{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:18:08Z","timestamp":1783556288475,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Youth Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China postdoctoral science foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Clinical Discipline, the Open Fund of Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"DOI":"10.1007\/s13402-026-01210-9","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:03:45Z","timestamp":1778731425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["USP10 confers lenvatinib resistance in hepatocellular carcinoma by deubiquitinating the GPX2"],"prefix":"10.1007","volume":"49","author":[{"given":"Cheng-Rui","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Le","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"issue":"1","key":"1210_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","volume":"73","author":"RL Siegel","year":"2023","unstructured":"R.L. Siegel, K.D. Miller, N.S. Wagle, A. Jemal, Cancer statistics, 2023. CA Cancer J. Clin. 73(1), 17\u201348 (2023). https:\/\/doi.org\/10.3322\/caac.21763","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"1210_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"H. Sung, J. Ferlay, R.L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, CA Cancer J. Clin. 71(3), 209\u2013249 (2021). https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"1210_CR3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","volume":"7","author":"JM Llovet","year":"2021","unstructured":"J.M. Llovet, R.K. Kelley, A. Villanueva, A.G. Singal, E. Pikarsky, S. Roayaie, R. Lencioni, K. Koike, J. Zucman-Rossi, R.S. Finn, Nat. Rev. Dis. Primers. 7(1), 6 (2021). https:\/\/doi.org\/10.1038\/s41572-020-00240-3","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"1210_CR4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"JM Llovet","year":"2008","unstructured":"J.M. Llovet, S. Ricci, V. Mazzaferro, P. Hilgard, E. Gane, J.F. Blanc, A.C. de Oliveira, A. Santoro, J.L. Raoul, A. Forner, M. Schwartz, C. Porta, S. Zeuzem, L. Bolondi, T.F. Greten, P.R. Galle, J.F. Seitz, I. Borbath, D. Haussinger, T. Giannaris, M. Shan, M. Moscovici, D. Voliotis, J. Bruix, S.I.S. Group, N Engl. J. Med. 359(4), 378\u2013390 (2008). https:\/\/doi.org\/10.1056\/NEJMoa0708857","journal-title":"N Engl. J. Med."},{"issue":"1","key":"1210_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S1470-2045(08)70285-7","volume":"10","author":"AL Cheng","year":"2009","unstructured":"A.L. Cheng, Y.K. Kang, Z. Chen, C.J. Tsao, S. Qin, J.S. Kim, R. Luo, J. Feng, S. Ye, T.S. Yang, J. Xu, Y. Sun, H. Liang, J. Liu, J. Wang, W.Y. Tak, H. Pan, K. Burock, J. Zou, D. Voliotis, Z. Guan, Lancet Oncol. 10(1), 25\u201334 (2009). https:\/\/doi.org\/10.1016\/S1470-2045(08)70285-7","journal-title":"Lancet Oncol."},{"issue":"2","key":"1210_CR6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s13402-024-01017-6","volume":"48","author":"Z Yang","year":"2025","unstructured":"Z. Yang, Y. Yuan, Y. Niu, D. Zuo, W. Liu, K. Li, Y. Shi, Z. Qiu, K. Li, Z. Lin, C. Zhong, Z. Huang, W. He, X. Guan, Y. Yuan, W. Zeng, J. Qiu, B. Li, Cell. Oncol. (Dordr). 48(2), 505\u2013522 (2025). https:\/\/doi.org\/10.1007\/s13402-024-01017-6","journal-title":"Cell. Oncol. (Dordr)"},{"key":"1210_CR7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.21037\/atm-20-5360","volume":"9","author":"Z Qiu","year":"2021","unstructured":"Z. Qiu, L. Shen, Y. Jiang, J. Qiu, Z. Xu, M. Shi, Z. Yu, Y. Ma, W. He, Y. Zheng, B. Li, G. Wang, Y. Yuan, Ann. Transl Med. 9, 4 (2021). https:\/\/doi.org\/10.21037\/atm-20-5360","journal-title":"Ann. Transl Med."