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The protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Shanghai Jiao Tong University, the Animal Protocol number is RJ2022-1010. Ethical approval was obtained from the Research Ethics Committee of Renji Hospital, School of Medicine, Shanghai Jiao Tong University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors Dongxi Xiang, Jiaoduan Li, Lixin Jiang have submitted a patent (Application NO: 202310685260.6) related to this work. Dongxi Xiang is an editorial board member. Siyuan Shao is an employee of Shanghai OneTar Biomedicine.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}