{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:19:14Z","timestamp":1792466354551,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103271"],"award-info":[{"award-number":["82103271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A04J2126"],"award-info":[{"award-number":["2023A04J2126"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s13402-023-00848-z","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T17:01:37Z","timestamp":1690477297000},"page":"1821-1835","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in \u201cdriver gene-negative\u201d non-small cell lung cancer via activating the Wnt\/\u03b2-catenin signaling"],"prefix":"10.1007","volume":"46","author":[{"given":"Wenjian","family":"Cen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qitao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaobin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"848_CR1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ccell.2022.02.002","volume":"40","author":"NS Patil","year":"2022","unstructured":"N.S. Patil, B.Y. Nabet, S. M\u00fcller, H. Koeppen, W. Zou, J. Giltnane, A. Au-Yeung, S. Srivats, J.H. Cheng, C. Takahashi, P.E. de Almeida, A.S. Chitre, J.L. Grogan, L. Rangell, S. Jayakar, M. Peterson, A.W. Hsia, W.E. O\u2019Gorman, M. Ballinger, R. Banchereau, D.S. Shames, Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer. Cancer Cell. 40, 289\u2013300e284 (2022)","journal-title":"Cancer Cell"},{"key":"848_CR2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.semcancer.2020.07.009","volume":"84","author":"SR Yang","year":"2022","unstructured":"S.R. Yang, A.M. Schultheis, H. Yu, D. Mandelker, M. Ladanyi, R. B\u00fcttner, Precision medicine in non-small cell lung cancer: current applications and future directions. Semin Cancer Biol. 84, 184\u2013198 (2022)","journal-title":"Semin Cancer Biol"},{"key":"848_CR3","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1056\/NEJMoa1917239","volume":"383","author":"DS Hong","year":"2020","unstructured":"D.S. Hong, M.G. Fakih, J.H. Strickler, J. Desai, G.A. Durm, G.I. Shapiro, G.S. Falchook, T.J. Price, A. Sacher, C.S. Denlinger, Y.J. Bang, G.K. Dy, J.C. Krauss, Y. Kuboki, J.C. Kuo, A.L. Coveler, K. Park, T.W. Kim, F. Barlesi, P.N. Munster, S.S. Ramalingam, T.F. Burns, F. Meric-Bernstam, H. Henary, J. Ngang, G. Ngarmchamnanrith, J. Kim, B.E. Houk, J. Canon, J.R. Lipford, G. Friberg, P. Lito, R. Govindan, B.T. Li, KRAS(G12C) inhibition with Sotorasib in Advanced Solid Tumors. N Engl. J. Med. 383, 1207\u20131217 (2020)","journal-title":"N Engl. J. Med"},{"key":"848_CR4","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1158\/1078-0432.CCR-18-2545","volume":"25","author":"Y Cui","year":"2019","unstructured":"Y. Cui, W. Fang, C. Li, K. Tang, J. Zhang, Y. Lei, W. He, S. Peng, M. Kuang, H. Zhang, L. Chen, D. Xu, C. Tang, W. Zhang, Y. Zhu, W. Jiang, N. Jiang, Y. Sun, Y. Chen, H. Wang, Y. Lai, S. Li, Q. He, J. Zhou, Y. Zhang, M. Lin, H. Chen, C. Zhou, C. Wang, J. Wang, X. Zou, L. Wang, Z. Ke, Development and validation of a Novel signature to predict overall survival in \u201cDriver Gene-negative\u201d lung adenocarcinoma (LUAD): results of a Multicenter Study. Clin. Cancer Res. 25, 1546\u20131556 (2019)","journal-title":"Clin. Cancer Res"},{"key":"848_CR5","doi-asserted-by":"crossref","unstructured":"Y. Chai, X. Wu, H. Bai, J. Duan, Combined immunotherapy with Chemotherapy versus Bevacizumab with Chemotherapy in First-Line treatment of driver-gene-negative non-squamous non-small cell Lung Cancer: an updated systematic review and network Meta-analysis, J. Clin. Med., 