{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:55:41Z","timestamp":1781700941614,"version":"3.54.5"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s13402-018-0417-1","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T19:26:03Z","timestamp":1546457163000},"page":"157-171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation"],"prefix":"10.1007","volume":"42","author":[{"given":"Anmada","family":"Nayak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmayee","family":"Sethy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanakya Nath","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,3]]},"reference":[{"key":"417_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s13402-017-0366-0","volume":"41","author":"L Wasim","year":"2018","unstructured":"L. Wasim, M. Chopra, Synergistic anticancer effect of panobinostat and topoisomerase inhibitors through ROS generation and intrinsic apoptotic pathway induction in cervical cancer cells. Cell Oncol 41, 201\u2013212 (2018)","journal-title":"Cell Oncol"},{"key":"417_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s13402-016-0307-3","volume":"40","author":"A Sathyanarayanan","year":"2017","unstructured":"A. Sathyanarayanan, K.S. Chandrasekaran, D. Karunagaran, microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells. Cell Oncol 40, 119\u2013131 (2017)","journal-title":"Cell Oncol"},{"key":"417_CR3","first-page":"633","volume":"31","author":"Y Osaka","year":"2011","unstructured":"Y. Osaka, M. Shinohara, S. Hoshino, T. Ogata, Y. Takagi, A. Tsuchida, T. Aoki, Phase II study of combined chemotherapy with docetaxel, CDDP and 5-FU for highly advanced esophageal cancer. Anticancer Res 31, 633\u2013638 (2011)","journal-title":"Anticancer Res"},{"key":"417_CR4","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.phymed.2012.10.009","volume":"20","author":"S Hemaiswarya","year":"2013","unstructured":"S. Hemaiswarya, M. Doble, Combination of phenylpropanoids with 5-fluorouracil as anti-cancer agents against human cervical cancer (HeLa) cell line. Phytomedicine 20, 151\u2013158 (2013)","journal-title":"Phytomedicine"},{"key":"417_CR5","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1038\/bjc.2011.387","volume":"105","author":"M Nagata","year":"2011","unstructured":"M. Nagata, H. Nakayama, T. Tanaka, R. Yoshida, Y. Yoshitake, D. Fukuma, K. Kawahara, Y. Nakagawa, K. Ota, A. Hiraki, M. Shinohara, Overexpression of cIAP2 contributes to 5-FU resistance and a poor prognosis in oral squamous cell carcinoma. Br J Cancer 105, 1322\u20131330 (2011)","journal-title":"Br J Cancer"},{"key":"417_CR6","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.3892\/ol.2017.6512","volume":"14","author":"R Mori","year":"2017","unstructured":"R. Mori, M. Futamura, T. Tanahashi, Y. Tanaka, N. Matsuhashi, K. Yamaguchi, K. Yoshida, 5FU resistance caused by reduced fluoro-deoxyuridine monophosphate and its reversal using deoxyuridine. Oncol Lett 14, 3162\u20133168 (2017)","journal-title":"Oncol Lett"},{"key":"417_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13578-017-0145-7","volume":"7","author":"L Zhang","year":"2017","unstructured":"L. Zhang, R. Song, D. Gu, X. Zhang, B. Yu, B. Liu, J. Xie, The role of GLI1 for 5-Fu resistance in colorectal cancer. Cell Biosci 7, 17 (2017)","journal-title":"Cell Biosci"},{"key":"417_CR8","doi-asserted-by":"crossref","unstructured":"A. Rengaraj, B. Subbiah, Y. Haldorai, D. Yesudhas, H.J.G. Yun, S. Kwon, Y.K. Sangdun