{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:28:13Z","timestamp":1790180893897,"version":"4.1.0"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/073"],"award-info":[{"award-number":["C24\/17\/073"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/073"],"award-info":[{"award-number":["C24\/17\/073"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/073"],"award-info":[{"award-number":["C24\/17\/073"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/073"],"award-info":[{"award-number":["C24\/17\/073"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/073"],"award-info":[{"award-number":["C24\/17\/073"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/073"],"award-info":[{"award-number":["C24\/17\/073"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s13402-023-00895-6","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T03:02:30Z","timestamp":1700103750000},"page":"793-818","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer"],"prefix":"10.1007","volume":"47","author":[{"given":"C\u00e9lie","family":"Cokelaere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcveyda","family":"Dok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela E.","family":"Cortesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9526-4014","authenticated-orcid":false,"given":"Anna","family":"Sablina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-4796","authenticated-orcid":false,"given":"Sandra","family":"Nuyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-0677","authenticated-orcid":false,"given":"Rita","family":"Derua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-8448","authenticated-orcid":false,"given":"Veerle","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"895_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"F. Bray, J. Ferlay, I. Soerjomataram, R.L. Siegel, L.A. Torre, A. Jemal, Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: Cancer J. Clin. 68, 394\u2013424 (2018). https:\/\/doi.org\/10.3322\/caac.21492","journal-title":"CA: Cancer J. Clin."},{"issue":"1","key":"895_CR2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"K.K. Ang, J. Harris, R. Wheeler, R. Weber, D.I. Rosenthal, P.F. Nguyen-T\u00e2n, W.H. Westra, C.H. Chung, R.C. Jordan, C. Lu et al., Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer. N. Engl. J. Med. 363(1), 24\u201335 (2010). https:\/\/doi.org\/10.1056\/NEJMoa0912217","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"895_CR3","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.radonc.2010.04.022","volume":"95","author":"P Lassen","year":"2010","unstructured":"P. Lassen, The role of Human papillomavirus in head and neck cancer and the impact on radiotherapy outcome. Radiother. Oncol. 95(3), 371\u2013380 (2010). https:\/\/doi.org\/10.1016\/j.radonc.2010.04.022","journal-title":"Radiother. Oncol."},{"issue":"1","key":"895_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc2982","volume":"11","author":"CR Leemans","year":"2011","unstructured":"C.R. Leemans, B.J.M. Braakhuis, R.H. Brakenhoff, The molecular biology of head and neck cancer. Nat. Rev. Cancer 11(1), 9\u201322 (2011). https:\/\/doi.org\/10.1038\/nrc2982","journal-title":"Nat. Rev. Cancer"},{"key":"895_CR5","doi-asserted-by":"publisher","first-page":"e1018","DOI":"10.1038\/cddis.2013.548","volume":"5","author":"Y Suh","year":"2014","unstructured":"Y. Suh, I. Amelio, T. Guerrero Urbano, M. Tavassoli, Clinical update on cancer: molecular oncology of head and neck cancer. Cell Death Dis. 5, e1018 (2014). https:\/\/doi.org\/10.1038\/cddis.2013.548","journal-title":"Cell Death Dis."},{"issue":"2","key":"895_CR6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.coms.2014.01.001","volume":"26","author":"N Vigneswaran","year":"2014","unstructured":"N. Vigneswaran, M.D. Williams, Epidemiologic Trends in Head and Neck Cancer and Aids in Diagnosis. Oral Maxillofac. Surg. Clin. North Am. 26(2), 123\u2013141 (2014). https:\/\/doi.org\/10.1016\/j.coms.2014.01.001","journal-title":"Oral Maxillofac. Surg. Clin. North Am."},{"issue":"3","key":"895_CR7","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ijrobp.2016.10.011","volume":"97","author":"M Buglione","year":"2017","unstructured":"M. Buglione, M. Maddalo, R. Corv\u00f2, L. Pirtoli, F. Paiar, L. Lastrucci, M. Stefanacci, L. Belgioia, M. Crociani, S. Vecchio et al., Subgroup Analysis According to Human Papillomavirus Status and Tumor Site of a Randomized Phase II Trial Comparing Cetuximab and Cisplatin Combined With Radiation Therapy for Locally Advanced Head and Neck Cancer. Int. J. Radiat. Oncol. Biol. Phys. 97(3), 462\u2013472 (2017). https:\/\/doi.org\/10.1016\/j.ijrobp.2016.10.011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"5","key":"895_CR8","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1200\/JCO.2015.63.1671","volume":"34","author":"SM Magrini","year":"2016","unstructured":"S.M. Magrini, M. Buglione, R. Corv\u00f2, L. Pirtoli, F. Paiar, P. Ponticelli, A. Petrucci, A. Bacigalupo, M. Crociani, L. Lastrucci et al., Cetuximab and Radiotherapy Versus Cisplatin and Radiotherapy for Locally Advanced Head and Neck Cancer: A Randomized Phase II Trial. J. Clin. Oncol. 34(5), 427\u2013435 (2016). https:\/\/doi.org\/10.1200\/JCO.2015.63.1671","journal-title":"J. Clin. Oncol."},{"key":"895_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbcan.2008.05.005","volume":"1795","author":"PJA Eichhorn","year":"2009","unstructured":"P.J.A. Eichhorn, M.P. Creyghton, R. Bernards, Protein phosphatase 2A regulatory subunits and cancer. Biochim. Biophys. Acta Rev. Cancer 1795, 1\u201315 (2009). https:\/\/doi.org\/10.1016\/j.bbcan.2008.05.005","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"895_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/0264-6021:3530417","volume":"353","author":"V Janssens","year":"2001","unstructured":"V. Janssens, J. Goris, Protein phosphatase 2A: a highly regulated family of serine\/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417\u2013439 (2001). https:\/\/doi.org\/10.1042\/0264-6021:3530417","journal-title":"Biochem. J."