11, (2022)","DOI":"10.3390\/jcm11061655"},{"key":"848_CR6","doi-asserted-by":"publisher","first-page":"107438","DOI":"10.1016\/j.pharmthera.2019.107438","volume":"206","author":"WJ Liu","year":"2020","unstructured":"W.J. Liu, Y. Du, R. Wen, M. Yang, J. Xu, Drug resistance to targeted therapeutic strategies in non-small cell lung cancer. Pharmacol. Ther. 206, 107438 (2020)","journal-title":"Pharmacol. Ther"},{"key":"848_CR7","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1200\/JCO.19.03022","volume":"38","author":"NH Hanna","year":"2020","unstructured":"N.H. Hanna, B.J. Schneider, S. Temin, S. Jr. Baker, J. Brahmer, P.M. Ellis, L.E. Gaspar, R.Y. Haddad, P.J. Hesketh, D. Jain, I. Jaiyesimi, D.H. Johnson, N.B. Leighl, T. Phillips, G.J. Riely, A.G. Robinson, R. Rosell, J.H. Schiller, N. Singh, D.R. Spigel, J.O. Stabler, J. Tashbar, G. Masters, Therapy for Stage IV Non-Small-Cell Lung Cancer without driver alterations: ASCO and OH (CCO) Joint Guideline Update. J. Clin. Oncol. 38, 1608\u20131632 (2020)","journal-title":"J. Clin. Oncol"},{"key":"848_CR8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/1759-7714.13757","volume":"12","author":"X Si","year":"2021","unstructured":"X. Si, R. Pan, S. Ma, L. Li, L. Liang, P. Zhang, Y. Chu, H. Wang, M. Wang, X. Zhang, L. Zhang, Genomic characteristics of driver genes in chinese patients with non-small cell lung cancer. Thorac. Cancer. 12, 357\u2013363 (2021)","journal-title":"Thorac. Cancer"},{"key":"848_CR9","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1093\/annonc\/mdz167","volume":"30","author":"J Mazieres","year":"2019","unstructured":"J. Mazieres, A. Drilon, A. Lusque, L. Mhanna, A.B. Cortot, L. Mezquita, A.A. Thai, C. Mascaux, S. Couraud, R. Veillon, M. Van den Heuvel, J. Neal, N. Peled, M. Fr\u00fch, T.L. Ng, V. Gounant, S. Popat, J. Diebold, J. Sabari, V.W. Zhu, S.I. Rothschild, P. Bironzo, A. Martinez-Marti, A. Curioni-Fontecedro, R. Rosell, M. Lattuca-Truc, M. Wiesweg, B. Besse, B. Solomon, F. Barlesi, R.D. Schouten, H. Wakelee, D.R. Camidge, G. Zalcman, S. Novello, S.I. Ou, J. Milia, O. Gautschi, Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry. Ann. Oncol. 30, 1321\u20131328 (2019)","journal-title":"Ann. Oncol"},{"key":"848_CR10","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s00262-021-03045-9","volume":"71","author":"M Russano","year":"2022","unstructured":"M. Russano, A. Cortellini, R. Giusti, A. Russo, F. Zoratto, F. Rastelli, A. Gelibter, R. Chiari, O. Nigro, M. De Tursi, S. Bracarda, S. Gori, F. Grossi, M. Bersanelli, L. Calvetti, V. Di Noia, M. Scartozzi, M. Di Maio, P. Bossi, A. Falcone, F. Citarella, F. Pantano, C. Ficorella, M. Filetti, V. Adamo, E. Veltri, F. Pergolesi, M.A. Occhipinti, L. Nicolardi, A. Tuzi, P. Di Marino, S. Macrini, A. Inno, M. Ghidini, S. Buti, G. Aprile, E. Lai, M. Audisio, S. Intagliata, R. Marconcini, D. Brocco, G. Porzio, M. Piras, E. Rijavec, F. Simionato, C. Natoli, M. Tiseo, B. Vincenzi, G. Tonini, D. Santini, Clinical outcomes of NSCLC patients experiencing early immune-related adverse events to PD-1\/PD-L1 checkpoint inhibitors leading to treatment discontinuation. Cancer Immunol. Immunother. 71, 865\u2013874 (2022)","journal-title":"Cancer Immunol. Immunother"},{"key":"848_CR11","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.21037\/tlcr-20-827","volume":"9","author":"WY Xia","year":"2020","unstructured":"W.Y. Xia, W. Feng, C.C. Zhang, Y.J. Shen, Q. Zhang, W. Yu, X.W. Cai, X.L. Fu, Radiotherapy for non-small cell lung cancer in the immunotherapy era: the opportunity and challenge-a narrative review. Transl Lung Cancer Res. 9, 2120\u20132136 (2020)","journal-title":"Transl Lung Cancer Res"},{"key":"848_CR12","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1093\/annonc\/mdx286","volume":"28","author":"L Khoja","year":"2017","unstructured":"L. Khoja, D. Day, T. Wei-Wu, L.L. Chen, A.R. Siu, Hansen, Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review. Ann. Oncol. 