Choi, E.S. Han, H.S.N. Kim, Y.S. Huh, PAMAM\/5-fluorouracil drug conjugate for targeting E6 and E7 oncoproteins in cervical cancer: A combined experimental\/in silico approach. RSC Adv 7, 5046\u20135054 (2017)","DOI":"10.1039\/C6RA26511A"},{"key":"417_CR9","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1038\/onc.2011.43","volume":"30","author":"P Dhawan","year":"2011","unstructured":"P. Dhawan, R. Ahmad, R. Chaturvedi, J.J. Smith, R. Midha, M.K. Mittal, M. Krishnan, X. Chen, S. Eschrich, T.J. Yeatman, R.C. Harris, M.K. Washington, K.T. Wilson, R.D. Beauchamp, A.B. Singh, Claudin-2 expression increases tumorigenicity of colon cancer cells: Role of epidermal growth factor receptor activation. Oncogene 30, 3234\u20133247 (2011)","journal-title":"Oncogene"},{"key":"417_CR10","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nrm2457","volume":"9","author":"Y Takai","year":"2008","unstructured":"Y. Takai, J. Miyoshi, W. Ikeda, H. Ogita, Nectins and nectin-like molecules: Roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol 9, 603\u2013615 (2008)","journal-title":"Nat Rev Mol Cell Biol"},{"key":"417_CR11","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1309\/AJCPGXK0FR4MHIHB","volume":"134","author":"MS Derycke","year":"2010","unstructured":"M.S. Derycke, S.E. Pambuccian, C.B. Gilks, S.E. Kalloger, A. Ghidouche, M. Lopez, R.L. Bliss, M.A. Geller, P.A. Argenta, K.M. Harrington, A.P. Skubitz Nectin, 4 overexpression in ovarian cancer tissues and serum: Potential role as a serum biomarker. Am J Clin Pathol 134, 835\u2013845 (2010)","journal-title":"Am J Clin Pathol"},{"key":"417_CR12","doi-asserted-by":"publisher","first-page":"6694","DOI":"10.1158\/0008-5472.CAN-09-0016","volume":"69","author":"A Takano","year":"2009","unstructured":"A. Takano, N. Ishikawa, R. Nishino, K. Masuda, W. Yasui, K. Inai, H. Nishimura, H. Ito, H. Nakayama, Y. Miyagi, E. Tsuchiya, N. Kohno, Y. Nakamura, Y. Daigo, Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer Res 69, 6694\u20136703 (2009)","journal-title":"Cancer Res"},{"key":"417_CR13","doi-asserted-by":"publisher","first-page":"19543","DOI":"10.1074\/jbc.M410943200","volume":"280","author":"S Fabre-Lafay","year":"2005","unstructured":"S. Fabre-Lafay, S. Garrido-Urbani, N. Reymond, A. Goncalves, P. Dubreuil, M. Lopez, Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factoralpha-converting enzyme (TACE)\/ADAM-17. J Biol Chem 280, 19543\u201319550 (2005)","journal-title":"J Biol Chem"},{"key":"417_CR14","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00280-015-2794-8","volume":"76","author":"D Das","year":"2015","unstructured":"D. Das, S.R. Satapathy, S. Siddharth, A. Nayak, C.N. Kundu, NECTIN-4 increased the 5-FU resistance in colon cancer cells by inducing the PI3K\u2013AKT cascade. Cancer Chemother Pharmacol 76, 471\u2013479 (2015)","journal-title":"Cancer Chemother Pharmacol"},{"key":"417_CR15","doi-asserted-by":"crossref","unstructured":"S. Nishiwada, M. Sho, S. Yasuda, K .Shimada, I. Yamato, T. Akahori, S. Kinoshita, M. Nagai, N. Konishi, Y. Nakajima, Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer. J Exp Clin Cancer Res 34, 30 (2015)","DOI":"10.1186\/s13046-015-0144-7"},{"key":"417_CR16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.canlet.2016.02.049","volume":"375","author":"Y Zhang","year":"2016","unstructured":"Y. Zhang, S. Liu, L. Wang, Y. Wu, J. Hao, Z. Wang, W. Lu, X.A. Wang, F. Zhang, Y. Cao, H. Liang, H. Li, Y. Ye, Q. Ma, S. Zhao, Y. Shu, R. Bao, L. Jiang, Y. Hu, J. Zhou, L. Chen, Y. Liu, A