{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:53Z","timestamp":1790776613401,"version":"4.1.0"},"reference-count":160,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"DOI":"10.1007\/s13402-026-01250-1","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:07:42Z","timestamp":1783084062000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural regulation of cancer: from synaptic integration to neuro-immune regulation"],"prefix":"10.1007","volume":"49","author":[{"given":"Xiaomeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-8370","authenticated-orcid":false,"given":"Yunyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1078-1819","authenticated-orcid":false,"given":"Shaoping","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"issue":"2","key":"1250_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.trecan.2024.11.011","volume":"11","author":"K. Ma","year":"2025","unstructured":"K. Ma, L. Wang, W. Li, T. Tang, B. Ma, L. Zhang, L. Zhang, Turning cold into hot: emerging strategies to fire up the tumor microenvironment. Trends Cancer 11(2), 117\u2013134 (2025). https:\/\/doi.org\/10.1016\/j.trecan.2024.11.011.","journal-title":"Trends Cancer"},{"issue":"8","key":"1250_CR2","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/s41568-025-00831-w","volume":"25","author":"M. Amit","year":"2025","unstructured":"M. Amit, T. Eichwald, A. Roger, J. Anderson, A. Chang, P.D. Vermeer, K.O. Dixon, N.N. Scheff, S. Talbot, Neuro-immune cross-talk in cancer. Nat. Rev. Cancer 25(8), 573\u2013589 (2025). https:\/\/doi.org\/10.1038\/s41568-025-00831-w.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1250_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41392-025-02241-8","volume":"10","author":"T. Pu","year":"2025","unstructured":"T. Pu, J. Sun, G. Ren, H. Li, Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications. Sig. Transduct. Target. Ther. 10(1), 176 (2025). https:\/\/doi.org\/10.1038\/s41392-025-02241-8.","journal-title":"Sig Transduct Target Ther."},{"issue":"1","key":"1250_CR4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12943-025-02246-5","volume":"24","author":"Y. Zhang","year":"2025","unstructured":"Y. Zhang, Q. Liao, X. Wen, J. Fan, T. Yuan, X. Tong, R. Jia, P. Chai, X. Fan, Hijacking of the nervous system in cancer: mechanism and therapeutic targets. Mol. Cancer 24(1), 44 (2025). https:\/\/doi.org\/10.1186\/s12943-025-02246-5.","journal-title":"Mol Cancer"},{"issue":"7997","key":"1250_CR5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/d41586-024-00240-3","volume":"626","author":"M. Prillaman","year":"2024","unstructured":"M. Prillaman, How cancer hijacks the nervous system to grow and spread. Nature 626(7997), 22\u201324 (2024). https:\/\/doi.org\/10.1038\/d41586-024-00240-3.","journal-title":"Nature"},{"issue":"7775","key":"1250_CR6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/s41586-019-1563-y","volume":"573","author":"H.S. Venkatesh","year":"2019","unstructured":"H.S. Venkatesh, W. Morishita, A.C. Geraghty, D. Silverbush, S.M. Gillespie, M. Arzt, L.T. Tam, C. Espenel, A. Ponnuswami, L. Ni, P.J. Woo, K.R. Taylor, A. Agarwal, A. Regev, D. Brang, H. Vogel, S. Hervey-Jumper, D.E. Bergles, M.L. Suv\u00e0, R.C. Malenka, M. Monje, Electrical and synaptic integration of glioma into neural circuits. Nature 573(7775), 539\u2013545 (2019). https:\/\/doi.org\/10.1038\/s41586-019-1563-y.","journal-title":"Nature"},{"issue":"7775","key":"1250_CR7","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/s41586-019-1564-x","volume":"573","author":"V. Venkataramani","year":"2019","unstructured":"V. Venkataramani, D.I. Tanev, C. Strahle, A. Studier-Fischer, L. Fankhauser, T. Kessler, C. K\u00f6rber, M. Kardorff, M. Ratliff, R. Xie, H. Horstmann, M. Messer, S.P. Paik, J. Knabbe, F. Sahm, F.T. Kurz, A.A. Acikg\u00f6z, F. Herrmannsd\u00f6rfer, A. Agarwal, D.E. Bergles, A. Chalmers, H. Miletic, S. Turcan, C. Mawrin, D. H\u00e4nggi, H.-K. Liu, W. Wick, F. Winkler, T. Kuner, Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature 573(7775), 532\u2013538 (2019). https:\/\/doi.org\/10.1038\/s41586-019-1564-x.","journal-title":"Nature"},{"issue":"8061","key":"1250_CR8","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/s41586-025-08634-7","volume":"641","author":"Y. Sun","year":"2025","unstructured":"Y. Sun, X. Wang, D.Y. Zhang, Z. Zhang, J.P. Bhattarai, Y. Wang, K.H. Park, W. Dong, Y.-F. Hung, Q. Yang, F. Zhang, K. Rajamani, S. Mu, B.C. Kennedy, Y. Hong, J. Galanaugh, A. Sambangi, S.H. Kim, G. Wheeler, T. Gon\u00e7alves, Q. Wang, D.H. Geschwind, R. Kawaguchi, A.N. Viaene, I. Helbig, S.K. Kessler, A. Hoke, H. Wang, F. Xu, Z.A. Binder, H. Isaac Chen, E.-L.-L. Pai, S. Stone, M.P. Nasrallah, K.M. Christian, M. Fuccillo, N. Toni, Z. Wu, H.-J. Cheng, D.M. O\u2019Rourke et al., Brain-wide neuronal circuit connectome of human glioblastoma. Nature 641(8061), 222\u2013231 (2025). https:\/\/doi.org\/10.1038\/s41586-025-08634-7.","journal-title":"Nature"},{"issue":"11","key":"1250_CR9","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1016\/j.ccell.2025.07.024","volume":"43","author":"Y. Yang","year":"2025","unstructured":"Y. Yang, C. Yang, X. Chen, Y. Jiang, X. Lei, K. Ma, Y. Quan, T. Li, C. Guo, Y. Meng, L. Kang, X. Zhang, L. Jin, J. Huang, N. Mu, Z. Yan, Q. Ma, S. Wang, Y. Wang, Y.-N. Shang, C. Chen, Y. Shi, S. Hu, L. Yang, C. Lan, R. Hu, Y. Zhang, X. Li, Y. Li, C. Liu, Y.-H. Wang, F. Li, H. Feng, X.-W. Bian, T. Chen, Long-range cholinergic input promotes glioblastoma progression. Cancer Cell. 43(11), 2089\u20132105.e10 (2025). https:\/\/doi.org\/10.1016\/j.ccell.2025.07.024.","journal-title":"Cancer Cell."},{"issue":"12","key":"1250_CR10","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1016\/j.ccell.2025.09.003","volume":"43","author":"L. Ren","year":"2025","unstructured":"L. Ren, C. Liu, K. \u00c7ifciba\u015f\u0131, M. Ballmann, G. Rammes, C. Mota Reyes, S. Tokalov, A. Klingl, J. Gr\u00fcnert, K. Goyal, P.H. Neckel, U. Mattheus, B. Schoeps, S.E. Y\u0131ld\u0131zhan, O.U. Sezerman, N.C. Cevik, E.A. Sever, D. Karakas, O. Safak, K. Steiger, A. Muckenhuber, K. G\u00f6rg\u00fcl\u00fc, Z. Chen, J. Zhang, L. Ye, M.I. Maula Ali, V.K. Tiwari, N. Romanyuk, F. Giesert, D. Saur, R. Rad, R.M. Schmid, H. Alg\u00fcl, A. Kr\u00fcger, H. Friess, G.O. Ceyhan, R. Istvanffy, I.E. Demir, Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses. Cancer Cell. 43(12), 2241\u20132258.e8 (2025). https:\/\/doi.org\/10.1016\/j.ccell.2025.09.003.","journal-title":"Cancer Cell."},{"issue":"7775","key":"1250_CR11","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41586-019-1576-6","volume":"573","author":"Q. Zeng","year":"2019","unstructured":"Q. Zeng, I.P. Michael, P. Zhang, S. Saghafinia, G. Knott, W. Jiao, B.D. McCabe, J.A. Galv\u00e1n, H.P.C. Robinson, I. Zlobec, G. Ciriello, D. Hanahan, Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature 573(7775), 526\u2013531 (2019). https:\/\/doi.org\/10.1038\/s41586-019-1576-6.","journal-title":"Nature"},{"issue":"8087","key":"1250_CR12","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/s41586-025-09492-z","volume":"646","author":"S. Savchuk","year":"2025","unstructured":"S. Savchuk, K.M. Gentry, W. Wang, E. Carleton, C.A.O. Biagi-Junior, K. Luthria, B. Yal\u00e7\u0131n, L. Ni, H.C. Farnsworth, R.A. Davis, R. Drexler, J.C. Melms, Y. Liu, L. Acosta-Alvarez, G.G. Hartmann, E.C. Pavarino, J. LaBelle, P.J. Woo, A.M. Toland, F. Qu, Y.S. Kim, M.G. Filbin, M.A. Krasnow, K.L. Ligon, B. Izar, J. Sage, B.L. Sabatini, M. Monje, H.S. Venkatesh, Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis. Nature 646(8087), 1232\u20131242 (2025). https:\/\/doi.org\/10.1038\/s41586-025-09492-z.","journal-title":"Nature"},{"issue":"8087","key":"1250_CR13","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/s41586-025-09434-9","volume":"646","author":"V. Sakthivelu","year":"2025","unstructured":"V. Sakthivelu, A. Schmitt, F. Odenthal, K. Ndoci, M. Touet, A.H. Shaib, A. Chihab, G.A. Wani, P. Nieper, G.G. Hartmann, I. Pintelon, I. Kisis, M. Boecker, N.M. Eckert, M. Iannicelli Caiaffa, O. Ibruli, J. Weber, R. Maresch, C.M. Bebber, A. Chitsaz, A. L\u00fctz, M. Kim Alves Carpinteiro, K.M. Morris, C.A. Franchino, J. Benz, L. P\u00e9rez-Revuelta, J.A. Soriano-Campos, M.A. Huetzen, J. Goergens, M. Jevtic, H.M. Jahn-Kelleter, H. Zempel, A. Placzek, A.A. Hennrich, K.-K. Conzelmann, H.L. Tumbrink, P. Hunold, J. Isensee, L. Werr, F. Gaedke et al., Functional synapses between neurons and small cell lung cancer. Nature 646(8087), 1243\u20131253 (2025). https:\/\/doi.org\/10.1038\/s41586-025-09434-9.","journal-title":"Nature"},{"issue":"3","key":"1250_CR14","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/ph18030384","volume":"18","author":"D.P. Radin","year":"2025","unstructured":"D.P. Radin, AMPA receptor modulation in the treatment of high-grade glioma: translating Good Science into Better outcomes. Pharmaceuticals (Basel) 18(3), 384 (2025). https:\/\/doi.org\/10.3390\/ph18030384.","journal-title":"Pharmaceuticals (Basel)"},{"issue":"19","key":"1250_CR15","doi-asserted-by":"publisher","first-page":"9463","DOI":"10.1158\/0008-5472.CAN-07-2034","volume":"67","author":"S.A. Lyons","year":"2007","unstructured":"S.A. Lyons, W.J. Chung, A.K. Weaver, T. Ogunrinu, H. Sontheimer, Autocrine glutamate signaling promotes glioma cell invasion. Cancer Res. 67(19), 9463\u20139471 (2007). https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-2034.","journal-title":"Cancer Res."