{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:25:59Z","timestamp":1770974759071,"version":"3.50.1"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82122010, 82070659"],"award-info":[{"award-number":["82122010, 82070659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-E-003"],"award-info":[{"award-number":["2022-PUMCH-E-003"]}]},{"name":"CAMS Innovation Fund for Medical Science","award":["2023-I2M-3-001"],"award-info":[{"award-number":["2023-I2M-3-001"]}]},{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"crossref","award":["22ZR1480500"],"award-info":[{"award-number":["22ZR1480500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s13402-023-00874-x","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T11:01:47Z","timestamp":1695034907000},"page":"383-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fibroblast subtypes in pancreatic cancer and pancreatitis: from mechanisms to therapeutic strategies"],"prefix":"10.1007","volume":"47","author":[{"given":"Huizhen","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiachun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"874_CR1","doi-asserted-by":"crossref","unstructured":"P.A.M.J. Phillips, S. Park et al., Rat pancreatic stellate cells secrete matrix metalloproteinases implications for extracellular matrix turnover. Gut 52, 275\u2013282 (2003)","DOI":"10.1136\/gut.52.2.275"},{"key":"874_CR2","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.biocel.2006.11.005","volume":"39","author":"RJ McAnulty","year":"2007","unstructured":"R.J. McAnulty, Fibroblasts and myofibroblasts: their source, function and role in disease. Int. J. Biochem. Cell. Biol. 39, 666\u2013671 (2007)","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"874_CR3","first-page":"301","volume":"7","author":"IA Darby","year":"2014","unstructured":"I.A. Darby, B. Laverdet, F. Bonte et al., Fibroblasts and myofibroblasts in wound healing. Clin. Cosmet. Investig Dermatol. 7, 301\u2013311 (2014)","journal-title":"Clin. Cosmet. Investig Dermatol."},{"key":"874_CR4","doi-asserted-by":"publisher","first-page":"7551","DOI":"10.1073\/pnas.1600363113","volume":"113","author":"A Arina","year":"2016","unstructured":"A. Arina, C. Idel, E.M. Hyjek et al., Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc. Natl. Acad. Sci. U S A 113, 7551\u20137556 (2016)","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"874_CR5","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","volume":"20","author":"E Sahai","year":"2020","unstructured":"E. Sahai, I. Astsaturov, E. Cukierman et al., A framework for advancing our understanding of cancer-associated fibroblasts. Nat. Rev. Cancer. 20, 174\u2013186 (2020)","journal-title":"Nat. Rev. Cancer"},{"key":"874_CR6","doi-asserted-by":"crossref","unstructured":"M. Erkan, G. Adler, M.V. Apte, ea. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut 2012","DOI":"10.1136\/gutjnl-2011-301220"},{"key":"874_CR7","doi-asserted-by":"publisher","first-page":"7707","DOI":"10.1158\/0008-5472.CAN-08-1132","volume":"68","author":"A Vonlaufen","year":"2008","unstructured":"A. Vonlaufen, P.A. Phillips, Z. Xu et al., Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance. Cancer Res. 68, 7707\u20137710 (2008)","journal-title":"Cancer Res."},{"key":"874_CR8","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1053\/j.gastro.2004.12.036","volume":"128","author":"MG Bachem","year":"2005","unstructured":"M.G. Bachem, M. Schunemann, M. Ramadani et al., Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology. 128, 907\u2013921 (2005)","journal-title":"Gastroenterology"},{"key":"874_CR9","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1053\/j.gastro.2012.11.037","volume":"144","author":"MV Apte","year":"2013","unstructured":"M.V. Apte, J.S. Wilson, A. Lugea et al., A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology. 144, 1210\u20131219 (2013)","journal-title":"Gastroenterology"},{"key":"874_CR10","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1158\/2159-8290.CD-21-0601","volume":"12","author":"EJ Helms","year":"2022","unstructured":"E.J. Helms, M.W. Berry, R.C. Chaw et al., Mesenchymal lineage heterogeneity underlies nonredundant functions of pancreatic Cancer-Associated fibroblasts. Cancer Discov. 12, 484\u2013501 (2022)","journal-title":"Cancer Discov"},{"key":"874_CR11","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/cr.2010.10","volume":"20","author":"G Sparmann","year":"2010","unstructured":"G. Sparmann, M.L. Kruse, N. Hofmeister-Mielke et al., Bone marrow-derived pancreatic stellate cells in rats. Cell. Res. 20, 288\u2013298 (2010)","journal-title":"Cell. Res."