novel PI3K\/AKT signalling axis mediates Nectin-4-induced gallbladder cancer cell proliferation, metastasis and tumor growth. Cancer Lett 375, 179\u2013189 (2016)","journal-title":"Cancer Lett"},{"key":"417_CR17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.biocel.2017.06.007","volume":"89","author":"S Siddharth","year":"2017","unstructured":"S. Siddharth, K. Goutam, S. Das, A. Nayak, D. Nayak, C. Sethy, M.D. Wyatt, C.N. Kundu, Nectin-4 is a breast cancer stem cell marker that induces WNT\/\u03b2-catenin signalling via Pi3k\/Akt axis. Int J Biochem Cell Biol 89, 85\u201394 (2017)","journal-title":"Int J Biochem Cell Biol"},{"key":"417_CR18","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3109\/1354750X.2014.940503","volume":"19","author":"ES Nabih","year":"2014","unstructured":"E.S. Nabih, F.I. Abdel Motaleb, F.A. Salama, The diagnostic efficacy of nectin 4 expression in ovarian cancer patients. Biomarker 19, 498\u2013504 (2014)","journal-title":"Biomarker"},{"key":"417_CR19","doi-asserted-by":"publisher","first-page":"7374","DOI":"10.3748\/wjg.v19.i42.7374","volume":"19","author":"D Das","year":"2013","unstructured":"D. Das, R. Preet, P. Mohapatra, S.R. Satapathy, C.N. Kundu, 1, 3-Bis (2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive\/resistant colon cancer cells. World J Gastroenterol 19, 7374\u20137388 (2013)","journal-title":"World J Gastroenterol"},{"key":"417_CR20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4331\/wjbc.v6.i3.57","volume":"6","author":"QE Wang","year":"2015","unstructured":"Q.E. Wang, DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies. World J Biol Chem 6, 57\u201364 (2015)","journal-title":"World J Biol Chem"},{"key":"417_CR21","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1158\/1535-7163.MCT-11-1040","volume":"11","author":"M Maugeri-Sacc\u00e0","year":"2012","unstructured":"M. Maugeri-Sacc\u00e0, M. Bartucci, R. De Maria, DNA damage repair pathways in cancer stem cells. Mol Cancer Ther 11, 1627\u20131636 (2012)","journal-title":"Mol Cancer Ther"},{"key":"417_CR22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-1-4614-0899-4_2","volume":"727","author":"AJ Groot","year":"2012","unstructured":"A.J. Groot, M.A. Vooijs, The role of Adams in notch signalling. Adv Exp Med Biol 727, 15\u201336 (2012)","journal-title":"Adv Exp Med Biol"},{"key":"417_CR23","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1242\/dev.063610","volume":"138","author":"ER Andersson","year":"2011","unstructured":"E.R. Andersson, R. Sandberg, U. Lendahl, Notch signalling: Simplicity in design, versatility in function. Development 138, 3593\u20133612 (2011)","journal-title":"Development"},{"key":"417_CR24","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1756-9966-32-26","volume":"32","author":"Z Guo","year":"2013","unstructured":"Z. Guo, X. Jin, H. Jia, Inhibition of ADAM-17 more effectively down-regulates the notch pathway than that of \u03b3-secretase in renal carcinoma. J Exp Clin Cancer Res 32, 26 (2013)","journal-title":"J Exp Clin Cancer Res"},{"key":"417_CR25","doi-asserted-by":"publisher","first-page":"5368","DOI":"10.1158\/0008-5472.CAN-09-3763","volume":"70","author":"A Baumgart","year":"2010","unstructured":"A. Baumgart, S. Seidl, P. Vlachou, L. Michel, N. Mitova, N. Schatz, K. Specht, I. Koch, T. Schuster, R. Grundler, M. Kremer, F. Fend, J.T. Siveke, C. Peschel, J. Duyster, T. Dechow, ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer. Cancer