{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T13:42:32Z","timestamp":1786196552824,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Neurovirol."],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s13365-026-01320-y","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:31:50Z","timestamp":1782408710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hantavirus infection: Neurologic manifestations should not be overlooked"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-1211","authenticated-orcid":false,"given":"Annarita","family":"Botta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-7863","authenticated-orcid":false,"given":"Christian","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"1320_CR1","doi-asserted-by":"publisher","unstructured":"Afzal S et al (2023a) Hantavirus: an overview and advancements in therapeutic approaches for infection. Front Microbiol 14. https:\/\/doi.org\/10.3389\/fmicb.2023.1233433","DOI":"10.3389\/fmicb.2023.1233433"},{"key":"1320_CR2","doi-asserted-by":"publisher","unstructured":"Afzal S et al (2023b) Corrigendum: Hantavirus: an overview and advancements in therapeutic approaches for infection, Front. Microbiol., vol. 14, Dec. https:\/\/doi.org\/10.3389\/fmicb.2023.1343080","DOI":"10.3389\/fmicb.2023.1343080"},{"issue":"6","key":"1320_CR3","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s13365-017-0576-2","volume":"23","author":"D Anderson","year":"2017","unstructured":"Anderson D, Beecher G, Power C, Bridgland L, Zochodne DW (2017) A neuropathic pain syndrome associated with hantavirus infection. J Neurovirol 23(6):919\u2013921. https:\/\/doi.org\/10.1007\/s13365-017-0576-2","journal-title":"J Neurovirol"},{"key":"1320_CR4","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.3346\/jkms.2010.25.8.1244","volume":"25","author":"S-H Baek","year":"2010","unstructured":"Baek S-H et al (2010) Reversible Splenium Lesion of the Corpus Callosum in Hemorrhagic Fever with Renal Failure Syndrome. J Korean Med Sci 25:1244. https:\/\/doi.org\/10.3346\/jkms.2010.25.8.1244","journal-title":"J Korean Med Sci"},{"key":"1320_CR5","doi-asserted-by":"publisher","unstructured":"Cerar D, Av\u0161i\u010d-\u017dupanc T, Jereb M, Strle F (2007) Case report: Severe neurological manifestation of dobrava hantavirus infection, J. Med. Virol., vol. 79, no. 12, pp. 1841\u20131843, Dec. https:\/\/doi.org\/10.1002\/jmv.21021","DOI":"10.1002\/jmv.21021"},{"key":"1320_CR6","doi-asserted-by":"publisher","unstructured":"Fawcett SJ, Chen JS, Fawcett RW (2022) Acute Hantavirus Infection Presenting With Fever and Altered Mentation in the Absence of Pulmonary or Renal Manifestations. Open Forum Infect Dis 9(9). https:\/\/doi.org\/10.1093\/ofid\/ofac430","DOI":"10.1093\/ofid\/ofac430"},{"issue":"6","key":"1320_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/v13061040","volume":"13","author":"N Hautala","year":"2021","unstructured":"Hautala N, Partanen T, Kubin A-M, Kauma H, Hautala T (2021) Central nervous system and ocular manifestations in Puumala Hantavirus infection. Viruses 13(6):1040. https:\/\/doi.org\/10.3390\/v13061040","journal-title":"Viruses"},{"key":"1320_CR8","doi-asserted-by":"publisher","unstructured":"Hautala T et al (2002) Hypophyseal Hemorrhage and Panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and Detection of Viral Antigen in the Hypophysis, Clinical Infectious Diseases, vol. 35, no. 1, pp. 96\u2013101, Jul. https:\/\/doi.org\/10.1086\/340859","DOI":"10.1086\/340859"},{"key":"1320_CR9","doi-asserted-by":"publisher","unstructured":"Hautala T et al (2010) Central nervous system-related symptoms and findings are common in acute Puumala hantavirus infection, Ann. Med., vol. 42, no. 5, pp. 