},{"key":"874_CR12","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1002\/2211-5463.12976","volume":"10","author":"Y Miyazaki","year":"2020","unstructured":"Y. Miyazaki, T. Oda, N. Mori et al., Adipose-derived mesenchymal stem cells differentiate into pancreatic cancer\u2010associated fibroblasts in vitro. FEBS Open. Bio. 10, 2268\u20132281 (2020)","journal-title":"FEBS Open. Bio"},{"key":"874_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ccr.2011.01.020","volume":"19","author":"M Quante","year":"2011","unstructured":"M. Quante, S.P. Tu, H. Tomita et al., Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 19, 257\u2013272 (2011)","journal-title":"Cancer Cell."},{"key":"874_CR14","doi-asserted-by":"publisher","first-page":"10123","DOI":"10.1158\/0008-5472.CAN-07-3127","volume":"67","author":"EM Zeisberg","year":"2007","unstructured":"E.M. Zeisberg, S. Potenta, L. Xie et al., Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 67, 10123\u201310128 (2007)","journal-title":"Cancer Res."},{"key":"874_CR15","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1002\/ctm2.41","volume":"10","author":"X Huang","year":"2020","unstructured":"X. Huang, C. He, X. Hua et al., Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma. Clin. Transl Med. 10, e41 (2020)","journal-title":"Clin. Transl Med."},{"key":"874_CR16","doi-asserted-by":"crossref","unstructured":"F. Marrache, S. Pendyala, G. Bhagat, K.S. Betz, Z. Song, T.C. Wang, Role of bone marrow-derived Cells in Experimental Chronic Pancreatitis. Gut 57, 1113\u20131120 (2008)","DOI":"10.1136\/gut.2007.143271"},{"key":"874_CR17","doi-asserted-by":"crossref","unstructured":"Y. Sunami, J. H\u00e4u\u00dfler, J. Kleeff, Cellular Heterogeneity of pancreatic stellate cells, mesenchymal stem cells, and Cancer-Associated fibroblasts in pancreatic Cancer. Cancers. 12, 3770 (2020)","DOI":"10.3390\/cancers12123770"},{"key":"874_CR18","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1158\/2159-8290.CD-19-1353","volume":"10","author":"E Helms","year":"2020","unstructured":"E. Helms, M.K. Onate, M.H. Sherman, Fibroblast heterogeneity in the pancreatic Tumor Microenvironment. Cancer Discov. 10, 648\u2013656 (2020)","journal-title":"Cancer Discov"},{"key":"874_CR19","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1084\/jem.20162024","volume":"214","author":"D Ohlund","year":"2017","unstructured":"D. Ohlund, A. Handly-Santana, G. Biffi et al., Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J. Exp. Med. 214, 579\u2013596 (2017)","journal-title":"J. Exp. Med."},{"key":"874_CR20","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1158\/2159-8290.CD-18-0710","volume":"9","author":"G Biffi","year":"2019","unstructured":"G. Biffi, T.E. Oni, B. Spielman et al., IL1-Induced JAK\/STAT signaling is antagonized by TGFbeta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. Cancer Discov. 9, 282\u2013301 (2019)","journal-title":"Cancer Discov"},{"key":"874_CR21","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","volume":"9","author":"E Elyada","year":"2019","unstructured":"E. Elyada, M. Bolisetty, P. Laise et al., Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals Antigen-Presenting Cancer-Associated fibroblasts. Cancer Discov. 9, 1102\u20131123 (2019)","journal-title":"Cancer Discov."},{"key":"874_CR22","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41421-021-00271-4","volume":"7","author":"Y Wang","year":"2021","unstructured":"Y. Wang, Y. Liang, H. Xu et al., Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response. Cell. Discov. 7, 36 (2021)","journal-title":"Cell. Discov"},{"key":"874_CR23","doi-asserted-by":"publisher","first-page":"216095","DOI":"10.1016\/j.canlet.2023.216095","volume":"558","author":"W Ge","year":"2023","unstructured":"W. Ge, M. Yue, R. Lin et al., PLA2G2A(+) cancer-associated fibroblasts mediate pancreatic cancer immune escape via impeding antitumor immune response of CD8(+) cytotoxic T cells. Cancer Lett. 558, 216095 (2023)","journal-title":"Cancer Lett."},{"key":"874_CR24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/path.5224","volume":"248","author":"C Neuzillet","year":"2019","unstructured":"C. Neuzillet, A. Tijeras-Raballand, C. Ragulan et al., Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma. J. Pathol. 248, 51\u201365 (2019)","journal-title":"J. Pathol."},{"key":"874_CR25","doi-asserted-by":"crossref","unstructured":"C. Neuzillet, R. Nicolle, J. Raffenne et al., Periostin- and podoplanin-positive cancer-associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma. J. Pathol. 