},{"issue":"October 2017","key":"895_CR11","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.biocel.2017.10.002","volume":"96","author":"B Meeusen","year":"2018","unstructured":"B. Meeusen, V. Janssens, Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification. Int. J. Biochem. Cell Biol. 96(October 2017), 98\u2013134 (2018). https:\/\/doi.org\/10.1016\/j.biocel.2017.10.002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"895_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-562-0_17","author":"C Lambrecht","year":"2013","unstructured":"C. Lambrecht, D. Haesen, W. Sents, E. Ivanova, V. Janssens, Structure, Regulation, and Pharmacological Modulation of PP2A Phosphatases. Methods Mol. Biol. (2013). https:\/\/doi.org\/10.1007\/978-1-62703-562-0_17","journal-title":"Methods Mol. Biol."},{"issue":"27","key":"895_CR13","first-page":"1","volume":"8","author":"AK Freeman","year":"2010","unstructured":"A.K. Freeman, A.N.A. Monteiro, Phosphatases in the cellular response to DNA damage. Cell Commun. Signal. 8(27), 1\u201312 (2010). (Retrieved from papers3:\/\/publication\/uuid\/EF6F07AF-1C3F-463E-B489-19FE4E4D4591)","journal-title":"Cell Commun. Signal."},{"issue":"11","key":"895_CR14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.pmrj.2014.02.014.Lumbar","volume":"36","author":"DH Lee","year":"2011","unstructured":"D.H. Lee, D. Chowdhury, What Goes On Must Come Off: phosphatases gate-crash the DNA damage response. Trends Biochem. Sci. 36(11), 569\u2013577 (2011). https:\/\/doi.org\/10.1016\/j.pmrj.2014.02.014.Lumbar","journal-title":"Trends Biochem. Sci."},{"key":"895_CR15","doi-asserted-by":"publisher","first-page":"5977","DOI":"10.1038\/onc.2010.371","volume":"29","author":"A Peng","year":"2010","unstructured":"A. Peng, J.L. Maller, Serine\/threonine phosphatases in the DNA damage response and cancer. Oncogene 29, 5977\u20135988 (2010). https:\/\/doi.org\/10.1038\/onc.2010.371","journal-title":"Oncogene"},{"key":"895_CR16","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00018-022-04550-5","volume":"79","author":"A Sule","year":"2022","unstructured":"A. Sule, S.E. Golding, S.F. Ahmad, J. Watson, M.H. Ahmed, G.E. Kellogg, T. Bernas, S. Koebley, J.C. Reed, L.F. Povirk et al., ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response. Cell. Mol. Life Sci. 79, 603 (2022). https:\/\/doi.org\/10.1007\/s00018-022-04550-5","journal-title":"Cell. Mol. Life Sci."},{"key":"895_CR17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.dnarep.2015.04.014","volume":"32","author":"XF Zheng","year":"2015","unstructured":"X.F. Zheng, P. Kalev, D. Chowdhury, Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response. DNA Repair 32, 58\u201365 (2015). https:\/\/doi.org\/10.1016\/j.dnarep.2015.04.014","journal-title":"DNA Repair"},{"issue":"12","key":"895_CR18","doi-asserted-by":"publisher","first-page":"102656","DOI":"10.1016\/j.jbc.2022.102656","volume":"298","author":"TJ Haanen","year":"2022","unstructured":"T.J. Haanen, C.M. O\u2019Connor, G. Narla, Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules. J. Biol. Chem. 298(12), 102656 (2022). https:\/\/doi.org\/10.1016\/j.jbc.2022.102656","journal-title":"J. Biol. Chem."},{"issue":"6","key":"895_CR19","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1111\/febs.13573","volume":"283","author":"J Sangodkar","year":"2016","unstructured":"J. Sangodkar, C.C. Farrington, K. McClinch, M.D. Galsky, D.B. Kastrinsky, G. Narla, All roads lead to PP2A: Exploiting the therapeutic potential of this phosphatase. FEBS J. 283(6), 1004\u20131024 (2016). https:\/\/doi.org\/10.1111\/febs.13573","journal-title":"FEBS J."},{"key":"895_CR20","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1002\/jcp.26001","volume":"233","author":"BK Velmurugan","year":"2018","unstructured":"B.K. Velmurugan, C.H. Lee, S.L. Chiang, C.H. Hua, M.C. Chen, S.H. Lin, K.T. Yeh, Y.C. Ko, PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential. J. Cell. Physiol. 233, 1300\u20131311 (2018). https:\/\/doi.org\/10.1002\/jcp.26001","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"895_CR21","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1631\/jzus.B1900179","volume":"20","author":"HY Wang","year":"2019","unstructured":"H.Y. Wang, H. Yuan, J.H. Liu, B.L. Wang, K.L. Xu, P. Huang, Z.H. Lin, L.H. Xu, Comparative analysis of a panel of biomarkers related to protein phosphatase 2A between laryngeal squamous cell carcinoma tissues and adjacent normal tissues. J. Zhejiang Univ.: Sci. B 20(9), 776\u2013780 (2019). https:\/\/doi.org\/10.1631\/jzus.B1900179","journal-title":"J. Zhejiang Univ.: Sci. B"},{"key":"895_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2022.904719","volume":"10","author":"OG Gouttia","year":"2022","unstructured":"O.G. Gouttia, J. Zhao, Y. Li, M.J. Zwiener, L. Wang, G.G. Oakley, A. Peng, The MASTL-ENSA-PP2A\/B55 axis modulates cisplatin resistance in oral squamous cell carcinoma. Front. Cell Dev. Biol. 10, 1\u201310 (2022). https:\/\/doi.org\/10.3389\/fcell.2022.904719","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"895_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.cell.2007.04.044","volume":"130","author":"MR Junttila","year":"2007","unstructured":"M.R. Junttila, P. Puustinen, M. Niemel\u00e4, R. Ahola, H. Arnold, T. B\u00f6ttzauw, R. Ala-aho, C. Nielsen, J. Ivaska, Y. Taya et al., CIP2A Inhibits PP2A in Human Malignancies. Cell 130(1), 51\u201362 (2007). https:\/\/doi.org\/10.1016\/j.cell.2007.04.044","journal-title":"Cell"},{"issue":"7","key":"895_CR24","doi-asserted-by":"publisher","first-page":"694","DOI":"10.4161\/cbt.10.7.12895","volume":"10","author":"J Katz","year":"2010","unstructured":"J. Katz, A. Jakymiw, M.K. Ducksworth, C.M. Stewart, I. Bhattacharyya, S. Cha, E.K.L. Chan, CIP2A expression and localization in oral carcinoma and dysplasia. Cancer Biol. Ther. 10(7), 694\u2013699 (2010). https:\/\/doi.org\/10.4161\/cbt.10.7.12895","journal-title":"Cancer Biol. Ther."