},{"issue":"5","key":"1250_CR16","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.devcel.2024.01.010","volume":"59","author":"K. Ishibashi","year":"2024","unstructured":"K. Ishibashi, T. Ichinose, R. Kadokawa, R. Mizutani, S. Iwabuchi, S. Togi, H. Ura, S. Tange, K. Shinjo, J. Nakayama, S. Nanjo, Y. Niida, Y. Kondo, S. Hashimoto, E. Sahai, S. Yano, M. Nakada, E. Hirata, Astrocyte-induced mGlur1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR. Dev. Cell. 59(5), 579\u2013594.e6 (2024). https:\/\/doi.org\/10.1016\/j.devcel.2024.01.010.","journal-title":"Dev. Cell."},{"issue":"4","key":"1250_CR17","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.trecan.2025.01.003","volume":"11","author":"A.A. Martel Matos","year":"2025","unstructured":"A.A. Martel Matos, N.N. Scheff, Sensory neurotransmission and pain in solid tumor progression. Trends Cancer 11(4), 309\u2013320 (2025). https:\/\/doi.org\/10.1016\/j.trecan.2025.01.003.","journal-title":"Trends Cancer"},{"key":"1250_CR18","doi-asserted-by":"publisher","unstructured":"N. Dalavaikodihalli Nanjaiah, P. Ramaswamy, P08.11 NMDA receptor activation differentially expresses NMDA and AMPA subtypes of glutamate receptors and mediate migration and invasion of glioma. Neuro-Oncology 19(suppl_3), iii56\u2013iii56 (2017). https:\/\/doi.org\/10.1093\/neuonc\/nox036.201.","DOI":"10.1093\/neuonc\/nox036.201"},{"issue":"2","key":"1250_CR19","doi-asserted-by":"publisher","first-page":"101388","DOI":"10.1016\/j.xcrm.2023.101388","volume":"5","author":"J. Wang","year":"2024","unstructured":"J. Wang, J. Wei, T. Pu, A. Zeng, V. Karthikeyan, B. Bechtold, K. Vo, J. Chen, T.-P. Lin, A.P. Chang, E. Corey, M. Puhr, H. Klocker, Z. Culig, T. Bland, B.J. Wu, Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer. Cell. Rep. Med. 5(2), 101388 (2024). https:\/\/doi.org\/10.1016\/j.xcrm.2023.101388.","journal-title":"Cell. Rep. Med."},{"issue":"9","key":"1250_CR20","doi-asserted-by":"publisher","first-page":"101042831879902","DOI":"10.1177\/1010428318799028","volume":"40","author":"P.H. Nguyen","year":"2018","unstructured":"P.H. Nguyen, Y. Touchefeu, T. Durand, P. Aubert, E. Duchalais, S. Bruley Des Varannes, C. Varon, M. Neunlist, T. Matysiak-Budnik, Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type. Tumour Biol. 40(9), 1010428318799028 (2018). https:\/\/doi.org\/10.1177\/1010428318799028.","journal-title":"Tumour Biol."},{"key":"1250_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.suronc.2019.09.003","volume":"31","author":"J. Chen","year":"2019","unstructured":"J. Chen, I.W.Y. Cheuk, V.Y. Shin, A. Kwong, Acetylcholine receptors: key players in cancer development. Surg. Oncol. 31, 46\u201353 (2019). https:\/\/doi.org\/10.1016\/j.suronc.2019.09.003.","journal-title":"Surg Oncol."},{"issue":"8","key":"1250_CR22","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1158\/0008-5472.CAN-25-3092","volume":"86","author":"F. Liao","year":"2026","unstructured":"F. Liao, Y. Tong, H. Sun, S. Chen, S. Wen, Y.-E. Du, L. Jiang, T. Huang, M. Liu, W. Chen, L. Yang, Nerves stimulate cross-talk between gastric cancer and group 3 innate lymphoid cells to enhance immunosuppression. Cancer Res. 86(8), 1968\u20131986 (2026). https:\/\/doi.org\/10.1158\/0008-5472.CAN-25-3092.","journal-title":"Cancer Res."},{"issue":"1","key":"1250_CR23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s12943-025-02441-4","volume":"24","author":"C. Zhang","year":"2025","unstructured":"C. Zhang, X. Guo, Y. Wang, S. Zhang, Z. Wang, The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets. Mol. Cancer 24(1), 231 (2025). https:\/\/doi.org\/10.1186\/s12943-025-02441-4.","journal-title":"Mol Cancer"},{"issue":"7","key":"1250_CR24","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.7150\/ijbs.79583","volume":"19","author":"Y. Guan","year":"2023","unstructured":"Y. Guan, W. Yao, H. Yu, Y. Feng, Y. Zhao, X. Zhan, Y. Wang, Chronic stress promotes colorectal cancer progression by enhancing glycolysis through \u03b22-AR\/CREB1 signal pathway. Int. J. Biol. Sci. 19(7), 2006\u20132020 (2023). https:\/\/doi.org\/10.7150\/ijbs.79583.","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"1250_CR25","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1186\/s12964-024-01747-y","volume":"22","author":"J. Lu","year":"2024","unstructured":"J. Lu, X. Zhang, K. Su, H. Luo, C. Liu, Y. Yang, B. He, C. Wang, Z. Zhao, X. Liu, X. Wang, P. Meng, D. Lv, C. Wang, K.W. Kelley, L. Wang, B. Cui, Q. Liu, F. Peng, Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress. Cell. Commun. Signal. 22(1), 375 (2024). https:\/\/doi.org\/10.1186\/s12964-024-01747-y.","journal-title":"Cell. Commun. Signal."},{"key":"1250_CR26","doi-asserted-by":"publisher","unstructured":"H.D. Reavis, S.M. Gysler, G.B. McKenney, M. Knarr, H.J. Lusk, P. Rawat, H.S. Rendulich, M.A. Mitchell, D.S. Berger, J.S. Moon, S. Ryu, M. Mainigi, M.P. Iwanicki, D.S. Hoon, L.M. Sanchez, R. Drapkin, Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells. JCI Insight 9(5. 2024). https:\/\/doi.org\/10.1172\/jci.insight.170961.","DOI":"10.1172\/jci.insight.170961"},{"issue":"26","key":"1250_CR27","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1038\/onc.2014.270","volume":"34","author":"M.J. Choi","year":"2015","unstructured":"M.J. Choi, K.H. Cho, S. Lee, Y.J. Bae, K.J. Jeong, S.Y. Rha, E.J. Choi, J.H. Park, J.M. Kim, J.-S. Lee, G.B. Mills, H.Y. Lee, hTERT mediates norepinephrine-induced slug expression and ovarian cancer aggressiveness. Oncogene 34(26), 3402\u20133412 (2015). https:\/\/doi.org\/10.1038\/onc.2014.270.","journal-title":"Oncogene"},{"issue":"1","key":"1250_CR28","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12935-022-02678-9","volume":"22","author":"M. Taheri","year":"2022","unstructured":"M. Taheri, S. Ghafouri-Fard, S. Najafi, J. Kallenbach, E. Keramatfar, G. Atri Roozbahani, M. Heidari Horestani, B.M. Hussen, A. Baniahmad, Hormonal regulation of telomerase activity and hTERT expression in steroid-regulated tissues and cancer. Cancer Cell. Int. 22(1), 258 (2022). https:\/\/doi.org\/10.1186\/s12935-022-02678-9.","journal-title":"Cancer Cell. Int."},{"issue":"2","key":"1250_CR29","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3892\/ijo.2015.3038","volume":"47","author":"A. Barbieri","year":"2015","unstructured":"A. Barbieri, S. Bimonte, G. Palma, A. Luciano, D. Rea, A. Giudice, G. Scognamiglio, E. La Mantia, R. Franco, S. Perdon\u00e0, O. De Cobelli, M. Ferro, S. Zappavigna, P. Stiuso, M. Caraglia, C. Arra, The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo. Int. J. Oncol. 47(2), 527\u2013534 (2015). https:\/\/doi.org\/10.3892\/ijo.2015.3038.","journal-title":"Int J Oncol."},{"issue":"11","key":"1250_CR30","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/s41419-019-2030-2","volume":"10","author":"X. Zhang","year":"2019","unstructured":"X. Zhang, Y. Zhang, Z. He, K. Yin, B. Li, L. Zhang, Z. Xu, Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2. Cell. Death Dis. 10(11), 788 (2019). https:\/\/doi.org\/10.1038\/s41419-019-2030-2.","journal-title":"Cell. Death Dis."},{"issue":"10","key":"1250_CR31","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/cac2.12198","volume":"41","author":"C. Pan","year":"2021","unstructured":"C. Pan, J. Wu, S. Zheng, H. Sun, Y. Fang, Z. Huang, M. Shi, L. Liang, J. Bin, Y. Liao, J. Chen, W. Liao, Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine\/\u03b2 2 -AR\/MACC1 axis. Cancer Commun. (Lond) 41(10), 1049\u20131070 (2021). https:\/\/doi.org\/10.1002\/cac2.12198.","journal-title":"Cancer Commun (Lond)"},{"issue":"1","key":"1250_CR32","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1186\/s12967-025-06657-2","volume":"23","author":"C. Sun","year":"2025","unstructured":"C. Sun, Y. Shen, F. Wang, T. Lu, J. Zhang, Sympathetic nervous system in tumor progression and metabolic regulation: mechanisms and clinical potential. J. Transl. Med. 23(1), 836 (2025). https:\/\/doi.org\/10.1186\/s12967-025-06657-2.","journal-title":"J Transl Med."},{"key":"1250_CR33","doi-asserted-by":"publisher","first-page":"116985","DOI":"10.1016\/j.biopha.2024.116985","volume":"177","author":"J. Zhang","year":"2024","unstructured":"J. Zhang, F. Teng, T. Wu, S. Li, K. Li, Quercetin inhibits chronic stress-mediated progression of triple-negative breast cancer by blocking \u03b22-AR\/ERK1\/2 pathway. Biomed. Pharmacother. 177, 116985 (2024). https:\/\/doi.org\/10.1016\/j.biopha.2024.116985.","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"1250_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10555-025-10241-x","volume":"44","author":"A. Sattler","year":"2025","unstructured":"A. Sattler, T. Korzun, K. Gupta, P. Diba, N. Kyprianou, S.E. Eksi, Sympathetic nerve signaling rewires the tumor microenvironment: a shift in \u201cmicroenvironmental-ity\u201d. Cancer Metastasis Rev. 44(1), 25 (2025). https:\/\/doi.org\/10.1007\/s10555-025-10241-x.","journal-title":"Cancer Metastasis Rev."