{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:57:50Z","timestamp":1783367870443,"version":"3.54.6"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2014\/15\/B\/NZ3\/00421"],"award-info":[{"award-number":["2014\/15\/B\/NZ3\/00421"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s13402-016-0289-1","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T04:47:05Z","timestamp":1469076425000},"page":"473-481","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Ovarian cancer-derived ascitic fluids induce a senescence-dependent pro-cancerogenic phenotype in normal peritoneal mesothelial cells"],"prefix":"10.1007","volume":"39","author":[{"given":"Justyna","family":"Miku\u0142a-Pietrasik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Uruski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Matuszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Szubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Moszy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Szpurek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sajdak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Tykarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-5747","authenticated-orcid":false,"given":"Krzysztof","family":"Ksi\u0105\u017cek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"289_CR1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s13402-014-0206-4","volume":"37","author":"Y Li","year":"2014","unstructured":"Y. Li, K. Wang, Y. Z. Jiang, X. W. Chang, C. F. Dai, J. Zheng, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Inhibits human ovarian cancer cell proliferation. Cell. Oncol. 37, 429\u2013437 (2014)","journal-title":"Cell. Oncol."},{"key":"289_CR2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13402-014-0174-8","volume":"37","author":"M Momeni","year":"2014","unstructured":"M. Momeni, T. Kalir, S. Farag, L. Chuang, D. Fishman, D. E. Burstein, Expression of H1.5 and PLZF in granulosa cell tumors and normal ovarian tissues: a short report. Cell. Oncol. 37, 229\u2013234 (2014)","journal-title":"Cell. Oncol."},{"key":"289_CR3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s13402-015-0235-7","volume":"38","author":"S Patel","year":"2015","unstructured":"S. Patel, L. Kumar, N. Singh, Metformin and epithelial ovarian cancer therapeutics. Cell. Oncol. 38, 365\u2013375 (2015)","journal-title":"Cell. Oncol."},{"key":"289_CR4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1477-7827-1-68","volume":"1","author":"D Cvetkovic","year":"2003","unstructured":"D. Cvetkovic, Early events in ovarian oncogenesis. Reprod. Biol. Endocrinol. 1, 68 (2003)","journal-title":"Reprod. Biol. Endocrinol."},{"key":"289_CR5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijgo.2007.11.004","volume":"101","author":"F Odicino","year":"2008","unstructured":"F. Odicino, S. Pecorelli, L. Zigliani, W. T. Creasman, History of the FIGO cancer staging system. Int. J. Gynaecol. Obstet. 101, 205\u2013210 (2008)","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"289_CR6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/dc.20279","volume":"33","author":"EC Kohn","year":"2005","unstructured":"E. C. Kohn, L. A. Travers, J. Kassis, U. Broome, J. Klominek, Malignant effusions are sources of fibronectin and other promigratory and proinvasive components. Diagn. Cytopathol. 33, 300\u2013308 (2005)","journal-title":"Diagn. Cytopathol."},{"key":"289_CR7","first-page":"566","volume":"2","author":"I Matte","year":"2012","unstructured":"I. Matte, D. Lane, C. Laplante, C. Rancourt, A. Piche, Profiling of cytokines in human epithelial ovarian cancer ascites. Am. J. Cancer Res. 2, 566\u2013580 (2012)","journal-title":"Am. J. Cancer Res."},{"key":"289_CR8","first-page":"14","volume":"13","author":"MR Simpson-Abelson","year":"2013","unstructured":"M. R. Simpson-Abelson, J. L. Loyall, H. K. Lehman, J. L. Barnas, H. Minderman, K. L. O'Loughlin, P. K. Wallace, T. C. George, P. Peng, R. J. Kelleher Jr., K. Odunsi, R. B. Bankert, Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-kappaB and NFAT signaling in tumor-associated T cells. Cancer Immun. 13, 14 (2013)","journal-title":"Cancer Immun."