{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:00:25Z","timestamp":1774256425841,"version":"3.50.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"DOI":"10.1007\/s13402-026-01194-6","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:19:15Z","timestamp":1774253955000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35"],"prefix":"10.1007","volume":"49","author":[{"given":"Boxiang","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longyuchen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinyan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangyu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongke","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"1194_CR1","doi-asserted-by":"publisher","unstructured":"M.J. L\u00f3pez, J. Carbajal, A.L. Alfaro, L.G. Saravia, D. Zanabria, J.M. Araujo, L. Quispe, A. Zevallos, J.L. Buleje, C.E. Cho, M. Sarmiento, J.A. Pinto, W. Fajardo, Crit. Rev. Oncol. Hematol. 181, 103841 (2023). https:\/\/doi.org\/10.1016\/j.critrevonc.2022.103841","DOI":"10.1016\/j.critrevonc.2022.103841"},{"key":"1194_CR2","doi-asserted-by":"publisher","unstructured":"N.Y. Chia, P. Tan, Ann Oncol. 27, 763\u2013769 (2016). https:\/\/doi.org\/10.1093\/annonc\/mdw040","DOI":"10.1093\/annonc\/mdw040"},{"key":"1194_CR3","doi-asserted-by":"publisher","unstructured":"T. Yasuda, Y.A. Wang, Trends Cancer 10, 627\u2013642 (2024). https:\/\/doi.org\/10.1016\/j.trecan.2024.03.008","DOI":"10.1016\/j.trecan.2024.03.008"},{"key":"1194_CR4","doi-asserted-by":"publisher","unstructured":"X. Rao, C. Zhang, H. Luo, J. Zhang, Z. Zhuang, Z. Liang, X. Wu, Cells 11 (2022). https:\/\/doi.org\/10.3390\/cells11182828","DOI":"10.3390\/cells11182828"},{"key":"1194_CR5","doi-asserted-by":"publisher","unstructured":"Q. Yuan, D. Deng, C. Pan, J. Ren, T. Wei, Z. Wu, B. Zhang, S. Li, P. Yin, D. Shang, Front. Immunol. 13, 951137 (2022). https:\/\/doi.org\/10.3389\/fimmu.2022.951137","DOI":"10.3389\/fimmu.2022.951137"},{"key":"1194_CR6","doi-asserted-by":"publisher","unstructured":"J. Wang, T. Kunzke, V.M. Prade, J. Shen, A. Buck, A. Feuchtinger, I. Haffner, B. Luber, D.H.W. Liu, R. Langer, F. Lordick, N. Sun, A. Walch, Clin. Cancer Res. 28, 2865\u20132877 (2022). https:\/\/doi.org\/10.1158\/1078-0432.Ccr-21-4383","DOI":"10.1158\/1078-0432.Ccr-21-4383"},{"key":"1194_CR7","doi-asserted-by":"publisher","unstructured":"H.S. Han, G. Kang, J.S. Kim, B.H. Choi, S.H. Koo, Exp. Mol. Med. 48, e218 (2016). https:\/\/doi.org\/10.1038\/emm.2015.122","DOI":"10.1038\/emm.2015.122"},{"key":"1194_CR8","doi-asserted-by":"publisher","unstructured":"H. Li, C. Guglielmetti, Y.J. Sei, M. Zilberter, L.M. Le Page, L. Shields, J. Yang, K. Nguyen, B. Tiret, X. Gao, N. Bennett, I. Lo, T.L. Dayton, M. Kampmann, Y. Huang, J.C. Rathmell, M.V. Heiden, M.M. Chaumeil, K. Nakamura, Cell. Rep. 