},{"issue":"11","key":"895_CR25","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.oraloncology.2012.05.014","volume":"48","author":"AM Leopoldino","year":"2012","unstructured":"A.M. Leopoldino, C.H. Squarize, C.B. Garcia, L.O. Almeida, C.R. Pestana, L.M. Sobral, S.A. Uyemura, E.H. Tajara, S.J. Gutkind, C. Curti, SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncol. 48(11), 1106\u20131113 (2012). https:\/\/doi.org\/10.1016\/j.oraloncology.2012.05.014","journal-title":"Oral Oncol."},{"issue":"4","key":"895_CR26","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1158\/1078-0432.CCR-07-1497","volume":"14","author":"V Patel","year":"2008","unstructured":"V. Patel, B.L. Hood, A.A. Molinolo, N.H. Lee, T.P. Conrads, J.C. Braisted, D.B. Krizman, T.D. Veenstra, J.S. Gutkind, Proteomic analysis of laser-captured paraffin-embedded tissues: A molecular portrait of head and neck cancer progression. Clin. Cancer Res. 14(4), 1002\u20131014 (2008). https:\/\/doi.org\/10.1158\/1078-0432.CCR-07-1497","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"895_CR27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.18632\/oncotarget.2670","volume":"6","author":"S Ventel\u00e4","year":"2014","unstructured":"S. Ventel\u00e4, E. Sittig, L. Mannermaa, J.-A. M\u00e4kel\u00e4, J. Kulmala, E. L\u00f6yttyniemi, L. Strauss, O. C\u00e1rpen, J. Toppari, R. Gr\u00e9nman et al., CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance. Oncotarget 6(1), 144\u2013158 (2014). https:\/\/doi.org\/10.18632\/oncotarget.2670","journal-title":"Oncotarget"},{"issue":"1","key":"895_CR28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.15430\/jcp.2020.25.1.21","volume":"25","author":"R Alzahrani","year":"2020","unstructured":"R. Alzahrani, A.A. Alrehaili, A.F. Gharib, F. Anjum, K.A. Ismail, W.H. Elsawy, Cancerous Inhibitor of Protein Phosphatase 2A as a Molecular Marker for Aggressiveness and Survival in Oral Squamous Cell Carcinoma. J. Cancer Prev. 25(1), 21\u201326 (2020). https:\/\/doi.org\/10.15430\/jcp.2020.25.1.21","journal-title":"J. Cancer Prev."},{"key":"895_CR29","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1038\/bjc.2011.167","volume":"104","author":"C B\u00f6ckelman","year":"2011","unstructured":"C. B\u00f6ckelman, J. Hagstr\u00f6m, L.K. M\u00e4kinen, H. Keski-S\u00e4ntti, V. H\u00e4yry, J. Lundin, T. Atula, A. Ristim\u00e4ki, C. Haglund, High CIP2A immunoreactivity is an independent prognostic indicator in early-stage tongue cancer. Br. J. Cancer 104, 1890\u20131895 (2011). https:\/\/doi.org\/10.1038\/bjc.2011.167","journal-title":"Br. J. Cancer"},{"issue":"1","key":"895_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/1476-4598-13-111","volume":"13","author":"N Liu","year":"2014","unstructured":"N. Liu, Q.-M. He, J.-W. Chen, Y.-Q. Li, Y.-F. Xu, X.-Y. Ren, Y. Sun, H.-Q. Mai, J.-Y. Shao, W.-H. Jia et al., Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth. Mol. Cancer 13(1), 111 (2014). https:\/\/doi.org\/10.1186\/1476-4598-13-111","journal-title":"Mol. Cancer"},{"key":"895_CR31","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.bbamcr.2019.01.005","volume":"1866","author":"AT Ouchida","year":"2019","unstructured":"A.T. Ouchida, V.T. Uyemura, A.L. Queiroz, V.S. Brauer, M.P. Cavalcanti-Neto, L.O. Sousa, S.A. Uyemura, C. Curti, A.M. Leopoldino, SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy. Biochim. Biophys. Acta \u2013 Mol. Cell Res. 1866, 623\u2013637 (2019). https:\/\/doi.org\/10.1016\/j.bbamcr.2019.01.005","journal-title":"Biochim. Biophys. Acta \u2013 Mol. Cell Res."},{"key":"895_CR32","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/jop.12372","volume":"45","author":"J Routila","year":"2016","unstructured":"J. Routila, T. Bilgen, O. Saram\u00e4ki, R. Gr\u00e9nman, T. Visakorpi, J. Westermarck, S. Ventel\u00e4, Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma. J. Oral Pathol. Med. 45, 329\u2013337 (2016). https:\/\/doi.org\/10.1111\/jop.12372","journal-title":"J. Oral Pathol. Med."},{"issue":"32","key":"895_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-4598-13-32","volume":"13","author":"LM Sobral","year":"2014","unstructured":"L.M. Sobral, L.O. Sousa, R.D. Coletta, H. Cabral, L.J. Greene, E.H. Tajara, J.S. Gutkind, C. Curti, A.M. Leopoldino, Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Mol. Cancer 13(32), 1\u201313 (2014). https:\/\/doi.org\/10.1186\/1476-4598-13-32","journal-title":"Mol. Cancer"},{"issue":"2","key":"895_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsyr\/fow009","volume":"16","author":"J Feng","year":"2016","unstructured":"J. Feng, Y. Duan, W. Sun, Y. Qin, Z. Zhuang, D. Zhu, X. Sun, L. Jiang, CaTip41 regulates protein phosphatase 2A activity, CaRad53 deactivation and the recovery of DNA damage-induced filamentation to yeast form in Candida albicans. FEMS Yeast Res. 16(2), 1\u20139 (2016). https:\/\/doi.org\/10.1093\/femsyr\/fow009","journal-title":"FEMS Yeast Res."