{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:04:18Z","timestamp":1786982658632,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Multidisciplinary Cooperative Diagnosis and Treatment Capacity Building Project for Major Diseases","award":["Lung Cancer"],"award-info":[{"award-number":["Lung Cancer"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903020"],"award-info":[{"award-number":["81903020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2022JJ30072"],"award-info":[{"award-number":["2022JJ30072"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s13402-023-00873-y","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:02:30Z","timestamp":1695168150000},"page":"447-461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immune characteristics associated with lymph node metastasis in early-stage NSCLC"],"prefix":"10.1007","volume":"47","author":[{"given":"Ziyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbo","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NanNan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pansong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"issue":"10066","key":"873_CR1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0140-6736(16)30958-8","volume":"389","author":"FR Hirsch","year":"2017","unstructured":"F.R. Hirsch, G.V. Scagliotti, J.L. Mulshine, R. Kwon, W.J. Curran Jr., Y.L. Wu, L. Paz-Ares, Lung cancer: current therapies and new targeted treatments. Lancet 389(10066), 299\u2013311 (2017)","journal-title":"Lancet"},{"key":"873_CR2","unstructured":"Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, Nicholson AG, Groome P, Mitchell A, Bolejack V; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Boards, and Participating Institutions; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee Advisory Boards and Participating Institutions. The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer. J. Thorac. Oncol. 11(1):39\u201351 (2016)"},{"issue":"8","key":"873_CR3","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s00262-020-02792-5","volume":"70","author":"MJ O'Melia","year":"2021","unstructured":"M.J. O\u2019Melia, M.P. Manspeaker, S.N. Thomas, Tumor-draining lymph nodes are survival niches that support T cell priming against lymphatic transported tumor antigen and effects of immune checkpoint blockade in TNBC. Cancer. Immunol. Immunother. 70(8), 2179\u20132195 (2021)","journal-title":"Cancer Immunol Immunother."},{"issue":"12","key":"873_CR4","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1093\/jnci\/djx097","volume":"109","author":"V Murthy","year":"2017","unstructured":"V. Murthy, J. Minehart, D. Sterman, Local immunotherapy of cancer: innovative approaches to harnessing tumor-specific immune responses. J. Natl. Cancer. Inst. 109(12), 117\u2013129 (2017)","journal-title":"J. Natl. Cancer. Inst."},{"issue":"11","key":"873_CR5","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/nri1222","volume":"3","author":"UH von Andrian","year":"2003","unstructured":"U.H. von Andrian, T.R. Mempel, Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol.\u00a03(11), 867\u2013878 (2003)","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"873_CR6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1158\/1078-0432.107.11.1","volume":"11","author":"JH Lee","year":"2005","unstructured":"J.H. Lee, H. Torisu-Itakara, A.J. Cochran, A. Kadison, Y. Huynh, D.L. Morton, R. Essner, Quantitative analysis of melanoma-induced cytokine-mediated immunosuppression in melanoma sentinel nodes. Clin. Cancer Res.