42, 112335 (2023). https:\/\/doi.org\/10.1016\/j.celrep.2023.112335","DOI":"10.1016\/j.celrep.2023.112335"},{"key":"1194_CR9","doi-asserted-by":"publisher","unstructured":"Y. Chen, B.C. Fry, A.T. Layton, Bull Math Biol. 78, 1318\u20131336 (2016). https:\/\/doi.org\/10.1007\/s11538-016-0188-7","DOI":"10.1007\/s11538-016-0188-7"},{"key":"1194_CR10","doi-asserted-by":"publisher","unstructured":"Z. Li, H. Zhang, Cell. Mol. Life Sci. 73, 377\u2013392 (2016). https:\/\/doi.org\/10.1007\/s00018-015-2070-4","DOI":"10.1007\/s00018-015-2070-4"},{"key":"1194_CR11","doi-asserted-by":"publisher","unstructured":"R.J. DeBerardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, C.B. Thompson, Proc. Natl. Acad. Sci. U. S. A. 104, 19345\u201319350 (2007). https:\/\/doi.org\/10.1073\/pnas.0709747104","DOI":"10.1073\/pnas.0709747104"},{"key":"1194_CR12","doi-asserted-by":"publisher","unstructured":"K.E. Wellen, C. Lu, A. Mancuso, J.M. Lemons, M. Ryczko, J.W. Dennis, J.D. Rabinowitz, H.A. Coller, C.B. Thompson, Genes Dev. 24, 2784\u20132799 (2010). https:\/\/doi.org\/10.1101\/gad.1985910","DOI":"10.1101\/gad.1985910"},{"key":"1194_CR13","doi-asserted-by":"publisher","unstructured":"D. Thomas, A.K. Rathinavel, P. Radhakrishnan, Biochim Biophys Acta Rev Cancer, 1875 188464 (2021). https:\/\/doi.org\/10.1016\/j.bbcan.2020.188464","DOI":"10.1016\/j.bbcan.2020.188464"},{"key":"1194_CR14","doi-asserted-by":"publisher","unstructured":"U. Kuliesiute, K. Joseph, J. Straehle, V.M. Ravi, J. Kueckelhaus, J.K. Benotmane, J. Zhang, A. Vlachos, J. Beck, O. Schnell, U. Neniskyte, D.H. Heiland, Neuro Oncol. 25, 1963\u20131975 (2023). https:\/\/doi.org\/10.1093\/neuonc\/noad101","DOI":"10.1093\/neuonc\/noad101"},{"key":"1194_CR15","doi-asserted-by":"publisher","unstructured":"L.Y. Chang, S.Y. Liang, S.C. Lu, H.C. Tseng, H.Y. Tsai, C.J. Tang, M. Sugata, Y.J. Chen, Y.J. Chen, S.J. Wu, K.I. Lin, K.H. Khoo, T. Angata, Front. Immunol. 13, 840388 (2022). https:\/\/doi.org\/10.3389\/fimmu.2022.840388","DOI":"10.3389\/fimmu.2022.840388"},{"key":"1194_CR16","doi-asserted-by":"publisher","unstructured":"M. Rossi, P. Altea-Manzano, M. Demicco, G. Doglioni, L. Bornes, M. Fukano, A. Vandekeere, A.M. Cuadros, J. Fern\u00e1ndez-Garc\u00eda, C. Riera-Domingo, C. Jauset, M. Planque, H.F. Alkan, D. Nittner, D. Zuo, L.A. Broadfield, S. Parik, A.A. Pane, F. Rizzollo, G. Rinaldi, T. Zhang, S.T. Teoh, A.B. Aurora, P. Karras, I. Vermeire, D. Broekaert, J.V. Elsen, M.M.L. Knott, M.F. Orth, S. Demeyer, G. Eelen, L.E. Dobrolecki, A. Bassez, T.V. Brussel, K. Sotlar, M.T. Lewis, H. Bartsch, M. Wuhrer, P.V. Veelen, P. Carmeliet et al., Nature 605, 747\u2013753 (2022). https:\/\/doi.org\/10.1038\/s41586-022-04758-2","DOI":"10.1038\/s41586-022-04758-2"},{"key":"1194_CR17","doi-asserted-by":"publisher","unstructured":"T. Chen, L. Zhao, S. Chen, B. Zheng, H. Chen, T. Zeng, H. Sun, S. Zhong, W. Wu, X. Lin, L. Wang, Food Chem. Toxicol. 