{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:38:17Z","timestamp":1785328697178,"version":"3.55.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["ZR2023QH366"],"award-info":[{"award-number":["ZR2023QH366"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303959"],"award-info":[{"award-number":["82303959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970849"],"award-info":[{"award-number":["31970849"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s13402-024-00994-y","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T15:03:04Z","timestamp":1728313384000},"page":"2147-2162","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer"],"prefix":"10.1007","volume":"47","author":[{"given":"Xu-ru","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-he","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-tong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-qing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-jiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-ting","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-ya","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"issue":"5","key":"994_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3322\/caac.21565","volume":"69","author":"KD Miller","year":"2019","unstructured":"K.D. Miller, L. Nogueira, A.B. Mariotto et al., Cancer treatment and survivorship statistics, 2019. Cancer J. Clin. 69(5), 363\u2013385 (2019). https:\/\/doi.org\/10.3322\/caac.21565","journal-title":"Cancer J. Clin."},{"issue":"7","key":"994_CR2","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1002\/cncr.21778","volume":"106","author":"KR Hess","year":"2006","unstructured":"K.R. Hess, G.R. Varadhachary, S.H. Taylor et al., Metastatic patterns in adenocarcinoma. Cancer 106(7), 1624\u20131633 (2006). https:\/\/doi.org\/10.1002\/cncr.21778","journal-title":"Cancer"},{"issue":"7069","key":"994_CR3","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/nature04186","volume":"438","author":"RN Kaplan","year":"2005","unstructured":"R.N. Kaplan, R.D. Riba, S. Zacharoulis et al., VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438(7069), 820\u2013827 (2005). https:\/\/doi.org\/10.1038\/nature04186","journal-title":"Nature"},{"issue":"6","key":"994_CR4","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1158\/0008-5472.Can-14-1990","volume":"75","author":"Y Sharon","year":"2015","unstructured":"Y. Sharon, Y. Raz, N. Cohen et al., Tumor-derived osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast Cancer. Cancer Res. 75(6), 963\u2013973 (2015). https:\/\/doi.org\/10.1158\/0008-5472.Can-14-1990","journal-title":"Cancer Res."},{"key":"994_CR5","doi-asserted-by":"publisher","unstructured":"Y. Tang, Y. Lu, Y. Chen et al., Pre-metastatic niche triggers SDF-1\/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1. J. Experimental Clin. Cancer Res. 38(1) (2019). https:\/\/doi.org\/10.1186\/s13046-019-1475-6","DOI":"10.1186\/s13046-019-1475-6"},{"issue":"5","key":"994_CR6","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.ccell.2016.09.011","volume":"30","author":"Y Liu","year":"2016","unstructured":"Y. Liu, X. Cao, Characteristics and significance of the pre-metastatic niche. Cancer Cell. 30(5), 668\u2013681 (2016). https:\/\/doi.org\/10.1016\/j.ccell.2016.09.011","journal-title":"Cancer Cell."},{"key":"994_CR7","doi-asserted-by":"publisher","unstructured":"Z. Zeng, Y. Li, Y. Pan et al., Cancer-derived exosomal mir-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis. Nat. Commun. 9(1) (2018). https:\/\/doi.org\/10.1038\/s41467-018-07810-w","DOI":"10.1038\/s41467-018-07810-w"},{"key":"994_CR8","doi-asserted-by":"publisher","unstructured":"N. Leary, S. Walser, Y. He et al., Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes. J. Extracell. Vesicles. 