{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:45:29Z","timestamp":1781214329410,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273300"],"award-info":[{"award-number":["82273300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772850"],"award-info":[{"award-number":["81772850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s13402-023-00845-2","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T14:28:30Z","timestamp":1692800910000},"page":"1777-1789","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["CircGLIS3 inhibits thyroid cancer invasion and metastasis through miR-146b-3p\/AIF1L axis"],"prefix":"10.1007","volume":"46","author":[{"given":"Siting","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiman","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rengyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"845_CR1","doi-asserted-by":"crossref","unstructured":"Siegel, R.L., et al., Cancer Statistics, 2021. CA Cancer J Clin  71(1), 7-33 (2021)","DOI":"10.3322\/caac.21654"},{"issue":"3","key":"845_CR2","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1089\/thy.2021.0361","volume":"32","author":"L Shobab","year":"2022","unstructured":"L. Shobab, K.D. Burman, L. Wartofsky, Sex differences in differentiated thyroid Cancer. Thyroid. 32(3), 224\u2013235 (2022)","journal-title":"Thyroid"},{"issue":"3","key":"845_CR3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2265.2011.04231.x","volume":"76","author":"IC Huang","year":"2012","unstructured":"I.C. Huang et al., Long-term outcomes of distant metastasis from differentiated thyroid carcinoma. Clin. Endocrinol. (Oxf). 76(3), 439\u2013447 (2012)","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"3","key":"845_CR4","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nrc3431","volume":"13","author":"M Xing","year":"2013","unstructured":"M. Xing, Molecular pathogenesis and mechanisms of thyroid cancer. Nat. Rev. Cancer. 13(3), 184\u2013199 (2013)","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"845_CR5","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41467-018-03033-1","volume":"9","author":"R Liu","year":"2018","unstructured":"R. Liu et al., Regulation of mutant TERT by BRAF V600E\/MAP kinase pathway through FOS\/GABP in human cancer. Nat. Commun. 9(1), 579 (2018)","journal-title":"Nat. Commun"},{"issue":"11","key":"845_CR6","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"20","author":"LS Kristensen","year":"2019","unstructured":"L.S. Kristensen et al., The biogenesis, biology and characterization of circular RNAs. Nat. Rev. Genet. 20(11), 675\u2013691 (2019)","journal-title":"Nat. Rev. Genet"},{"issue":"7441","key":"845_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"S Memczak","year":"2013","unstructured":"S. Memczak et al., Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495(7441), 333\u2013338 (2013)","journal-title":"Nature"},{"issue":"3","key":"845_CR8","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41571-021-00585-y","volume":"19","author":"LS Kristensen","year":"2022","unstructured":"L.S. Kristensen et al., The emerging roles of circRNAs in cancer and oncology. Nat. Rev. Clin. Oncol. 19(3), 188\u2013206 (2022)","journal-title":"Nat. Rev. Clin. Oncol"},{"issue":"1","key":"845_CR9","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41467-023-35998-z","volume":"14","author":"Y Liu","year":"2023","unstructured":"Y. Liu et al., Circular RNA circGlis3 protects against islet \u03b2-cell dysfunction and apoptosis in obesity. Nat. Commun. 14(1), 351 (2023)","journal-title":"Nat. Commun"},{"key":"845_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.canlet.2017.11.022","volume":"414","author":"S Qu","year":"2018","unstructured":"S. Qu et al., The emerging functions and roles of circular RNAs in cancer. Cancer Lett. 414, 301\u2013309 (2018)","journal-title":"Cancer Lett"},{"key":"845_CR11","doi-asserted-by":"crossref","unstructured":"X. Peng et al., Circular RNA_0057209 Acts as ceRNA to Inhibit Thyroid Cancer Progression by Promoting the STK4-Mediated Hippo Pathway via Sponging MicroRNA-183. Oxid. Med. Cell. Longev., 9974639 (2022).","DOI":"10.1155\/2022\/9974639"},{"key":"845_CR12","doi-asserted-by":"publisher","first-page":"103662","DOI":"10.1016\/j.critrevonc.2022.103662","volume":"173","author":"BM Shifman","year":"2022","unstructured":"B.M. Shifman et al., Circular RNAs and thyroid cancer: closed molecules, open possibilities. Crit. Rev. Oncol. Hematol. 