137, 111131 (2020). https:\/\/doi.org\/10.1016\/j.fct.2020.111131","DOI":"10.1016\/j.fct.2020.111131"},{"key":"1194_CR18","doi-asserted-by":"publisher","unstructured":"L. Wang, C. Wang, Z. Tao, L. Zhao, Z. Zhu, W. Wu, Y. He, H. Chen, B. Zheng, X. Huang, Y. Yu, L. Yang, G. Liang, R. Cui, T. Chen, J. Exp. Clin. Cancer Res. 38, 460 (2019). https:\/\/doi.org\/10.1186\/s13046-019-1424-4","DOI":"10.1186\/s13046-019-1424-4"},{"key":"1194_CR19","doi-asserted-by":"publisher","unstructured":"L. Wang, Z. Zhu, L. Han, L. Zhao, J. Weng, H. Yang, S. Wu, K. Chen, L. Wu, T. Chen, Food Funct. 10, 3748\u20133757 (2019). https:\/\/doi.org\/10.1039\/c8fo02448k","DOI":"10.1039\/c8fo02448k"},{"key":"1194_CR20","unstructured":"J. Zhang, Z. Feng, C. Wang, H. Zhou, W. Liu, K. Kanchana, X. Dai, P. Zou, J. Gu, L. Cai, G. Liang, Am J Cancer Res. 7, 275\u2013288 (2017)"},{"key":"1194_CR21","doi-asserted-by":"publisher","unstructured":"X. Dai, J. Zhang, G. Guo, Y. Cai, R. Cui, C. Yin, W. Liu, R. Vinothkumar, T. Zhang, G. Liang, X. Zhang, Cancer Manag. Res. 10, 3069\u20133082 (2018). https:\/\/doi.org\/10.2147\/cmar.S159660","DOI":"10.2147\/cmar.S159660"},{"key":"1194_CR22","doi-asserted-by":"publisher","unstructured":"X. Zhang, M. Chen, P. Zou, K. Kanchana, Q. Weng, W. Chen, P. Zhong, J. Ji, H. Zhou, L. He, G. Liang, BMC Cancer 15, 866 (2015). https:\/\/doi.org\/10.1186\/s12885-015-1851-3","DOI":"10.1186\/s12885-015-1851-3"},{"key":"1194_CR23","doi-asserted-by":"publisher","unstructured":"M. Chen, B. Zhou, P. Zhong, V. Rajamanickam, X. Dai, K. Karvannan, H. Zhou, X. Zhang, G. Liang, Prostate 77, 489\u2013504 (2017). https:\/\/doi.org\/10.1002\/pros.23287","DOI":"10.1002\/pros.23287"},{"key":"1194_CR24","doi-asserted-by":"publisher","unstructured":"Z. Pang, Y. Lu, G. Zhou, F. Hui, L. Xu, C. Viau, A.F. Spigelman, P.E. MacDonald, D.S. Wishart, S. Li, J. Xia, Nucleic Acids Res. 52, W398\u2013w406 (2024). https:\/\/doi.org\/10.1093\/nar\/gkae253","DOI":"10.1093\/nar\/gkae253"},{"key":"1194_CR25","doi-asserted-by":"publisher","unstructured":"S. Jin, M.V. Plikus, Q. Nie, Nat Protoc 20, 180\u2013219 (2025). https:\/\/doi.org\/10.1038\/s41596-024-01045-4","DOI":"10.1038\/s41596-024-01045-4"},{"key":"1194_CR26","doi-asserted-by":"publisher","unstructured":"J. Braisted, A. Patt, C. Tindall, T. Sheils, J. Neyra, K. Spencer, T. Eicher, E.A. Math\u00e9, Bioinformatics 39 (2023). https:\/\/doi.org\/10.1093\/bioinformatics\/btac726","DOI":"10.1093\/bioinformatics\/btac726"},{"key":"1194_CR27","doi-asserted-by":"publisher","unstructured":"A. Frolkis, C. Knox, E. Lim, T. Jewison, V. Law, D.D. Hau, P. Liu, B. Gautam, S. Ly, A.C. Guo, J. Xia, Y. Liang, S. Shrivastava, D.S. Wishart, Nucleic