Res 70, 5368\u20135378 (2010)","journal-title":"Cancer Res"},{"key":"417_CR26","doi-asserted-by":"crossref","unstructured":"A. Sommer, F. Kordowski, J. B\u00fcch, T. Maretzky, A. Evers, J. Andr\u00e4, S. D\u00fcsterh\u00f6ft, M. Michalek, I. Lorenzen, P. Somasundaram, A. Tholey, F.D. S\u00f6nnichsen, K. Kunzelmann, L. Heinbockel, C. Nehls, T. Gutsmann, J. Gr\u00f6tzinger, S. Bhakdi, K. Reiss, Phosphatidylserine exposure is required for ADAM17 sheddase function. Nat Commun 7, 11523 (2016)","DOI":"10.1038\/ncomms11523"},{"key":"417_CR27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.taap.2017.07.008","volume":"330","author":"A Nayak","year":"2017","unstructured":"A. Nayak, S. Siddharth, S. Das, D. Nayak, C. Sethy, C.N. Kundu, Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and \u03b2 catenin through activation of GSK3\u03b2. Toxicol Appl Pharmacol 330, 53\u201364 (2017)","journal-title":"Toxicol Appl Pharmacol"},{"key":"417_CR28","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/carcin\/bgs351","volume":"34","author":"R Preet","year":"2013","unstructured":"R. Preet, P. Mohapatra, D. Das, S.R. Satapathy, T. Choudhuri, M.D. Wyatt, C.N. Kundu, Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signalling in breast cancer cells through APC. Carcinogenesis 34, 277\u2013286 (2013)","journal-title":"Carcinogenesis"},{"key":"417_CR29","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1021\/acs.molpharmaceut.5b00461","volume":"12","author":"SR Satapathy","year":"2015","unstructured":"S.R. Satapathy, S. Siddharth, D. Das, A. Nayak, C.N.Kundu enhancement of cytotoxicity and inhibition of angiogenesis in Oral Cancer stem cells by a hybrid nanoparticle of bioactive Quinacrine and silver: Implication of base excision repair Cascade. Mol Pharm 12, 4011\u20134025 (2015)","journal-title":"Mol Pharm"},{"key":"417_CR30","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s10585-016-9809-7","volume":"33","author":"S Siddharth","year":"2016","unstructured":"S. Siddharth, S. Das, A. Nayak, C.N. Kundu, SURVIVIN as a marker for quiescent-breast cancer stem cells-an intermediate, adherent, pre-requisite phase of breast cancer metastasis. Clin Exp Metastasis 33, 661\u2013675 (2016)","journal-title":"Clin Exp Metastasis"},{"key":"417_CR31","doi-asserted-by":"crossref","unstructured":"A. Nayak, S.R. Satapathy, D. Das, S. Siddharth, N. Tripathi, P.V. Bharatam, C. Kundu, Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1. Sci Rep 6, 20600 (2016)","DOI":"10.1038\/srep20600"},{"key":"417_CR32","doi-asserted-by":"publisher","first-page":"32593","DOI":"10.18632\/oncotarget.25961","volume":"9","author":"SS Virtanen","year":"2018","unstructured":"S.S. Virtanen, T. Ishizu, J.A. Sandholm, E. L\u00f6yttyniemi, H.K. V\u00e4\u00e4n\u00e4nen, J.M. Tuomela, P.L. H\u00e4rk\u00f6nen, Alendronate-induced disruption of actin cytoskeleton and inhibition of migration\/invasion are associated with cofilin downregulation in PC-3 prostate cancer cells. Oncotarget 9, 32593\u201332608 (2018)","journal-title":"Oncotarget"},{"key":"417_CR33","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1038\/sj.onc.1209925","volume":"26","author":"CN Kundu","year":"2007","unstructured":"C.N. Kundu, R. Balusu, A.S. Jaiswal, C.G. Gairola, S. Narayan, Cigarette smokecondensate-induced level of adenomatous polyposis coli blocks long-patchbase excision repair in breast epithelial cells. Oncogene 26, 1428\u20131438 (2007)","journal-title":"Oncogene"},{"key":"417_CR34","doi-asserted-by":"publisher","first-page":"9717","DOI":"10.18632\/oncotarget.14206","volume":"8","author":"KL Boylan","year":"2017","unstructured":"K.L. Boylan, P.C. Buchanan, R.D. Manion, D.M. Shukla, K. Braumberger, C. Bruggemeyer, A.P. Skubitz, The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. Oncotarget 8, 9717\u20139738 (2017)","journal-title":"Oncotarget"},{"key":"417_CR35","doi-asserted-by":"crossref","unstructured":"S. Fabre-Lafay, F. Monville, S. Garrido-Urbani, C. Berruyer-Pouyet, C. Ginestier, N. Reymond, P. Finetti, R. Sauvan, J. Ad\u00e9la\u00efde, J. Geneix, E. Lecocq, C. Popovici, P. Dubreuil, P. Viens, A. Gon\u00e7alves, E. Charafe-Jauffret, J. Jacquemier, D. Birnbaum, M. Lopez, Nectin-4 is a new histological and serological tumor associated marker for breast cancer. BMC Cancer 7, 73 (2007)","DOI":"10.1186\/1471-2407-7-73"},{"key":"417_CR36","doi-asserted-by":"publisher","first-page":"702","DOI":"10.7150\/ijbs.9326","volume":"10","author":"Y Huang","year":"2014","unstructured":"Y. Huang, N. Benaich, C. Tape, H.F. Kwok, G. Murphy, Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cellcarcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation. Int J Biol Sci 10, 702\u2013714 (2014)","journal-title":"Int J Biol Sci"},{"key":"417_CR37","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1038\/onc.2011.522","volume":"31","author":"T Rzymski","year":"2012","unstructured":"T. Rzymski, A. Petry, D. Kra\u010dun, F. Rie\u00df, L. Pike, A.L. Harris, A. G\u00f6rlach, The unfolded protein response controls induction and activation of ADAM17\/TACE by severe hypoxia and ER stress. Oncogene 31, 3621\u20133634 (2012)","journal-title":"Oncogene"},{"key":"417_CR38","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1093\/carcin\/bgt127","volume":"34","author":"KM Capaccione","year":"2013","unstructured":"K.M. Capaccione, S.R. Pine, The notch signalling pathway as a mediator of tumorsurvival. Carcinogenesis 34, 1420\u20131430 (2013)","journal-title":"Carcinogenesis"},{"key":"417_CR39","doi-asserted-by":"publisher","first-page":"e00358","DOI":"10.7554\/eLife.00358","volume":"2","author":"NN Pavlova","year":"2013","unstructured":"N.N. Pavlova, C. Pallasch, A.E. Elia, C.J. Braun, T.F. Westbrook, M. Hemann, S. Elledge, A role for PVRL4-driven cell-cell interactions in tumorigenesis. eLife 2, e00358 (2013)","journal-title":"eLife"},{"key":"417_CR40","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1097\/MD.0000000000004765","volume":"95","author":"WH Matsui","year":"2016","unstructured":"W.H. Matsui, Cancer stem cell signalling pathways. Medicine (Baltimore) 95, S8\u2013S19 (2016)","journal-title":"Medicine (Baltimore)"}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-018-0417-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13402-018-0417-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-018-0417-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T19:19:13Z","timestamp":1577992753000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13402-018-0417-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,3]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["417"],"URL":"https:\/\/doi.org\/10.1007\/s13402-018-0417-1","relation":{},"ISSN":["2211-3428","2211-3436"],"issn-type":[{"value":"2211-3428","type":"print"},{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,3]]},"assertion":[{"value":"23 November 2018","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}