173, 103662 (2022)","journal-title":"Crit. Rev. Oncol. Hematol"},{"key":"845_CR13","doi-asserted-by":"crossref","unstructured":"Q. Zhang et al., Hsa_circ_0023990 promotes Tumor Growth and Glycolysis in Dedifferentiated TC via Targeting miR-485-5p\/FOXM1 Axis. Endocrinology 162(12) (2021)","DOI":"10.1210\/endocr\/bqab172"},{"issue":"9","key":"845_CR14","first-page":"5399","volume":"12","author":"W Yu","year":"2020","unstructured":"W. Yu et al., The combination of circRNA-UMAD1 and Galectin-3 in peripheral circulation is a co-biomarker for predicting lymph node metastasis of thyroid carcinoma. Am. J. Transl Res. 12(9), 5399\u20135415 (2020)","journal-title":"Am. J. Transl Res"},{"issue":"1","key":"845_CR15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrc.2017.99","volume":"18","author":"E Anastasiadou","year":"2018","unstructured":"E. Anastasiadou, L.S. Jacob, F.J. Slack, Non-coding RNA networks in cancer. Nat. Rev. Cancer 18(1), 5\u201318 (2018)","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"845_CR16","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12943-020-01203-8","volume":"19","author":"Z Luo","year":"2020","unstructured":"Z. Luo, R.N.A. Circular et al., circCCDC9 acts as a mir-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression. Mol. Cancer 19(1), 86 (2020)","journal-title":"Mol. Cancer"},{"issue":"1","key":"845_CR17","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.1038\/s41467-019-11162-4","volume":"10","author":"Z Cheng","year":"2019","unstructured":"Z. Cheng et al., circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1. Nat. Commun. 10(1), 3200 (2019)","journal-title":"Nat. Commun"},{"issue":"1","key":"845_CR18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12943-020-01196-4","volume":"19","author":"X Guo","year":"2020","unstructured":"X. Guo et al., Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p\/MET\/Akt axis. Mol. Cancer. 19(1), 83 (2020)","journal-title":"Mol. Cancer"},{"issue":"23","key":"845_CR19","doi-asserted-by":"publisher","first-page":"10791","DOI":"10.7150\/thno.47239","volume":"10","author":"H Liu","year":"2020","unstructured":"H. Liu et al., circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p\/MMP14 axis. Theranostics. 10(23), 10791\u201310807 (2020)","journal-title":"Theranostics"},{"issue":"2","key":"845_CR20","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1093\/bib\/bbaa001","volume":"22","author":"L Chen","year":"2021","unstructured":"L. Chen et al., The bioinformatics toolbox for circRNA discovery and analysis. Brief. Bioinform. 22(2), 1706\u20131728 (2021)","journal-title":"Brief. Bioinform"},{"issue":"4","key":"845_CR21","doi-asserted-by":"publisher","first-page":"109439","DOI":"10.1016\/j.celrep.2021.109439","volume":"36","author":"C Xu","year":"2021","unstructured":"C. Xu, J. Zhang, Mammalian circular RNAs result largely from splicing errors. Cell. Rep. 36(4), 109439 (2021)","journal-title":"Cell. Rep"},{"issue":"7648","key":"845_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nature21715","volume":"544","author":"T Akta\u015f","year":"2017","unstructured":"T. Akta\u015f et al., DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature. 544(7648), 115\u2013119 (2017)","journal-title":"Nature"},{"issue":"3","key":"845_CR23","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","volume":"146","author":"L Salmena","year":"2011","unstructured":"L. Salmena et al., A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell. 146(3), 353\u2013358 (2011)","journal-title":"Cell"},{"issue":"5","key":"845_CR24","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1089\/thy.2009.0027","volume":"20","author":"CK Chou","year":"2010","unstructured":"C.K. Chou et al., miR-146b is highly expressed in adult papillary thyroid carcinomas with high risk features including extrathyroidal invasion and the BRAF(V600E) mutation. Thyroid 20(5), 489\u2013494 (2010)","journal-title":"Thyroid"},{"issue":"15","key":"845_CR25","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1038\/onc.2011.381","volume":"31","author":"MV Geraldo","year":"2012","unstructured":"M.V. Geraldo, A.S. Yamashita, E.T. Kimura, MicroRNA miR-146b-5p regulates signal transduction of TGF-\u03b2 by repressing SMAD4 in thyroid cancer. Oncogene 31(15), 1910\u20131922 (2012)","journal-title":"Oncogene"},{"issue":"1","key":"845_CR26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1159\/000369676","volume":"35","author":"X Deng","year":"2015","unstructured":"X. Deng et al., MiR-146b-5p promotes metastasis and induces epithelial-mesenchymal transition in thyroid cancer by targeting ZNRF3. Cell. Physiol. Biochem. 