},{"issue":"1","key":"1250_CR35","doi-asserted-by":"publisher","first-page":"7094","DOI":"10.1038\/s41467-025-62299-4","volume":"16","author":"H. Haidar","year":"2025","unstructured":"H. Haidar, A. Bellon, K. Sleiman, M. Hocine, N. Rama, N. Gadot, D.R. Carpizo, P. Mehlen, F. Mann, Neural function of Netrin-1 in precancerous lesions of the pancreas. Nat. Commun. 16(1), 7094 (2025). https:\/\/doi.org\/10.1038\/s41467-025-62299-4.","journal-title":"Nat Commun."},{"key":"1250_CR36","doi-asserted-by":"publisher","first-page":"1635331","DOI":"10.3389\/fimmu.2025.1635331","volume":"16","author":"F. Zhang","year":"2025","unstructured":"F. Zhang, Y. Wang, F. Liu, Y. Li, X. Liu, X. Ren, X. Yuan, Impact of beta blockers on cancer neuroimmunology: a systematic review and meta-analysis of survival outcomes and immune modulation. Front Immunol. 16, 1635331 (2025). https:\/\/doi.org\/10.3389\/fimmu.2025.1635331.","journal-title":"Front Immunol."},{"key":"1250_CR37","doi-asserted-by":"publisher","first-page":"104587","DOI":"10.1016\/j.phrs.2019.104587","volume":"151","author":"C. Fumagalli","year":"2020","unstructured":"C. Fumagalli, N. Maurizi, N. Marchionni, D. Fornasari, \u03b2-blockers: their new life from hypertension to cancer and migraine. Pharmacol. Res. 151, 104587 (2020). https:\/\/doi.org\/10.1016\/j.phrs.2019.104587.","journal-title":"Pharmacol. Res."},{"key":"1250_CR38","doi-asserted-by":"publisher","first-page":"122191","DOI":"10.1016\/j.lfs.2023.122191","volume":"334","author":"K. Luo","year":"2023","unstructured":"K. Luo, X. Zhao, Y. Shan, X. Wang, Y. Xu, M. Chen, Q. Wang, Y. Song, GABA regulates the proliferation and apoptosis of head and neck squamous cell carcinoma cells by promoting the expression of CCND2 and BCL2L1. Life Sci. 334, 122191 (2023). https:\/\/doi.org\/10.1016\/j.lfs.2023.122191.","journal-title":"Life Sci."},{"issue":"20","key":"1250_CR39","doi-asserted-by":"publisher","first-page":"9704","DOI":"10.1158\/0008-5472.CAN-07-2099","volume":"67","author":"A. Takehara","year":"2007","unstructured":"A. Takehara, M. Hosokawa, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Nakamura, H. Nakagawa, \u03b3-Aminobutyric Acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor \u03c0 subunit. Cancer Res. 67(20), 9704\u20139712 (2007). https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-2099.","journal-title":"Cancer Res."},{"issue":"6","key":"1250_CR40","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1084\/jem.178.6.2219","volume":"178","author":"P. De Camilli","year":"1993","unstructured":"P. De Camilli, A. Thomas, R. Cofiell, F. Folli, B. Lichte, G. Piccolo, H.M. Meinck, M. Austoni, G. Fassetta, G. Bottazzo, The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of stiff-man syndrome with breast cancer. J. Exp. Med. 178(6), 2219\u20132223 (1993). https:\/\/doi.org\/10.1084\/jem.178.6.2219.","journal-title":"J. Exp. Med."},{"issue":"3","key":"1250_CR41","first-page":"377","volume":"7","author":"M. Matuszek","year":"2001","unstructured":"M. Matuszek, M. Jesipowicz, Z. Kleinrok, GABA content and GAD activity in gastric cancer. Med. Sci. Monit. 7(3), 377\u2013381 (2001).","journal-title":"Med Sci Monit."},{"issue":"7","key":"1250_CR42","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.devcel.2024.12.007","volume":"60","author":"L. Li","year":"2025","unstructured":"L. Li, Y. Kang, R. Cheng, F. Liu, F. Wu, Z. Liu, J. Kou, Z. Zhang, W. Li, H. Zhao, X. He, W. Du, The de novo synthesis of GABA and its gene regulatory function control hepatocellular carcinoma metastasis. Dev. Cell. 60(7), 1053\u20131069.e (2025). https:\/\/doi.org\/10.1016\/j.devcel.2024.12.007.","journal-title":"Dev. Cell."},{"issue":"1","key":"1250_CR43","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13046-025-03315-9","volume":"44","author":"M. Xie","year":"2025","unstructured":"M. Xie, H. Qin, L. Liu, J. Wu, Z. Zhao, Y. Zhao, Y. Fang, X. Yu, C. Su, GABA regulates metabolic reprogramming to mediate the development of brain metastasis in non-small cell lung cancer. J. Exp. Clin. Cancer Res. 44(1), 61 (2025). https:\/\/doi.org\/10.1186\/s13046-025-03315-9.","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"18","key":"1250_CR44","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.3390\/cancers16183167","volume":"16","author":"D. Bhattacharya","year":"2024","unstructured":"D. Bhattacharya, R. Barrile, D.K. Toukam, V.S. Gawali, L. Kallay, T. Ahmed, H. Brown, S. Rezvanian, A. Karve, P.B. Desai, M. Medvedovic, K. Wang, D. Ionascu, N. Harun, S. Vallabhapurapu, C. Wang, X. Qi, A.M. Baschnagel, J.A. Kritzer, J.M. Cook, D.A. Pomeranz Krummel, S. Sengupta, GABA(A) receptor activation drives GABARAP\u2013Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors. Cancers (Basel) 16(18), 3167 (2024). https:\/\/doi.org\/10.3390\/cancers16183167.","journal-title":"Cancers (Basel)"},{"issue":"8056","key":"1250_CR45","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1038\/s41586-024-08579-3","volume":"639","author":"T. Barron","year":"2025","unstructured":"T. Barron, B. Yal\u00e7\u0131n, M. Su, Y.G. Byun, A. Gavish, K. Shamardani, H. Xu, L. Ni, N. Soni, V. Mehta, S. Maleki Jahan, Y.S. Kim, K.R. Taylor, M.B. Keough, M.A. Quezada, A.C. Geraghty, R. Mancusi, L.T. Vo, E.H. Casta\u00f1eda, P.J. Woo, C.K. Petritsch, H. Vogel, K. Kaila, M. Monje, Gabaergic neuron-to-glioma synapses in diffuse midline gliomas. Nature 639(8056), 1060\u20131068 (2025). https:\/\/doi.org\/10.1038\/s41586-024-08579-3.","journal-title":"Nature"},{"issue":"1","key":"1250_CR46","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1046\/j.1460-9568.1998.00036.x","volume":"10","author":"C. Labrakakis","year":"1998","unstructured":"C. Labrakakis, S. Patt, J. Hartmann, H. Kettenmann, Functional GABA a receptors on human glioma cells. Eur. J. Neurosci. 10(1), 231\u2013238 (1998). https:\/\/doi.org\/10.1046\/j.1460-9568.1998.00036.x.","journal-title":"Eur J Neurosci."},{"issue":"1","key":"1250_CR47","doi-asserted-by":"publisher","first-page":"33695","DOI":"10.1038\/s41598-025-18894-y","volume":"15","author":"M. Khodaei","year":"2025","unstructured":"M. Khodaei, N. Hosseinmardi, M. Sirati-Sabet, S. Sahranavard, M.R. Shahmohammadi, S. Salami, Distinctive GABA a receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer. Sci. Rep. 15(1), 33695 (2025). https:\/\/doi.org\/10.1038\/s41598-025-18894-y.","journal-title":"Sci Rep."},{"key":"1250_CR48","doi-asserted-by":"publisher","first-page":"819688","DOI":"10.3389\/fonc.2022.819688","volume":"12","author":"J. Wang","year":"2022","unstructured":"J. Wang, W. Liu, W. Xu, B. Yang, M. Cui, Z. Li, H. Zhang, C. Jin, H. Xue, J. Zhang, Comprehensive analysis of the oncogenic, genomic alteration, and immunological landscape of cation-Chloride cotransporters in Pan-cancer. Front. Oncol. 12, 819688 (2022). https:\/\/doi.org\/10.3389\/fonc.2022.819688.","journal-title":"Front. Oncol."},{"issue":"22","key":"1250_CR49","doi-asserted-by":"publisher","first-page":"5447","DOI":"10.1523\/JNEUROSCI.2164-16.2017","volume":"37","author":"R. Wright","year":"2017","unstructured":"R. Wright, S.E. Newey, A. Ilie, W. Wefelmeyer, J.V. Raimondo, R. Ginham, R.A.J. Mcllhinney, C.J. Akerman, Neuronal Chloride regulation via KCC2 is Modulated through a GABA B receptor protein complex. J. Neurosci. 37(22), 5447\u20135462 (2017). https:\/\/doi.org\/10.1523\/JNEUROSCI.2164-16.2017.","journal-title":"J Neurosci."},{"key":"1250_CR50","doi-asserted-by":"publisher","first-page":"114410","DOI":"10.1016\/j.biopha.2023.114410","volume":"161","author":"Y. Yang","year":"2023","unstructured":"Y. Yang, L. Ren, W. Li, Y. Zhang, S. Zhang, B. Ge, H. Yang, G. Du, B. Tang, H. Wang, J. Wang, Gabaergic signaling as a potential therapeutic target in cancers. Biomed. Pharmacother. 161, 114410 (2023). https:\/\/doi.org\/10.1016\/j.biopha.2023.114410.","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"1250_CR51","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1756-9966-30-97","volume":"30","author":"D. Guo","year":"2011","unstructured":"D. Guo, X. Hou, H. Zhang, W. Sun, L. Zhu, J. Liang, X. Jiang, More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells. J. Exp. Clin. Cancer Res. 30(1), 97 (2011). https:\/\/doi.org\/10.1186\/1756-9966-30-97.","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"1250_CR52","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","volume":"31","author":"Y. Hayakawa","year":"2017","unstructured":"Y. Hayakawa, K. Sakitani, M. Konishi, S. Asfaha, R. Niikura, H. Tomita, B.W. Renz, Y. Tailor, M. Macchini, M. Middelhoff, Z. Jiang, T. Tanaka, Z.A. Dubeykovskaya, W. Kim, X. Chen, A.M. Urbanska, K. Nagar, C.B. Westphalen, M. Quante, C.-S. Lin, M.D. Gershon, A. Hara, C.-M. Zhao, D. Chen, D.L. Worthley, K. Koike, T.C. Wang, Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling. Cancer Cell. 31(1), 21\u201334 (2017). https:\/\/doi.org\/10.1016\/j.ccell.2016.11.005.","journal-title":"Cancer Cell."