},{"issue":"11","key":"895_CR35","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1074\/mcp.M500231-MCP200","volume":"4","author":"AC Gingras","year":"2005","unstructured":"A.C. Gingras, M. Caballero, M. Zarske, A. Sanchez, T.R. Hazbun, S. Fields, N. Sonenberg, E. Hafen, B. Raught, R. Aebersold, A Novel, Evolutionarily Conserved Protein Phosphatase Complex Involved in Cisplatin Sensitivity. Mol. Cell. Proteomics 4(11), 1725\u20131740 (2005). https:\/\/doi.org\/10.1074\/mcp.M500231-MCP200","journal-title":"Mol. Cell. Proteomics"},{"issue":"41","key":"895_CR36","doi-asserted-by":"publisher","first-page":"6021","DOI":"10.1038\/sj.onc.1210406","volume":"26","author":"JL McConnell","year":"2007","unstructured":"J.L. McConnell, R.J. Gomez, L.R.A. McCorvey, B.K. Law, B.E. Wadzinski, Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM\/ATR signaling pathway. Oncogene 26(41), 6021\u20136030 (2007). https:\/\/doi.org\/10.1038\/sj.onc.1210406","journal-title":"Oncogene"},{"issue":"12","key":"895_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0145938","volume":"10","author":"KR Rosales","year":"2015","unstructured":"K.R. Rosales, M.A. Reid, Y. Yang, T.Q. Tran, W.-I. Wang, X. Lowman, M. Pan, M. Kong, TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. PLoS ONE 10(12), 1\u201313 (2015). https:\/\/doi.org\/10.1371\/journal.pone.0145938","journal-title":"PLoS ONE"},{"key":"895_CR38","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/S1097-2765(01)00386-0","volume":"8","author":"E Jacinto","year":"2001","unstructured":"E. Jacinto, B. Guo, K.T. Arndt, T. Schmelzle, M.N. Hall, TIP41 Interacts with TAP42 and Negatively Regulates the TOR Signaling Pathway. Mol. Cell 8, 1017\u20131026 (2001). https:\/\/doi.org\/10.1016\/S1097-2765(01)00386-0","journal-title":"Mol. Cell"},{"issue":"19","key":"895_CR39","doi-asserted-by":"publisher","first-page":"5719","DOI":"10.1158\/0008-5472.CAN-15-3342","volume":"76","author":"D Haesen","year":"2016","unstructured":"D. Haesen, L.A. Asbagh, R. Derua, A. Hubert, S. Schrauwen, Y. Hoorne, F. Amant, E. Waelkens, A. Sablina, V. Janssens, Recurrent PPP2R1A mutations in uterine cancer act through a dominant-negative mechanism to promote malignant cell growth. Can. Res. 76(19), 5719\u20135731 (2016). https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-3342","journal-title":"Cancer Res."},{"key":"895_CR40","doi-asserted-by":"publisher","first-page":"5891","DOI":"10.1111\/j.1742-4658.2007.06112.x","volume":"274","author":"JHC Smetana","year":"2007","unstructured":"J.H.C. Smetana, N.I.T. Zanchin, Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, \u03b14 and the mammalian ortholog of yeast Tip41 (TIPRL). FEBS J. 274, 5891\u20135904 (2007). https:\/\/doi.org\/10.1111\/j.1742-4658.2007.06112.x","journal-title":"FEBS J."},{"issue":"July","key":"895_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep30813","volume":"6","author":"V Scorsato","year":"2016","unstructured":"V. Scorsato, T.B. Lima, G.L. Righetto, N.I.T. Zanchin, J. Brand\u00e3o-Neto, J. Sandy, H.D.M. Pereira, \u00c1.J.R. Ferrari, F.C. Gozzo, J.H.C. Smetana et al., Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus. Sci. Rep. 6(July), 1\u201312 (2016). https:\/\/doi.org\/10.1038\/srep30813","journal-title":"Sci. Rep."},{"issue":"1","key":"895_CR42","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1038\/s41467-017-02405-3","volume":"8","author":"CG Wu","year":"2017","unstructured":"C.G. Wu, A. Zheng, L. Jiang, M. Rowse, V. Stanevich, H. Chen, Y. Li, K.A. Satyshur, B. Johnson, T.-J. Gu et al., Methylation-regulated decommissioning of multimeric PP2A complexes. Nat. Commun. 8(1), 2272 (2017). https:\/\/doi.org\/10.1038\/s41467-017-02405-3","journal-title":"Nat. Commun."},{"key":"895_CR43","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/j.1742-4658.2012.08579.x","volume":"280","author":"W Sents","year":"2013","unstructured":"W. Sents, E. Ivanova, C. Lambrecht, D. Haesen, V. Janssens, The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity. FEBS J. 280, 644\u2013661 (2013). https:\/\/doi.org\/10.1111\/j.1742-4658.2012.08579.x","journal-title":"FEBS J."},{"key":"895_CR44","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.molcel.2009.09.025","volume":"36","author":"M Kong","year":"2009","unstructured":"M. Kong, D. Ditsworth, T. Lindsten, C.B. Thompson, \u03b14 Is an Essential Regulator of PP2A Phosphatase Activity. Mol. Cell 36, 51\u201360 (2009). https:\/\/doi.org\/10.1016\/j.molcel.2009.09.025","journal-title":"Mol. Cell"},{"issue":"18","key":"895_CR45","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1016\/j.febslet.2013.07.027","volume":"587","author":"A Nakashima","year":"2013","unstructured":"A. Nakashima, K. Tanimura-Ito, N. Oshiro, S. Eguchi, T. Miyamoto, A. Momonami, S. Kamada, K. Yonezawa, U. Kikkawa, A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A. FEBS Lett. 587(18), 2924\u20132929 (2013). https:\/\/doi.org\/10.1016\/j.febslet.2013.07.027","journal-title":"FEBS Lett."},{"issue":"5","key":"895_CR46","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1053\/j.gastro.2012.07.103","volume":"143","author":"IS Song","year":"2012","unstructured":"I.S. Song, S.Y. Jun, H.-J. Na, H.-T. Kim, S.Y. Jung, G.H. Ha, Y.-H. Park, L.Z. Long, D.-Y. Yu, J.-M. Kim et al., Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Gastroenterology 143(5), 1341\u20131351 (2012). https:\/\/doi.org\/10.1053\/j.gastro.2012.07.103","journal-title":"Gastroenterology"},{"issue":"11","key":"895_CR47","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1038\/nprot.2013.143","volume":"8","author":"FA Ran","year":"2013","unstructured":"F.A. Ran, P.D. Hsu, J. Wright, V. Agarwala, D.A. Scott, F. Zhang, Genome engineering using the CRISPR-Cas9 system. Nat. Protoc. 8(11), 2281\u20132308 (2013). https:\/\/doi.org\/10.1038\/nprot.2013.143","journal-title":"Nat. Protoc."},{"issue":"24","key":"895_CR48","doi-asserted-by":"publisher","first-page":"6825","DOI":"10.1158\/0008-5472.CAN-16-2911","volume":"77","author":"W Sents","year":"2017","unstructured":"W. Sents, B. Meeusen, P. Kalev, E. Radaelli, X. Sagaert, E. Miermans, D. Haesen, C. Lambrecht, M. Dewerchin, P. Carmeliet et al., PP2A inactivation mediated by PPP2R4 haploinsufficiency promotes cancer development. Can. Res. 77(24), 6825\u20136838 (2017). https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-2911","journal-title":"Cancer Res."