Acids Res. 38, D480\u2013487 (2010). https:\/\/doi.org\/10.1093\/nar\/gkp1002","DOI":"10.1093\/nar\/gkp1002"},{"key":"1194_CR28","doi-asserted-by":"publisher","unstructured":"T. Jewison, Y. Su, F.M. Disfany, Y. Liang, C. Knox, A. Maciejewski, J. Poelzer, J. Huynh, Y. Zhou, D. Arndt, Y. Djoumbou, Y. Liu, L. Deng, A.C. Guo, B. Han, A. Pon, M. Wilson, S. Rafatnia, P. Liu, D.S. Wishart, Nucleic Acids Res. 42, D478\u2013484 (2014). https:\/\/doi.org\/10.1093\/nar\/gkt1067","DOI":"10.1093\/nar\/gkt1067"},{"key":"1194_CR29","doi-asserted-by":"publisher","unstructured":"A. Sathe, K. Mason, S.M. Grimes, Z. Zhou, B.T. Lau, X. Bai, A. Su, X. Tan, H. Lee, C.J. Suarez, Q. Nguyen, G. Poultsides, N.R. Zhang, H.P. Ji, Clin. Cancer Res. 29, 244\u2013260 (2023). https:\/\/doi.org\/10.1158\/1078-0432.Ccr-22-2041","DOI":"10.1158\/1078-0432.Ccr-22-2041"},{"key":"1194_CR30","doi-asserted-by":"publisher","unstructured":"S. Liu, Z. Zhang, Z. Wang, C. Liu, G. Liang, T. Xu, Z. Li, X. Duan, G. Xu, X. Feng, Q. Feng, Q. Wang, D. Han, C. Zhang, J. Li, L. Shen, Cancer Res. 86, 58\u201379 (2026). https:\/\/doi.org\/10.1158\/0008-5472.Can-24-4916","DOI":"10.1158\/0008-5472.Can-24-4916"},{"key":"1194_CR31","doi-asserted-by":"publisher","unstructured":"X. Liu, J. Qin, J. Nie, R. Gao, S. Hu, H. Sun, S. Wang, Y. Pan, Front. Immunol. 14, 1185208 (2023). https:\/\/doi.org\/10.3389\/fimmu.2023.1185208","DOI":"10.3389\/fimmu.2023.1185208"},{"key":"1194_CR32","doi-asserted-by":"publisher","unstructured":"S. Chen, Y. Liu, K. Zhang, L. Chen, Cancer Manag. Res. 13, 1901\u20131907 (2021). https:\/\/doi.org\/10.2147\/cmar.S277770","DOI":"10.2147\/cmar.S277770"},{"key":"1194_CR33","doi-asserted-by":"publisher","unstructured":"D. Li, Y. Wang, C. Dong, T. Chen, A. Dong, J. Ren, W. Li, G. Shu, J. Yang, W. Shen, L. Qin, L. Hu, J. Zhou, Oncogene 42, 83\u201398 (2023). https:\/\/doi.org\/10.1038\/s41388-022-02537-x","DOI":"10.1038\/s41388-022-02537-x"},{"key":"1194_CR34","doi-asserted-by":"publisher","unstructured":"K. Domanegg, J.P. Sleeman, A. Schmaus, Cancers (Basel) 14 (2022). https:\/\/doi.org\/10.3390\/cancers14205093","DOI":"10.3390\/cancers14205093"},{"key":"1194_CR35","doi-asserted-by":"publisher","unstructured":"B. Zhang, J. Li, Q. Hua, H. Wang, G. Xu, J. Chen, Y. Zhu, R. Li, Q. Liang, L. Wang, M. Jin, J. Tang, Z. Lin, L. Zhao, D. Zhang, D. Yu, J. Ren, T. Zhang, J. Immunother. Cancer. 