258, 408\u2013425 (2022)","DOI":"10.1002\/path.6011"},{"key":"874_CR26","doi-asserted-by":"crossref","unstructured":"D.S. Foster, M. Januszyk, D. Delitto et al., Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin. Cancer Cell. 40, 1392\u20131406 (2022)","DOI":"10.1016\/j.ccell.2022.09.015"},{"key":"874_CR27","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1158\/2159-8290.CD-19-0644","volume":"10","author":"CX Dominguez","year":"2020","unstructured":"C.X. Dominguez, S. Muller, S. Keerthivasan et al., Single-cell RNA sequencing reveals stromal evolution into LRRC15(+) Myofibroblasts as a determinant of patient response to Cancer Immunotherapy. Cancer Discov. 10, 232\u2013253 (2020)","journal-title":"Cancer Discov"},{"key":"874_CR28","doi-asserted-by":"crossref","unstructured":"A.T. Krishnamurty, J.A. Shyer, M. Thai et al., LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature 611, 148\u2013154 (2022)","DOI":"10.1038\/s41586-022-05272-1"},{"key":"874_CR29","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1158\/2159-8290.CD-20-0775","volume":"11","author":"R Francescone","year":"2021","unstructured":"R. Francescone, D. Barbosa Vendramini-Costa, J. Franco-Barraza et al., Netrin G1 promotes pancreatic tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. Cancer Discov. 11, 446\u2013479 (2021)","journal-title":"Cancer Discov"},{"key":"874_CR30","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.ccell.2021.06.017","volume":"39","author":"C Hutton","year":"2021","unstructured":"C. Hutton, F. Heider, A. Blanco-Gomez et al., Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 39, 1227\u20131244e20 (2021)","journal-title":"Cancer Cell."},{"key":"874_CR31","doi-asserted-by":"crossref","unstructured":"Y. Chen, J. Kim, S. Yang et al., Type I collagen deletion in alphaSMA(+) myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. Cancer Cell. 39, 548\u2013565 (2021)","DOI":"10.1016\/j.ccell.2021.02.007"},{"key":"874_CR32","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1136\/gut.43.1.128","volume":"43","author":"MV Apte","year":"1998","unstructured":"M.V. Apte, P.S. Haber, T.L. Applegate et al., Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 43, 128\u2013133 (1998)","journal-title":"Gut"},{"key":"874_CR33","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/S0002-9440(10)65211-X","volume":"155","author":"PS Haber","year":"1999","unstructured":"P.S. Haber, G.W. Keogh, M.V. Apte et al., Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am. J. Pathol. 155, 1087\u20131095 (1999)","journal-title":"Am. J. Pathol."},{"key":"874_CR34","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/S0016-5085(00)70148-X","volume":"118","author":"MV Apte","year":"2000","unstructured":"M.V. Apte, P.A. Phillips, R.G. Fahmy et al., Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology. 118, 780\u2013794 (2000)","journal-title":"Gastroenterology"},{"key":"874_CR35","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1111\/acer.12882","volume":"39","author":"AT Lee","year":"2015","unstructured":"A.T. Lee, Z. Xu, S.P. Pothula et al., Alcohol and cigarette smoke components activate human pancreatic stellate cells: implications for the progression of chronic pancreatitis. Alcohol Clin. Exp. Res. 39, 2123\u20132133 (2015)","journal-title":"Alcohol Clin. Exp. Res."},{"key":"874_CR36","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.immuni.2022.06.001","volume":"55","author":"X Yang","year":"2022","unstructured":"X. Yang, J. Chen, J. Wang et al., Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis. Immunity. 55, 1185\u20131199 (2022). e8","journal-title":"Immunity"},{"key":"874_CR37","doi-asserted-by":"publisher","first-page":"e10250","DOI":"10.7554\/eLife.10250","volume":"5","author":"H Zhao","year":"2016","unstructured":"H. Zhao, L. Yang, J. Baddour et al., Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife. 5, e10250 (2016)","journal-title":"Elife"},{"issue":"4","key":"874_CR38","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.3892\/or.2017.5479","volume":"37","author":"T Shan","year":"2017","unstructured":"T. Shan, S. Chen, X. Chen, W. Lin, Run, W. Li, Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism. Oncol. Rep. 37(4), 1971\u20131979 (2017)","journal-title":"Oncol. Rep."},{"key":"874_CR39","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1158\/2159-8290.CD-18-1212","volume":"9","author":"FR Auciello","year":"2019","unstructured":"F.R. Auciello, V. Bulusu, C. Oon et al., A stromal Lysolipid-Autotaxin Signaling Axis promotes pancreatic tumor progression. Cancer Discov. 