35(1), 71\u201382 (2015)","journal-title":"Cell. Physiol. Biochem"},{"issue":"12","key":"845_CR27","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1089\/thy.2017.0626","volume":"28","author":"C Yu","year":"2018","unstructured":"C. Yu et al., MicroRNA-146b-3p promotes cell metastasis by directly targeting NF2 in human papillary thyroid Cancer. Thyroid 28(12), 1627\u20131641 (2018)","journal-title":"Thyroid"},{"issue":"19","key":"845_CR28","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1158\/0008-5472.CAN-14-3547","volume":"75","author":"G Riesco-Eizaguirre","year":"2015","unstructured":"G. Riesco-Eizaguirre et al., The miR-146b-3p\/PAX8\/NIS Regulatory Circuit modulates the differentiation phenotype and function of thyroid cells during carcinogenesis. Cancer Res. 75(19), 4119\u20134130 (2015)","journal-title":"Cancer Res"},{"key":"845_CR29","doi-asserted-by":"publisher","first-page":"566365","DOI":"10.3389\/fonc.2020.566365","volume":"10","author":"S Hou","year":"2020","unstructured":"S. Hou et al., Downregulation of miR-146b-3p inhibits Proliferation and Migration and modulates the expression and location of Sodium\/Iodide Symporter in dedifferentiated thyroid Cancer by potentially targeting MUC20. Front. Oncol. 10, 566365 (2020)","journal-title":"Front. Oncol"},{"issue":"18","key":"845_CR30","doi-asserted-by":"publisher","first-page":"4627","DOI":"10.1111\/j.1742-4658.2008.06605.x","volume":"275","author":"JO Schulze","year":"2008","unstructured":"J.O. Schulze et al., Structural and functional characterization of human iba proteins. FEBS J. 275(18), 4627\u20134640 (2008)","journal-title":"FEBS J"},{"issue":"7","key":"845_CR31","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S1357-2725(01)00046-2","volume":"33","author":"R Donato","year":"2001","unstructured":"R. Donato, S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int. J. Biochem. Cell. Biol. 33(7), 637\u2013668 (2001)","journal-title":"Int. J. Biochem. Cell. Biol"},{"issue":"7","key":"845_CR32","doi-asserted-by":"publisher","first-page":"e0200487","DOI":"10.1371\/journal.pone.0200487","volume":"13","author":"M Yasuda-Yamahara","year":"2018","unstructured":"M. Yasuda-Yamahara et al., AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes. PLoS One 13(7), e0200487 (2018)","journal-title":"PLoS One"},{"key":"845_CR33","doi-asserted-by":"publisher","first-page":"5485","DOI":"10.2147\/OTT.S165874","volume":"11","author":"P Liu","year":"2018","unstructured":"P. Liu et al., Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer. Onco Targets Ther. 11, 5485\u20135498 (2018)","journal-title":"Onco Targets Ther"},{"issue":"15","key":"845_CR34","doi-asserted-by":"publisher","first-page":"4535","DOI":"10.1158\/0008-5472.CAN-15-2927","volume":"76","author":"Y Zhang","year":"2016","unstructured":"Y. Zhang, S. Wang, L. Li, E.F. Hand Protein, IBA2 promotes cell proliferation in breast cancers via Transcriptional Control of Cyclin D1. Cancer Res. 76(15), 4535\u20134545 (2016)","journal-title":"Cancer Res"}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00845-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-023-00845-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00845-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T17:05:50Z","timestamp":1701795950000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-023-00845-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["845"],"URL":"https:\/\/doi.org\/10.1007\/s13402-023-00845-2","relation":{},"ISSN":["2211-3428","2211-3436"],"issn-type":[{"value":"2211-3428","type":"print"},{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"12 July 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study, which involved human samples, obtained approval from the Institutional Research Ethics Committee of Sun Yat-sen University. Animal Experiment were carried out in accordance with the National Research Council\u2019s Guide for the Care and Use of Laboratory Animals and were conducted with the approval of the Ethics Committee of Sun Yat-sen University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no potential conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}