},{"issue":"24","key":"1250_CR53","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.3390\/cancers16244260","volume":"16","author":"I. Garajov\u00e1","year":"2024","unstructured":"I. Garajov\u00e1, E. Giovannetti, Targeting perineural invasion in pancreatic cancer. Cancers (Basel) 16(24), 4260 (2024). https:\/\/doi.org\/10.3390\/cancers16244260.","journal-title":"Cancers (Basel)"},{"issue":"9","key":"1250_CR54","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.2174\/0115680096317840240723071018","volume":"25","author":"J. Xu","year":"2025","unstructured":"J. Xu, S. Lou, H. Huang, J. Xu, F. Luo, Regulation and crosstalk of cells and factors in the pancreatic cancer microenvironment. CCDT 25(9), 1029\u20131048 (2025). https:\/\/doi.org\/10.2174\/0115680096317840240723071018.","journal-title":"CCDT"},{"issue":"1","key":"1250_CR55","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13046-021-02198-w","volume":"41","author":"W. Zhang","year":"2022","unstructured":"W. Zhang, R. He, W. Yang, Y. Zhang, Q. Yuan, J. Wang, Y. Liu, S. Chen, S. Zhang, W. Zhang, Z. Zhu, J. Zhang, Z. Wang, J. Li, Autophagic Schwann cells promote perineural invasion mediated by the NGF\/ATG7 paracrine pathway in pancreatic cancer. J. Exp. Clin. Cancer Res. 41(1), 48 (2022). https:\/\/doi.org\/10.1186\/s13046-021-02198-w.","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"1250_CR56","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13046-022-02314-4","volume":"41","author":"S. Trouvilliez","year":"2022","unstructured":"S. Trouvilliez, J. Cicero, R. L\u00e9v\u00eaque, L. Aubert, C. Corbet, A. Van Outryve, K. Streule, P.-O. Angrand, P. V\u00f6lkel, R. Magnez, G. Brysbaert, C. Mysiorek, F. Gosselet, R. Bourette, E. Adriaenssens, X. Thuru, C. Lagadec, J. de Ruyck, V. Orian-Rousseau, X. Le Bourhis, R.-A. Toillon, Direct interaction of TrkA\/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells. J. Exp. Clin. Cancer Res. 41(1), 110 (2022). https:\/\/doi.org\/10.1186\/s13046-022-02314-4.","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"20","key":"1250_CR57","doi-asserted-by":"publisher","first-page":"7657","DOI":"10.3390\/ijms21207657","volume":"21","author":"M.P. Garrido","year":"2020","unstructured":"M.P. Garrido, I. Torres, A. Avila, J. Chnaiderman, M. Valenzuela-Valderrama, J. Aramburo, L. Or\u00f3stica, E. Dur\u00e1n-Jara, L. Lobos-Gonzalez, C. Romero, NGF\/TRKA decrease miR-145-5p levels in epithelial ovarian cancer cells. IJMS 21(20), 7657 (2020). https:\/\/doi.org\/10.3390\/ijms21207657.","journal-title":"IJMS"},{"issue":"4","key":"1250_CR58","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.cell.2026.01.001","volume":"189","author":"S.W. Zhang","year":"2026","unstructured":"S.W. Zhang, H. Wang, Y. Xiao, L.-T. Liu, M. Shen, Z. Wang, S. Zhao, X.-H. Ding, Y. Wang, Q.-Y. Zhuang, J. Ni, Z.-M. Shao, Y.-Z. Jiang, Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment. Cell 189(4), 1039\u20131055.e (2026). https:\/\/doi.org\/10.1016\/j.cell.2026.01.001.","journal-title":"Cell"},{"issue":"2","key":"1250_CR59","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/labinvest.3780414","volume":"82","author":"G.-J. Kim","year":"2002","unstructured":"G.-J. Kim, C.J. Kim, S.Y. Cho, I.P. Chung, S.-H. Park, M.J. Lee, J.G. Chi, Activation of trkA induces differentiation and inhibits the growth of JK-GMS Askin tumor cells. Lab. Invest. 82(2), 221\u2013229 (2002). https:\/\/doi.org\/10.1038\/labinvest.3780414.","journal-title":"Lab. Invest."},{"issue":"21","key":"1250_CR60","doi-asserted-by":"publisher","first-page":"5293","DOI":"10.3390\/cancers13215293","volume":"13","author":"L. Funke","year":"2021","unstructured":"L. Funke, T. Bracht, S. Oeck, K. Schork, M. Stepath, S. Dreesmann, M. Eisenacher, B. Sitek, A. Schramm, NTRK1\/TrkA signaling in neuroblastoma cells induces Nuclear reorganization and intra-Nuclear aggregation of lamin A\/C. Cancers 13(21), 5293 (2021). https:\/\/doi.org\/10.3390\/cancers13215293.","journal-title":"Cancers"},{"issue":"1","key":"1250_CR61","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3390\/cancers3010510","volume":"3","author":"N.H. Molloy","year":"2011","unstructured":"N.H. Molloy, D.E. Read, A.M. Gorman, Nerve growth factor in cancer cell death and survival. cancers (Basel). 3(1), 510\u2013530 (2011). https:\/\/doi.org\/10.3390\/cancers3010510.","journal-title":"Cancers"},{"issue":"7935","key":"1250_CR62","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/s41586-022-05374-w","volume":"611","author":"M. Balood","year":"2022","unstructured":"M. Balood, M. Ahmadi, T. Eichwald, A. Ahmadi, A. Majdoubi, K. Roversi, K. Roversi, C.T. Lucido, A.C. Restaino, S. Huang, L. Ji, K.-C. Huang, E. Semerena, S.C. Thomas, A.E. Trevino, H. Merrison, A. Parrin, B. Doyle, D.W. Vermeer, W.C. Spanos, C.S. Williamson, C.R. Seehus, S.L. Foster, H. Dai, C.J. Shu, M. Rangachari, J. Thibodeau, S. V. Del Rincon, R. Drapkin, M. Rafei, N. Ghasemlou, P.D. Vermeer, C.J. Woolf, S. Talbot, Nociceptor neurons affect cancer immunosurveillance. Nature 611(7935), 405\u2013412 (2022). https:\/\/doi.org\/10.1038\/s41586-022-05374-w.","journal-title":"Nature"},{"key":"1250_CR63","doi-asserted-by":"publisher","unstructured":"T. Eichwald, M. Ahmadi, A.M. Matos, A.R. Nikpoor, K. Roversi, M. Balood, F. Obuekwe, M.L. Nilsen, A.T. Ruffin, G. Pinheiro, L. Brabenec, M. Rafei, P. Vermeer, T.C. Bruno, N.N. Scheff, S. Talbot, Opioid-expressing B cells silence tumor-infiltrating nociceptor neurons. Res. Sq. (2025). https:\/\/doi.org\/10.21203\/rs.3.rs-7389517\/v1.","DOI":"10.21203\/rs.3.rs-7389517\/v1"},{"issue":"8059","key":"1250_CR64","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/s41586-025-08591-1","volume":"640","author":"X. Zhi","year":"2025","unstructured":"X. Zhi, F. Wu, J. Qian, Y. Ochiai, G. Lian, E. Malagola, B. Zheng, R. Tu, Y. Zeng, H. Kobayashi, Z. Xia, R. Wang, Y. Peng, Q. Shi, D. Chen, S.W. Ryeom, T.C. Wang, Nociceptive neurons promote gastric tumour progression via a CGRP\u2013RAMP1 axis. Nature 640(8059), 802\u2013810 (2025). https:\/\/doi.org\/10.1038\/s41586-025-08591-1.","journal-title":"Nature"},{"issue":"2","key":"1250_CR65","doi-asserted-by":"publisher","first-page":"116994","DOI":"10.1016\/j.celrep.2026.116994","volume":"45","author":"L.A. McIlvried","year":"2026","unstructured":"L.A. McIlvried, A.A.M. Matos, R.S. Krane, K.T. Eskew, T. LeGrande, M.A. Atherton, M.A. Ottley, M.L. Nilsen, D. Bell, M. Ahmadi, A.R. Nikpoor, S. Talbot, N.N. Scheff, CGRP signaling links tumor-associated pain to immune evasion in oral squamous cell carcinoma. Cell. Rep. 45(2), 116994 (2026). https:\/\/doi.org\/10.1016\/j.celrep.2026.116994.","journal-title":"Cell. Rep."},{"key":"1250_CR66","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/B978-0-443-22194-1.00001-X","volume-title":"Substance P","author":"E. Aslam","year":"2025","unstructured":"E. Aslam, A. Gijasi, C. Perner et al., Chapter 26 - immunobiology and pharmacology of neuropeptide substance P, in Substance P, ed. by R. Vink (Academic Press, 2025), pp. 625\u2013660."},{"issue":"8028","key":"1250_CR67","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41586-024-07767-5","volume":"633","author":"V. Padmanaban","year":"2024","unstructured":"V. Padmanaban, I. Keller, E.S. Seltzer, B.N. Ostendorf, Z. Kerner, S.F. Tavazoie, Neuronal substance P drives metastasis through an extracellular RNA\u2013TLR7 axis. Nature 633(8028), 207\u2013215 (2024). https:\/\/doi.org\/10.1038\/s41586-024-07767-5.","journal-title":"Nature"},{"issue":"1","key":"1250_CR68","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/cei\/uxac074","volume":"210","author":"P. Han","year":"2022","unstructured":"P. Han, L. Chen, D. Chen, R. Yang, W. Wang, J. Liu, S. He, H. Zhang, Upregulated expression of substance P and NK1R in blood monocytes and B cells of patients with allergic rhinitis and asthma. Clin. Exp. Immunol. 210(1), 39\u201352 (2022). https:\/\/doi.org\/10.1093\/cei\/uxac074.","journal-title":"Clin. Exp. Immunol."},{"issue":"12","key":"1250_CR69","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.3390\/cancers17121900","volume":"17","author":"H.F. Bahmad","year":"2025","unstructured":"H.F. Bahmad, C. Wegner, J. Nuraj, R. Avellan, J. Gonzalez, T. Mendez, D. Jabbour, C. Gomez-Fernandez, Perineural invasion in breast cancer: a comprehensive review. Cancers (Basel) 17(12), 1900 (2025). https:\/\/doi.org\/10.3390\/cancers17121900.","journal-title":"Cancers (Basel)"},{"key":"1250_CR70","doi-asserted-by":"publisher","unstructured":"S. Zhang, F.-Y. Dong, S. Cai, B. Zhou, L. Jiang, L.-P. Hu, Y.-H. Zhu, H. Li, X.-M. Yang, Z. Cai, L.-L. Yao, H. Wang, H.-F. Yao, J. Li, Q. Li, L. Zhu, Q. Yang, L.-M. Liu, Y.-Q. Yu, J.-F. Zhang, R. Hua, X.-L. Zhang, H.H. Zhu, N. Niu, J. Xue, C. Jiang, Y.-W. Sun, Q. Han, D.-X. Li, D.-J. Liu, Z.-G. Zhang, S.-H. Jiang, A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma. Neuron (2026). https:\/\/doi.org\/10.1016\/j.neuron.2026.03.039.","DOI":"10.1016\/j.neuron.2026.03.039"},{"issue":"9","key":"1250_CR71","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1016\/j.ccell.2025.06.020","volume":"43","author":"M.M. Chen","year":"2025","unstructured":"M.M. Chen, Q. Gao, H. Ning, K. Chen, Y. Gao, M. Yu, C.-Q. Liu, W. Zhou, J. Pan, L. Wei, W. Dou, D. Zhang, L. Zhu, Q. Zhang, R. Chen, Z. Zhang, Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer. Cancer Cell. 43(9), 1656\u20131676.e (2025). https:\/\/doi.org\/10.1016\/j.ccell.2025.06.020.","journal-title":"Cancer Cell."