\u00a011(1), 107\u2013112 (2005)","journal-title":"Clin Cancer Res"},{"issue":"4","key":"873_CR7","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/modpathol.2010.227","volume":"24","author":"AS Mansfield","year":"2011","unstructured":"A.S. Mansfield, S.G. Holtan, T.E. Grotz, J.B. Allred, J.W. Jakub, L.A. Erickson, S.N. Markovic, Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis. Mod. Pathol.\u00a024(4), 487\u2013494 (2011)","journal-title":"Mod Pathol"},{"issue":"1","key":"873_CR8","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s40425-019-0605-1","volume":"7","author":"KM van Pul","year":"2019","unstructured":"K.M. van Pul, R.J.C.L.M. Vuylsteke, R. van de Ven, E.A. Te Velde, E.J.T. Rutgers, P.M. van den Tol, H.B.A.C. Stockmann, T.D. de Gruijl, Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node. J. Immunother. Cancer 7(1), 133 (2019)","journal-title":"J Immunother Cancer"},{"issue":"6","key":"873_CR9","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1002\/cncr.21729","volume":"106","author":"K Matsuura","year":"2006","unstructured":"K. Matsuura, Y. Yamaguchi, H. Ueno, A. Osaki, K. Arihiro, T. Toge, Maturation of dendritic cells and T-cell responses in sentinel lymph nodes from patients with breast carcinoma. Cancer 106(6), 1227\u20131236 (2006)","journal-title":"Cancer"},{"issue":"11","key":"873_CR10","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1158\/2326-6066.CIR-17-0110","volume":"5","author":"MFCM van den Hout","year":"2017","unstructured":"M.F.C.M. van den Hout, B.D. Koster, B.J.R. Sluijter, B.G. Molenkamp, R. van de Ven, A.J.M. van den Eertwegh, R.J. Scheper, P.A.M. van Leeuwen, M.P. van den Tol, T.D. de Gruijl, Melanoma sequentially suppresses different DC subsets in the sentinel lymph node, affecting disease spread and recurrence. Cancer Immunol. Res.\u00a05(11), 969\u2013977 (2017)","journal-title":"Cancer Immunol Res"},{"issue":"16","key":"873_CR11","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1158\/1078-0432.CCR-10-1073","volume":"16","author":"L Deng","year":"2010","unstructured":"L. Deng, H. Zhang, Y. Luan, J. Zhang, Q. Xing, S. Dong, X. Wu, M. Liu, S. Wang, Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients. Clin. Cancer Res.\u00a016(16), 4105\u20134112 (2010)","journal-title":"Clin Cancer Res"},{"issue":"1","key":"873_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jhep.2016.07.044","volume":"66","author":"G Li","year":"2017","unstructured":"G. Li, D. Liu, T.K. Cooper, E.T. Kimchi, X. Qi, D.M. Avella, N. Li, Q.X. Yang, M. Kester, C.B. Rountree, J.T. Kaifi, D.J. Cole, D.C. Rockey, T.D. Schell, K.F. Staveley-O\u2019Carroll, Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model. J. Hepatol.\u00a066(1), 75\u201385 (2017)","journal-title":"J Hepatol"},{"issue":"1","key":"873_CR13","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1038\/s41467-020-17046-2","volume":"11","author":"NG N\u00fa\u00f1ez","year":"2020","unstructured":"N.G. N\u00fa\u00f1ez, J. Tosello Boari, R.N. Ramos, W. Richer, N. Cagnard, C.D. Anderfuhren, L.L. Niborski, J. Bigot, D. Meseure, P. De La Rochere, M. Milder, S. Viel, D. Loirat, L. P\u00e9rol, A. Vincent-Salomon, X. Sastre-Garau, B. Burkhard, C. Sedlik, O. Lantz, S. Amigorena, E. Piaggio, Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients. Nat. Commun.\u00a011(1), 3272 (2020)","journal-title":"Nat Commun"},{"issue":"11","key":"873_CR14","doi-asserted-by":"publisher","first-page":"e501","DOI":"10.1016\/S1470-2045(21)00383-1","volume":"22","author":"SPL Saw","year":"2021","unstructured":"S.P.L. Saw, B.H. Ong, K.L.M. Chua, A. Takano, D.S.W. Tan, Revisiting neoadjuvant therapy in non-small-cell lung cancer. Lancet Oncol.\u00a022(11), e501\u2013e516 (2021)","journal-title":"Lancet Oncol"},{"issue":"6","key":"873_CR15","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1200\/JCO.21.01589","volume":"40","author":"JE Chaft","year":"2022","unstructured":"J.E. Chaft, Y. Shyr, B. Sepesi, P.M. Forde, Preoperative and postoperative systemic therapy for operable non-small-cell lung cancer. J. Clin. Oncol. 