},{"issue":"10126","key":"1210_CR8","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/S0140-6736(18)30207-1","volume":"391","author":"M Kudo","year":"2018","unstructured":"M. Kudo, R.S. Finn, S. Qin, K.H. Han, K. Ikeda, F. Piscaglia, A. Baron, J.W. Park, G. Han, J. Jassem, J.F. Blanc, A. Vogel, D. Komov, T.R.J. Evans, C. Lopez, C. Dutcus, M. Guo, K. Saito, S. Kraljevic, T. Tamai, M. Ren, A.L. Cheng, Lancet. 391(10126), 1163\u20131173 (2018). https:\/\/doi.org\/10.1016\/S0140-6736(18)30207-1","journal-title":"Lancet"},{"issue":"7869","key":"1210_CR9","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/s41586-021-03741-7","volume":"595","author":"H Jin","year":"2021","unstructured":"H. Jin, Y. Shi, Y. Lv, S. Yuan, C.F.A. Ramirez, C. Lieftink, L. Wang, S. Wang, C. Wang, M.H. Dias, F. Jochems, Y. Yang, A. Bosma, E.M. Hijmans, M.H.P. de Groot, S. Vegna, D. Cui, Y. Zhou, J. Ling, H. Wang, Y. Guo, X. Zheng, N. Isima, H. Wu, C. Sun, R.L. Beijersbergen, L. Akkari, W. Zhou, B. Zhai, W. Qin, R. Bernards, Nature. 595(7869), 730\u2013734 (2021). https:\/\/doi.org\/10.1038\/s41586-021-03741-7","journal-title":"Nature"},{"key":"1210_CR10","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41392-021-00594-4","volume":"6","author":"J Xu","year":"2021","unstructured":"J. Xu, L. Ji, Y. Ruan, Z. Wan, Z. Lin, S. Xia, L. Tao, J. Zheng, L. Cai, Y. Wang, X. Liang, X. Cai, Signal. Transduct. Target. Ther. 6, 190 (2021). https:\/\/doi.org\/10.1038\/s41392-021-00594-4","journal-title":"Signal. Transduct. Target. Ther."},{"key":"1210_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jare.2022.03.012","volume":"44","author":"W Tan","year":"2023","unstructured":"W. Tan, K. Zhang, X. Chen, L. Yang, S. Zhu, Y. Wei, Z. Xie, Y. Chen, C. Shang, J. Adv. Res. 44, 173\u2013183 (2023). https:\/\/doi.org\/10.1016\/j.jare.2022.03.012","journal-title":"J. Adv. Res."},{"key":"1210_CR12","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/s41419-020-2519-8","volume":"11","author":"C Hu","year":"2020","unstructured":"C. Hu, M. Zhang, N. Moses, C.L. Hu, L. Polin, W. Chen, H. Jang, J. Heyza, A. Malysa, J.A. Caruso, S. Xiang, S. Patrick, P. Stemmer, Z. Lou, W. Bai, C. Wang, G. Bepler, X.M. Zhang, Cell. Death Dis. 11, 328 (2020). https:\/\/doi.org\/10.1038\/s41419-020-2519-8","journal-title":"Cell. Death Dis."},{"key":"1210_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.canlet.2024.216712","volume":"587","author":"C Lin","year":"2024","unstructured":"C. Lin, P. Lin, H. Yao, S. Liu, X. Lin, R. He, Z. Teng, X. Zuo, Y. Li, J. Ye, G. Zhu, Cancer Lett. 587, 10 (2024). https:\/\/doi.org\/10.1016\/j.canlet.2024.216712","journal-title":"Cancer Lett."},{"key":"1210_CR14","doi-asserted-by":"publisher","unstructured":"Q.J. Li, X.L. Fang, Y.Q. Li, J.Y. Lin, C.L. Huang, S.W. He, S.Y. Huang, J.Y. Li, S. Gong, N. Liu, J. Ma, Y. Zhao, L.L. Tang, Adv. Sci. (Weinh). 11(36) (2024). https:\/\/doi.org\/10.1002\/advs.202403262. e2403262","DOI":"10.1002\/advs.202403262"},{"issue":"1","key":"1210_CR15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13046-025-03357-z","volume":"44","author":"X Liu","year":"2025","unstructured":"X. Liu, S. Zhang, Y. An, B. Xu, G. Yan, M. Sun, J. Exp. Clin. Cancer Res. 44(1), 94 (2025). https:\/\/doi.org\/10.1186\/s13046-025-03357-z","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"1210_CR16","doi-asserted-by":"publisher","first-page":"e1511","DOI":"10.1002\/ctm2.1511","volume":"13","author":"Z Qiu","year":"2023","unstructured":"Z. Qiu, C. Wang, P. Huang, Y. Yuan, Y. Shi, Z. Lin, Z. Huang, D. Zuo, J. Qiu, W. He, J. Shen, Y. Niu, Y. Yuan, B. Li, Clin. Transl Med. 13(12), e1511 (2023). https:\/\/doi.org\/10.1002\/ctm2.1511","journal-title":"Clin. Transl Med."