344\u2013351, Jul. https:\/\/doi.org\/10.3109\/07853890.2010.480979","DOI":"10.3109\/07853890.2010.480979"},{"key":"1320_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/634632","volume":"2013","author":"T Hautala","year":"2013","unstructured":"Hautala T et al (2013) Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection. Clin Dev Immunol 2013:1\u20134. https:\/\/doi.org\/10.1155\/2013\/634632","journal-title":"Clin Dev Immunol"},{"issue":"2","key":"1320_CR11","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1080\/13550280802491485","volume":"15","author":"BN Huisa","year":"2009","unstructured":"Huisa BN, Chapin JE, Adair JC (2009) Central nervous system complications following Hanta virus cardiopulmonary syndrome. J Neurovirol 15(2):202\u2013205. https:\/\/doi.org\/10.1080\/13550280802491485","journal-title":"J Neurovirol"},{"issue":"1","key":"1320_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3049-1","volume":"18","author":"J Jiao","year":"2018","unstructured":"Jiao J, Wu L, Yin J, Quan X, Chen W, Hu J (2018) Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report. BMC Infect Dis 18(1):143. https:\/\/doi.org\/10.1186\/s12879-018-3049-1","journal-title":"BMC Infect Dis"},{"key":"1320_CR13","doi-asserted-by":"publisher","first-page":"s877","DOI":"10.1136\/bmj.s877","volume":"393","author":"K Lang","year":"2026","unstructured":"Lang K (2026) Hantavirus: what you need to know. BMJ 393:s877. https:\/\/doi.org\/10.1136\/bmj.s877","journal-title":"BMJ"},{"issue":"8","key":"1320_CR14","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1093\/ndt\/13.8.2113","volume":"13","author":"E Lee","year":"1998","unstructured":"Lee E (1998) Isolated abducens nerve palsy as a complication of haemorrhagic fever with renal syndrome. Nephrol Dial Transplant 13(8):2113\u20132114. https:\/\/doi.org\/10.1093\/ndt\/13.8.2113","journal-title":"Nephrol Dial Transplant"},{"issue":"49","key":"1320_CR15","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005580","volume":"95","author":"JY Lim","year":"2016","unstructured":"Lim JY, Lim Y-H, Choi E-H (2016) Acute-onset chronic inflammatory demyelinating polyneuropathy in hantavirus and hepatitis B virus coinfection. Medicine (Baltimore) 95(49):e5580. https:\/\/doi.org\/10.1097\/MD.0000000000005580","journal-title":"Medicine (Baltimore)"},{"key":"1320_CR16","doi-asserted-by":"publisher","unstructured":"Liu E et al (2022) Central nervous system infection with Seoul Orthohantavirus in a child after hematopoietic stem cell transplantation: a case report. Virol J 19(1):75. https:\/\/doi.org\/10.1186\/s12985-022-01766-6","DOI":"10.1186\/s12985-022-01766-6"},{"key":"1320_CR17","doi-asserted-by":"publisher","unstructured":"Lo S-H, Chen P-T, Yu W-J, Hsieh K-S, Chen T-C (2021) Case Report: Spinal Subarachnoid Hemorrhage: A Rare Complication of Hemorrhagic Fever with Renal Syndrome, Am. J. Trop. Med. Hyg., vol. 104, no. 4, pp. 1432\u20131434, Apr. https:\/\/doi.org\/10.4269\/ajtmh.20-0823","DOI":"10.4269\/ajtmh.20-0823"},{"issue":"3","key":"1320_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/neurolint18030053","volume":"18","author":"C Messina","year":"2026","unstructured":"Messina C (2026) Treating the patient, not only the amyloid: symptomatic management in transthyretin amyloidosis. Neurol Int 18(3):53. https:\/\/doi.org\/10.3390\/neurolint18030053","journal-title":"Neurol Int"},{"issue":"5","key":"1320_CR19","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1080\/20477724.2023.2272097","volume":"118","author":"G Moirano","year":"2024","unstructured":"Moirano G, Botta A, Yang M, Mangeruga M, Murray K, Vineis P (2024) Land-cover, land-use and human hantavirus infection risk: a systematic review. Pathog Glob Health 118(5):361\u2013375. https:\/\/doi.org\/10.1080\/20477724.2023.2272097","journal-title":"Pathog Glob