},{"key":"289_CR9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2407-14-288","volume":"14","author":"I Matte","year":"2014","unstructured":"I. Matte, D. Lane, D. Bachvarov, C. Rancourt, A. Piche, Role of malignant ascites on human mesothelial cells and their gene expression profiles. BMC Cancer 14, 288 (2014)","journal-title":"BMC Cancer"},{"key":"289_CR10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ijc.29385","volume":"137","author":"I Matte","year":"2015","unstructured":"I. Matte, D. Lane, C. Laplante, P. Garde-Granger, C. Rancourt, A. Piche, Ovarian cancer ascites enhance the migration of patient-derived peritoneal mesothelial cells via cMet pathway through HGF-dependent and -independent mechanisms. Int. J. Cancer 137, 289\u2013298 (2015)","journal-title":"Int. J. Cancer"},{"key":"289_CR11","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1172\/JCI74778","volume":"124","author":"HA Kenny","year":"2014","unstructured":"H. A. Kenny, C. Y. Chiang, E. A. White, E. M. Schryver, M. Habis, I. L. Romero, A. Ladanyi, C. V. Penicka, J. George, K. Matlin, A. Montag, K. Wroblewski, S. D. Yamada, A. P. Mazar, D. Bowtell, E. Lengyel, Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J. Clin. Invest. 124, 4614\u20134628 (2014)","journal-title":"J. Clin. Invest."},{"key":"289_CR12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.canlet.2014.09.041","volume":"355","author":"J Mikula-Pietrasik","year":"2014","unstructured":"J. Mikula-Pietrasik, P. Sosinska, M. Kucinska, M. Murias, K. Maksin, A. Malinska, A. Ziolkowska, H. Piotrowska, A. Wozniak, K. Ksiazek, Peritoneal mesothelium promotes the progression of ovarian cancer cells in vitro and in a mice xenograft model in vivo. Cancer Lett. 355, 310\u2013315 (2014)","journal-title":"Cancer Lett."},{"key":"289_CR13","first-page":"681","volume":"11","author":"K Ksiazek","year":"2008","unstructured":"K. Ksiazek, A. Jorres, J. Witowski, Senescence induces a proangiogenic switch in human peritoneal mesothelial cells. Rejuvenation. Res. 11, 681\u2013683 (2008)","journal-title":"Res."},{"key":"289_CR14","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.2353\/ajpath.2009.080613","volume":"174","author":"K Ksiazek","year":"2009","unstructured":"K. Ksiazek, J. Mikula-Pietrasik, K. Korybalska, G. Dworacki, A. Jorres, J. Witowski, Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesion: the role of oxidative stress-induced fibronectin. Am. J. Pathol. 174, 1230\u20131240 (2009)","journal-title":"Am. J. Pathol."},{"key":"289_CR15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10585-015-9753-y","volume":"33","author":"J Mikula-Pietrasik","year":"2016","unstructured":"J. Mikula-Pietrasik, P. Sosinska, E. Naumowicz, K. Maksin, H. Piotrowska, A. Wozniak, D. Szpurek, K. Ksiazek, Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo. Clin. Exp. Metastasis 33, 15\u201327 (2016)","journal-title":"Clin. Exp. Metastasis"},{"key":"289_CR16","doi-asserted-by":"crossref","unstructured":"K.Ksiazek, Mesothelial cell: a multifaceted model of aging. Ageing Res. Rev. 12, 595\u2013604 (2013)","DOI":"10.1016\/j.arr.2013.01.008"},{"key":"289_CR17","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.biocel.2013.07.004","volume":"45","author":"J Mikula-Pietrasik","year":"2013","unstructured":"J. Mikula-Pietrasik, P. Sosinska, J. Janus, B. Rubis, M. Brewinska-Olchowik, K. Piwocka, K. Ksiazek, Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-beta1. Int. J. Biochem. Cell. Biol. 45, 2087\u20132096 (2013)","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"289_CR18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10522-014-9505-4","volume":"15","author":"P Sosinska","year":"2014","unstructured":"P. Sosinska, J. Mikula-Pietrasik, M. Ryzek, E. Naumowicz, K. Ksiazek, Specificity of cytochemical and fluorescence methods of senescence-associated beta-galactosidase detection for ageing driven by replication and time. Biogerontology 15, 407\u2013413 (2014)","journal-title":"Biogerontology"},{"key":"289_CR19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10456-012-9266-0","volume":"15","author":"J Mikula-Pietrasik","year":"2012","unstructured":"J. Mikula-Pietrasik, A. Kuczmarska, M. Kucinska, M. Murias, M. Wierzchowski, M. Winckiewicz, R. Staniszewski, A. Breborowicz, K. Ksiazek, Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8\/CXCL8. Angiogenesis 15, 361\u2013376 (2012)","journal-title":"Angiogenesis"},{"key":"289_CR20","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0002-9440(10)65406-5","volume":"154","author":"K Lessan","year":"1999","unstructured":"K. Lessan, D. J. Aguiar, T. Oegema, L. Siebenson, A. P. Skubitz, CD44 and beta1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells. Am. J. Pathol. 