},{"key":"1210_CR17","doi-asserted-by":"publisher","unstructured":"C. Zhong, Y. Niu, W. Liu, Y. Yuan, K. Li, Y. Shi, Z. Qiu, K. Li, Z. Lin, Z. Huang, D. Zuo, Z. Yang, Y. Liao, Y. Zhang, C. Wang, J. Qiu, W. He, Y. Yuan, B. Li, Adv. Sci. (Weinh). 9(30) (2022). https:\/\/doi.org\/10.1002\/advs.202202206. e2202206","DOI":"10.1002\/advs.202202206"},{"issue":"2","key":"1210_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41422-019-0257-1","volume":"30","author":"K Li","year":"2020","unstructured":"K. Li, J.L. Wu, B. Qin, Z. Fan, Q. Tang, W. Lu, H. Zhang, F. Xing, M. Meng, S. Zou, W. Wei, H. Chen, J. Cai, H. Wang, H. Zhang, J. Cai, L. Fang, X. Bian, C. Chen, P. Lan, B. Ghesquiere, L. Fang, M.H. Lee, Cell. Res. 30(2), 163\u2013178 (2020). https:\/\/doi.org\/10.1038\/s41422-019-0257-1","journal-title":"Cell. Res."},{"issue":"1","key":"1210_CR19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","volume":"5","author":"W Tang","year":"2020","unstructured":"W. Tang, Z. Chen, W. Zhang, Y. Cheng, B. Zhang, F. Wu, Q. Wang, S. Wang, D. Rong, F.P. Reiter, E.N. De Toni, X. Wang, Signal. Transduct. Target. Ther. 5(1), 87 (2020). https:\/\/doi.org\/10.1038\/s41392-020-0187-x","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"10","key":"1210_CR20","doi-asserted-by":"publisher","first-page":"e1452","DOI":"10.1002\/ctm2.1452","volume":"13","author":"W Guo","year":"2023","unstructured":"W. Guo, S. Li, Y. Qian, L. Li, F. Wang, Y. Tong, Q. Li, Z. Zhu, W.Q. Gao, Y. Liu, Clin. Transl Med. 13(10), e1452 (2023). https:\/\/doi.org\/10.1002\/ctm2.1452","journal-title":"Clin. Transl Med."},{"issue":"1","key":"1210_CR21","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1186\/s12967-024-05233-4","volume":"22","author":"J Gong","year":"2024","unstructured":"J. Gong, G. Han, Z. Chen, Y. Zhang, B. Xu, C. Xu, W. Gao, J. Wu, J. Transl Med. 22(1), 517 (2024). https:\/\/doi.org\/10.1186\/s12967-024-05233-4","journal-title":"J. Transl Med."},{"key":"1210_CR22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.bbrc.2021.02.097","volume":"549","author":"J Ao","year":"2021","unstructured":"J. Ao, T. Chiba, S. Shibata, A. Kurosugi, N. Qiang, Y. Ma, M. Kan, T. Iwanaga, T. Sakuma, H. Kanzaki, K. Kanayama, R. Kojima, Y. Kusakabe, M. Nakamura, T. Saito, R. Nakagawa, T. Kondo, S. Ogasawara, E. Suzuki, R. Muroyama, J. Kato, N. Mimura, T. Kanda, H. Maruyama, N. Kato, Biochem. Biophys. Res. Commun. 549, 171\u2013178 (2021). https:\/\/doi.org\/10.1016\/j.bbrc.2021.02.097","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"1210_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s12032-020-01350-4","volume":"37","author":"R Fu","year":"2020","unstructured":"R. Fu, S. Jiang, J. Li, H. Chen, X. Zhang, Med. Oncol. 37(4), 24 (2020). https:\/\/doi.org\/10.1007\/s12032-020-01350-4","journal-title":"Med. Oncol."},{"issue":"4","key":"1210_CR24","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41419-020-2413-4","volume":"11","author":"L Ji","year":"2020","unstructured":"L. Ji, Z. Lin, Z. Wan, S. Xia, S. Jiang, D. Cen, L. Cai, J. Xu, X. Cai, Cell. Death Dis. 11(4), 250 (2020). https:\/\/doi.org\/10.1038\/s41419-020-2413-4","journal-title":"Cell. Death Dis."},{"issue":"6","key":"1210_CR25","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s40265-019-01116-x","volume":"79","author":"ZT Al-Salama","year":"2019","unstructured":"Z.T. Al-Salama, Y.Y. Syed, L.J. Scott, Drugs. 