11 (2023). https:\/\/doi.org\/10.1136\/jitc-2022-005592","DOI":"10.1136\/jitc-2022-005592"},{"key":"1194_CR36","doi-asserted-by":"publisher","unstructured":"M. AlHossiny, L. Luo, W.R. Frazier, N. Steiner, Y. Gusev, B. Kallakury, E. Glasgow, K. Creswell, S. Madhavan, R. Kumar, G. Upadhyay, Cancer Res. 76, 3376\u20133386 (2016). https:\/\/doi.org\/10.1158\/0008-5472.Can-15-2654","DOI":"10.1158\/0008-5472.Can-15-2654"},{"key":"1194_CR37","doi-asserted-by":"publisher","unstructured":"R.N. Sugiyanto, C. Metzger, A. Inal, F. Truckenmueller, K. G\u00fcr, E. Eiteneuer, T. Huth, A. Fraas, I. Heinze, J. Kirkpatrick, C. Sticht, T. Albrecht, B. Goeppert, T. Poth, S. Pusch, A. Mehrabi, P. Schirmacher, J. Ji, A. Ori, S. Roessler, Cell. Death Dis. 15, 780 (2024). https:\/\/doi.org\/10.1038\/s41419-024-07171-x","DOI":"10.1038\/s41419-024-07171-x"},{"key":"1194_CR38","doi-asserted-by":"publisher","unstructured":"T. Angata, A. Varki, Chem. Rev. 102, 439\u2013469 (2002). https:\/\/doi.org\/10.1021\/cr000407m","DOI":"10.1021\/cr000407m"},{"key":"1194_CR39","doi-asserted-by":"publisher","unstructured":"F. Filipsky, H. L\u00e4ubli, Carbohydr Res. 539, 109123 (2024). https:\/\/doi.org\/10.1016\/j.carres.2024.109123","DOI":"10.1016\/j.carres.2024.109123"},{"key":"1194_CR40","doi-asserted-by":"publisher","unstructured":"R. Schauer, J.P. Kamerling, Adv. Carbohydr. Chem. Biochem. 75, 1\u2013213 (2018). https:\/\/doi.org\/10.1016\/bs.accb.2018.09.001","DOI":"10.1016\/bs.accb.2018.09.001"},{"key":"1194_CR41","doi-asserted-by":"publisher","unstructured":"E.A. Visser, S.J. Moons, S. Timmermans, H. de Jong, T.J. Boltje, C. B\u00fcll, J. Biol. Chem. 297, 100906 (2021). https:\/\/doi.org\/10.1016\/j.jbc.2021.100906","DOI":"10.1016\/j.jbc.2021.100906"},{"key":"1194_CR42","doi-asserted-by":"publisher","unstructured":"H. L\u00e4ubli, S.C. Nalle, D. Maslyar, Cancer Immunol Res. 10, 1423\u20131432 (2022). https:\/\/doi.org\/10.1158\/2326-6066.Cir-22-0366","DOI":"10.1158\/2326-6066.Cir-22-0366"},{"key":"1194_CR43","doi-asserted-by":"publisher","unstructured":"B. Revilla-Nuin, L.B. Rodriguez-Aparicio, M.A. Ferrero, A. Reglero, FEBS Lett. 426, 191\u2013195 (1998). https:\/\/doi.org\/10.1016\/s0014-5793(98)00339-1","DOI":"10.1016\/s0014-5793(98)00339-1"},{"key":"1194_CR44","doi-asserted-by":"publisher","unstructured":"V. Kumar, K. Ramnarayanan, R. Sundar, N. Padmanabhan, S. Srivastava, M. Koiwa, T. Yasuda, V. Koh, K.K. Huang, S.T. Tay, S.W.T. Ho, A.L.K. Tan, T. Ishimoto, G. Kim, A. Shabbir, Q. Chen, B. Zhang, S. Xu, K.P. Lam, H.Y.J. Lum, M. Teh, W.P. Yong, J.B.Y. So P. Tan, Cancer Discov. 12, 670\u2013691 (2022). https:\/\/doi.org\/10.1158\/2159-8290.Cd-21-0683","DOI":"10.1158\/2159-8290.Cd-21-0683"},{"key":"1194_CR45","doi-asserted-by":"publisher","unstructured":"Y. Li, X. Hu, R. Lin, G. Zhou, L. Zhao, D. Zhao, Y. Zhang, W. Li, Y. Zhang, P. Ma, H. Ren, X. Liao, P. Niu, T. Wang, X. Zhang, W. Wang, R. Gao, Q. Li, G. Church, J. He Y. Chen, Theranostics 12, 3818\u20133833 (2022). https:\/\/doi.org\/10.7150\/thno.71833","DOI":"10.7150\/thno.71833"},{"key":"1194_CR46","doi-asserted-by":"publisher","unstructured":"K.N. Balogh, D.J. Templeton, J.V. Cross, PLoS