40(6), 546\u2013555 (2022). https:\/\/doi.org\/10.1200\/JCO.21.01589","journal-title":"J Clin Oncol."},{"issue":"1","key":"873_CR16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41698-020-00135-2","volume":"4","author":"Y Ling","year":"2020","unstructured":"Y. Ling, N. Li, L. Li, C. Guo, J. Wei, P. Yuan, F. Tan, X. Tao, S. Wang, Z. Wang, N. Wu, J. Wang, J. Ying, S. Gao, J. He, Different pathologic responses to neoadjuvant anti-PD-1 in primary squamous lung cancer and regional lymph nodes. NPJ Precis. Oncol.\u00a04(1), 32 (2020)","journal-title":"NPJ Precis Oncol"},{"issue":"9","key":"873_CR17","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1016\/j.immuni.2021.08.019","volume":"54","author":"AK Molodtsov","year":"2021","unstructured":"A.K. Molodtsov, N. Khatwani, J.L. Vella, K.A. Lewis, Y. Zhao, J. Han, D.E. Sullivan, T.G. Searles, N.K. Preiss, T.B. Shabaneh, P. Zhang, A.R. Hawkes, B.T. Malik, F.W. Kolling 4th., E.J. Usherwood, S.L. Wong, J.D. Phillips, K. Shirai, C.V. Angeles, S. Yan, T.J. Curiel, Y.H. Huang, C. Cheng, M.J. Turk, Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma. Immunity 54(9), 2117-2132.e7 (2021)","journal-title":"Immunity"},{"issue":"10","key":"873_CR18","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/j.immuni.2021.08.026","volume":"54","author":"JM Schenkel","year":"2021","unstructured":"J.M. Schenkel, R.H. Herbst, D. Canner, A. Li, M. Hillman, S.L. Shanahan, G. Gibbons, O.C. Smith, J.Y. Kim, P. Westcott, W.L. Hwang, W.A. Freed-Pastor, G. Eng, M.S. Cuoco, P. Rogers, J.K. Park, M.L. Burger, O. Rozenblatt-Rosen, L. Cong, K.E. Pauken, A. Regev, T. Jacks, Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes. Immunity 54(10), 2338-2353.e6 (2021)","journal-title":"Immunity"},{"issue":"64","key":"873_CR19","doi-asserted-by":"publisher","first-page":"eabg7836","DOI":"10.1126\/sciimmunol.abg7836","volume":"6","author":"KA Connolly","year":"2021","unstructured":"K.A. Connolly, M. Kuchroo, A. Venkat, A. Khatun, J. Wang, I. William, N.I. Hornick, B.L. Fitzgerald, M. Damo, M.Y. Kasmani, C. Cui, E. Fagerberg, I. Monroy, A. Hutchins, J.F. Cheung, G.G. Foster, D.L. Mariuzza, M. Nader, H. Zhao, W. Cui, S. Krishnaswamy, N.S. Joshi, A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response. Sci. Immunol.\u00a06(64), eabg7836 (2021)","journal-title":"Sci Immunol"},{"issue":"3","key":"873_CR20","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.cell.2019.02.005","volume":"177","author":"M Binnewies","year":"2019","unstructured":"M. Binnewies, A.M. Mujal, J.L. Pollack, A.J. Combes, E.A. Hardison, K.C. Barry, J. Tsui, M.K. Ruhland, K. Kersten, M.A. Abushawish, M. Spasic, J.P. Giurintano, V. Chan, A.I. Daud, P. Ha, C.J. Ye, E.W. Roberts, M.F. Krummel, Unleashing Type-2 dendritic cells to drive protective antitumor CD4+ T cell immunity. Cell 177(3), 556-571.e16 (2019)","journal-title":"Cell"},{"issue":"3","key":"873_CR21","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.celrep.2012.01.005","volume":"1","author":"AW Lund","year":"2012","unstructured":"A.W. Lund, F.V. Duraes, S. Hirosue, V.R. Raghavan, C. Nembrini, S.N. Thomas, A. Issa, S. Hugues, M.A. Swartz, VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics. Cell Rep.