28, 2377\u20132385 (2017)","journal-title":"Ann. Oncol"},{"key":"848_CR13","doi-asserted-by":"publisher","first-page":"114113","DOI":"10.1016\/j.addr.2022.114113","volume":"182","author":"G Kara","year":"2022","unstructured":"G. Kara, G.A. Calin, B. Ozpolat, RNAi-based therapeutics and tumor targeted delivery in cancer. Adv. Drug Deliv Rev. 182, 114113 (2022)","journal-title":"Adv. Drug Deliv Rev"},{"key":"848_CR14","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.7150\/thno.41120","volume":"10","author":"N Jiang","year":"2020","unstructured":"N. Jiang, C. Zou, Y. Zhu, Y. Luo, L. Chen, Y. Lei, K. Tang, Y. Sun, W. Zhang, S. Li, Q. He, J. Zhou, Y. Chen, J. Luo, W. Jiang, Z. Ke, HIF-1\u0251-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt\/\u03b2-catenin and notch signaling. Theranostics. 10, 2553\u20132570 (2020)","journal-title":"Theranostics"},{"key":"848_CR15","doi-asserted-by":"publisher","first-page":"471","DOI":"10.2174\/1381612827666211109113305","volume":"28","author":"AA Sayyed","year":"2022","unstructured":"A.A. Sayyed, P. Gondaliya, P. Bhat, M. Mali, N. Arya, A. Khairnar, K. Kalia, Role of miRNAs in Cancer Diagnostics and Therapy: a recent update. Curr. Pharm. Des. 28, 471\u2013487 (2022)","journal-title":"Curr. Pharm. Des"},{"key":"848_CR16","doi-asserted-by":"publisher","first-page":"e1662","DOI":"10.1002\/wrna.1662","volume":"12","author":"LF Sempere","year":"2021","unstructured":"L.F. Sempere, A.S. Azmi, A. Moore, microRNA-based diagnostic and therapeutic applications in cancer medicine. Wiley Interdiscip Rev RNA 12, e1662 (2021)","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"848_CR17","doi-asserted-by":"publisher","first-page":"e12169","DOI":"10.1002\/jev2.12169","volume":"10","author":"K Yamana","year":"2021","unstructured":"K. Yamana, J. Inoue, R. Yoshida, J. Sakata, H. Nakashima, H. Arita, S. Kawaguchi, S. Gohara, Y. Nagao, H. Takeshita, M. Maeshiro, R. Liu, Y. Matsuoka, M. Hirayama, K. Kawahara, M. Nagata, A. Hirosue, R. Toya, R. Murakami, Y. Kuwahara, M. Fukumoto, H. Nakayama, Extracellular vesicles derived from radioresistant oral squamous cell carcinoma cells contribute to the acquisition of radioresistance via the mir-503-3p-BAK axis. J. Extracell. Vesicles. 10, e12169 (2021)","journal-title":"J. Extracell. Vesicles"},{"key":"848_CR18","doi-asserted-by":"publisher","first-page":"8640","DOI":"10.1038\/ncomms9640","volume":"6","author":"L Fang","year":"2015","unstructured":"L. Fang, J. Cai, B. Chen, S. Wu, R. Li, X. Xu, Y. Yang, H. Guan, X. Zhu, L. Zhang, J. Yuan, J. Wu, M. Li, Aberrantly expressed mir-582-3p maintains lung cancer stem cell-like traits by activating Wnt\/\u03b2-catenin signalling. Nat. Commun. 6, 8640 (2015)","journal-title":"Nat. Commun"},{"key":"848_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","volume":"13","author":"Y Zhang","year":"2020","unstructured":"Y. Zhang, X. Wang, Targeting the Wnt\/\u03b2-catenin signaling pathway in cancer. J. Hematol. Oncol. 13, 165 (2020)","journal-title":"J. Hematol. Oncol"},{"key":"848_CR20","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2217\/nnm-2021-0210","volume":"17","author":"A Shams","year":"2022","unstructured":"A. Shams, R. Shabani, H. Asgari, M. Karimi, M. Najafi, M. Asghari-Jafarabadi, S.M. Razavi, S.R. Miri, M. Abbasi, A. Mohammadi, M. Koruji, In vitro elimination of EL4 cancer cells from spermatogonia stem cells by miRNA-143- and 206-loaded folic acid-conjugated PLGA nanoparticles. Nanomed. (Lond). 