One 13, e0197702 (2018). https:\/\/doi.org\/10.1371\/journal.pone.0197702","DOI":"10.1371\/journal.pone.0197702"},{"key":"1194_CR47","doi-asserted-by":"publisher","unstructured":"G. Huang, L. Ma, L. Shen, Y. Lei, L. Guo, Y. Deng, Y. Ding, J. Cell. Mol. Med. 26, 3410\u20133422 (2022). https:\/\/doi.org\/10.1111\/jcmm.17352","DOI":"10.1111\/jcmm.17352"},{"key":"1194_CR48","doi-asserted-by":"publisher","unstructured":"M. Chen, H. Liu, B. Hong, Y. Xiao, Y. Qian, Faseb J. 38, e23696 (2024). https:\/\/doi.org\/10.1096\/fj.202400578R","DOI":"10.1096\/fj.202400578R"},{"key":"1194_CR49","doi-asserted-by":"publisher","unstructured":"Z.F. Chen, Z.M. Huang, H.B. Xue, X.Q. Lin, R.P. Chen, M.J. Chen, R.F. Jin, Onco Targets Ther. 10, 2017\u20132023 (2017). https:\/\/doi.org\/10.2147\/ott.S131443","DOI":"10.2147\/ott.S131443"},{"key":"1194_CR50","doi-asserted-by":"publisher","unstructured":"T. Zheng, D. Zhang, Q. Fu, M. Wang, Z. Cheng, Y. Cao, L. Wang, J. Liu, Y. Zhao, Aging (Albany NY). 16, 12866\u201312892 (2024). https:\/\/doi.org\/10.18632\/aging.206115","DOI":"10.18632\/aging.206115"},{"key":"1194_CR51","doi-asserted-by":"publisher","unstructured":"S. Battista, M.R. Ambrosio, F. Limarzi, G. Gallo, L. Saragoni, Int J Mol Sci. 22 (2021). https:\/\/doi.org\/10.3390\/ijms22136652","DOI":"10.3390\/ijms22136652"},{"key":"1194_CR52","doi-asserted-by":"publisher","unstructured":"H. Jiang, H. Hu, X. Tong, Q. Jiang, H. Zhu, S. Zhang, J. Cancer Res. Clin. Oncol. 138, 1\u20139 (2012). https:\/\/doi.org\/10.1007\/s00432-011-1062-5","DOI":"10.1007\/s00432-011-1062-5"},{"key":"1194_CR53","doi-asserted-by":"publisher","unstructured":"R. Liang, Z.W. Ye, Z. Qin, Y. Xie, X. Yang, H. Sun, Q. Du, P. Luo, K. Tang, B. Hu, J. Cao, X.H. Wong, G.S. Ling, H. Chu, J. Shen, F. Yin, D.Y. Jin, J.F. Chan, K.Y. Yuen, S. Yuan, Nat Commun. 15, 2144 (2024). https:\/\/doi.org\/10.1038\/s41467-024-46415-4","DOI":"10.1038\/s41467-024-46415-4"},{"key":"1194_CR54","doi-asserted-by":"publisher","unstructured":"A. Berthe, M. Zaffino, C. Muller, F. Foulquier, M. Houdou, C. Schulz, F. Bost, E.D. Fay, S. Mazerbourg, S. Flament, Breast Cancer Res. Treat. 171, 581\u2013591 (2018). https:\/\/doi.org\/10.1007\/s10549-018-4874-z","DOI":"10.1007\/s10549-018-4874-z"},{"key":"1194_CR55","doi-asserted-by":"publisher","unstructured":"L. Araujo, P. Khim, H. Mkhikian, C.L. Mortales, M. Demetriou, Elife 6 (2017). https:\/\/doi.org\/10.7554\/eLife.21330","DOI":"10.7554\/eLife.21330"},{"key":"1194_CR56","doi-asserted-by":"publisher","unstructured":"Y. Lin, D.M. Lubman, Acta Pharm Sin B 14, 1098\u20131110 (2024). https:\/\/doi.org\/10.1016\/j.apsb.2023.10.014","DOI":"10.1016\/j.apsb.2023.10.014"},{"key":"1194_CR57","doi-asserted-by":"publisher","unstructured":"J. Zhu, Y. Ruan, X. Fu, L. Zhang, G. Ge, J.G. Wall, T. Zou, Y. Zheng, N. Ding, X. Hu, Front Bioeng Biotechnol. 