\u00a01(3), 191\u2013199 (2012)","journal-title":"Cell Rep"},{"issue":"9","key":"873_CR22","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/s41568-020-0273-y","volume":"20","author":"RD Leone","year":"2020","unstructured":"R.D. Leone, J.D. Powell, Metabolism of immune cells in cancer. Nat. Rev. Cancer 20(9), 516\u2013531 (2020)","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"873_CR23","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.cell.2022.04.019","volume":"185","author":"NE Reticker-Flynn","year":"2022","unstructured":"N.E. Reticker-Flynn, W. Zhang, J.A. Belk, P.A. Basto, N.K. Escalante, G.O.W. Pilarowski, A. Bejnood, M.M. Martins, J.A. Kenkel, I.L. Linde, S. Bagchi, R. Yuan, S. Chang, M.H. Spitzer, Y. Carmi, J. Cheng, L.L. Tolentino, O. Choi, N. Wu, C.S. Kong, A.J. Gentles, J.B. Sunwoo, A.T. Satpathy, S.K. Plevritis, E.G. Engleman, Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Cell 185(11), 1924-1942.e23 (2022)","journal-title":"Cell"},{"key":"873_CR24","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.immuni.2022.12.002","volume":"56","author":"N Prokhnevska","year":"2023","unstructured":"N. Prokhnevska, M.A. Cardenas, R.M. Valanparambil et al., CD8(+) T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor. Immunity 56, 107-124.e105 (2023)","journal-title":"Immunity"},{"issue":"6","key":"873_CR25","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/jso.21815","volume":"103","author":"SP Leong","year":"2011","unstructured":"S.P. Leong, M. Zuber, R.L. Ferris, Y. Kitagawa, R. Cabanas, C. Levenback, M. Faries, S. Saha, Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients. J. Surg. Oncol.\u00a0103(6), 518\u2013530 (2011)","journal-title":"J Surg Oncol"},{"issue":"5","key":"873_CR26","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.ccell.2020.09.001","volume":"38","author":"F Dammeijer","year":"2020","unstructured":"F. Dammeijer, M. van Gulijk, E.E. Mulder, M. Lukkes, L. Klaase, T. van den Bosch, M. van Nimwegen, S.P. Lau, K. Latupeirissa, S. Schetters, Y. van Kooyk, L. Boon, A. Moyaart, Y.M. Mueller, P.D. Katsikis, A.M. Eggermont, H. Vroman, R. Stadhouders, R.W. Hendriks, J.V. Th\u00fcsen, D.J. Gr\u00fcnhagen, C. Verhoef, T. van Hall, J.G. Aerts, The PD-1\/PD-L1-checkpoint restrains T cell immunity in tumor-draining lymph nodes. Cancer Cell 38(5), 685-700.e8 (2020)","journal-title":"Cancer Cell"},{"issue":"3","key":"873_CR27","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.cell.2016.12.022","volume":"168","author":"MH Spitzer","year":"2017","unstructured":"M.H. Spitzer, Y. Carmi, N.E. Reticker-Flynn, S.S. Kwek, D. Madhireddy, M.M. Martins, P.F. Gherardini, T.R. Prestwood, J. Chabon, S.C. Bendall, L. Fong, G.P. Nolan, E.G. Engleman, Systemic immunity is required for effective cancer immunotherapy. Cell 168(3), 487-502.e15 (2017)","journal-title":"Cell"},{"issue":"23","key":"873_CR28","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124507","volume":"3","author":"MF Fransen","year":"2018","unstructured":"M.F. Fransen, M. Schoonderwoerd, P. Knopf, M.G. Camps, L.J. Hawinkels, M. Kneilling, T. van Hall, F. Ossendorp, Tumor-draining lymph nodes are pivotal in PD-1\/PD-L1 checkpoint therapy. JCI Insight 3(23), e124507 (2018)","journal-title":"JCI Insight"},{"issue":"11","key":"873_CR29","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/S1470-2045(20)30453-8","volume":"21","author":"M Provencio","year":"2020","unstructured":"M. Provencio, E. Nadal, A. Insa, M.R. Garc\u00eda-Campelo, J. Casal-Rubio, M. D\u00f3mine, M. Majem, D. Rodr\u00edguez-Abreu, A. Mart\u00ednez-Mart\u00ed, C.J. De Castro, M. Cobo, G. L\u00f3pez Vivanco, E. Del Barco, R. Bernab\u00e9 Caro, N. Vi\u00f1olas, I. Barneto Aranda, S. Viteri, E. Pereira, A. Royuela, M. Casarrubios, C. Salas Ant\u00f3n, E.R. Parra, I. Wistuba, V. Calvo, R. Laza-Briviesca, A. Romero, B. Massuti, A. Cruz-Berm\u00fadez, Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial. Lancet Oncol.