11(2) (2022). https:\/\/doi.org\/10.1002\/jev2.12197","DOI":"10.1002\/jev2.12197"},{"issue":"6","key":"994_CR9","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.ccell.2016.10.009","volume":"30","author":"A Becker","year":"2016","unstructured":"A. Becker, B.K. Thakur, J.M. Weiss, H.S. Kim, H. Peinado, D. Lyden, Extracellular vesicles in Cancer: cell-to-cell mediators of Metastasis. Cancer Cell. 30(6), 836\u2013848 (2016). https:\/\/doi.org\/10.1016\/j.ccell.2016.10.009","journal-title":"Cancer Cell."},{"issue":"1","key":"994_CR10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s40425-018-0452-5","volume":"18","author":"ZF Wen","year":"2018","unstructured":"Z.F. Wen, H. Liu, R. Gao et al., Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1. J. Immunother Cancer 18(1), 151 (2018). https:\/\/doi.org\/10.1186\/s40425-018-0452-5","journal-title":"J. Immunother Cancer"},{"issue":"1","key":"994_CR11","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s40425-019-0646-5","volume":"12","author":"YQ Chen","year":"2019","unstructured":"Y.Q. Chen, P.C. Li, N. Pan et al., Tumor-released autophagosomes induces CD4(+) T cell-mediated immunosuppression via a TLR2-IL-6 cascade. J. Immunother Cancer. 12(1), 178 (2019). https:\/\/doi.org\/10.1186\/s40425-019-0646-5","journal-title":"J. Immunother Cancer"},{"key":"994_CR12","doi-asserted-by":"publisher","unstructured":"R. Gao, J. Ma, Z. Wen et al., Tumor cell-released autophagosomes (TRAP) enhance apoptosis and immunosuppressive functions of neutrophils. OncoImmunology. 7(6) (2018). https:\/\/doi.org\/10.1080\/2162402x.2018.1438108","DOI":"10.1080\/2162402x.2018.1438108"},{"issue":"10","key":"994_CR13","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1111\/cas.15507","volume":"113","author":"X Sun","year":"2022","unstructured":"X. Sun, X. Wang, C. Yan et al., Tumor cell-released LC3-positive EVs promote lung metastasis of breast cancer through enhancing premetastatic niche formation. Cancer Sci. 113(10), 3405\u20133416 (2022). https:\/\/doi.org\/10.1111\/cas.15507","journal-title":"Cancer Sci."},{"issue":"7","key":"994_CR14","doi-asserted-by":"publisher","first-page":"e1180485","DOI":"10.1080\/2162402X.2016.1180485","volume":"5","author":"M Zhou","year":"2016","unstructured":"M. Zhou, Z. Wen, F. Cheng et al., Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-kappaB signal pathway. Oncoimmunology 5(7), e1180485 (2016). https:\/\/doi.org\/10.1080\/2162402X.2016.1180485","journal-title":"Oncoimmunology"},{"issue":"15","key":"994_CR15","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.1158\/0008-5472.Can-21-0633","volume":"81","author":"N Cousin","year":"2021","unstructured":"N. Cousin, S. Cap, M. Dihr, C. Tacconi, M. Detmar, L.C. Dieterich, Lymphatic PD-L1 expression restricts tumor-specific CD8\u2009+\u2009T-cell responses. Cancer Res. 81(15), 4133\u20134144 (2021). https:\/\/doi.org\/10.1158\/0008-5472.Can-21-0633","journal-title":"Cancer Res."},{"issue":"18","key":"994_CR16","doi-asserted-by":"publisher","first-page":"4715","DOI":"10.1158\/0008-5472.Can-19-0053","volume":"79","author":"V Fleming","year":"2019","unstructured":"V. Fleming, X. Hu, C. Weller et al., Melanoma Extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signaling. Cancer Res. 79(18), 4715\u20134728 (2019). https:\/\/doi.org\/10.1158\/0008-5472.Can-19-0053","journal-title":"Cancer Res."},{"key":"994_CR17","doi-asserted-by":"publisher","unstructured":"I. Arkhypov, F.G. \u00d6zbay Kurt, R. Bitsch et al., HSP90\u03b1 induces immunosuppressive myeloid cells in melanoma via TLR4 signaling. J. Immunother. Cancer 10(9) (2022). https:\/\/doi.org\/10.1136\/jitc-2022-005551","DOI":"10.1136\/jitc-2022-005551"},{"issue":"12","key":"994_CR18","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1161\/circresaha.108.192880","volume":"104","author":"S-H Choi","year":"2009","unstructured":"S.