9, 617\u2013627 (2019)","journal-title":"Cancer Discov"},{"key":"874_CR40","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nature19084","volume":"536","author":"CM Sousa","year":"2016","unstructured":"C.M. Sousa, D.E. Biancur, X. Wang et al., Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 536, 479\u2013483 (2016)","journal-title":"Nature"},{"key":"874_CR41","doi-asserted-by":"publisher","first-page":"16031","DOI":"10.1038\/ncomms16031","volume":"8","author":"O Olivares","year":"2017","unstructured":"O. Olivares, J.R. Mayers, V. Gouirand et al., Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat. Commun. 8, 16031 (2017)","journal-title":"Nat. Commun."},{"key":"874_CR42","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/s43018-022-00426-6","volume":"3","author":"M Yuan","year":"2022","unstructured":"M. Yuan, B. Tu, H. Li et al., Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth. Nat. Cancer. 3, 945\u2013960 (2022)","journal-title":"Nat. Cancer"},{"key":"874_CR43","doi-asserted-by":"publisher","first-page":"216040","DOI":"10.1016\/j.canlet.2022.216040","volume":"555","author":"H Liu","year":"2023","unstructured":"H. Liu, H. Zhang, X. Liu et al., Pancreatic stellate cells exploit Wnt\/beta-catenin\/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth. Cancer Lett. 555, 216040 (2023)","journal-title":"Cancer Lett."},{"key":"874_CR44","doi-asserted-by":"publisher","first-page":"5995","DOI":"10.1158\/1078-0432.CCR-08-0291","volume":"14","author":"JM Bailey","year":"2008","unstructured":"J.M. Bailey, B.J. Swanson, T. Hamada et al., Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin. Cancer Res. 14, 5995\u20136004 (2008)","journal-title":"Clin. Cancer Res."},{"key":"874_CR45","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nature07275","volume":"455","author":"RL Yauch","year":"2008","unstructured":"R.L. Yauch, S.E. Gould, S.J. Scales et al., A paracrine requirement for hedgehog signalling in cancer. Nature. 455, 406\u2013410 (2008)","journal-title":"Nature"},{"key":"874_CR46","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1016\/j.surg.2012.05.030","volume":"152","author":"DE Rosow","year":"2012","unstructured":"D.E. Rosow, A.S. Liss, O. Strobel et al., Sonic hedgehog in pancreatic cancer: from bench to bedside, then back to the bench. Surgery. 152, S19\u201332 (2012)","journal-title":"Surgery"},{"key":"874_CR47","doi-asserted-by":"publisher","first-page":"E3091","DOI":"10.1073\/pnas.1411679111","volume":"111","author":"JJ Lee","year":"2014","unstructured":"J.J. Lee, R.M. Perera, H. Wang et al., Stromal response to hedgehog signaling restrains pancreatic cancer progression. Proc. Natl. Acad. Sci. U S A 111, E3091\u2013E3100 (2014)","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"874_CR48","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1158\/1078-0432.CCR-20-3715","volume":"27","author":"NG Steele","year":"2021","unstructured":"N.G. Steele, G. Biffi, S.B. Kemp et al., Inhibition of hedgehog signaling alters fibroblast composition in pancreatic Cancer. Clin. Cancer Res. 27, 2023\u20132037 (2021)","journal-title":"Clin. Cancer Res."},{"key":"874_CR49","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007","volume":"21","author":"P Provenzano Paolo","year":"2012","unstructured":"P. Provenzano Paolo, C. Cuevas, E. Chang Amy et al., Enzymatic targeting of the Stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 21, 418\u2013429 (2012)","journal-title":"Cancer Cell."},{"key":"874_CR50","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1158\/1535-7163.MCT-10-0470","volume":"9","author":"CB Thompson","year":"2010","unstructured":"C.B. Thompson, H.M. Shepard, P.M. O\u2019Connor et al., Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models. Mol. Cancer Ther. 9, 3052\u20133064 (2010)","journal-title":"Mol. Cancer Ther."},{"key":"874_CR51","doi-asserted-by":"crossref","unstructured":"A.N. Hosein, R.A. Brekken, A. Maitra, Pancreatic cancer stroma: an update on therapeutic targeting strategies. Nat. Rev. Gastroenterol. Hepatol. 17, 487\u2013505 (2020)","DOI":"10.1038\/s41575-020-0300-1"},{"key":"874_CR52","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1158\/2159-8290.CD-20-1484","volume":"12","author":"KM McAndrews","year":"2022","unstructured":"K.M. McAndrews, Y. Chen, J.K. Darpolor et al., Identification of functional heterogeneity of Carcinoma-Associated fibroblasts with distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer. Cancer Discov. 12, 1580\u20131597 (2022)","journal-title":"Cancer Discov"},{"key":"874_CR53","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1038\/onc.2016.353","volume":"36","author":"KE Richards","year":"2017","unstructured":"K.E. Richards, A.E. Zeleniak, M.L. Fishel et al., Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells. Oncogene. 