\u00a021(11), 1413\u20131422 (2020)","journal-title":"Lancet Oncol"},{"issue":"8","key":"873_CR30","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1038\/s41591-019-0522-3","volume":"25","author":"KE Yost","year":"2019","unstructured":"K.E. Yost, A.T. Satpathy, D.K. Wells, Y. Qi, C. Wang, R. Kageyama, K.L. McNamara, J.M. Granja, K.Y. Sarin, R.A. Brown, R.K. Gupta, C. Curtis, S.L. Bucktrout, M.M. Davis, A.L.S. Chang, H.Y. Chang, Clonal replacement of tumor-specific T cells following PD-1 blockade. Nat. Med.\u00a025(8), 1251\u20131259 (2019)","journal-title":"Nat Med"},{"issue":"1","key":"873_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41392-020-00448-5","volume":"6","author":"Z Ding","year":"2021","unstructured":"Z. Ding, Q. Li, R. Zhang, L. Xie, Y. Shu, S. Gao, P. Wang, X. Su, Y. Qin, Y. Wang, J. Fang, Z. Zhu, X. Xia, G. Wei, H. Wang, H. Qian, X. Guo, Z. Gao, Y. Wang, Y. Wei, Q. Xu, H. Xu, L. Yang, Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer. Signal Transduct. Target Ther.\u00a06(1), 26 (2021)","journal-title":"Signal Transduct Target Ther"},{"issue":"7662","key":"873_CR32","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nature22991","volume":"547","author":"PA Ott","year":"2017","unstructured":"P.A. Ott, Z. Hu, D.B. Keskin, S.A. Shukla, J. Sun, D.J. Bozym, W. Zhang, A. Luoma, A. Giobbie-Hurder, L. Peter, C. Chen, O. Olive, T.A. Carter, S. Li, D.J. Lieb, T. Eisenhaure, E. Gjini, J. Stevens, W.J. Lane, I. Javeri, K. Nellaiappan, A.M. Salazar, H. Daley, M. Seaman, E.I. Buchbinder, C.H. Yoon, M. Harden, N. Lennon, S. Gabriel, S.J. Rodig, D.H. Barouch, J.C. Aster, G. Getz, K. Wucherpfennig, D. Neuberg, J. Ritz, E.S. Lander, E.F. Fritsch, N. Hacohen, C.J. Wu, An immunogenic personal neoantigen vaccine for patients with melanoma. Nature 547(7662), 217\u2013221 (2017)","journal-title":"Nature"},{"issue":"15","key":"873_CR33","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1016\/j.cell.2022.06.035","volume":"185","author":"MC Sellars","year":"2022","unstructured":"M.C. Sellars, C.J. Wu, E.F. Fritsch, Cancer vaccines: Building a bridge over troubled waters. Cell 185(15), 2770\u20132788 (2022)","journal-title":"Cell"},{"issue":"3","key":"873_CR34","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.immuni.2021.02.014","volume":"54","author":"SH Chiou","year":"2021","unstructured":"S.H. Chiou, D. Tseng, A. Reuben, V. Mallajosyula, I.S. Molina, S. Conley, J. Wilhelmy, A.M. McSween, X. Yang, D. Nishimiya, R. Sinha, B.Y. Nabet, C. Wang, J.B. Shrager, M.F. Berry, L. Backhus, N.S. Lui, H.A. Wakelee, J.W. Neal, S.K. Padda, G.J. Berry, A. Delaidelli, P.H. Sorensen, E. Sotillo, P. Tran, J.A. Benson, R. Richards, L. Labanieh, D.D. Klysz, D.M. Louis, S.A. Feldman, M. Diehn, I.L. Weissman, J. Zhang, I.I. Wistuba, P.A. Futreal, J.V. Heymach, K.C. Garcia, C.L. Mackall, M.M. Davis, Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery. Immunity 54(3), 586-602.e8 (2021)","journal-title":"Immunity"},{"issue":"1","key":"873_CR35","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/s41467-019-08534-1","volume":"10","author":"PC Rosato","year":"2019","unstructured":"P.C. Rosato, S. Wijeyesinghe, J.M. Stolley, C.E. Nelson, R.L. Davis, L.S. Manlove, C.A. Pennell, B.R. Blazar, C.C. Chen, M.A. Geller, V. Vezys, D. Masopust, Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy. Nat. Commun.\u00a010(1), 567 (2019)","journal-title":"Nat Commun"},{"issue":"7","key":"873_CR36","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1158\/0008-5472.CAN-11-2614","volume":"72","author":"RS Andersen","year":"2012","unstructured":"R.S. Andersen, C.A. Thrue, N. Junker, R. Lyngaa, M. Donia, E. Elleb\u00e6k, I.M. Svane, T.N. Schumacher, P. Thor Straten, S.R. Hadrup, Dissection of T-cell antigen specificity in human melanoma. Cancer Res.