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The Nanfang Hospital ethics committee at Southern Medical University (Guangzhou, China) permitted tissue sample utilization. All participants provided written informed consent. Animals: The First Affiliated Hospital ethics committee at Guangzhou Medical University (Guangzhou, China) approved all animal experiments. Experimental work was carried out according to the institutional guidelines and local legislation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"71"}}