-H. Choi, R. Harkewicz, J.H. Lee et al., Lipoprotein accumulation in macrophages via toll-like receptor-4\u2013dependent fluid phase uptake. Circul. Res. 104(12), 1355\u20131363 (2009). https:\/\/doi.org\/10.1161\/circresaha.108.192880","journal-title":"Circul. Res."},{"issue":"20","key":"994_CR19","doi-asserted-by":"publisher","first-page":"9083","DOI":"10.7150\/thno.46467","volume":"10","author":"H-J Liu","year":"2020","unstructured":"H.-J. Liu, Y. Qin, Z.-H. Zhao et al., Lentinan-functionalized selenium nanoparticles target tumor cell mitochondria via TLR4\/TRAF3\/MFN1 pathway. Theranostics. 10(20), 9083\u20139099 (2020). https:\/\/doi.org\/10.7150\/thno.46467","journal-title":"Theranostics"},{"key":"994_CR20","doi-asserted-by":"publisher","unstructured":"C.-H. Liu, Z.-H. Huang, S.-C. Huang, T.-S. Jou, Endocytosis of peroxiredoxin 1 links sterile inflammation to immunoparalysis in pediatric patients following cardiopulmonary bypass. Redox Biol. 46 (2021). https:\/\/doi.org\/10.1016\/j.redox.2021.102086","DOI":"10.1016\/j.redox.2021.102086"},{"issue":"11","key":"994_CR21","doi-asserted-by":"publisher","first-page":"6389","DOI":"10.1002\/ptr.7292","volume":"35","author":"M Tian","year":"2021","unstructured":"M. Tian, K. Chen, J. Huang et al., Asiatic acid inhibits angiogenesis and vascular permeability through the VEGF\/VEGFR2 signaling pathway to inhibit the growth and metastasis of breast cancer in mice. Phytother. Res. 35(11), 6389\u20136400 (2021). https:\/\/doi.org\/10.1002\/ptr.7292","journal-title":"Phytother. Res."},{"key":"994_CR22","doi-asserted-by":"publisher","unstructured":"E. Alsina-Sanchis, R. M\u00fclfarth, A. Fischer, Control of tumor progression by angiocrine factors. Cancers 13(11) (2021). https:\/\/doi.org\/10.3390\/cancers13112610","DOI":"10.3390\/cancers13112610"},{"key":"994_CR23","doi-asserted-by":"publisher","unstructured":"Y.-H. Wang, Y.-Y. Dong, W.-M. Wang et al., Vascular endothelial cells facilitated HCC invasion and metastasis through the akt and NF-\u03baB pathways induced by paracrine cytokines. J. Experimental Clin. Cancer Res. 32(1) (2013). https:\/\/doi.org\/10.1186\/1756-9966-32-51","DOI":"10.1186\/1756-9966-32-51"},{"key":"994_CR24","doi-asserted-by":"publisher","unstructured":"Z. Ma, K. Wei, F. Yang et al., Tumor-derived exosomal mir-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP\/KLF2 in non-small cell lung cancer. Cell Death Dis. 12(9) (2021). https:\/\/doi.org\/10.1038\/s41419-021-04037-4","DOI":"10.1038\/s41419-021-04037-4"},{"issue":"3","key":"994_CR25","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1111\/cas.14807","volume":"112","author":"Y Yokota","year":"2021","unstructured":"Y. Yokota, T. Noda, Y. Okumura et al., Serum exosomal miR-638 is a prognostic marker of HCC via downregulation of VE\u2010cadherin and ZO\u20101 of endothelial cells. Cancer Sci. 112(3), 1275\u20131288 (2021). https:\/\/doi.org\/10.1111\/cas.14807","journal-title":"Cancer Sci."},{"issue":"4","key":"994_CR26","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.gendis.2022.07.024","volume":"10","author":"S Kumar","year":"2023","unstructured":"S. Kumar, M. Chatterjee, P. Ghosh, K.K. Ganguly, M. Basu, M.K. Ghosh, Targeting PD-1\/PD-L1 in cancer immunotherapy: an effective strategy for treatment of triple-negative breast cancer (TNBC) patients. Genes Dis. 10(4), 1318\u20131350 (2023). https:\/\/doi.org\/10.1016\/j.gendis.2022.07.024","journal-title":"Genes Dis."},{"issue":"4","key":"994_CR27","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1158\/0008-5472.Can-11-1620","volume":"72","author":"S-R Woo","year":"2012","unstructured":"S.-R. Woo, M.E. Turnis, M.V. Goldberg et al., Immune Inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote Tumoral Immune escape. Cancer Res. 72(4), 917\u2013927 (2012). https:\/\/doi.org\/10.1158\/0008-5472.Can-11-1620","journal-title":"Cancer Res."