17, 531\u2013545 (2022)","journal-title":"Nanomed. (Lond)"},{"key":"848_CR21","doi-asserted-by":"crossref","unstructured":"W. Du, R.E. Menjivar, K.L. Donahue, P. Kadiyala, A. Velez-Delgado, K.L. Brown, H.R. Watkoske, X. He, E.S. Carpenter, C.V. Angeles, Y. Zhang, M. Pasca di Magliano, WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer, J. Exp. Med., 220 (2023)","DOI":"10.1084\/jem.20220503"},{"key":"848_CR22","doi-asserted-by":"crossref","unstructured":"J. Wang, H. Yu, W. Dong, C. Zhang, M. Hu, W. Ma, X. Jiang, H. Li, P. Yang, D. Xiang, M6A-mediated upregulation of FZD10 regulates liver cancer stem cells properties and lenvatinib resistance through WNT\/\u03b2-catenin and Hippo signaling pathways, Gastroenterology, (2023)","DOI":"10.1053\/j.gastro.2023.01.041"},{"key":"848_CR23","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1158\/2159-8290.CD-21-0190","volume":"11","author":"MJ Parsons","year":"2021","unstructured":"M.J. Parsons, T. Tammela, L.E. Dow, WNT as a driver and dependency in Cancer. Cancer Discov. 11, 2413\u20132429 (2021)","journal-title":"Cancer Discov"},{"key":"848_CR24","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41392-021-00701-5","volume":"6","author":"F Yu","year":"2021","unstructured":"F. Yu, C. Yu, F. Li, Y. Zuo, Y. Wang, L. Yao, C. Wu, C. Wang, L. Ye, Wnt\/\u03b2-catenin signaling in cancers and targeted therapies. Signal. Transduct. Target. Ther. 6, 307 (2021)","journal-title":"Signal. Transduct. Target. Ther"},{"key":"848_CR25","doi-asserted-by":"crossref","unstructured":"H.B. Park, J.W. Kim, K.H. Baek, Regulation of wnt signaling through Ubiquitination and Deubiquitination in Cancers, Int. J. Mol. Sci., 21 (2020)","DOI":"10.3390\/ijms21113904"},{"key":"848_CR26","doi-asserted-by":"publisher","first-page":"djt356","DOI":"10.1093\/jnci\/djt356","volume":"106","author":"DJ Stewart","year":"2014","unstructured":"D.J. Stewart, Wnt signaling pathway in non-small cell lung cancer. J. Natl. Cancer Inst. 106, djt356 (2014)","journal-title":"J. Natl. Cancer Inst"},{"key":"848_CR27","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.bbrc.2018.05.184","volume":"502","author":"Z Wu","year":"2018","unstructured":"Z. Wu, W. Shi, C. Jiang, Overexpressing circular RNA hsa_circ_0002052 impairs osteosarcoma progression via inhibiting Wnt\/\u03b2-catenin pathway by regulating miR-1205\/APC2 axis. Biochem. Biophys. Res. Commun. 502, 465\u2013471 (2018)","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"848_CR28","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.7150\/thno.66142","volume":"12","author":"W Zhang","year":"2022","unstructured":"W. Zhang, X. Ruan, Y. Li, J. Zhi, L. Hu, X. Hou, X. Shi, X. Wang, J. Wang, W. Ma, P. Gu, X. Zheng, M. Gao, KDM1A promotes thyroid cancer progression and maintains stemness through the Wnt\/\u03b2-catenin signaling pathway. Theranostics. 12, 1500\u20131517 (2022)","journal-title":"Theranostics"},{"key":"848_CR29","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.4143\/crt.2018.638","volume":"51","author":"F Yang","year":"2019","unstructured":"F. Yang, H. Xiong, L. Duan, Q. Li, X. Li, Y. Zhou, MiR-1246 promotes Metastasis and Invasion of A549 cells by targeting GSK-3\u03b2\u2013Mediated Wnt\/\u03b2-Catenin pathway. Cancer Res. Treat. 