain Res"},{"key":"1238_CR53","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1007\/s12640-021-00393-3","volume":"39","author":"V Sovrani","year":"2021","unstructured":"Sovrani V, Bobermin LD, Schmitz I et al (2021) Potential glioprotective strategies against Diabetes-Induced Brain toxicity. Neurotox Res 39:1651\u20131664. https:\/\/doi.org\/10.1007\/s12640-021-00393-3","journal-title":"Neurotox Res"},{"key":"1238_CR54","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.tips.2022.05.004","volume":"43","author":"S Squillace","year":"2022","unstructured":"Squillace S, Salvemini D (2022) Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions. Trends Pharmacol Sci 43:726\u2013739. https:\/\/doi.org\/10.1016\/j.tips.2022.05.004","journal-title":"Trends Pharmacol Sci"},{"key":"1238_CR55","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1007\/s11064-012-0722-4","volume":"37","author":"AC Tramontina","year":"2012","unstructured":"Tramontina AC, Nardin P, Quincozes-Santos A et al (2012) High-glucose and S100B stimulate glutamate uptake in C6 glioma cells. Neurochem Res 37:1399\u20131408. https:\/\/doi.org\/10.1007\/s11064-012-0722-4","journal-title":"Neurochem Res"},{"key":"1238_CR56","doi-asserted-by":"publisher","first-page":"102247","DOI":"10.1016\/j.coi.2022.102247","volume":"78","author":"D Van Der Horst","year":"2022","unstructured":"Van Der Horst D, Carter-Timofte M, Van Grevenynghe J et al (2022) Regulation of innate immunity by Nrf2. Curr Opin Immunol 78:102247. https:\/\/doi.org\/10.1016\/j.coi.2022.102247","journal-title":"Curr Opin Immunol"},{"key":"1238_CR57","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s12974-022-02612-w","volume":"19","author":"AFK Vizuete","year":"2022","unstructured":"Vizuete AFK, Fr\u00f3es F, Seady M et al (2022) Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. J Neuroinflammation 19:255. https:\/\/doi.org\/10.1186\/s12974-022-02612-w","journal-title":"J Neuroinflammation"},{"key":"1238_CR58","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1089\/ars.2010.3216","volume":"13","author":"N Wakabayashi","year":"2010","unstructured":"Wakabayashi N, Slocum SL, Skoko JJ et al (2010) When NRF2 talks, who\u2019s listening? Antioxid Redox Signal 13:1649\u20131663. https:\/\/doi.org\/10.1089\/ars.2010.3216","journal-title":"Antioxid Redox Signal"},{"key":"1238_CR59","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/s0076-6879(81)77046-0","volume":"77","author":"A Wendel","year":"1981","unstructured":"Wendel A (1981) Glutathione peroxidase. Methods Enzymol 77:325\u2013333. https:\/\/doi.org\/10.1016\/s0076-6879(81)77046-0","journal-title":"Methods Enzymol"},{"key":"1238_CR60","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","volume":"48","author":"J Xu","year":"2023","unstructured":"Xu J, N\u00fa\u00f1ez G (2023) The NLRP3 inflammasome: activation and regulation. Trends Biochem Sci 48:331\u2013344. https:\/\/doi.org\/10.1016\/j.tibs.2022.10.002","journal-title":"Trends Biochem Sci"},{"key":"1238_CR61","doi-asserted-by":"publisher","first-page":"108952","DOI":"10.1016\/j.celrep.2021.108952","volume":"35","author":"T Zehnder","year":"2021","unstructured":"Zehnder T, Petrelli F, Romanos J et al (2021) Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation. Cell Rep 35:108952. https:\/\/doi.org\/10.1016\/j.celrep.2021.108952","journal-title":"Cell Rep"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-024-01238-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13365-024-01238-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-024-01238-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T17:41:08Z","timestamp":1743874868000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13365-024-01238-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1238"],"URL":"https:\/\/doi.org\/10.1007\/s13365-024-01238-3","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,3]]},"assertion":[{"value":"31 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}