36, 1770\u20131778 (2017)","journal-title":"Oncogene"},{"key":"874_CR54","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41586-019-1130-6","volume":"569","author":"Y Shi","year":"2019","unstructured":"Y. Shi, W. Gao, N.K. Lytle et al., Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 569, 131\u2013135 (2019)","journal-title":"Nature"},{"key":"874_CR55","doi-asserted-by":"publisher","first-page":"5723","DOI":"10.1158\/0008-5472.CAN-19-0960","volume":"79","author":"S Dalin","year":"2019","unstructured":"S. Dalin, M.R. Sullivan, A.N. Lau et al., Deoxycytidine Release from pancreatic stellate cells promotes Gemcitabine Resistance. Cancer Res. 79, 5723\u20135733 (2019)","journal-title":"Cancer Res."},{"key":"874_CR56","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/1878-0261.12399","volume":"13","author":"J Cao","year":"2019","unstructured":"J. Cao, J. Li, L. Sun et al., Hypoxia-driven paracrine osteopontin\/integrin alphavbeta3 signaling promotes pancreatic cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating forkhead box protein M1. Mol. Oncol. 13, 228\u2013245 (2019)","journal-title":"Mol. Oncol."},{"key":"874_CR57","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1158\/0008-5472.CAN-17-1366","volume":"78","author":"D Zhang","year":"2018","unstructured":"D. Zhang, L. Li, H. Jiang et al., Tumor-stroma IL1beta-IRAK4 Feedforward Circuitry drives Tumor Fibrosis, Chemoresistance, and poor prognosis in pancreatic Cancer. Cancer Res. 78, 1700\u20131712 (2018)","journal-title":"Cancer Res."},{"key":"874_CR58","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.canlet.2021.12.025","volume":"528","author":"P Nan","year":"2022","unstructured":"P. Nan, X. Dong, X. Bai et al., Tumor-stroma TGF-\u03b21-THBS2 feedback circuit drives pancreatic ductal adenocarcinoma progression via integrin \u03b1v\u03b23\/CD36-mediated activation of the MAPK pathway. Cancer Lett. 528, 59\u201375 (2022)","journal-title":"Cancer Lett."},{"key":"874_CR59","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s13046-022-02519-7","volume":"41","author":"S Schuth","year":"2022","unstructured":"S. Schuth, Le S. Blanc, T.G. Krieger et al., Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system. J. Exp. Clin. Cancer Res. 41, 312 (2022)","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"874_CR60","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1038\/s41588-022-01157-1","volume":"54","author":"D Cui Zhou","year":"2022","unstructured":"D. Cui Zhou, R.G. Jayasinghe, S. Chen et al., Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat. Genet. 54, 1390\u20131405 (2022)","journal-title":"Nat. Genet."},{"key":"874_CR61","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.pan.2016.03.012","volume":"16","author":"M Blauer","year":"2016","unstructured":"M. Blauer, M. Laaninen, J. Sand et al., Reciprocal stimulation of pancreatic acinar and stellate cells in a novel long-term in vitro co-culture model. Pancreatology. 16, 570\u2013577 (2016)","journal-title":"Pancreatology"},{"key":"874_CR62","doi-asserted-by":"publisher","first-page":"17397","DOI":"10.1073\/pnas.1000359107","volume":"107","author":"PA Phillips","year":"2010","unstructured":"P.A. Phillips, L. Yang, A. Shulkes et al., Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion. Proc. Natl. Acad. Sci. U S A 107, 17397\u201317402 (2010)","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"874_CR63","doi-asserted-by":"crossref","unstructured":"J.S. Liu, Z.J. Cui, Pancreatic stellate cells serve as a Brake mechanism on pancreatic Acinar Cell Calcium Signaling modulated by Methionine Sulfoxide reductase expression. Cells 8, 109 (2019).","DOI":"10.3390\/cells8020109"},{"key":"874_CR64","doi-asserted-by":"crossref","unstructured":"W. Yao, D. Luo, Z. Lv et al., The Rabep1-Mediated endocytosis and activation of trypsinogen to promote pancreatic stellate cell activation. Biomolecules 12, 1063 (2022).","DOI":"10.3390\/biom12081063"},{"key":"874_CR65","doi-asserted-by":"crossref","unstructured":"M.A. Jakubowska, P.E. Ferdek, O.V. Gerasimenko et al., Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open. Biol. 6, 160149 (2016)","DOI":"10.1098\/rsob.160149"},{"key":"874_CR66","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1113\/JP275395","volume":"596","author":"O Gryshchenko","year":"2018","unstructured":"O. Gryshchenko, J.V. Gerasimenko, S. Peng et al., Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology. J. Physiol. 596, 2663\u20132678 (2018)","journal-title":"J. Physiol."