8, 313 (2020). https:\/\/doi.org\/10.3389\/fbioe.2020.00313","DOI":"10.3389\/fbioe.2020.00313"},{"key":"1194_CR58","doi-asserted-by":"publisher","unstructured":"W.Y. Wang, Y.X. Cao, X. Zhou, B. Wei, L. Zhan, S.Y. Sun, Cancer Cell. Int. 19(86 (2019). https:\/\/doi.org\/10.1186\/s12935-019-0780-7","DOI":"10.1186\/s12935-019-0780-7"},{"key":"1194_CR59","doi-asserted-by":"publisher","unstructured":"Y. Luo, H. Cao, C. Lei, J. Liu, Genes Genomics 45, 1367\u20131376 (2023). https:\/\/doi.org\/10.1007\/s13258-023-01445-y","DOI":"10.1007\/s13258-023-01445-y"},{"key":"1194_CR60","doi-asserted-by":"publisher","unstructured":"M.S. Ahmad, M. Braoudaki, S.S. Siddiqui, PLoS One 19, e0311212 (2024). https:\/\/doi.org\/10.1371\/journal.pone.0311212","DOI":"10.1371\/journal.pone.0311212"},{"key":"1194_CR61","doi-asserted-by":"publisher","unstructured":"A. O\u2019Neill, N. Zakaria, C. Bull, H. Egan, S.M. Corry, N.A. Leonard, C. O\u2019Meara, L. Howard, A. Walsh, E. Reidy, J. Che, L. Peng, L. Cao, L.J. Egan, T. Ritter, M. Sheehan, A. Canney, K. Culligan, A.M. Hogan, S.O. Hynes, P.D. Dunne, M. O\u2019Dwyer, O. Treacy, A.E. Ryan, J. Immunother. Cancer. 13 (2025). https:\/\/doi.org\/10.1136\/jitc-2025-012491","DOI":"10.1136\/jitc-2025-012491"},{"key":"1194_CR62","doi-asserted-by":"publisher","unstructured":"X. Xu, J. Liu, W. Qin, C. Ding, Z. Cai, D. Shu, H. Zhong, Y. Hu, M. Yu, L. Zhou, J. Li, M. Zheng, B. Li, S. Zhang, X. Yang, B. Feng, Adv Sci (Weinh) 12, e06225 (2025). https:\/\/doi.org\/10.1002\/advs.202406225","DOI":"10.1002\/advs.202406225"},{"key":"1194_CR63","doi-asserted-by":"publisher","unstructured":"N.K. Dashzeveg, Y. Jia, Y. Zhang, L. Gerratana, P. Patel, A. Shajahan, T. Dandar, E.K. Ramos, H.F. Almubarak, V. Adorno-Cruz, R. Taftaf, E.J. Schuster, D. Scholten, M.T. Sokolowski, C. Reduzzi, L. El-Shennawy, A.D. Hoffmann, M. Manai, Q. Zhang, P. D\u2019Amico, P. Azadi, K.J. Colley, L.C. Platanias, A.N. Shah, W.J. Gradishar, M. Cristofanilli, W.A. Muller, B.A. Cobb, H. Liu, Cancer Discov. 13, 2050\u20132071 (2023). https:\/\/doi.org\/10.1158\/2159-8290.Cd-22-0644","DOI":"10.1158\/2159-8290.Cd-22-0644"},{"key":"1194_CR64","doi-asserted-by":"publisher","unstructured":"E. Kurz, S. Chen, E. Vucic, G. Baptiste, C. Loomis, P. Agrawal, C. Hajdu, D. Bar-Sagi, L.K. Mahal, Mol. Cell. Proteomics 20, 100160 (2021). https:\/\/doi.org\/10.1016\/j.mcpro.2021.100160","DOI":"10.1016\/j.mcpro.2021.100160"},{"key":"1194_CR65","doi-asserted-by":"publisher","unstructured":"S. Dalangood, Z. Zhu, Z. Ma, J. Li, Q. Zeng, Y. Yan, B. Shen, J. Yan, R. Huang, Theranostics 10, 10078\u201310091 (2020). https:\/\/doi.org\/10.7150\/thno.48711","DOI":"10.7150\/thno.48711"},{"key":"1194_CR66","doi-asserted-by":"publisher","unstructured":"J. Jiang, Y. Chen, Y. Zheng, Y. Ding, H. Wang, Q. Zhou, L. Teng, X. Zhang, Cancer Cell. Int. 25, 61 (2025). https:\/\/doi.org\/10.1186\/s12935-025-03695-0","DOI":"10.1186\/s12935-025-03695-0"},{"key":"1194_CR67","doi-asserted-by":"publisher","unstructured":"A. Gong, X. Zhao, Y. Pan, Y. Qi, S. Li, Y. Huang, Y. Guo, X. Qi, W. Zheng, L. Jia, J Cell. Sci. 133 (2020). https:\/\/doi.org\/10.1242\/jcs.244020","DOI":"10.1242\/jcs.244020"},{"key":"1194_CR68","doi-asserted-by":"publisher","unstructured":"X. Wu, J. Zhao, Y. Ruan, L. Sun, C. Xu, H. Jiang, Cell. Death Dis. 9, 1102 (2018). https:\/\/doi.org\/10.1038\/s41419-018-1101-0","DOI":"10.1038\/s41419-018-1101-0"},{"key":"1194_CR69","doi-asserted-by":"publisher","unstructured":"T.C. Fan, H.L. Yeo, T.H. Hung, N.C. Chang, Y.H. Tang, J. Yu, S.H. Chen, A.L. Yu, J. Biol. Chem. 301, 108368 (2025). https:\/\/doi.org\/10.1016\/j.jbc.2025.108368","DOI":"10.1016\/j.jbc.2025.108368"},{"key":"1194_CR70","doi-asserted-by":"publisher","unstructured":"J.C. Penticuff, B.L. Woolbright, T.M. Sielecki, S.J. Weir, T. J.A 3rd, Nat Rev Urol. 16, 318\u2013328 (2019). https:\/\/doi.org\/10.1038\/s41585-019-0171-9","DOI":"10.1038\/s41585-019-0171-9"},{"key":"1194_CR71","doi-asserted-by":"publisher","unstructured":"B. Liu, H. Shen, J. He, B. Jin, Y. Tian, W. Li, L. Hou, W. Zhao, J. Nan, J. Zhao, J. Shen, H. Yu, Y. Wang, G. Shan, L. Shi, X. Cai, Proc. Natl. Acad. Sci. U. S. A. 120, e2220296120 (2023). https:\/\/doi.org\/10.1073\/pnas.2220296120","DOI":"10.1073\/pnas.2220296120"},{"key":"1194_CR72","doi-asserted-by":"publisher","unstructured":"S.J. Moons, E. Rossing, M. Janssen, T. Heise, C. B\u00fcll, G.J. Adema, T.J. Boltje, ACS Chem. Biol. 17, 590\u2013597 (2022). https:\/\/doi.org\/10.1021\/acschembio.1c00868","DOI":"10.1021\/acschembio.1c00868"}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-026-01194-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-026-01194-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-026-01194-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:19:17Z","timestamp":1774253957000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-026-01194-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["1194"],"URL":"https:\/\/doi.org\/10.1007\/s13402-026-01194-6","relation":{},"ISSN":["2211-3436"],"issn-type":[{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"12 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study has been approved by Wenzhou Medical University Ethics Committee Review Committee(2019\u2013089)","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The study individuals gave written consent to the storage of their samples for future use in studies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"60"}}