51, 1420\u20131429 (2019)","journal-title":"Cancer Res. Treat"},{"key":"848_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fphar.2017.00111","volume":"8","author":"CL Busceti","year":"2017","unstructured":"C.L. Busceti, S. Marchitti, F. Bianchi, P. Di Pietro, B. Riozzi, R. Stanzione, M. Cannella, G. Battaglia, V. Bruno, M. Volpe, F. Fornai, F. Nicoletti, S. Rubattu, Dickkopf-3 upregulates VEGF in cultured human endothelial cells by activating activin receptor-like kinase 1 (ALK1) pathway. Front. Pharmacol. 8, 111 (2017)","journal-title":"Front. Pharmacol"},{"key":"848_CR31","doi-asserted-by":"crossref","unstructured":"M.H. Soheilifar, M. Pornour, M. Saidijam, R. Najafi, F. Azizi Jalilian, H. Keshmiri Neghab, R. Amini, miR-1290 contributes to oncogenesis and angiogenesis via targeting of THBS1, DKK3 and, SCAI, Bioimpacts, 12, 349\u2013358 (2022)","DOI":"10.34172\/bi.2021.23571"},{"key":"848_CR32","doi-asserted-by":"crossref","unstructured":"R. Kalluri, V.S. LeBleu, The biology, function, and biomedical applications of exosomes, Science, 367 (2020)","DOI":"10.1126\/science.aau6977"},{"key":"848_CR33","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.annonc.2021.01.074","volume":"32","author":"W Yu","year":"2021","unstructured":"W. Yu, J. Hurley, D. Roberts, S.K. Chakrabortty, D. Enderle, M. Noerholm, X.O. Breakefield, J.K. Skog, Exosome-based liquid biopsies in cancer: opportunities and challenges. Ann. Oncol. 32, 466\u2013477 (2021)","journal-title":"Ann. Oncol"},{"key":"848_CR34","doi-asserted-by":"publisher","first-page":"5395","DOI":"10.1038\/s41467-018-07810-w","volume":"9","author":"Z Zeng","year":"2018","unstructured":"Z. Zeng, Y. Li, Y. Pan, X. Lan, F. Song, J. Sun, K. Zhou, X. Liu, X. Ren, F. Wang, J. Hu, X. Zhu, W. Yang, W. Liao, G. Li, Y. Ding, L. Liang, Cancer-derived exosomal mir-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis. Nat. Commun. 9, 5395 (2018)","journal-title":"Nat. Commun"},{"key":"848_CR35","doi-asserted-by":"publisher","first-page":"8206","DOI":"10.7150\/thno.37455","volume":"9","author":"L He","year":"2019","unstructured":"L. He, W. Zhu, Q. Chen, Y. Yuan, Y. Wang, J. Wang, X. Wu, Ovarian cancer cell-secreted exosomal miR-205 promotes metastasis by inducing angiogenesis. Theranostics. 9, 8206\u20138220 (2019)","journal-title":"Theranostics"},{"key":"848_CR36","doi-asserted-by":"crossref","unstructured":"G. Kyriakopoulos, V. Katopodi, I. Skeparnias, E.G. Kaliatsi, K. Grafanaki, C. Stathopoulos, KRAS(G12C) can either promote or impair Cap-Dependent translation in two different lung Adenocarcinoma Cell Lines, Int. J. Mol. Sci., 22 (2021)","DOI":"10.3390\/ijms22042222"},{"key":"848_CR37","doi-asserted-by":"publisher","first-page":"1629865","DOI":"10.1080\/20013078.2019.1629865","volume":"8","author":"Y Zeng","year":"2019","unstructured":"Y. Zeng, X. Yao, X. Liu, X. He, L. Li, X. Liu, Z. Yan, J. Wu, B.M. Fu, Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis. J. Extracell. Vesicles. 8, 1629865 (2019)","journal-title":"J. Extracell. Vesicles"},{"key":"848_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10456-022-09839-4","volume":"26","author":"Y Zhang","year":"2023","unstructured":"Y. Zhang, L. Zhou, Y. Xu, J. Zhou, T. Jiang, J. Wang, C. Li, X. Sun, H. Song, J. Song, Targeting SMYD2 inhibits angiogenesis and increases the efficiency of apatinib by suppressing EGFL7 in colorectal cancer. Angiogenesis. 26, 1\u201318 (2023)","journal-title":"Angiogenesis"},{"key":"848_CR39","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12943-020-01184-8","volume":"19","author":"K Han","year":"2020","unstructured":"K. Han, F.W. Wang, C.H. Cao, H. Ling, J.W. Chen, R.X. Chen, Z.H. Feng, J. Luo, X.H. Jin, J.L. Duan, S.M. Li, N.F. Ma, J.P. Yun, X.Y. Guan, Z.Z. Pan, P. Lan, R.H. Xu, D. Xie, CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17. Mol. Cancer. 