\u00a072(7), 1642\u20131650 (2012)","journal-title":"Cancer Res"},{"issue":"7706","key":"873_CR37","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-018-0130-2","volume":"557","author":"Y Simoni","year":"2018","unstructured":"Y. Simoni, E. Becht, M. Fehlings, C.Y. Loh, S.L. Koo, K.W.W. Teng, J.P.S. Yeong, R. Nahar, T. Zhang, H. Kared, K. Duan, N. Ang, M. Poidinger, Y.Y. Lee, A. Larbi, A.J. Khng, E. Tan, C. Fu, R. Mathew, M. Teo, W.T. Lim, C.K. Toh, B.H. Ong, T. Koh, A.M. Hillmer, A. Takano, T.K.H. Lim, E.H. Tan, W. Zhai, D.S.W. Tan, I.B. Tan, E.W. Newell, Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates. Nature 557(7706), 575\u2013579 (2018)","journal-title":"Nature"},{"issue":"7844","key":"873_CR38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41586-020-03075-w","volume":"590","author":"IK Choi","year":"2021","unstructured":"I.K. Choi, Z. Wang, Q. Ke, M. Hong, D.W. Paul Jr., S.M. Fernandes, Z. Hu, J. Stevens, I. Guleria, H.J. Kim, H. Cantor, K.W. Wucherpfennig, J.R. Brown, J. Ritz, B. Zhang, Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature 590(7844), 157\u2013162 (2021)","journal-title":"Nature"},{"issue":"2","key":"873_CR39","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1073\/pnas.1904022116","volume":"117","author":"JH Newman","year":"2020","unstructured":"J.H. Newman, C.B. Chesson, N.L. Herzog, Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer. Proc. Natl. Acad. Sci. U S A 117(2), 1119\u20131128 (2020)","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6371","key":"873_CR40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1126\/science.aan4236","volume":"359","author":"V Gopalakrishnan","year":"2018","unstructured":"V. Gopalakrishnan, C.N. Spencer, L. Nezi, Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359(6371), 97\u2013103 (2018)","journal-title":"Science"},{"issue":"8","key":"873_CR41","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135597","volume":"5","author":"CA Bessell","year":"2020","unstructured":"C.A. Bessell, A. Isser, J.J. Havel, Commensal bacteria stimulate antitumor responses via T cell cross-reactivity. JCI Insight. 5(8), e135597 (2020)","journal-title":"JCI Insight."},{"issue":"6506","key":"873_CR42","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1126\/science.aax0701","volume":"369","author":"A Fluckiger","year":"2020","unstructured":"A. Fluckiger, R. Daill\u00e8re, M. Sassi, Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage. Science 369(6506), 936\u2013942 (2020)","journal-title":"Science"},{"issue":"6390","key":"873_CR43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/359079a0","volume":"359","author":"M R\u00f6cken","year":"1992","unstructured":"M. R\u00f6cken, J.F. Urban, E.M. Shevach, Infection breaks T-cell tolerance. Nature 359(6390), 79\u201382 (1992)","journal-title":"Nature"}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00873-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-023-00873-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00873-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:21:01Z","timestamp":1715584861000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-023-00873-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["873"],"URL":"https:\/\/doi.org\/10.1007\/s13402-023-00873-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2897344\/v1","asserted-by":"object"}]},"ISSN":["2211-3428","2211-3436"],"issn-type":[{"value":"2211-3428","type":"print"},{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]},"assertion":[{"value":"30 August 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board (IRB) of Xiangya Hospital. The study was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed content was obtained from every patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}