},{"issue":"February","key":"895_CR49","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.canlet.2021.06.022","volume":"520","author":"B Meeusen","year":"2021","unstructured":"B. Meeusen, E.E. Cortesi, J. Dom\u00e8nech Omella, A. Sablina, J.J. Ventura, V. Janssens, PPP2R4 dysfunction promotes KRAS-mutant lung adenocarcinoma development and mediates opposite responses to MEK and mTOR inhibition. Cancer Lett. 520(February), 57\u201367 (2021). https:\/\/doi.org\/10.1016\/j.canlet.2021.06.022","journal-title":"Cancer Lett."},{"issue":"9","key":"895_CR50","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1038\/s41596-018-0014-9","volume":"13","author":"SJ Humphrey","year":"2018","unstructured":"S.J. Humphrey, O. Karayel, D.E. James, M. Mann, High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform. Nat. Protoc. 13(9), 1897\u20131916 (2018). https:\/\/doi.org\/10.1038\/s41596-018-0014-9","journal-title":"Nat. Protoc."},{"key":"895_CR51","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"B.T. Sherman, M. Hao, J. Qiu, X. Jiao, M.W. Baseler, H.C. Lane, T. Imamichi, W. Chang, DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 50, W216\u2013W221 (2022). https:\/\/doi.org\/10.1093\/nar\/gkac194","journal-title":"Nucleic Acids Res."},{"key":"895_CR52","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s00066-020-01595-y","volume":"196","author":"S Deschuymer","year":"2020","unstructured":"S. Deschuymer, B.S. S\u00f8rensen, R. Dok, A. Laenen, E. Hauben, J. Overgaard, S. Nuyts, Prognostic value of a 15-gene hypoxia classifier in oropharyngeal cancer treated with accelerated chemoradiotherapy. Strahlenther. Onkol. 196, 552\u2013560 (2020). https:\/\/doi.org\/10.1007\/s00066-020-01595-y","journal-title":"Strahlenther. Onkol."},{"issue":"5","key":"895_CR53","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"E. Cerami, J. Gao, U. Dogrusoz, B.E. Gross, S.O. Sumer, B.A. Aksoy, A. Jacobsen, C.J. Byrne, M.L. Heuer, E. Larsson et al., The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2(5), 401\u2013404 (2012). https:\/\/doi.org\/10.1158\/2159-8290.CD-12-0095","journal-title":"Cancer Discov."},{"issue":"269","key":"895_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"J. Gao, B.A. Aksoy, U. Dogrusoz, G. Dresdner, B. Gross, S.O. Sumer, Y. Sun, A. Jacobsen, R. Sinha, E. Larsson et al., Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal. 6(269), 1\u201320 (2013). https:\/\/doi.org\/10.1126\/scisignal.2004088","journal-title":"Sci. Signal."},{"key":"895_CR55","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nature14129","volume":"517","author":"The Cancer Genome Atlas Network","year":"2015","unstructured":"The Cancer Genome Atlas Network, Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517, 576\u2013582 (2015). https:\/\/doi.org\/10.1038\/nature14129","journal-title":"Nature"},{"issue":"2","key":"895_CR56","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2307\/3578897","volume":"140","author":"MFMA Smeets","year":"1994","unstructured":"M.F.M.A. Smeets, E.H.M. Mooren, A.H.A. Abdel-Wahab, H. Bartelink, A.C. Begg, Differential repair of radiation-induced DNA damage in cells of human squamous cell carcinoma and the effect of caffeine and cysteamine on induction and repair of DNA double-strand breaks. Radiat. Res. 140(2), 153\u2013160 (1994). https:\/\/doi.org\/10.2307\/3578897","journal-title":"Radiat. Res."},{"issue":"7","key":"895_CR57","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0968-0004(98)01232-8","volume":"23","author":"P Baumann","year":"1998","unstructured":"P. Baumann, S.C. West, Role of the human RAD51 protein in homologous recombination and double- stranded-break repair. Trends Biochem. Sci. 23(7), 247\u2013251 (1998). https:\/\/doi.org\/10.1016\/S0968-0004(98)01232-8","journal-title":"Trends Biochem. Sci."},{"issue":"12","key":"895_CR58","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/s41580-021-00394-2","volume":"22","author":"JH Lee","year":"2021","unstructured":"J.H. Lee, T.T. Paull, Cellular functions of the protein kinase ATM and their relevance to human disease. Nat. Rev. Mol. Cell Biol. 22(12), 796\u2013814 (2021). https:\/\/doi.org\/10.1038\/s41580-021-00394-2","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"895_CR59","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","volume":"66","author":"AN Blackford","year":"2017","unstructured":"A.N. Blackford, S.P. Jackson, ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response. Mol. Cell 66, 801\u2013817 (2017). https:\/\/doi.org\/10.1016\/j.molcel.2017.05.015","journal-title":"Mol. Cell"},{"issue":"53","key":"895_CR60","doi-asserted-by":"publisher","first-page":"37538","DOI":"10.1074\/jbc.274.53.37538","volume":"274","author":"ST Kim","year":"1999","unstructured":"S.T. Kim, D.S. Lim, C.E. Canman, M.B. Kastan, Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274(53), 37538\u201337543 (1999). https:\/\/doi.org\/10.1074\/jbc.274.53.37538","journal-title":"J. Biol. Chem."},{"issue":"30","key":"895_CR61","doi-asserted-by":"publisher","first-page":"22719","DOI":"10.1074\/jbc.M001002200","volume":"275","author":"T O\u2019Neill","year":"2000","unstructured":"T. O\u2019Neill, A.J. Dwyer, Y. Ziv, D.W. Chan, S.P. Lees-Miller, R.H. Abraham, J.H. Lai, D. Hill, Y. Shiloh, L.C. Cantley et al., Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J. Biol. Chem. 275(30), 22719\u201322727 (2000). https:\/\/doi.org\/10.1074\/jbc.M001002200","journal-title":"J. Biol. Chem."},{"key":"895_CR62","doi-asserted-by":"publisher","first-page":"16802","DOI":"10.1038\/s41598-019-53191-5","volume":"9","author":"SY Jun","year":"2019","unstructured":"S.Y. Jun, S.J. Jeon, J.Y. Yoon, J.J. Lee, H.R. Yoon, M.H. Choi, D. Halder, K. Lee, N.S. Kim, The positive correlation of TIPRL with LC3 and CD133 contributes to cancer aggressiveness: potential biomarkers for early liver cancer. Sci. Rep. 9, 16802 (2019). https:\/\/doi.org\/10.1038\/s41598-019-53191-5","journal-title":"Sci. Rep."