},{"key":"874_CR67","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ajpath.2015.09.022","volume":"186","author":"S Hausmann","year":"2016","unstructured":"S. Hausmann, I. Regel, K. Steiger et al., Loss of Periostin results in impaired regeneration and pancreatic atrophy after Cerulein-Induced Pancreatitis. Am. J. Pathol. 186, 24\u201331 (2016)","journal-title":"Am. J. Pathol."},{"key":"874_CR68","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1101\/gad.283499.116","volume":"30","author":"X Liu","year":"2016","unstructured":"X. Liu, J.R. Pitarresi, M.C. Cuitino et al., Genetic ablation of smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev. 30, 1943\u20131955 (2016)","journal-title":"Genes Dev."},{"key":"874_CR69","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1001\/jama.2019.19411","volume":"322","author":"VK Singh","year":"2019","unstructured":"V.K. Singh, D. Yadav, P.K. Garg, Diagnosis and management of chronic pancreatitis: a review. JAMA 322, 2422\u20132434 (2019)","journal-title":"JAMA"},{"key":"874_CR70","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1016\/S0002-9440(10)61125-X","volume":"160","author":"FW Shek","year":"2002","unstructured":"F.W. Shek, R.C. Benyon, F.M. Walker et al., Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am. J. Pathol. 160, 1787\u20131798 (2002)","journal-title":"Am. J. Pathol."},{"key":"874_CR71","doi-asserted-by":"crossref","unstructured":"J. Tahara, K. Shimizu, K. Shiratori, Engulfment of necrotic acinar cells by pancreatic stellate cells inhibits pancreatic fibrogenesis. Pancreas. 37, 69\u201374 (2008)","DOI":"10.1097\/MPA.0b013e318160a5cb"},{"key":"874_CR72","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.bbrc.2013.02.095","volume":"433","author":"K Kikuta","year":"2013","unstructured":"K. Kikuta, A. Masamune, S. Hamada et al., Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic beta-cells. Biochem. Biophys. Res. Commun. 433, 292\u2013297 (2013)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"874_CR73","doi-asserted-by":"publisher","first-page":"111653","DOI":"10.1016\/j.mce.2022.111653","volume":"551","author":"X Zhu","year":"2022","unstructured":"X. Zhu, D. Liu, G. Li et al., Exosomal mir-140-3p and mir-143-3p from TGF-beta1-treated pancreatic stellate cells target BCL2 mRNA to increase beta-cell apoptosis. Mol. Cell. Endocrinol. 551, 111653 (2022)","journal-title":"Mol. Cell. Endocrinol."},{"key":"874_CR74","doi-asserted-by":"crossref","unstructured":"Q. Li, Y. Zhu, L. Liu et al., Pancreatic stellate cells and TGF\u03b2 in the Pathogenesis of Pain in Chronic Pancreatitis. Gastroenterology 2017;152","DOI":"10.1016\/S0016-5085(17)34354-8"},{"key":"874_CR75","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12943-021-01428-1","volume":"20","author":"X Mao","year":"2021","unstructured":"X. Mao, J. Xu, W. Wang et al., Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol. Cancer. 20, 131 (2021)","journal-title":"Mol. Cancer"},{"key":"874_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/imm.13496","volume":"167","author":"Z Zhang","year":"2022","unstructured":"Z. Zhang, H. Zhang, L. Shi et al., Heterogeneous cancer-associated fibroblasts: a new perspective for understanding immunosuppression in pancreatic cancer. Immunology. 167, 1\u201314 (2022)","journal-title":"Immunology"},{"key":"874_CR77","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1084\/jem.20101876","volume":"208","author":"L De Monte","year":"2011","unstructured":"De L. Monte, M. Reni, E. Tassi et al., Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J. Exp. Med. 208, 469\u2013478 (2011)","journal-title":"J. Exp. Med."},{"key":"874_CR78","doi-asserted-by":"publisher","first-page":"20212","DOI":"10.1073\/pnas.1320318110","volume":"110","author":"C Feig","year":"2013","unstructured":"C. Feig, J.O. Jones, M. Kraman et al., Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc. Natl. Acad. Sci. U S A 110, 20212\u201320217 (2013)","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"874_CR79","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1053\/j.gastro.2013.07.025","volume":"145","author":"A Ene-Obong","year":"2013","unstructured":"A. Ene-Obong, A.J. Clear, J. Watt et al., Activated pancreatic stellate cells sequester CD8 + T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology. 145, 1121\u20131132 (2013)","journal-title":"Gastroenterology"},{"key":"874_CR80","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1136\/gutjnl-2018-317570","volume":"68","author":"D Goehrig","year":"2019","unstructured":"D. Goehrig, J. Nigri, R. Samain et al., Stromal protein betaig-h3 reprogrammes tumour microenvironment in pancreatic cancer. Gut. 68, 693\u2013707 (2019)","journal-title":"Gut"},{"key":"874_CR81","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.ccell.2022.04.011","volume":"40","author":"H Huang","year":"2022","unstructured":"H. Huang, Z. Wang, Y. Zhang et al., Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Cancer Cell. 40, 656\u2013673 (2022). e7","journal-title":"Cancer Cell."