Health"},{"key":"1320_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/1017689","volume":"2020","author":"E Muco","year":"2020","unstructured":"Muco E, Hasa A, Rroji A, Kushi A, Puca E, Kraja D (2020) Posterior reversible encephalopathy syndrome in a patient with hemorrhagic fever with renal syndrome. Case Rep Infect Dis 2020:1\u20135. https:\/\/doi.org\/10.1155\/2020\/1017689","journal-title":"Case Rep Infect Dis"},{"key":"1320_CR21","doi-asserted-by":"publisher","unstructured":"Partanen T et al (2020) Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis, J. Clin. Immunol., vol. 40, no. 8, pp. 1156\u20131162, Nov. https:\/\/doi.org\/10.1007\/s10875-020-00834-2","DOI":"10.1007\/s10875-020-00834-2"},{"key":"1320_CR22","doi-asserted-by":"publisher","unstructured":"Qin X, Wang H (2024) Central nervous system infection with Hantavirus in a solid organ transplant patient. Transpl Infect Disease 26(6). https:\/\/doi.org\/10.1111\/tid.14352","DOI":"10.1111\/tid.14352"},{"key":"1320_CR23","doi-asserted-by":"publisher","unstructured":"Schwab S et al (2020) When polyuria does not stop: a case report on an unusual complication of hantavirus infection. BMC Infect Dis 20(1):713. https:\/\/doi.org\/10.1186\/s12879-020-05429-1","DOI":"10.1186\/s12879-020-05429-1"},{"issue":"6","key":"1320_CR24","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1089\/vim.2014.0019","volume":"27","author":"OS Shin","year":"2014","unstructured":"Shin OS, Song GS, Kumar M, Yanagihara R, Lee H-W, Song J-W (2014) Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain. Viral Immunol 27(6):256\u2013266. https:\/\/doi.org\/10.1089\/vim.2014.0019","journal-title":"Viral Immunol"},{"key":"1320_CR25","doi-asserted-by":"publisher","unstructured":"Solomon T et al (2012) Management of suspected viral encephalitis in adults \u2013 Association of British Neurologists and British Infection Association National Guidelines. J Infect 64(4):347\u2013373. https:\/\/doi.org\/10.1016\/j.jinf.2011.11.014","DOI":"10.1016\/j.jinf.2011.11.014"},{"issue":"2","key":"1320_CR26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s13365-010-0011-4","volume":"17","author":"L Talamonti","year":"2011","unstructured":"Talamonti L, Padula PJ, Canteli MS, Posner F, Marczeski FP, Weller C (2011) Hantavirus pulmonary syndrome: encephalitis caused by virus Andes. J Neurovirol 17(2):189\u2013192. https:\/\/doi.org\/10.1007\/s13365-010-0011-4","journal-title":"J Neurovirol"},{"key":"1320_CR27","doi-asserted-by":"publisher","unstructured":"Vial PA et al (2023) Hantavirus in humans: a review of clinical aspects and management. Lancet Infect Dis 23(9):e371\u2013e382. https:\/\/doi.org\/10.1016\/S1473-3099(23)00128-7","DOI":"10.1016\/S1473-3099(23)00128-7"},{"key":"1320_CR28","doi-asserted-by":"publisher","unstructured":"Wichmann D et al (2002) Hantaan Virus Infection Causes an Acute Neurological Disease That Is Fatal in Adult Laboratory Mice. J Virol 76(17):8890\u20138899. https:\/\/doi.org\/10.1128\/JVI.76.17.8890-8899.2002","DOI":"10.1128\/JVI.76.17.8890-8899.2002"}],"container-title":["Journal of NeuroVirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-026-01320-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13365-026-01320-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13365-026-01320-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T12:51:11Z","timestamp":1786193471000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13365-026-01320-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["1320"],"URL":"https:\/\/doi.org\/10.1007\/s13365-026-01320-y","relation":{},"ISSN":["1355-0284","1538-2443"],"issn-type":[{"value":"1355-0284","type":"print"},{"value":"1538-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"10 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"23"}}