},{"key":"895_CR63","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.3390\/cancers13122925","volume":"13","author":"SY Jun","year":"2021","unstructured":"S.Y. Jun, H.R. Yoon, J.Y. Yoon, S.J. Jeon, J.J. Lee, D. Halder, J.M. Kim, N.S. Kim, The human TOR signaling regulator is the key indicator of liver cancer patients\u2019 overall survival: TIPRL\/LC3\/CD133\/CD44 as potential biomarkers for early liver cancers. Cancers 13, 2925 (2021). https:\/\/doi.org\/10.3390\/cancers13122925","journal-title":"Cancers"},{"key":"895_CR64","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12967-023-04145-z","volume":"21","author":"J van Pelt","year":"2023","unstructured":"J. van Pelt, B. Meeusen, R. Derua, L. Guffens, E. Van Cutsem, V. Janssens, C. Verslype, Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality. J. Transl. Med. 21, 217 (2023). https:\/\/doi.org\/10.1186\/s12967-023-04145-z","journal-title":"J. Transl. Med."},{"issue":"3","key":"895_CR65","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/ijc.29431","volume":"138","author":"A Khanna","year":"2016","unstructured":"A. Khanna, J.E. Pimanda, Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers. Int. J. Cancer 138(3), 525\u2013532 (2016). https:\/\/doi.org\/10.1002\/ijc.29431","journal-title":"Int. J. Cancer"},{"key":"895_CR66","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/j.celrep.2016.04.047","volume":"15","author":"S Boeing","year":"2016","unstructured":"S. Boeing, L. Williamson, V. Encheva, I. Gori, R.E. Saunders, R. Instrell, O. Ayg\u00fcn, M. Rodriguez-Martinez, J.C. Weems, G.P. Kelly et al., Multiomic analysis of the UV-Induced DNA damage response. Cell Rep. 15, 1597\u20131610 (2016). https:\/\/doi.org\/10.1016\/j.celrep.2016.04.047","journal-title":"Cell Rep."},{"key":"895_CR67","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1126\/science.1140321","volume":"316","author":"S Matsuoka","year":"2007","unstructured":"S. Matsuoka, B.A. Ballif, A. Smogorzewska, E.R. McDonald, K.E. Hurov, J. Luo, C.E. Bakalarski, Z. Zhao, N. Solimini, Y. Lerenthal et al., ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160\u20131166 (2007). https:\/\/doi.org\/10.1126\/science.1140321","journal-title":"Science"},{"key":"895_CR68","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.celrep.2014.07.036","volume":"8","author":"K Sharma","year":"2014","unstructured":"K. Sharma, R.C.J. D\u2019Souza, S. Tyanova, C. Schaab, J.R. Wi\u015bniewski, J. Cox, M. Mann, Ultradeep human phosphoproteome Reveals a distinct regulatory nature of tyr and ser\/thr-based signaling. Cell Rep. 8, 1583\u20131594 (2014). https:\/\/doi.org\/10.1016\/j.celrep.2014.07.036","journal-title":"Cell Rep."},{"key":"895_CR69","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1021\/pr300630k","volume":"12","author":"H Zhou","year":"2013","unstructured":"H. Zhou, S. Di Palma, C. Preisinger, M. Peng, A.N. Polat, A.J.R. Heck, S. Mohammed, Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. 12, 260\u2013271 (2013). https:\/\/doi.org\/10.1021\/pr300630k","journal-title":"J. Proteome Res."},{"issue":"4","key":"895_CR70","doi-asserted-by":"publisher","first-page":"e13208","DOI":"10.1111\/cpr.13208","volume":"55","author":"C Mei","year":"2022","unstructured":"C. Mei, Z.-E. Sun, L.-M. Tan, J.-P. Gong, X. Li, Z.-Q. Liu, eIF3a-PPP2R5A-mediated ATM\/ATR dephosphorylation is essential for irinotecan-induced DNA damage response. Cell Prolif. 55(4), e13208 (2022). https:\/\/doi.org\/10.1111\/cpr.13208","journal-title":"Cell Prolif."},{"key":"895_CR71","doi-asserted-by":"publisher","first-page":"110169","DOI":"10.1016\/j.cellsig.2021.110169","volume":"89","author":"RN Tamaddondoust","year":"2022","unstructured":"R.N. Tamaddondoust, Y. Wang, S.M. Jafarnejad, T.E. Graber, T. Alain, The highs and lows of ionizing radiation and its effects on protein synthesis. Cell. Signal. 89, 110169 (2022). https:\/\/doi.org\/10.1016\/j.cellsig.2021.110169","journal-title":"Cell. Signal."},{"issue":"7","key":"895_CR72","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1158\/2159-8290.CD-16-0908","volume":"7","author":"J Chen","year":"2017","unstructured":"J. Chen, J. Crutchley, D. Zhang, K. Owzar, M.B. Kastan, Identification a DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers. Cancer Discov. 7(7), 766\u2013781 (2017). https:\/\/doi.org\/10.1158\/2159-8290.CD-16-0908","journal-title":"Cancer Discov."},{"key":"895_CR73","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/genes10050331","volume":"10","author":"Z Li","year":"2019","unstructured":"Z. Li, X. Xu, Post-Translational Modifications of the Mini- Chromosome Maintenance Proteins in DNA Replication. Genes 10, 331 (2019). https:\/\/doi.org\/10.3390\/genes10050331","journal-title":"Genes"},{"key":"895_CR74","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1042\/BST20220681","volume":"51","author":"NJ Curtin","year":"2023","unstructured":"N.J. Curtin, Targeting the DNA damage response for cancer therapy. Biochem. Soc. Trans. 51, 207\u2013221 (2023). https:\/\/doi.org\/10.1042\/BST20220681","journal-title":"Biochem. Soc. Trans."},{"key":"895_CR75","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3390\/genes12091370","volume":"12","author":"A Shibata","year":"2021","unstructured":"A. Shibata, P.A. Jeggo, ATM\u2019s Role in the Repair of DNA Double-Strand Breaks. Genes 12, 1370 (2021). https:\/\/doi.org\/10.3390\/genes12091370","journal-title":"Genes"},{"issue":"6","key":"895_CR76","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1128\/mcb.00741-09","volume":"30","author":"P Douglas","year":"2010","unstructured":"P. Douglas, J. Zhong, R. Ye, G.B.G. Moorhead, X. Xu, S.P. Lees-Miller, Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates \u03b3-H2AX. Mol. Cell. Biol. 30(6), 1368\u20131381 (2010). https:\/\/doi.org\/10.1128\/mcb.00741-09","journal-title":"Mol. Cell. Biol."