},{"key":"874_CR82","doi-asserted-by":"crossref","unstructured":"F.S.R. Picard, V. Lutz, A. Brichkina et al., IL-17A-producing CD8(+) T Cells Promote PDAC via Induction of Inflammatory cancer-associated Fibroblasts. Gut 72, 1510\u20131522 (2023)","DOI":"10.1136\/gutjnl-2022-327855"},{"key":"874_CR83","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3389\/fimmu.2019.00847","volume":"10","author":"L Gorchs","year":"2019","unstructured":"L. Gorchs, C. Fernandez Moro, P. Bankhead et al., Human Pancreatic Carcinoma-Associated fibroblasts promote expression of co-inhibitory markers on CD4(+) and CD8(+) T-Cells. Front. Immunol. 10, 847 (2019)","journal-title":"Front. Immunol."},{"key":"874_CR84","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40169-019-0226-9","volume":"8","author":"SK Daniel","year":"2019","unstructured":"S.K. Daniel, K.M. Sullivan, K.P. Labadie et al., Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma. Clin. Transl Med. 8, 10 (2019)","journal-title":"Clin. Transl Med."},{"key":"874_CR85","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1158\/0008-5472.CAN-12-4601","volume":"73","author":"TA Mace","year":"2013","unstructured":"T.A. Mace, Z. Ameen, A. Collins et al., Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Res. 73, 3007\u20133018 (2013)","journal-title":"Cancer Res."},{"key":"874_CR86","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/s41419-020-03168-4","volume":"11","author":"K Kesh","year":"2020","unstructured":"K. Kesh, V.T. Garrido, A. Dosch et al., Stroma secreted IL6 selects for stem-like population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways. Cell. Death Dis. 11, 967 (2020)","journal-title":"Cell. Death Dis."},{"key":"874_CR87","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/cam4.993","volume":"6","author":"A Zhang","year":"2017","unstructured":"A. Zhang, Y. Qian, Z. Ye et al., Cancer-associated fibroblasts promote M2 polarization of macrophages in pancreatic ductal adenocarcinoma. Cancer Med. 6, 463\u2013470 (2017)","journal-title":"Cancer Med."},{"key":"874_CR88","doi-asserted-by":"crossref","unstructured":"C.J. Garcia Garcia, Y. Huang, N.R. Fuentes et al., Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment. Gastroenterology 2022;162:2018\u20132031","DOI":"10.1053\/j.gastro.2022.02.024"},{"key":"874_CR89","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41571-020-0426-7","volume":"18","author":"JA Myers","year":"2021","unstructured":"J.A. Myers, J.S. Miller, Exploring the NK cell platform for cancer immunotherapy. Nat. Rev. Clin. Oncol. 18, 85\u2013100 (2021)","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"874_CR90","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41423-018-0014-2","volume":"16","author":"Q Huang","year":"2019","unstructured":"Q. Huang, M. Huang, F. Meng et al., Activated pancreatic stellate cells inhibit NK cell function in the human pancreatic cancer microenvironment. Cell. Mol. Immunol. 16, 87\u201389 (2019)","journal-title":"Cell. Mol. Immunol."},{"key":"874_CR91","doi-asserted-by":"publisher","first-page":"7158","DOI":"10.1038\/ncomms8158","volume":"6","author":"J Xue","year":"2015","unstructured":"J. Xue, V. Sharma, M.H. Hsieh et al., Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. Nat. Commun. 6, 7158 (2015)","journal-title":"Nat. Commun."},{"key":"874_CR92","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1111\/jcmm.16213","volume":"25","author":"N Wu","year":"2020","unstructured":"N. Wu, X.F. Xu, J.Q. Xin et al., The effects of nuclear factor-kappa B in pancreatic stellate cells on inflammation and fibrosis of chronic pancreatitis. J. Cell. Mol. Med. 25, 2213\u20132227 (2020)","journal-title":"J. Cell. Mol. Med."},{"key":"874_CR93","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1053\/j.gastro.2005.03.025","volume":"128","author":"K Shimizu","year":"2005","unstructured":"K. Shimizu, M. Kobayashi, J. Tahara et al., Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology. 128, 2105\u20132118 (2005)","journal-title":"Gastroenterology"},{"key":"874_CR94","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/path.4727","volume":"239","author":"EF Carapuca","year":"2016","unstructured":"E.F. Carapuca, E. Gemenetzidis, C. Feig et al., Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma. J. Pathol. 239, 286\u2013296 (2016)","journal-title":"J. Pathol."