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All animal experiments were conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and the Chinese national guidelines for animal welfare, including the \"Guidance on the Humane Treatment of Laboratory Animals\". The study was approved by the Institutional Animal Care and Use Committee of Quanzhou Medical College (Approval No. 2024078). The genomic analyses included in this study also utilized existing, publicly available sequencing data from the GEO database. None of the utilized public datasets involved human or animal subjects, and an official ethics exemption statement has been reviewed and granted by the Ethics Committee of Quanzhou First Hospital accordingly.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The RNA-seq data from this study are available in the SRA database (\n                      \n                      ) with the BioProject ID PRJNA1081606. The Cut&Tag data from this study are available in the SRA database (\n                      \n                      ) with the BioProject ID PRJNA1308015. The data supporting the findings of this study are available from the corresponding author upon reasonable request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data access statement"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Registry and registration no. of the study\/trial"}},{"value":"N\/A.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}