},{"issue":"10","key":"895_CR77","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1593\/neo.09720","volume":"11","author":"Q Wang","year":"2009","unstructured":"Q. Wang, F. Gao, T. Wang, T. Flagg, X. Deng, A Nonhomologous End-joining Pathway Is Required for Protein Phosphatase 2A Promotion of DNA Double-Strand Break Repair. Neoplasia 11(10), 1012\u20131021 (2009). https:\/\/doi.org\/10.1593\/neo.09720","journal-title":"Neoplasia"},{"issue":"2","key":"895_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0004395","volume":"4","author":"J Mi","year":"2009","unstructured":"J. Mi, J. Dziegielewski, E. Bolesta, D.L. Brautigan, J.M. Larner, Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6. PLoS ONE 4(2), 1\u20139 (2009). https:\/\/doi.org\/10.1371\/journal.pone.0004395","journal-title":"PLoS ONE"},{"key":"895_CR79","doi-asserted-by":"publisher","first-page":"e241","DOI":"10.1038\/cddis.2011.126","volume":"2","author":"Y Shen","year":"2011","unstructured":"Y. Shen, Y. Wang, K. Sheng, X. Fei, Q. Guo, J. Larner, X. Kong, Y. Qiu, J. Mi, Serine\/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma. Cell Death Dis. 2, e241 (2011). https:\/\/doi.org\/10.1038\/cddis.2011.126","journal-title":"Cell Death Dis."},{"key":"895_CR80","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.molcel.2005.10.003","volume":"20","author":"D Chowdhury","year":"2005","unstructured":"D. Chowdhury, M.C. Keogh, H. Ishii, C.L. Peterson, S. Buratowski, J. Lieberman, \u03b3-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol. Cell 20, 801\u2013809 (2005). https:\/\/doi.org\/10.1016\/j.molcel.2005.10.003","journal-title":"Mol. Cell"},{"issue":"13","key":"895_CR81","doi-asserted-by":"publisher","first-page":"7554","DOI":"10.1093\/nar\/gkab584","volume":"49","author":"B Peng","year":"2021","unstructured":"B. Peng, R. Shi, J. Bian, Y. Li, P. Wang, H. Wang, J. Liao, W.G. Zhu, X. Xu, PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair. Nucleic Acids Res. 49(13), 7554\u20137570 (2021). https:\/\/doi.org\/10.1093\/nar\/gkab584","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"895_CR82","doi-asserted-by":"publisher","first-page":"5748","DOI":"10.1038\/s41467-021-26079-0","volume":"12","author":"SM Ambj\u00f8rn","year":"2021","unstructured":"S.M. Ambj\u00f8rn, J.P. Duxin, E.P.T. Hertz, I. Nasa, J. Duro, T. Kruse, B. Lopez-Mendez, B. Rymarczyk, L.E. Cressey, T. van Overeem Hansen et al., A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination. Nat. Commun. 12(1), 5748 (2021). https:\/\/doi.org\/10.1038\/s41467-021-26079-0","journal-title":"Nat. Commun."},{"key":"895_CR83","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.3389\/fgene.2019.01117","volume":"10","author":"M Aouida","year":"2019","unstructured":"M. Aouida, A. Eshrif, D. Ramotar, Yeast lacking the PP2A phosphatase regulatory subunit Rts1 sensitizes rad51 mutants to specific DNA damaging agents. Front. Genet. 10, 1117 (2019). https:\/\/doi.org\/10.3389\/fgene.2019.01117","journal-title":"Front. Genet."},{"issue":"24","key":"895_CR84","doi-asserted-by":"publisher","first-page":"6414","DOI":"10.1158\/0008-5472.CAN-12-1667","volume":"72","author":"P Kalev","year":"2012","unstructured":"P. Kalev, M. Simicek, I. Vazquez, S. Munck, L. Chen, T. Soin, N. Danda, W. Chen, A. Sablina, Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition. Can. Res. 72(24), 6414\u20136424 (2012). https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-1667","journal-title":"Can. Res."},{"issue":"16","key":"895_CR85","doi-asserted-by":"publisher","first-page":"4422","DOI":"10.1158\/1078-0432.CCR-13-0788","volume":"19","author":"D Wei","year":"2013","unstructured":"D. Wei, L.A. Parsels, D. Karnak, M.A. Davis, J.D. Parsels, A.C. Marsh, L. Zhao, J. Maybaum, T.S. Lawrence, Y. Sun et al., Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C\/CDK1 and homologous recombination repair. Clin. Cancer Res. 19(16), 4422\u20134432 (2013). https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-0788","journal-title":"Clin. Cancer Res."},{"key":"895_CR86","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1158\/1535-7163.mct-21-0880","volume":"22","author":"RA Avelar","year":"2023","unstructured":"R.A. Avelar, A.J. Armstrong, G. Carvette, R. Gupta, N. Puleo, J.A. Colina, P. Joseph, A.M. Sobeck, C.M. O\u2019Connor, B. Raines et al., Small-molecule-mediated stabilization of PP2A modulates the homologous recombination pathway and potentiates DNA damage-induced cell death. Mol. Cancer Ther. 22, 599\u2013615 (2023). https:\/\/doi.org\/10.1158\/1535-7163.mct-21-0880","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"895_CR87","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.molcel.2008.05.016","volume":"31","author":"D Chowdhury","year":"2008","unstructured":"D. Chowdhury, X. Xu, X. Zhong, F. Ahmed, J. Zhong, J. Liao, D.M. Dykxhoorn, D.M. Weinstock, G.P. Pfeifer, J. Lieberman, A PP4-phosphatase complex dephosphorylates \u03b3-H2AX generated during DNA replication. Mol. Cell 31(1), 33\u201346 (2008). https:\/\/doi.org\/10.1016\/j.molcel.2008.05.016","journal-title":"Mol. Cell"},{"issue":"3","key":"895_CR88","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nsmb.1769","volume":"17","author":"DH Lee","year":"2010","unstructured":"D.H. Lee, Y. Pan, S. Kanner, P. Sung, J.A. Borowiec, D. Chowdhury, A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat. Struct. Mol. Biol. 17(3), 365\u2013372 (2010). https:\/\/doi.org\/10.1038\/nsmb.1769","journal-title":"Nat. Struct. Mol. Biol."