79(6), 665\u2013674 (2019). https:\/\/doi.org\/10.1007\/s40265-019-01116-x","journal-title":"Drugs"},{"key":"1210_CR26","doi-asserted-by":"publisher","unstructured":"N. Kumari, S.C. Wright, C.M. Witham, L. Monserrat, M. Palafox, J.L. Richard, C. Costa, M. Elkabets, M. Agostino, T. Klemm, M. Eccles, A. Garnham, T. Wu, J.A. Nilsson, N. Walz, V. Venugopal, A. Cerra, N. Vasilevski, S. Bridgeman, S. Bassi, A. Saei, M. Helal, P. Neundorf, A. Riedel, M. Rosenfeldt, J. Gill, N. Pahor, O. Hartmann, J. Chung, S.S. Sidhu, N. Moderau, S. Jha, J. Rodon, M.E. Diefenbacher, D. Komander, V. Serra, P.J.A. Eichhorn, J. Clin. Invest. 135(22) (2025). https:\/\/doi.org\/10.1172\/JCI180927. e180927","DOI":"10.1172\/JCI180927"},{"issue":"19","key":"1210_CR27","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1158\/0008-5472.CAN-25-0301","volume":"85","author":"RZ Li","year":"2025","unstructured":"R.Z. Li, G.Q. Pan, C. Xiong, Z.N. Ding, T.S. Zhang, L.J. Yan, D. Wang, X. Zhang, X.F. Dong, Y.C. Yan, Y. Zhou, R. Dong, Z.R. Dong, T. Li, Cancer Res. 85(19), 3671\u20133688 (2025). https:\/\/doi.org\/10.1158\/0008-5472.CAN-25-0301","journal-title":"Cancer Res."},{"issue":"7","key":"1210_CR28","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41419-022-05022-1","volume":"13","author":"K Vishnoi","year":"2022","unstructured":"K. Vishnoi, R. Ke, N. Viswakarma, P. Srivastava, S. Kumar, S. Das, S.K. Singh, D.R. Principe, A. Rana, B. Rana, Cell. Death Dis. 13(7), 581 (2022). https:\/\/doi.org\/10.1038\/s41419-022-05022-1","journal-title":"Cell. Death Dis."},{"issue":"1","key":"1210_CR29","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41419-025-07764-0","volume":"16","author":"X Yang","year":"2025","unstructured":"X. Yang, L. Yu, M. Shao, H. Yang, K. Qi, G. He, L. Wang, D. Kong, J. Gu, X. Xu, L. Wang, Cell. Death Dis. 16(1), 458 (2025). https:\/\/doi.org\/10.1038\/s41419-025-07764-0","journal-title":"Cell. Death Dis."},{"issue":"22","key":"1210_CR30","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1038\/s41388-025-03337-9","volume":"44","author":"X Bai","year":"2025","unstructured":"X. Bai, T. Duan, J. Shao, Y. Zhang, G. Xing, J. Wang, X. Liu, M. Wang, Y. He, H. Wang, Z.Y. Zhang, M. Ni, J.Y. Zhou, J. Pan, Oncogene. 44(22), 1678\u20131693 (2025). https:\/\/doi.org\/10.1038\/s41388-025-03337-9","journal-title":"Oncogene"},{"issue":"1","key":"1210_CR31","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s12916-023-03066-4","volume":"21","author":"X Lu","year":"2023","unstructured":"X. Lu, R. Liu, Y. Liao, L. Cui, H. Sun, D. Zhang, B. Wang, L. Fang, X. Guan, Y. Yao, C. Liu, Y. Zhang, BMC Med. 21(1), 366 (2023). https:\/\/doi.org\/10.1186\/s12916-023-03066-4","journal-title":"BMC Med."}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-026-01210-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-026-01210-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-026-01210-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:55:09Z","timestamp":1783554909000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-026-01210-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["1210"],"URL":"https:\/\/doi.org\/10.1007\/s13402-026-01210-9","relation":{},"ISSN":["2211-3436"],"issn-type":[{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"16 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed according to the international, national and institutional rules considering animal experiments, clinical studies and biodiversity rights. All patients have signed an informed consent form and this part of the data has been submitted to the ethics committee to obtain an ethical approval number. The Institutional Review Board of the Sixth Affiliated Hospital of Sun Yat-Sen University approved this study. Approval number: L2023ZSLYEC. The animal study protocol was approved by Experimental Animal Ethics Committee, Sun Yat-Sen University Cancer Center, Guangzhou, China. Approval number: L102042023080H.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"91"}}