},{"issue":"11","key":"1250_CR72","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1016\/j.ymthe.2025.07.043","volume":"33","author":"Y. Liu","year":"2025","unstructured":"Y. Liu, G. Han, K. Feng, X. Lin, W. Zhong, Y. Liu, C. Wang, C. Zhang, X. Liu, ITGA5-expressing tumor cells interact with Schwann cells to drive nerve growth factor-mediated immunosuppression of NK cells. Mol. Ther. 33(11), 5591\u20135610 (2025). https:\/\/doi.org\/10.1016\/j.ymthe.2025.07.043.","journal-title":"Mol. Ther."},{"key":"1250_CR73","doi-asserted-by":"publisher","unstructured":"S. Zhang, L. Jiang, S. Cai, Z. Weng, Y. Zhu, Z.-W. Cai, H. Li, Q. Li, L.-P. Hu, H.-F. Yao, R. Hua, Y. Zhao, D. Li, X.-M. Yang, J.-F. Zhang, S.-H. Jiang, Vitamin D binding protein, a ligand of Integrin beta 1, motivates both tumor cells and Schwann cells to promote perineural invasion in pancreatic ductal adenocarcinoma. Adv. Sci. 12(44), e11726 (2025). https:\/\/doi.org\/10.1002\/advs.202511726.","DOI":"10.1002\/advs.202511726"},{"issue":"1","key":"1250_CR74","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.bbrc.2015.06.140","volume":"464","author":"J. Lv","year":"2015","unstructured":"J. Lv, X. Sun, J. Ma, X. Ma, Y. Zhang, F. Li, Y. Li, Z. Zhao, Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor. Biochem. Bioph. Res. Co. 464(1), 263\u2013268 (2015). https:\/\/doi.org\/10.1016\/j.bbrc.2015.06.140.","journal-title":"Biochem. Bioph. Res. Co."},{"key":"1250_CR75","doi-asserted-by":"publisher","first-page":"11","DOI":"10.7554\/eLife.64773","volume":"11","author":"S. Ta\u00efb","year":"2022","unstructured":"S. Ta\u00efb, N. Lamand\u00e9, S. Martin, F. Coulpier, P. Topilko, I. Brunet, Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve. Elife 11, 11 (2022). https:\/\/doi.org\/10.7554\/eLife.64773.","journal-title":"Elife"},{"issue":"10","key":"1250_CR76","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1002\/glia.21194","volume":"59","author":"C.A. Webber","year":"2011","unstructured":"C.A. Webber, K.J. Christie, C. Cheng, J.A. Martinez, B. Singh, V. Singh, D. Thomas, D.W. Zochodne, Schwann cells direct peripheral nerve regeneration through the Netrin-1 receptors, DCC and Unc5H2. Glia 59(10), 1503\u20131517 (2011). https:\/\/doi.org\/10.1002\/glia.21194.","journal-title":"Glia"},{"issue":"8","key":"1250_CR77","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1158\/0008-5472.CAN-25-2243","volume":"86","author":"H. Kobayashi","year":"2026","unstructured":"H. Kobayashi, Y. Ochiai, J. Arai, M. Hata, F. Wu, M. Sunagawa, T. Iida, T. Baba, E. Malagola, T. Tanaka, Z. Jiang, R.A. White, X. Zhi, J. Qian, Q.T. Waterbury, R. Tu, B. Zheng, Y. Zeng, H. Zheng, P. Zhang, S. Li, L.B. Zamechek, J.S. LaBella, T. Sugie, A. Enomoto, H.K. Eltzschig, C.F. Palermo, I.I.C. Chio, K.P. Olive, T.C. Wang, Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1. Cancer Res. 86(8), 1883\u20131901 (2026). https:\/\/doi.org\/10.1158\/0008-5472.CAN-25-2243.","journal-title":"Cancer Res."},{"issue":"5","key":"1250_CR78","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s12032-025-02729-x","volume":"42","author":"N.A.A. Ebrahim","year":"2025","unstructured":"N.A.A. Ebrahim, S.M.A. Soliman, M.O. Othman, N.S. Tahoun, Molecular mechanisms and clinical significance of perineural invasion in malignancies: the pivotal role of tumor-associated Schwann cells in cancer progression and metastasis. Med. Oncol. 42(5), 171 (2025). https:\/\/doi.org\/10.1007\/s12032-025-02729-x.","journal-title":"Med. Oncol."},{"issue":"1","key":"1250_CR79","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13045-025-01773-4","volume":"19","author":"F. Ji","year":"2026","unstructured":"F. Ji, H. Chen, H. Li, J. Zhang, S. Li, P. Wang, H. Liu, C. Ge, B. Tang, H. Yin, X. Wang, J. Dong, A subcellular spatial atlas illuminates the microenvironmental remodeling of perineural invasion in distal cholangiocarcinoma. J. Hematol. Oncol. 19(1), 6 (2026). https:\/\/doi.org\/10.1186\/s13045-025-01773-4.","journal-title":"J. Hematol. Oncol."},{"issue":"5","key":"1250_CR80","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/s41422-025-01098-4","volume":"35","author":"K. Wang","year":"2025","unstructured":"K. Wang, B. Ni, Y. Xie, Z. Li, L. Yuan, C. Meng, T. Zhao, S. Gao, C. Huang, H. Wang, Y. Ma, T. Zhou, Y. Feng, A. Chang, C. Yang, J. Yu, W. Yu, F. Zang, Y. Zhang, R.-R. Ji, X. Wang, J. Hao, Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells. Cell. Res. 35(5), 362\u2013380 (2025). https:\/\/doi.org\/10.1038\/s41422-025-01098-4.","journal-title":"Cell. Res."},{"issue":"5","key":"1250_CR81","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1158\/2159-8290.CD-25-1337","volume":"16","author":"J. Nigri","year":"2026","unstructured":"J. Nigri, W. Lan, M.L. Fung, C. Kayser, A. Desch\u00eanes, J. Hinds, S. Kaushalya, S.A. Pawlak, J.S. Thalappillil, S. Nadella, M. Hilmi, W. Park, R. Kappagantula, Y. Park, Z. Zhao, J. Preall, C.A. Iacobuzio-Donahue, K.J. Tracey, J.C. Borniger, D.A. Tuveson, Myofibroblasts induce neuroplasticity to promote pancreatic inflammation and cancer progression. Cancer Discov. 16(5), 1014\u20131034 (2026). https:\/\/doi.org\/10.1158\/2159-8290.CD-25-1337.","journal-title":"Cancer Discov."},{"issue":"4","key":"1250_CR82","doi-asserted-by":"publisher","first-page":"102732","DOI":"10.1016\/j.omtn.2025.102732","volume":"36","author":"Y. Gao","year":"2025","unstructured":"Y. Gao, J. Guo, W. Yang, K. Liu, Q. Yang, S. Li, D. Lv, Y. Cai, K. Xu, W. Zhou, Q. Jiang, J. Xu, Y. Li, H. Sun, Pan-cancer neural regulation pattern with implications for patient stratification and immunotherapy. Mol. Ther. Nucleic. Acids. 36(4), 102732 (2025). https:\/\/doi.org\/10.1016\/j.omtn.2025.102732.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"6","key":"1250_CR83","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41422-025-01124-5","volume":"35","author":"C. Mota Reyes","year":"2025","unstructured":"C. Mota Reyes, H. Friess, I.E. Demir, Neural crossroads of pancreatic cancer: how nociceptors drive tumor progression and immune evasion. Cell. Res. 35(6), 393\u2013394 (2025). https:\/\/doi.org\/10.1038\/s41422-025-01124-5.","journal-title":"Cell. Res."},{"issue":"8075","key":"1250_CR84","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41586-025-09176-8","volume":"644","author":"G. Hoover","year":"2025","unstructured":"G. Hoover, S. Gilbert, O. Curley, C. Obellianne, M.T. Lin, W. Hixson, T.W. Pierce, J.F. Andrews, M.F. Alexeyev, Y. Ding, P. Bu, F. Behbod, D. Medina, J.T. Chang, G. Ayala, S. Grelet, Nerve-to-cancer transfer of mitochondria during cancer metastasis. Nature 644(8075), 252\u2013262 (2025). https:\/\/doi.org\/10.1038\/s41586-025-09176-8.","journal-title":"Nature"},{"issue":"22","key":"1250_CR85","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.1158\/0008-5472.CAN-25-4362","volume":"85","author":"K.W. Kim","year":"2025","unstructured":"K.W. Kim, H.J. Choi, J.H. Lee, White matter injury fuels early progression of glioblastoma. Cancer Res. 85(22), 4296\u20134298 (2025). https:\/\/doi.org\/10.1158\/0008-5472.CAN-25-4362.","journal-title":"Cancer Res."},{"issue":"8084","key":"1250_CR86","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41586-025-09411-2","volume":"646","author":"M. Clements","year":"2025","unstructured":"M. Clements, W. Tang, Z. Florjanic Baronik, H. Simpson Ragdale, R. Oria, D. Volteras, I.J. White, G. Beattie, I. Uddin, T. Lenn, R. Lindsay, S. Castro Devesa, S.R. Karamched, M.F. Lythgoe, V. Shahrezaei, V.M. Weaver, R. Sugisawa, F. Roncaroli, S. Marguerat, C.S. Hill, S. Parrinello, Axonal injury is a targetable driver of glioblastoma progression. Nature. 646(8084), 452\u2013461 (2025). https:\/\/doi.org\/10.1038\/s41586-025-09411-2.","journal-title":"Nature"},{"issue":"8084","key":"1250_CR87","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/s41586-025-09370-8","volume":"646","author":"E.N. Baruch","year":"2025","unstructured":"E.N. Baruch, F.O. Gleber-Netto, P. Nagarajan, X. Rao, S. Akhter, T. Eichwald, T. Xie, M. Balood, A. Adewale, S. Naara, H.N. Sathishkumar, S. Islam, W. McCarthy, B.J. Mattson, R. Ferrarotto, M.K. Wong, M.A. Davies, S. Jindal, S. Basu, K. Roversi, A.R. Nikpoor, M. Ahmadi, A. Ahmadi, C. Harwood, I. Leigh, D. Gong, P. Tall\u00f3n de Lara, D.L. Tao, T.M. Davidson, N.J. Ajami, A. Futreal, K. Rai, V. Kochat, M. Castillo, P. Gunaratne, R.P. Goepfert, S.D. Hernandez, N.I. Khushalani, J. Wang, S.S. Watowich et al., Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy. Nature. 646(8084), 462\u2013473 (2025). https:\/\/doi.org\/10.1038\/s41586-025-09370-8.","journal-title":"Nature"},{"issue":"1","key":"1250_CR88","doi-asserted-by":"publisher","first-page":"8603","DOI":"10.1038\/s41467-025-63692-9","volume":"16","author":"E.G. Graham-Gurysh","year":"2025","unstructured":"E.G. Graham-Gurysh, R.N. Woodring, S.R. Simpson, S.E. Mendell, N.R. Lukesh, E.S. Pena, K.M. Moore, L.A. Ontiveros-Padilla, A.T. Hendricksen, A.M. Lopez, G.L. Williamson, C.T. Murphy, C.J. Genito, K.A. Hipp, G. Singh, W.C. Zamboni, S.D. Hingtgen, P.E. Fecci, E.M. Bachelder, K.M. Ainslie, Post-resection delivery of a TLR7\/8 agonist from a biodegradable scaffold achieves immune-mediated glioblastoma clearance and protection against tumor challenge in mice. Nat. Commun. 16(1), 8603 (2025). https:\/\/doi.org\/10.1038\/s41467-025-63692-9.","journal-title":"Nat Commun."