19, 60 (2020)","journal-title":"Mol. Cancer"},{"key":"848_CR40","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41568-021-00332-6","volume":"21","author":"AW Lambert","year":"2021","unstructured":"A.W. Lambert, R.A. Weinberg, Linking EMT programmes to normal and neoplastic epithelial stem cells. Nat. Rev. Cancer. 21, 325\u2013338 (2021)","journal-title":"Nat. Rev. Cancer"},{"key":"848_CR41","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12943-022-01653-2","volume":"21","author":"P Liu","year":"2022","unstructured":"P. Liu, Z. Wang, X. Ou, P. Wu, Y. Zhang, S. Wu, X. Xiao, Y. Li, F. Ye, H. Tang, The FUS\/circEZH2\/KLF5\/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition. Mol. Cancer. 21, 198 (2022)","journal-title":"Mol. Cancer"},{"key":"848_CR42","doi-asserted-by":"publisher","first-page":"1769373","DOI":"10.1080\/20013078.2020.1769373","volume":"9","author":"K Ono","year":"2020","unstructured":"K. Ono, C. Sogawa, H. Kawai, M.T. Tran, E.A. Taha, Y. Lu, M.W. Oo, Y. Okusha, H. Okamura, S. Ibaragi, M. Takigawa, K.I. Kozaki, H. Nagatsuka, A. Sasaki, K. Okamoto, S.K. Calderwood, T. Eguchi, Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer. J. Extracell. Vesicles. 9, 1769373 (2020)","journal-title":"J. Extracell. Vesicles"},{"key":"848_CR43","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1172\/JCI42556","volume":"121","author":"JK Min","year":"2011","unstructured":"J.K. Min, H. Park, H.J. Choi, Y. Kim, B.J. Pyun, V. Agrawal, B.W. Song, J. Jeon, Y.S. Maeng, S.S. Rho, S. Shim, J.H. Chai, B.K. Koo, H.J. Hong, C.O. Yun, C. Choi, Y.M. Kim, K.C. Hwang, Y.G. Kwon, The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. J. Clin. Invest. 121, 1882\u20131893 (2011)","journal-title":"J. Clin. Invest"},{"key":"848_CR44","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1161\/CIRCRESAHA.115.306829","volume":"117","author":"L Jiang","year":"2015","unstructured":"L. Jiang, M. Yin, X. Wei, J. Liu, X. Wang, C. Niu, X. Kang, J. Xu, Z. Zhou, S. Sun, X. Wang, X. Zheng, S. Duan, K. Yao, R. Qian, N. Sun, A. Chen, R. Wang, J. Zhang, S. Chen, D. Meng, Bach1 represses Wnt\/\u03b2-Catenin signaling and angiogenesis. Circ. Res. 117, 364\u2013375 (2015)","journal-title":"Circ. Res"},{"key":"848_CR45","doi-asserted-by":"crossref","unstructured":"P.P. Wong, J.M. Mu\u00f1oz-F\u00e9lix, M. Hijazi, H. Kim, S.D. Robinson, B. De Lux\u00e1n-Delgado, I. Rodr\u00edguez-Hern\u00e1ndez, O. Maiques, Y.M. Meng, Q. Meng, N. Bodrug, M.S. Dukinfield, L.E. Reynolds, G. Elia, A. Clear, C. Harwood, Y. Wang, J.J. Campbell, R. Singh, P. Zhang, T.J. Schall, K.P. Matchett, N.C. Henderson, P.W. Szlosarek, S.A. Dreger, S. Smith, J.L. Jones, J.G. Gribben, P.R. Cutillas, P. Meier, V. Sanz-Moreno, K.M. Hodivala-Dilke, Cancer Burden is controlled by Mural Cell-\u03b23-Integrin regulated crosstalk with Tumor cells, cell, 181, 1346\u20131363e1321 (2020)","DOI":"10.1016\/j.cell.2020.02.003"},{"key":"848_CR46","first-page":"5546","volume":"11","author":"Y Jia","year":"2019","unstructured":"Y. Jia, T. Qin, X. Zhang, S. Liu, Z. Liu, C. Zhang, J. Wang, K. Li, Effect of bevacizumab on the tight junction proteins of vascular endothelial cells. Am. J. Transl Res. 11, 5546\u20135559 (2019)","journal-title":"Am. J. Transl Res"},{"key":"848_CR47","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s12943-019-1108-x","volume":"18","author":"H Wang","year":"2019","unstructured":"H. Wang, Q. Deng, Z. Lv, Y. Ling, X. Hou, Z. Chen, X. Dinglin, S. Ma, D. Li, Y. Wu, Y. Peng, H. Huang, L. Chen, N6-methyladenosine induced mir-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1. Mol. Cancer. 