},{"key":"874_CR95","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cell.2014.08.007","volume":"159","author":"MH Sherman","year":"2014","unstructured":"M.H. Sherman, R.T. Yu, D.D. Engle et al., Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 159, 80\u201393 (2014)","journal-title":"Cell"},{"key":"874_CR96","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1053\/j.gastro.2007.03.107","volume":"132","author":"M Rickmann","year":"2007","unstructured":"M. Rickmann, E.C. Vaquero, J.R. Malagelada et al., Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology. 132, 2518\u20132532 (2007)","journal-title":"Gastroenterology"},{"key":"874_CR97","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1158\/1535-7163.MCT-21-0083","volume":"20","author":"AR Dosch","year":"2021","unstructured":"A.R. Dosch, S. Singh, X. Dai et al., Targeting tumor\u2013stromal IL6\/STAT3 signaling through IL1 receptor inhibition in pancreatic Cancer. Mol. Cancer Ther. 20, 2280\u20132290 (2021)","journal-title":"Mol. Cancer Ther."},{"key":"874_CR98","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1136\/gutjnl-2016-311585","volume":"67","author":"TA Mace","year":"2018","unstructured":"T.A. Mace, R. Shakya, J.R. Pitarresi et al., IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. Gut. 67, 320\u2013332 (2018)","journal-title":"Gut"},{"key":"874_CR99","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41416-018-0246-z","volume":"119","author":"D Melisi","year":"2018","unstructured":"D. Melisi, R. Garcia-Carbonero, T. Macarulla et al., Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer. Br. J. Cancer. 119, 1208\u20131214 (2018)","journal-title":"Br. J. Cancer"},{"key":"874_CR100","doi-asserted-by":"crossref","unstructured":"E. O\u2019Reilly, T. Golan, M. Ikeda et al., P-22 phase III study (daNIS-2) of the anti\u2013TGF-\u03b2 monoclonal antibody NIS793 with nab-paclitaxel\/gemcitabine vs nab-paclitaxel\/gemcitabine alone in patients with first-line metastatic pancreatic ductal adenocarcinoma. Ann. Oncol. 33, S254 (2022)","DOI":"10.1016\/j.annonc.2022.04.113"},{"key":"874_CR101","doi-asserted-by":"publisher","first-page":"100530","DOI":"10.1016\/j.esmoop.2022.100530","volume":"7","author":"E Borazanci","year":"2022","unstructured":"E. Borazanci, A.M. Schram, E. Garralda et al., Phase I, first-in-human study of MSC-1 (AZD0171), a humanized anti-leukemia inhibitory factor monoclonal antibody, for advanced solid tumors. ESMO Open. 7, 100530 (2022)","journal-title":"ESMO Open."},{"key":"874_CR102","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1113\/JP271468","volume":"594","author":"O Gryshchenko","year":"2016","unstructured":"O. Gryshchenko, J.V. Gerasimenko, O.V. Gerasimenko et al., Ca(2+) signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific ca(2+) channel blockade. J. Physiol. 594, 281\u2013293 (2016)","journal-title":"J. Physiol."},{"key":"874_CR103","doi-asserted-by":"crossref","unstructured":"V. Szabo, N. Csakany-Papp, M. Gorog et al., Orai1 Calcium Channel Inhibition Prevents Progression of Chronic Pancreatitis. JCI Insight 8, e167645 (2023)","DOI":"10.1172\/jci.insight.167645"},{"key":"874_CR104","doi-asserted-by":"publisher","first-page":"104357","DOI":"10.1016\/j.phrs.2019.104357","volume":"147","author":"XP Zeng","year":"2019","unstructured":"X.P. Zeng, L.J. Wang, H.L. Guo et al., Dasatinib ameliorates chronic pancreatitis induced by caerulein via anti-fibrotic and anti-inflammatory mechanism. Pharmacol. Res. 147, 104357 (2019)","journal-title":"Pharmacol. Res."},{"key":"874_CR105","doi-asserted-by":"publisher","first-page":"4841","DOI":"10.1038\/s41467-020-18636-w","volume":"11","author":"HM Kocher","year":"2020","unstructured":"H.M. Kocher, B. Basu, F.E.M. Froeling et al., Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer. Nat. Commun. 11, 4841 (2020)","journal-title":"Nat. Commun."}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00874-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-023-00874-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00874-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:20:27Z","timestamp":1715599227000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-023-00874-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,18]]},"references-count":105,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["874"],"URL":"https:\/\/doi.org\/10.1007\/s13402-023-00874-x","relation":{},"ISSN":["2211-3428","2211-3436"],"issn-type":[{"value":"2211-3428","type":"print"},{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,18]]},"assertion":[{"value":"5 September 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}