},{"issue":"7","key":"1250_CR89","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41416-022-02132-7","volume":"128","author":"Q. Geng","year":"2023","unstructured":"Q. Geng, L. Li, Z. Shen, Y. Zheng, L. Wang, R. Xue, W. Xue, M. Peng, J. Zhao, Norepinephrine inhibits CD8+ T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma. Br. J. Cancer 128(7), 1223\u20131235 (2023). https:\/\/doi.org\/10.1038\/s41416-022-02132-7.","journal-title":"Br. J. Cancer"},{"issue":"1","key":"1250_CR90","doi-asserted-by":"publisher","first-page":"4100","DOI":"10.1038\/s41467-024-47481-4","volume":"15","author":"F.J.P. Sayegh","year":"2024","unstructured":"F.J.P. Sayegh, L. Mouledous, C. Macri, J. Pi Macedo, C. Lejards, C. Rampon, L. Verret, L. Dahan, Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning. Nat. Commun. 15(1), 4100 (2024). https:\/\/doi.org\/10.1038\/s41467-024-47481-4.","journal-title":"Nat Commun."},{"key":"1250_CR91","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.canlet.2019.12.009","volume":"471","author":"Z. Wang","year":"2020","unstructured":"Z. Wang, W. Liu, C. Wang, Y. Li, Z. Ai, Acetylcholine promotes the self-renewal and immune escape of CD133+ thyroid cancer cells through activation of CD133-Akt pathway. Cancer Lett. 471, 116\u2013124 (2020). https:\/\/doi.org\/10.1016\/j.canlet.2019.12.009.","journal-title":"Cancer Lett."},{"issue":"20","key":"1250_CR92","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1016\/j.neuron.2025.07.002","volume":"113","author":"H.Z. Wen","year":"2025","unstructured":"H.Z. Wen, S.Y. Xiong, Y.X. Lou, S.-Z. Yang, L. Sun, Y.-L. Yi, B.-Q. Tang, Q. Shu, Z.-Q. Wang, X.-J. Yan, Y.-R. Wu, P.-H. Chen, X.-W. Qi, Y. Zhang, L.-M. Dai, Y. Xiong, G.-Y. Wu, Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit. Neuron 113(20), 3374\u20133389.e9 (2025). https:\/\/doi.org\/10.1016\/j.neuron.2025.07.002.","journal-title":"Neuron"},{"issue":"2","key":"1250_CR93","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41556-021-00820-9","volume":"24","author":"D. Huang","year":"2022","unstructured":"D. Huang, Y. Wang, J.W. Thompson, T. Yin, P.B. Alexander, D. Qin, P. Mudgal, H. Wu, Y. Liang, L. Tan, C. Pan, L. Yuan, Y. Wan, Q.-J. Li, X.-F. Wang, Cancer-cell-derived GABA promotes \u03b2-catenin-mediated tumour growth and immunosuppression. Nat. Cell. Biol. 24(2), 230\u2013241 (2022). https:\/\/doi.org\/10.1038\/s41556-021-00820-9.","journal-title":"Nat Cell. Biol."},{"issue":"1","key":"1250_CR94","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12943-025-02413-8","volume":"24","author":"J. Yang","year":"2025","unstructured":"J. Yang, Y. Wu, X. Lv, S. Liu, Z. Yuan, Y. Chen, X. Ding, Z. Li, X. Wang, Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors. Mol. Cancer 24(1), 216 (2025). https:\/\/doi.org\/10.1186\/s12943-025-02413-8.","journal-title":"Mol Cancer"},{"issue":"24","key":"1250_CR95","doi-asserted-by":"publisher","first-page":"6754","DOI":"10.1016\/j.cell.2025.09.029","volume":"188","author":"Y. Zhang","year":"2025","unstructured":"Y. Zhang, Y. Guo, Z. Liu, Y. Sun, X. Yang, M. Chen, G. Feng, C. Lin, Y. Wang, Z. Zhang, Y. Zhu, J. Ye, J. Liu, J. Shi, X. Zhou, Q. Han, Y. Liu, Q. Jiang, Y. Yu, X. Wang, C. Zhang, Y. Sun, J. Zhou, J. Fan, T. Ji, Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance. Cell 188(24), 6754\u20136773.e29 (2025). https:\/\/doi.org\/10.1016\/j.cell.2025.09.029.","journal-title":"Cell"},{"issue":"6","key":"1250_CR96","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.ccell.2025.03.015","volume":"43","author":"Y. Zhu","year":"2025","unstructured":"Y. Zhu, Z. Zhou, X. Du, X. Lin, Z.-M. Liang, S. Chen, Y. Sun, Y. Wang, Z. Na, Z. Wu, J. Zhong, B. Han, X. Zhu, W. Fu, H. Li, M.-L. Luo, H. Hu, Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion. Cancer Cell. 43(6), 1045\u20131060.e (2025). https:\/\/doi.org\/10.1016\/j.ccell.2025.03.015.","journal-title":"Cancer Cell."},{"issue":"Pt 1","key":"1250_CR97","doi-asserted-by":"publisher","first-page":"115734","DOI":"10.1016\/j.intimp.2025.115734","volume":"168","author":"H. Wang","year":"2026","unstructured":"H. Wang, H. Luo, H. Zhong, A. Ockleton, F. Jiang, R. Yi, S. Yang, M. Li, Small-molecule therapies targeting tumor-associated macrophages in glioma: mechanisms and potential. Int. Immunopharmacol. 168(Pt 1), 115734 (2026). https:\/\/doi.org\/10.1016\/j.intimp.2025.115734.","journal-title":"Int Immunopharmacol."},{"key":"1250_CR98","doi-asserted-by":"publisher","first-page":"13","DOI":"10.7554\/eLife.92672.3","volume":"13","author":"S. Go","year":"2024","unstructured":"S. Go, C. Demetriou, G. Valenzano, S. Hughes, S. Lanfredini, H. Ferry, E. Arbe-Barnes, S. Sivakumar, R. Bashford-Rogers, M.R. Middleton, S. Mukherjee, J. Morton, K. Jones, E.O. Neill, Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity. Elife 13, 13 (2024). https:\/\/doi.org\/10.7554\/eLife.92672.3.","journal-title":"Elife"},{"issue":"11","key":"1250_CR99","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1016\/j.ccell.2025.05.011","volume":"43","author":"I. Nikolic","year":"2025","unstructured":"I. Nikolic, J. Cursons, B. Shields, S. Chappaz, H. Sudholz, X. Meng, P. Constantinescu, R. Vijayakumaran, M. D\u2019Angelo, M. Foroutan, D. Ladd, M. Veldman, J. Glab, T. Procter, H.-Y. Park, J. Contet, F. Deuss, K. Wong, Y. Sun, R. Berry, J. Rautela, N.D. Huntington, Enhancing anti-tumor immunity of natural killer cells through targeting IL-15R signaling. Cancer Cell. 43(11), 2034\u20132050.e11 (2025). https:\/\/doi.org\/10.1016\/j.ccell.2025.05.011.","journal-title":"Cancer Cell."},{"key":"1250_CR100","doi-asserted-by":"publisher","unstructured":"L. Zhang, J. Pan, M. Wang, J. Yang, S. Zhu, L. Li, X. Hu, Z. Wang, L. Pang, P. Li, F. Jia, G. Ren, Y. Zhang, D. Xu, F. Qiu, J. Huang, Chronic stress-induced and tumor derived SP1 + exosomes polarizing IL-1\u03b2 + neutrophils to increase lung metastasis of breast cancer. Adv. Sci. 12(4), e2310266 (2025). https:\/\/doi.org\/10.1002\/advs.202310266.","DOI":"10.1002\/advs.202310266"},{"issue":"5","key":"1250_CR101","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.stem.2025.02.016","volume":"32","author":"G. Zhang","year":"2025","unstructured":"G. Zhang, Y. Lian, Q. Li, S. Zhou, L. Zhang, L. Chen, J. Tang, H. Liu, N. Li, Q. Pan, Y. Gu, N. Lin, H. Wang, X. Wang, J. Guo, W. Zhang, Z. Jin, B. Xu, X. Su, M. Lin, Q. Han, J. Qin, Vagal pathway activation links chronic stress to decline in intestinal stem cell function. Cell. STEM Cell. 32(5), 778\u2013794.e10 (2025). https:\/\/doi.org\/10.1016\/j.stem.2025.02.016.","journal-title":"Cell. STEM Cell."},{"issue":"1","key":"1250_CR102","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41421-025-00818-9","volume":"11","author":"D. Wu","year":"2025","unstructured":"D. Wu, Y. Cao, H. Chen, M. Du, T. Wang, J. Zhao, M. Li, W. Wu, H. Zhang, E. Yang, J. Yang, J. Chen, Common signatures of neutrophils in diverse disease conditions. Cell. Discov. 11(1), 66 (2025). https:\/\/doi.org\/10.1038\/s41421-025-00818-9.","journal-title":"Cell. Discov."},{"issue":"5","key":"1250_CR103","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41590-025-02144-4","volume":"26","author":"C. Zheng","year":"2025","unstructured":"C. Zheng, S. Liu, N. Fazel Modares, M. St Paul, T.W. Mak, Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT. Nat. Immunol. 26(5), 665\u2013677 (2025). https:\/\/doi.org\/10.1038\/s41590-025-02144-4.","journal-title":"Nat. Immunol."},{"issue":"1","key":"1250_CR104","doi-asserted-by":"publisher","first-page":"5874","DOI":"10.1038\/s41467-025-60922-y","volume":"16","author":"X. Ju","year":"2025","unstructured":"X. Ju, E.M. Putz, Y. Liu, D. Yuan, G. Sun, S. Koda, Z. Fu, S. Shao, C. Tong, B. Deng, J. Hu, J. Yan, Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation. Nat. Commun. 16(1), 5874 (2025). https:\/\/doi.org\/10.1038\/s41467-025-60922-y.","journal-title":"Nat Commun."},{"key":"1250_CR105","doi-asserted-by":"publisher","unstructured":"T. Yu, K. Van der Jeught, H. Zhu, Z. Zhou, S. Sharma, S. Liu, H. Eyvani, K.M. So, N. Singh, J. Wang, G.E. Sandusky, Y. Liu, M. Opyrchal, S. Cao, J. Wan, C. Zhang, X. Zhang, Inhibition of glutamate-to-glutathione flux promotes tumor antigen presentation in colorectal cancer cells. Adv. Sci. 12(1), e2310308 (2025). https:\/\/doi.org\/10.1002\/advs.202310308.","DOI":"10.1002\/advs.202310308"},{"key":"1250_CR106","doi-asserted-by":"publisher","unstructured":"W. Cen, G. Fu, X. Wang, R. Wei, X. Zhou, W. Teng, Y. Ling, J. Tang, Z. Wang, L. Chu, GABRP mediates GABA-A receptor to shape tumor immunosuppressive microenvironment and promote tumor immune escape and corresponding targeted therapy. Cancer Med. 14(11), e70946 (2025). https:\/\/doi.org\/10.1002\/cam4.70946.","DOI":"10.1002\/cam4.70946"},{"key":"1250_CR107","doi-asserted-by":"publisher","first-page":"1645718","DOI":"10.3389\/fimmu.2025.1645718","volume":"16","author":"Y. Zhao","year":"2025","unstructured":"Y. Zhao, J. Xu, K. Yang, L. Bao, Targeting GABA signaling in the tumor microenvironment: implications for immune cell regulation and immunotherapy resistance. Front Immunol. 16, 1645718 (2025). https:\/\/doi.org\/10.3389\/fimmu.2025.1645718.","journal-title":"Front Immunol."