18, 181 (2019)","journal-title":"Mol. Cancer"},{"key":"848_CR48","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12943-022-01619-4","volume":"21","author":"L Liu","year":"2022","unstructured":"L. Liu, M. Gu, J. Ma, Y. Wang, M. Li, H. Wang, X. Yin, X. Li, CircGPR137B\/miR-4739\/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma. Mol. Cancer. 21, 149 (2022)","journal-title":"Mol. Cancer"},{"key":"848_CR49","doi-asserted-by":"publisher","first-page":"109557","DOI":"10.1016\/j.biopha.2019.109557","volume":"122","author":"X Wang","year":"2020","unstructured":"X. Wang, Q. Chen, X. Wang, W. Li, G. Yu, Z. Zhu, W. Zhang, ZEB1 activated-VPS9D1-AS1 promotes the tumorigenesis and progression of prostate cancer by sponging miR-4739 to upregulate MEF2D. Biomed. Pharmacother. 122, 109557 (2020)","journal-title":"Biomed. Pharmacother"},{"key":"848_CR50","doi-asserted-by":"publisher","first-page":"14066","DOI":"10.1080\/21655979.2022.2068783","volume":"13","author":"K Wu","year":"2022","unstructured":"K. Wu, Z. Liu, C. Dong, S. Gu, L. Li, W. Wang, Y. Zhou, MiR-4739 inhibits the malignant behavior of esophageal squamous cell carcinoma cells via the homeobox C10\/vascular endothelial growth factor A\/phosphatidylinositol 3-kinase\/AKT pathway. Bioengineered. 13, 14066\u201314079 (2022)","journal-title":"Bioengineered"},{"key":"848_CR51","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.cell.2019.03.046","volume":"177","author":"CX Liu","year":"2019","unstructured":"C.X. Liu, X. Li, F. Nan, S. Jiang, X. Gao, S.K. Guo, W. Xue, Y. Cui, K. Dong, H. Ding, B. Qu, Z. Zhou, N. Shen, L. Yang, L.L. Chen, Structure and degradation of circular RNAs regulate PKR activation in Innate Immunity. Cell. 177, 865\u2013880e821 (2019)","journal-title":"Cell"},{"key":"848_CR52","doi-asserted-by":"crossref","unstructured":"M. Correia de Sousa, M. Gjorgjieva, D. Dolicka, C. Sobolewski, M. Foti, Deciphering miRNAs\u2019 Action through miRNA Editing, Int. J. Mol. Sci., 20 (2019)","DOI":"10.3390\/ijms20246249"},{"key":"848_CR53","doi-asserted-by":"publisher","first-page":"e12186","DOI":"10.1002\/jev2.12186","volume":"11","author":"S Zhao","year":"2022","unstructured":"S. Zhao, Y. Mi, B. Zheng, P. Wei, Y. Gu, Z. Zhang, Y. Xu, S. Cai, X. Li, D. Li, Highly-metastatic colorectal cancer cell released miR-181a-5p-rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment. J. Extracell. Vesicles. 11, e12186 (2022)","journal-title":"J. Extracell. Vesicles"},{"key":"848_CR54","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.jtho.2021.04.003","volume":"16","author":"M Qiao","year":"2021","unstructured":"M. Qiao, T. Jiang, X. Liu, S. Mao, F. Zhou, X. Li, C. Zhao, X. Chen, C. Su, S. Ren, C. Zhou, Immune checkpoint inhibitors in EGFR-Mutated NSCLC: Dusk or Dawn? J. Thorac. Oncol. 16, 1267\u20131288 (2021)","journal-title":"J. Thorac. Oncol"},{"key":"848_CR55","doi-asserted-by":"crossref","unstructured":"E.D. Agerschou, P. Flagmeier, T. Saridaki, C. Galvagnion, D. Komnig, L. Heid, V. Prasad, H. Shaykhalishahi, D. Willbold, C.M. Dobson, A. Voigt, B. Falkenburger, W. Hoyer, A.K. Buell, An engineered monomer binding-protein for \u03b1-synuclein efficiently inhibits the proliferation of amyloid fibrils, Elife, 8 (2019)","DOI":"10.7554\/eLife.46112"},{"key":"848_CR56","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1158\/0008-5472.CAN-22-0026","volume":"82","author":"VS LeBleu","year":"2022","unstructured":"V.S. LeBleu, J.P. Thiery, The Continuing search for causality between epithelial-to-mesenchymal transition and the metastatic fitness of Carcinoma cells. Cancer Res. 82, 1467\u20131469 (2022)","journal-title":"Cancer Res"},{"key":"848_CR57","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1038\/s41467-022-29723-5","volume":"13","author":"N Mohammadi Ghahhari","year":"2022","unstructured":"N. Mohammadi Ghahhari, M.K. Sznurkowska, N. Hulo, L. Bernasconi, N. Aceto, D. Picard, Cooperative interaction between ER\u03b1 and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis. Nat. Commun. 