},{"key":"895_CR89","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1038\/emboj.2012.86","volume":"31","author":"DH Lee","year":"2012","unstructured":"D.H. Lee, A.A. Goodarzi, G.O. Adelmant, Y. Pan, P.A. Jeggo, J.A. Marto, D. Chowdhury, Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J. 31, 2403\u20132415 (2012). https:\/\/doi.org\/10.1038\/emboj.2012.86","journal-title":"EMBO J."},{"key":"895_CR90","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.molcel.2014.03.020","volume":"54","author":"DH Lee","year":"2014","unstructured":"D.H. Lee, S.S. Acharya, M. Kwon, P. Drane, Y. Guan, G. Adelmant, P. Kalev, J. Shah, D. Pellman, J.A. Marto et al., Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks. Mol. Cell 54, 512\u2013525 (2014). https:\/\/doi.org\/10.1016\/j.molcel.2014.03.020","journal-title":"Mol. Cell"},{"issue":"8","key":"895_CR91","doi-asserted-by":"publisher","first-page":"697","DOI":"10.14348\/molcells.2015.0066","volume":"38","author":"J Lee","year":"2015","unstructured":"J. Lee, G. Adelmant, J.A. Marto, D.H. Lee, Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions. Mol. Cells 38(8), 697\u2013704 (2015). https:\/\/doi.org\/10.14348\/molcells.2015.0066","journal-title":"Mol. Cells"},{"key":"895_CR92","doi-asserted-by":"publisher","first-page":"4252","DOI":"10.1038\/s41467-019-12084-x","volume":"10","author":"XF Zheng","year":"2019","unstructured":"X.F. Zheng, S.S. Acharya, K.N. Choe, K. Nikhil, G. Adelmant, S.R. Satapathy, S. Sharma, K. Viccaro, S. Rana, A. Natarajan et al., A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. Nat. Commun. 10, 4252 (2019). https:\/\/doi.org\/10.1038\/s41467-019-12084-x","journal-title":"Nat. Commun."},{"issue":"3","key":"895_CR93","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1080\/10409238.2019.1620676","volume":"54","author":"JJ Kim","year":"2019","unstructured":"J.J. Kim, S.Y. Lee, K.M. Miller, Preserving genome integrity and function: The DNA damage response and histone modifications. Crit. Rev. Biochem. Mol. Biol. 54(3), 208\u2013241 (2019). https:\/\/doi.org\/10.1080\/10409238.2019.1620676","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"895_CR94","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1007\/s10637-022-01216-8","volume":"40","author":"SN Waqar","year":"2022","unstructured":"S.N. Waqar, C. Robinson, A.J. Olszanski, A. Spira, M. Hackmaster, L. Lucas, L. Sponton, H. Jin, U. Hering, D. Cronier et al., Phase I trial of ATM inhibitor M3541 in combination with palliative radiotherapy in patients with solid tumors. Invest. New Drugs 40, 596\u2013605 (2022). https:\/\/doi.org\/10.1007\/s10637-022-01216-8","journal-title":"Invest. New Drugs"},{"key":"895_CR95","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.pharmthera.2014.12.001","volume":"149","author":"AM Weber","year":"2015","unstructured":"A.M. Weber, A.J. Ryan, ATM and ATR as therapeutic targets in cancer. Pharmacol. Ther. 149, 124\u2013138 (2015). https:\/\/doi.org\/10.1016\/j.pharmthera.2014.12.001","journal-title":"Pharmacol. Ther."},{"key":"895_CR96","doi-asserted-by":"publisher","first-page":"103874","DOI":"10.1016\/j.bioorg.2020.103874","volume":"100","author":"RL Arribas","year":"2020","unstructured":"R.L. Arribas, A. Bordas, J. Dom\u00e8nech Omella, J.L. Cedillo, V. Janssens, C. Montiel, C. de Los R\u00edos, An okadaic acid fragment analogue prevents nicotine-induced resistance to cisplatin by recovering PP2A activity in non-small cell lung cancer cells. Bioorg. Chem. 100, 103874 (2020). https:\/\/doi.org\/10.1016\/j.bioorg.2020.103874","journal-title":"Bioorg. Chem."},{"key":"895_CR97","doi-asserted-by":"publisher","first-page":"115245","DOI":"10.1016\/j.ejmech.2023.115245","volume":"251","author":"RL Arribas","year":"2023","unstructured":"R.L. Arribas, L. Viejo, I. Bravo, M. Mart\u00ednez, E. Ramos, A. Romero, E.M. Garc\u00eda-Frutos, V. Janssens, C. Montiel, C. de Los R\u00edos, C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer\u2019s disease targeting tauopathies. Eur. J. Med. Chem. 251, 115245 (2023). https:\/\/doi.org\/10.1016\/j.ejmech.2023.115245","journal-title":"Eur. J. Med. Chem."},{"issue":"D1","key":"895_CR98","doi-asserted-by":"publisher","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","volume":"50","author":"Y Perez-Riverol","year":"2022","unstructured":"Y. Perez-Riverol, J. Bai, C. Bandla, S. Hewapathirana, D. Garc\u00eda-Seisdedos, S. Kamatchinathan, D. Kundu, A. Prakash, A. Frericks-Zipper, M. Eisenacher, M. Walzer, S. Wang, A. Brazma, J.A. Vizca\u00edno, The PRIDE database resources in 2022: A Hub for mass spectrometry-based proteomics evidences. Nucleic Acids Res. 50(D1), D543\u2013D552 (2022). https:\/\/doi.org\/10.1093\/nar\/gkab1038","journal-title":"Nucleic Acids Res."}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00895-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-023-00895-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-023-00895-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:23:10Z","timestamp":1719922990000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-023-00895-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":98,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["895"],"URL":"https:\/\/doi.org\/10.1007\/s13402-023-00895-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.08.30.555468","asserted-by":"object"}]},"ISSN":["2211-3428","2211-3436"],"issn-type":[{"value":"2211-3428","type":"print"},{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,16]]},"assertion":[{"value":"23 October 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The HNSCC patient tissue sample study was approved by UZ\/KU Leuven Ethical committee (study approval: S54731).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"None of the authors have any competing interests to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}