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Informed consents were obtained from all the subjects. Ethics approval for human subjects was provided by the Ethics Committee of Fudan University Shanghai Cancer Center. Ethics approval for animal work was provided by the Institutional Animal Care and Use Committee of Shanghai Cancer Center.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}