13, 2104 (2022)","journal-title":"Nat. Commun"},{"key":"848_CR58","doi-asserted-by":"publisher","first-page":"120552","DOI":"10.1016\/j.biomaterials.2020.120552","volume":"268","author":"YD Zhao","year":"2021","unstructured":"Y.D. Zhao, M. Muhetaerjiang, H.W. An, X. Fang, Y. Zhao, H. Wang, Nanomedicine enables spatiotemporally regulating macrophage-based cancer immunotherapy. Biomaterials. 268, 120552 (2021)","journal-title":"Biomaterials"},{"key":"848_CR59","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/s41467-022-28440-3","volume":"13","author":"CS Blaha","year":"2022","unstructured":"C.S. Blaha, G. Ramakrishnan, S.M. Jeon, V. Nogueira, H. Rho, S. Kang, P. Bhaskar, A.R. Terry, A.F. Aissa, M.V. Frolov, K.C. Patra, R. Brooks Robey, N. Hay, A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Nat. Commun. 13, 899 (2022)","journal-title":"Nat. Commun"},{"key":"848_CR60","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1038\/s41388-018-0565-9","volume":"38","author":"J An","year":"2019","unstructured":"J. An, Y. Du, X. Fan, Y. Wang, C. Ivan, X.G. Zhang, A.K. Sood, Z. An, N. Zhang, EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis. Oncogene. 38, 2123\u20132134 (2019)","journal-title":"Oncogene"},{"key":"848_CR61","doi-asserted-by":"crossref","unstructured":"X. Liu, S. Tan, H. Liu, J. Jiang, X. Wang, L. Li, B. Wu, Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis, Hepatology, (2022)","DOI":"10.1002\/hep.32662"},{"key":"848_CR62","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41571-022-00639-9","volume":"19","author":"AJ Cooper","year":"2022","unstructured":"A.J. Cooper, L.V. Sequist, J.J. Lin, Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management. Nat. Rev. Clin. Oncol. 19, 499\u2013514 (2022)","journal-title":"Nat. Rev. Clin. Oncol"},{"key":"848_CR63","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/1759-7714.12927","volume":"10","author":"K Tang","year":"2019","unstructured":"K. Tang, N. Jiang, Y. Kuang, Q. He, S. Li, J. Luo, W. Jiang, Y. Chen, Y. Sun, L. Chen, Y. Chen, J. Zhu, Y. Cui, H. Wan, Z. Ke, Overcoming T790M mutant small cell lung cancer with the third-generation EGFR-TKI osimertinib. Thorac. Cancer. 10, 359\u2013364 (2019)","journal-title":"Thorac. Cancer"}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00848-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-023-00848-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00848-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T17:05:47Z","timestamp":1701795947000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-023-00848-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["848"],"URL":"https:\/\/doi.org\/10.1007\/s13402-023-00848-z","relation":{},"ISSN":["2211-3428","2211-3436"],"issn-type":[{"value":"2211-3428","type":"print"},{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]},"assertion":[{"value":"21 July 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All research adhered to the tenets of the Declaration of Helsinki. The Ethics Committee of Sun Yat-Sen University Cancer Center approved this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Patients signed informed consent regarding publishing their data and photographs.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}