},{"issue":"5","key":"994_CR28","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nrurol.2016.60","volume":"13","author":"P Sidaway","year":"2016","unstructured":"P. Sidaway, Atezolizumab effective against advanced-stage disease. Nat. Reviews Urol. 13(5), 238\u2013238 (2016). https:\/\/doi.org\/10.1038\/nrurol.2016.60","journal-title":"Nat. Reviews Urol."},{"issue":"22","key":"994_CR29","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1056\/NEJMoa1809615","volume":"379","author":"P Schmid","year":"2018","unstructured":"P. Schmid, S. Adams, H.S. Rugo et al., Atezolizumab and Nab-paclitaxel in advanced triple-negative breast cancer. N. Engl. J. Med. 379(22), 2108\u20132121 (2018). https:\/\/doi.org\/10.1056\/NEJMoa1809615","journal-title":"N. Engl. J. Med."},{"key":"994_CR30","doi-asserted-by":"publisher","unstructured":"S. Adams, J.R. Diamond, E. Hamilton et al., Atezolizumab Plus nab-Paclitaxel in the treatment of metastatic triple-negative breast Cancer with 2-Year Survival follow-up. JAMA Oncol. 5(3) (2019). https:\/\/doi.org\/10.1001\/jamaoncol.2018.5152","DOI":"10.1001\/jamaoncol.2018.5152"},{"issue":"5","key":"994_CR31","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1093\/cvr\/cvz026","volume":"115","author":"J-R Hu","year":"2019","unstructured":"J.-R. Hu, R. Florido, E.J. Lipson et al., Cardiovascular toxicities associated with immune checkpoint inhibitors. Cardiovascular. Res. 115(5), 854\u2013868 (2019). https:\/\/doi.org\/10.1093\/cvr\/cvz026","journal-title":"Cardiovascular. Res."},{"key":"994_CR32","doi-asserted-by":"publisher","unstructured":"D.B. Johnson, S. Chandra, J.A. Sosman, Immune checkpoint inhibitor toxicity in 2018. JAMA. 320(16) (2018). https:\/\/doi.org\/10.1001\/jama.2018.13995","DOI":"10.1001\/jama.2018.13995"},{"key":"994_CR33","doi-asserted-by":"publisher","unstructured":"N. Harbeck, H. Zhang, C.H. Barrios et al., LBA11 IMpassion031: results from a phase III study of neoadjuvant (neoadj) atezolizumab\u2009+\u2009chemotherapy in early triple-negative breast cancer (TNBC). Ann. Oncol. 31 (2020). https:\/\/doi.org\/10.1016\/j.annonc.2020.08.2239","DOI":"10.1016\/j.annonc.2020.08.2239"},{"issue":"8","key":"994_CR34","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.7150\/ijbs.73504","volume":"18","author":"H Dong","year":"2022","unstructured":"H. Dong, L. Zhang, S. Liu, Targeting HMGB1: an available therapeutic strategy for breast Cancer therapy. Int. J. Biol. Sci. 18(8), 3421\u20133434 (2022). https:\/\/doi.org\/10.7150\/ijbs.73504","journal-title":"Int. J. Biol. Sci."},{"issue":"7578","key":"994_CR35","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nature15756","volume":"527","author":"A Hoshino","year":"2015","unstructured":"A. Hoshino, B. Costa-Silva, T.-L. Shen et al., Tumour exosome integrins determine organotropic metastasis. Nature 527(7578), 329\u2013335 (2015). https:\/\/doi.org\/10.1038\/nature15756","journal-title":"Nature"}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-024-00994-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-024-00994-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-024-00994-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T21:18:17Z","timestamp":1736284697000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-024-00994-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["994"],"URL":"https:\/\/doi.org\/10.1007\/s13402-024-00994-y","relation":{},"ISSN":["2211-3428","2211-3436"],"issn-type":[{"value":"2211-3428","type":"print"},{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,7]]},"assertion":[{"value":"13 September 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Institutional Animal Care and Welfare Committee of Southeast University and strictly followed the animal welfare guidelines of the Institutional Animal Care and Welfare Committee of Southeast University (20210710068).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}