154, 1525\u20131537 (1999)","journal-title":"Am. J. Pathol."},{"key":"289_CR21","doi-asserted-by":"crossref","unstructured":"C. Bolitho, M. A. Hahn, R. C. Baxter, D. J. Marsh, The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor. Endocr. Relat. Cancer 17, 929\u2013940 (2010)","DOI":"10.1677\/ERC-10-0107"},{"key":"289_CR22","doi-asserted-by":"crossref","unstructured":"K.Fischer, V.Lutz, O.Wilhelm, M.Schmitt, H.Graeff, P.Heiss, T.Nishiguchi, N.Harbeck, H.Kessler, T.Luther, V.Magdolen, U.Reuning, Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function. FEBS Lett. 438, 101\u2013105 (1998)","DOI":"10.1016\/S0014-5793(98)01279-4"},{"key":"289_CR23","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1158\/1541-7786.MCR-07-0001","volume":"5","author":"N Said","year":"2007","unstructured":"N. Said, M. J. Socha, J. J. Olearczyk, A. A. Elmarakby, J. D. Imig, K. Motamed, Normalization of the ovarian cancer microenvironment by SPARC. Mol. Cancer Res. 5, 1015\u20131030 (2007)","journal-title":"Mol. Cancer Res."},{"key":"289_CR24","first-page":"365","volume":"2","author":"Y Wang","year":"2005","unstructured":"Y. Wang, J. Yang, Y. Gao, Y. Du, L. Bao, W. Niu, Z. Yao, Regulatory effect of e2, IL-6 and IL-8 on the growth of epithelial ovarian cancer cells. Cell. Mol. Immunol. 2, 365\u2013372 (2005)","journal-title":"Cell. Mol. Immunol."},{"key":"289_CR25","doi-asserted-by":"crossref","first-page":"26793","DOI":"10.1074\/jbc.M212187200","volume":"278","author":"Y Hirashima","year":"2003","unstructured":"Y. Hirashima, H. Kobayashi, M. Suzuki, Y. Tanaka, N. Kanayama, T. Terao, Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells. J. Biol. Chem. 278, 26793\u201326802 (2003)","journal-title":"J. Biol. Chem."},{"key":"289_CR26","first-page":"4785","volume":"33","author":"S Furukawa","year":"2013","unstructured":"S. Furukawa, S. Soeda, Y. Kiko, O. Suzuki, Y. Hashimoto, T. Watanabe, H. Nishiyama, K. Tasaki, H. Hojo, M. Abe, K. Fujimori, MCP-1 promotes invasion and adhesion of human ovarian cancer cells. Anticancer Res. 33, 4785\u20134790 (2013)","journal-title":"Anticancer Res."},{"key":"289_CR27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fonc.2013.00256","volume":"3","author":"N Ahmed","year":"2013","unstructured":"N. Ahmed, K. L. Stenvers, Getting to know ovarian cancer ascites: opportunities for targeted therapy-based translational research. Front. Oncol. 3, 256 (2013)","journal-title":"Front. Oncol."},{"key":"289_CR28","doi-asserted-by":"crossref","first-page":"29178","DOI":"10.18632\/oncotarget.4932","volume":"6","author":"J Mikula-Pietrasik","year":"2015","unstructured":"J. Mikula-Pietrasik, P. Sosinska, K. Maksin, M. G. Kucinska, H. Piotrowska, M. Murias, A. Wozniak, D. Szpurek, K. Ksiazek, Colorectal cancer-promoting activity of the senescent peritoneal mesothelium. Oncotarget 6, 29178\u201329195 (2015)","journal-title":"Oncotarget"},{"key":"289_CR29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2174\/1874189400802010007","volume":"2","author":"G D'Andrilli","year":"2008","unstructured":"G. D'Andrilli, A. Giordano, A. Bovicelli, Epithelial ovarian cancer: the role of cell cycle genes in the different histotypes. Open. Clin. Cancer J. 2, 7\u201312 (2008)","journal-title":"Open. Clin. Cancer J."},{"issue":"Suppl","key":"289_CR30","first-page":"S120","volume":"140","author":"GV Raghuram","year":"2014","unstructured":"G. V. Raghuram, P. K. Mishra, Stress induced premature senescence: a new culprit in ovarian tumorigenesis? Indian J. Med. Res. 140(Suppl) S120\u2013S129 (2014)","journal-title":"Indian J. Med. Res."