},{"key":"1250_CR108","doi-asserted-by":"publisher","first-page":"111217","DOI":"10.1016\/j.intimp.2023.111217","volume":"126","author":"Y. Dong","year":"2024","unstructured":"Y. Dong, G. Wang, D. Nie, Y. Xu, X. Bai, C. Lu, F. Jian, H. Wang, X. Zheng, Tumor-derived GABA promotes lung cancer progression by influencing TAMs polarization and neovascularization. Int. Immunopharmacol. 126, 111217 (2024). https:\/\/doi.org\/10.1016\/j.intimp.2023.111217.","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"1250_CR109","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s12672-024-01214-7","volume":"15","author":"C. Deng","year":"2024","unstructured":"C. Deng, H. Zhang, L. Song, Environment-responsive dopamine nanoplatform for tumor synergistic therapy. Discov. Oncol. 15(1), 334 (2024). https:\/\/doi.org\/10.1007\/s12672-024-01214-7.","journal-title":"Discov Oncol."},{"issue":"6","key":"1250_CR110","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/carcin\/bgac045","volume":"43","author":"C.E. Grant","year":"2022","unstructured":"C.E. Grant, A.L. Flis, B.M. Ryan, Understanding the role of dopamine in cancer: past, present and future. Carcinogenesis 43(6), 517\u2013527 (2022). https:\/\/doi.org\/10.1093\/carcin\/bgac045.","journal-title":"Carcinogenesis"},{"issue":"8","key":"1250_CR111","doi-asserted-by":"publisher","first-page":"6529","DOI":"10.1007\/s11033-023-08541-y","volume":"50","author":"O. Amjadi","year":"2023","unstructured":"O. Amjadi, A. Hedayatizadeh-Omran, E. Zaboli, M.M. Ghaffari-Hamedani, G. Janbabaei, G. Ahangari, Dopamine receptors gene overexpression in the microenvironment of invasive gastric cancer and its potential implications. Mol. Biol. Rep. 50(8), 6529\u20136542 (2023). https:\/\/doi.org\/10.1007\/s11033-023-08541-y.","journal-title":"Mol. Biol. Rep."},{"key":"1250_CR112","doi-asserted-by":"publisher","first-page":"1497468","DOI":"10.3389\/fimmu.2024.1497468","volume":"15","author":"R. Zhang","year":"2025","unstructured":"R. Zhang, W. Wang, A. Li, H. Wang, X. Liu, F. Fan, Y. Wang, H. Zhang, J. Chang, Y. Zhang, H. Wang, L. Miao, B. Huang, L. Yang, Y. Zhang, \u03b2-receptor blocker enhances anti-tumor immunity via inhibiting lactate-induced norepinephrine metabolism of macrophages during malignant pleural effusion. Front Immunol. 15, 1497468 (2025). https:\/\/doi.org\/10.3389\/fimmu.2024.1497468.","journal-title":"Front Immunol."},{"key":"1250_CR113","doi-asserted-by":"publisher","first-page":"6023","DOI":"10.2147\/IJN.S515895","volume":"20","author":"H. Wu","year":"2025","unstructured":"H. Wu, X. Huang, H. Xu, H. Yang, Z. Liu, F. Liu, F. Ji, M. Cao, Bupivacaine Nanoparticles inhibit triple-negative breast tumor growth by suppressing the noradrenergic nerves in tumor microenvironment. IJN 20, 6023\u20136041 (2025). https:\/\/doi.org\/10.2147\/IJN.S515895.","journal-title":"IJN"},{"issue":"14","key":"1250_CR114","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.3390\/cancers14143539","volume":"14","author":"R. Cove\u00f1as","year":"2022","unstructured":"R. Cove\u00f1as, M. Mu\u00f1oz, Involvement of the substance P\/Neurokinin-1 receptor system in cancer. Cancers (Basel) 14(14), 3539 (2022). https:\/\/doi.org\/10.3390\/cancers14143539.","journal-title":"Cancers (Basel)"},{"issue":"3","key":"1250_CR115","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.medj.2024.02.002","volume":"5","author":"L.B. Darragh","year":"2024","unstructured":"L.B. Darragh, A. Nguyen, T.T. Pham, S. Idlett-Ali, M.W. Knitz, J. Gadwa, S. Bukkapatnam, S. Corbo, N.A. Olimpo, D. Nguyen, B. Van Court, B. Neupert, J. Yu, R.B. Ross, M. Corbisiero, K.N.M. Abdelazeem, S.P. Maroney, D.C. Galindo, L. Mukdad, A. Saviola, M. Joshi, R. White, Y. Alhiyari, V. Samedi, A. Van Bokhoven, M. St. John, S.D. Karam, Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs. Med. 5(3), 254\u2013270.e8 (2024). https:\/\/doi.org\/10.1016\/j.medj.2024.02.002.","journal-title":"Med"},{"issue":"9","key":"1250_CR116","doi-asserted-by":"publisher","first-page":"5803","DOI":"10.1007\/s00432-022-04540-x","volume":"149","author":"D. Sigorski","year":"2023","unstructured":"D. Sigorski, W. Weso\u0142owski, A. Gruszecka, J. Gulczy\u0144ski, P. Zieli\u0144ski, S. Misiukiewicz, J. Kitli\u0144ska, E. I\u017cycka-\u015awieszewska, Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread. J. Cancer Res. Clin. Oncol. 149(9), 5803\u20135822 (2023). https:\/\/doi.org\/10.1007\/s00432-022-04540-x.","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"1250_CR117","doi-asserted-by":"publisher","unstructured":"Y. Cao, X. Ge, X. Zhu, Y. Han, P. Wang, O.U. Akakuru, A. Wu, J. Li, Transformable neuropeptide prodrug with tumor microenvironment responsiveness for tumor growth and metastasis inhibition of triple-negative breast cancer. Adv. Sci. 10(21), e2300545 (2023). https:\/\/doi.org\/10.1002\/advs.202300545.","DOI":"10.1002\/advs.202300545"},{"issue":"1","key":"1250_CR118","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41598-023-28073-6","volume":"13","author":"W. Kittikulsuth","year":"2023","unstructured":"W. Kittikulsuth, D. Nakano, K. Kitada, T. Uyama, N. Ueda, E. Asano, K. Okano, Y. Matsuda, A. Nishiyama, Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice. Sci. Rep. 13(1), 927 (2023). https:\/\/doi.org\/10.1038\/s41598-023-28073-6.","journal-title":"Sci Rep."},{"key":"1250_CR119","doi-asserted-by":"publisher","first-page":"852358","DOI":"10.3389\/fonc.2022.852358","volume":"12","author":"S. Asano","year":"2022","unstructured":"S. Asano, M. Yamasaka, K. Ozasa, K. Sakamoto, A. Hayata-Takano, T. Nakazawa, H. Hashimoto, J.A. Waschek, Y. Ago, Vasoactive intestinal peptide\u2013VIPR2 signaling regulates tumor cell migration. Front. Oncol. 12, 852358 (2022). https:\/\/doi.org\/10.3389\/fonc.2022.852358.","journal-title":"Front. Oncol."},{"issue":"20","key":"1250_CR120","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3390\/cells13201733","volume":"13","author":"T. Nakanishi","year":"2024","unstructured":"T. Nakanishi, Y.I. Koma, S. Miyako, R. Torigoe, H. Yokoo, M. Omori, K. Yamanaka, N. Ishihara, S. Tsukamoto, T. Kodama, M. Nishio, M. Shigeoka, H. Yokozaki, Y. Kakeji, AREG upregulation in cancer cells via direct interaction with cancer-associated fibroblasts promotes esophageal squamous cell carcinoma progression through EGFR-Erk\/p38 MAPK signaling. Cells 13(20), 1733 (2024). https:\/\/doi.org\/10.3390\/cells13201733.","journal-title":"Cells"},{"key":"1250_CR121","doi-asserted-by":"publisher","first-page":"111281","DOI":"10.1016\/j.cellsig.2024.111281","volume":"121","author":"S. Shukla","year":"2024","unstructured":"S. Shukla, P. Dalai, R. Agrawal-Rajput, Metabolic crosstalk: extracellular ATP and the tumor microenvironment in cancer progression and therapy. Cell. Signal. 121, 111281 (2024). https:\/\/doi.org\/10.1016\/j.cellsig.2024.111281.","journal-title":"Cell. Signal."},{"issue":"23","key":"1250_CR122","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.1158\/0008-5472.CAN-24-0018","volume":"84","author":"C.Y.-J. Wu","year":"2024","unstructured":"C.Y.-J. Wu, Y. Chen, Y.J. Lin, K.-C. Wei, K.-Y. Chang, L.-Y. Feng, K.-T. Chen, G. Li, A.L. Ren, R.T. Nitta, J.Y. Wu, K.B. Cho, A. Pant, J. Choi, C.L. Mackall, L.H. Kim, A.-C. Wu, J.-Y. Chuang, C.-Y. Huang, C.M. Jackson, P.-Y. Chen, M. Lim, Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression. Cancer Res. 84(23), 4017\u20134030 (2024). https:\/\/doi.org\/10.1158\/0008-5472.CAN-24-0018.","journal-title":"Cancer Res."},{"issue":"14","key":"1250_CR123","doi-asserted-by":"publisher","first-page":"3823","DOI":"10.1016\/j.cell.2025.04.032","volume":"188","author":"B. Li","year":"2025","unstructured":"B. Li, J. Elsten-Brown, M. Li, E. Zhu, Z. Li, Y. Chen, E. Kang, F. Ma, J. Chiang, Y.-R. Li, Y. Zhu, J. Huang, A. Fung, Q. Scarborough, R. Cadd, J.J. Zhou, A.I. Chin, M. Pellegrini, L. Yang, Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis. Cell 188(14), 3823\u20133842.e21 (2025). https:\/\/doi.org\/10.1016\/j.cell.2025.04.032.","journal-title":"Cell"},{"key":"1250_CR124","doi-asserted-by":"publisher","unstructured":"M.A. Schneider, L. Heeb, M.M. Beffinger, S. Pantelyushin, M. Linecker, L. Roth, K. Lehmann, U. Ungeth\u00fcm, S. Kobold, R. Graf, M. van den Broek, J. Vom Berg, A. Gupta, P.-A. Clavien, Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models. Sci. Transl. Med. 13(611), eabc 8188 (2021). https:\/\/doi.org\/10.1126\/scitranslmed.abc8188.","DOI":"10.1126\/scitranslmed.abc8188"},{"issue":"2","key":"1250_CR125","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cmet.2025.11.011","volume":"38","author":"J. Li","year":"2026","unstructured":"J. Li, J. Lu, C. Zheng, X. Huang, H. Li, Q. Mai, S. Chen, Z. Zhou, J. Zhu, T. Yu, M. Xu, H. Tan, C.-M. Zhang, Q. Gao, J. Liu, C. Pan, Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer. Cell. Metab. 38(2), 331\u2013349.e10 (2026). https:\/\/doi.org\/10.1016\/j.cmet.2025.11.011.","journal-title":"Cell. Metab."},{"issue":"8103","key":"1250_CR126","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/s41586-025-10028-8","volume":"650","author":"H.K. Wei","year":"2026","unstructured":"H.K. Wei, C.D. Yu, B. Hu, X. Zeng, H. Ichise, L. Li, Y. Wang, R.L. Wang, R.N. Germain, R.B. Chang, C. Jin, Tumour\u2013brain crosstalk restrains cancer immunity via a sensory\u2013sympathetic axis. Nature 650(8103), 1007\u20131016 (2026). https:\/\/doi.org\/10.1038\/s41586-025-10028-8.","journal-title":"Nature"},{"issue":"5","key":"1250_CR127","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.tips.2026.03.003","volume":"47","author":"W.