},{"key":"289_CR31","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1245\/s10434-013-3261-6","volume":"21","author":"K Lohani","year":"2014","unstructured":"K. Lohani, S. Shetty, P. Sharma, V. Govindarajan, P.Thomas, B.Loggie, Pseudomyxoma peritonei: inflammatory responses in the peritoneal microenvironment. Ann. Surg. Oncol. 21, 1441\u20131447 (2014)","journal-title":"Ann. Surg. Oncol."},{"key":"289_CR32","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1245\/s10434-015-4965-6","volume":"23","author":"S.Judge","year":"2016","unstructured":"S.Judge, P.Thomas, V. Govindarajan, P. Sharma, B. Loggie, Malignant peritoneal mesothelioma: characterization of the inflammatory response in the tumor microenvironment. Ann. Surg. Oncol. 23, 1496\u20131500 (2016)","journal-title":"Ann. Surg. Oncol."},{"key":"289_CR33","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1074\/jbc.M006809200","volume":"276","author":"C Frippiat","year":"2001","unstructured":"C. Frippiat, Q. M. Chen, S. Zdanov, J. P. Magalhaes, J. Remacle, O. Toussaint, Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem. 276, 2531\u20132537 (2001)","journal-title":"J. Biol. Chem."},{"key":"289_CR34","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/sj.onc.1203471","volume":"19","author":"R Tremain","year":"2000","unstructured":"R. Tremain, M. Marko, V. Kinnimulki, H. Ueno, E. Bottinger, A. Glick, Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene 19, 1698\u20131709 (2000)","journal-title":"Oncogene"},{"key":"289_CR35","doi-asserted-by":"crossref","first-page":"16472","DOI":"10.1073\/pnas.0605752103","volume":"103","author":"G Yang","year":"2006","unstructured":"G. Yang, D. G. Rosen, Z. Zhang, R. C. Bast Jr., G. B. Mills, J. A. Colacino, I. Mercado-Uribe, J. Liu, The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl. Acad. Sci. USA 103, 16472\u201316477 (2006)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"289_CR36","doi-asserted-by":"crossref","unstructured":"M. Miyazaki, E. Gohda, K. Kaji, M. Namba, Increased hepatocyte growth factor production by aging human fibroblasts mainly due to autocrine stimulation by interleukin-1. Biochem. Biophys. Res. Commun. 246, 255\u2013260 (1998)","DOI":"10.1006\/bbrc.1998.8593"},{"key":"289_CR37","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.18632\/oncotarget.2049","volume":"5","author":"M Mariani","year":"2014","unstructured":"M. Mariani, M. McHugh, M. Petrillo, S. Sieber, S. He, M. Andreoli, Z. Wu, P. Fiedler, G. Scambia, S. Shahabi, C. Ferlini, HGF\/c-met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer. Oncotarget 5, 4855\u20134867 (2014)","journal-title":"Oncotarget"},{"key":"289_CR38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fonc.2015.00158","volume":"5","author":"A Elkhattouti","year":"2015","unstructured":"A. Elkhattouti, M. Hassan, C. R. Gomez, Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target. Front. Oncol. 5, 158 (2015)","journal-title":"Front. Oncol."},{"key":"289_CR39","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1038\/ncomms3126","volume":"4","author":"S Domcke","year":"2013","unstructured":"S. Domcke, R. Sinha, D. A. Levine, C. Sander, N. Schultz, Evaluating cell lines as tumour models by comparison of genomic profiles. Nat. Commun. 4, 2126 (2013)","journal-title":"Nat. Commun."},{"key":"289_CR40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10555-010-9220-9","volume":"29","author":"AR Davalos","year":"2010","unstructured":"A. R. Davalos, J. P. Coppe, J. Campisi, P. Y. Desprez, Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 29, 273\u2013283 (2010)","journal-title":"Cancer Metastasis Rev."}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-016-0289-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13402-016-0289-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-016-0289-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T10:42:42Z","timestamp":1568198562000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13402-016-0289-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,21]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["289"],"URL":"https:\/\/doi.org\/10.1007\/s13402-016-0289-1","relation":{},"ISSN":["2211-3428","2211-3436"],"issn-type":[{"value":"2211-3428","type":"print"},{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,21]]}}}