-L. Jin","year":"2026","unstructured":"W.-L. Jin, M.-Z. Jin, Targeting the sensory\u2013sympathetic axis for cancer immunotherapy. Trends Pharmacological Sci. 47(5), 467\u2013469 (2026). https:\/\/doi.org\/10.1016\/j.tips.2026.03.003.","journal-title":"Trends Pharmacological Sci."},{"key":"1250_CR128","doi-asserted-by":"publisher","unstructured":"de la Torre E, L. Davel, M.A. Jasnis, T. Gotoh, E.S. de Lustig, M.E. Sales, E. de la Torre, Muscarinic receptors participation in angiogenic response induced by macrophages from mammary adenocarcinoma-bearing mice. Breast Cancer Res. 7(3), R345 (2005). https:\/\/doi.org\/10.1186\/bcr1005.","DOI":"10.1186\/bcr1005"},{"key":"1250_CR129","doi-asserted-by":"publisher","first-page":"217870","DOI":"10.1016\/j.canlet.2025.217870","volume":"628","author":"X. Li","year":"2025","unstructured":"X. Li, K. Liu, Z. Zhang, W. Zhu, M. Zhao, D. Zhao, Y. Zhao, Y. Zhang, F. Fu, H. Chen, Targeting the cholinergic-astrocyte axis: a novel strategy for brain metastasis prevention in lung adenocarcinoma. Cancer Lett. 628, 217870 (2025). https:\/\/doi.org\/10.1016\/j.canlet.2025.217870.","journal-title":"Cancer Lett."},{"issue":"11","key":"1250_CR130","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1158\/2159-8290.CD-18-0046","volume":"8","author":"B.W. Renz","year":"2018","unstructured":"B.W. Renz, T. Tanaka, M. Sunagawa, R. Takahashi, Z. Jiang, M. Macchini, Z. Dantes, G. Valenti, R.A. White, M.A. Middelhoff, M. Ilmer, P.E. Oberstein, M.K. Angele, H. Deng, Y. Hayakawa, C.B. Westphalen, J. Werner, H. Remotti, M. Reichert, Y.H. Tailor, K. Nagar, R.A. Friedman, A.C. Iuga, K.P. Olive, T.C. Wang, Cholinergic signaling via muscarinic receptors directly and indirectly suppresses pancreatic tumorigenesis and cancer stemness. Cancer Discov. 8(11), 1458\u20131473 (2018). https:\/\/doi.org\/10.1158\/2159-8290.CD-18-0046.","journal-title":"Cancer Discov."},{"issue":"17","key":"1250_CR131","doi-asserted-by":"publisher","first-page":"4640","DOI":"10.1016\/j.cell.2025.05.031","volume":"188","author":"R. Drexler","year":"2025","unstructured":"R. Drexler, A. Drinnenberg, A. Gavish, B. Yal\u00e7in, K. Shamardani, A.E. Rogers, R. Mancusi, V. Trivedi, K.R. Taylor, Y.S. Kim, P.J. Woo, N. Soni, M. Su, A. Ravel, E. Tatlock, A. Midler, S.H. Wu, C. Ramakrishnan, R. Chen, A.E. Ayala-Sarmiento, D.R. Fernandez Pacheco, L. Siverts, T.L. Daigle, B. Tasic, H. Zeng, J.J. Breunig, K. Deisseroth, M. Monje, Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling. Cell 188(17), 4640\u20134657.e30 (2025). https:\/\/doi.org\/10.1016\/j.cell.2025.05.031.","journal-title":"Cell"},{"key":"1250_CR132","doi-asserted-by":"publisher","first-page":"177196","DOI":"10.1016\/j.ejphar.2024.177196","volume":"987","author":"T. Grenda","year":"2025","unstructured":"T. Grenda, A. Makuch, A. Grenda, P. Domaradzki, The usefulness of botulinum toxin injections in oncology \u2013 clinical and laboratory perspectives. Eur. J. Pharmacol. 987, 177196 (2025). https:\/\/doi.org\/10.1016\/j.ejphar.2024.177196.","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"1250_CR133","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12943-025-02336-4","volume":"24","author":"S. Huang","year":"2025","unstructured":"S. Huang, J. Zhu, L. Yu, Y. Huang, Y. Hu, Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities. Mol. Cancer 24(1), 133 (2025). https:\/\/doi.org\/10.1186\/s12943-025-02336-4.","journal-title":"Mol Cancer"},{"issue":"1","key":"1250_CR134","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.1038\/s41467-020-17384-1","volume":"11","author":"C. Nuevo-Tapioles","year":"2020","unstructured":"C. Nuevo-Tapioles, F. Santacatterina, K. Stamatakis, C. N\u00fa\u00f1ez de Arenas, M. G\u00f3mez de Cedr\u00f3n, L. Formentini, J.M. Cuezva, Coordinate \u03b2-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth. Nat. Commun. 11(1), 3606 (2020). https:\/\/doi.org\/10.1038\/s41467-020-17384-1.","journal-title":"Nat Commun."},{"key":"1250_CR135","doi-asserted-by":"publisher","unstructured":"A. Blyufer, S. Lhamo, C. Tam, I. Tariq, T. Thavornwatanayong, S.S. Mahajan, Riluzole: a neuroprotective drug with potential as a novel anti\u2011cancer agent (Review). Int. J. Oncol. 59(5. 2021). https:\/\/doi.org\/10.3892\/ijo.2021.5275.","DOI":"10.3892\/ijo.2021.5275"},{"key":"1250_CR136","doi-asserted-by":"publisher","unstructured":"X. Sun, M. Lin, Z. Tian, Y. Ma, L. Lv, GABA\/baclofen stabilizes PD-L1 and enhances immunotherapy of breast cancer. Heliyon 10(7), e28600 (2024). https:\/\/doi.org\/10.1016\/j.heliyon.2024.e28600.","DOI":"10.1016\/j.heliyon.2024.e28600"},{"key":"1250_CR137","doi-asserted-by":"publisher","unstructured":"Z. Yang, L. Sun, H. Chen, C. Sun, L. Xia, New progress in the treatment of diffuse midline glioma with H3K27M alteration. Heliyon 10(2), e24877 (2024). https:\/\/doi.org\/10.1016\/j.heliyon.2024.e24877.","DOI":"10.1016\/j.heliyon.2024.e24877"},{"key":"1250_CR138","doi-asserted-by":"publisher","first-page":"108950","DOI":"10.1016\/j.bioorg.2025.108950","volume":"165","author":"P. Nasehi","year":"2025","unstructured":"P. Nasehi, N. Omidkhah, R. Ghodsi, A review: recent developments of co-targeted TRK (tropomyosin receptor kinases) inhibitors for cancer therapy. Bioorg. Chem. 165, 108950 (2025). https:\/\/doi.org\/10.1016\/j.bioorg.2025.108950.","journal-title":"Bioorg. Chem."},{"issue":"8","key":"1250_CR139","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1093\/jimmun\/vkaf148","volume":"214","author":"M.A. Heard","year":"2025","unstructured":"M.A. Heard, J. Qian, S. Sayeed, S. Mechlowicz, Q. Zhang, S. Yeluri, K. Pool, R. Yamane, G.P. Morris, B.P. Eliceiri, Genetic and pharmacological targeting of nicotinic acetylcholine receptor action blocks tumor progression in mouse models of breast cancer. J. Immunol. 214(8), 2098\u20132111 (2025). https:\/\/doi.org\/10.1093\/jimmun\/vkaf148.","journal-title":"The J Immunol."},{"key":"1250_CR140","doi-asserted-by":"publisher","unstructured":"C.M. Zhao, Y. Hayakawa, Y. Kodama, S. Muthupalani, C.B. Westphalen, G.T. Andersen, A. Flatberg, H. Johannessen, R.A. Friedman, B.W. Renz, A.K. Sandvik, V. Beisvag, H. Tomita, A. Hara, M. Quante, Z. Li, M.D. Gershon, K. Kaneko, J.G. Fox, T.C. Wang, D. Chen, Denervation suppresses gastric tumorigenesis. Sci. Transl. Med. 6(250), 250ra115 (2014). https:\/\/doi.org\/10.1126\/scitranslmed.3009569.","DOI":"10.1126\/scitranslmed.3009569"},{"issue":"9","key":"1250_CR141","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1158\/2326-6066.CIR-22-0110","volume":"10","author":"K. Vats","year":"2022","unstructured":"K. Vats, O. Kruglov, B. Sahoo, V. Soman, J. Zhang, G.V. Shurin, U.R. Chandran, P. Skums, M.R. Shurin, A. Zelikovsky, W.J. Storkus, Y.L. Bunimovich, Sensory nerves impede the formation of tertiary lymphoid structures and development of protective antimelanoma immune responses. Cancer Immunol. Res. 10(9), 1141\u20131154 (2022). https:\/\/doi.org\/10.1158\/2326-6066.CIR-22-0110.","journal-title":"Cancer Immunol Res."},{"issue":"3","key":"1250_CR142","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.21037\/tcr-24-1929","volume":"14","author":"K. Nakayama","year":"2025","unstructured":"K. Nakayama, S. Razia, T. Ishibashi, H. Yamashita, K. Kanno, M. Ishikawa, S. Sato, H. Takeshita, S. Kyo, Oncologic and obstetric outcomes of a novel nerve-sparing radical trachelectomy while preserving the uterine branches of the pelvic nerves. Transl. Cancer Res. 14(3), 1567\u20131575 (2025). https:\/\/doi.org\/10.21037\/tcr-24-1929.","journal-title":"Transl Cancer Res."},{"issue":"3","key":"1250_CR143","doi-asserted-by":"publisher","first-page":"283","DOI":"10.23736\/S2724-6051.20.04178-8","volume":"73","author":"A. Morozov","year":"2021","unstructured":"A. Morozov, E. Barret, D. Veneziano, V. Grigoryan, G. Salomon, I. Fokin, M. Taratkin, E. Poddubskaya, J. Gomez Rivas, S. Puliatti, Z. Okhunov, G.E. Cacciamani, E. Checcucci, J.L. Marenco Jim\u00e9nez, D. Enikeev, A systematic review of nerve-sparing surgery for high-risk prostate cancer. Minerva. Urol. Nephrol. 73(3), 283\u2013291 (2021). https:\/\/doi.org\/10.23736\/S2724-6051.20.04178-8.","journal-title":"Minerva Urol Nephrol."},{"issue":"3","key":"1250_CR144","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.euf.2024.05.008","volume":"10","author":"V. Khor","year":"2024","unstructured":"V. Khor, K. Chen, L.M. Somasundram, N. Lawrentschuk, Clinical consultation guide: nerve-sparing techniques for retroperitoneal lymph node dissection in testicular cancer. Eur. Urology Focus 10(3), 364\u2013366 (2024). https:\/\/doi.org\/10.1016\/j.euf.2024.05.008.","journal-title":"Eur. Urology Focus"},{"issue":"3","key":"1250_CR145","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41568-019-0237-2","volume":"20","author":"A.H. Zahalka","year":"2020","unstructured":"A.H. Zahalka, P.S. Frenette, Nerves in cancer. Nat. Rev. Cancer 20(3), 143\u2013157 (2020). https:\/\/doi.org\/10.1038\/s41568-019-0237-2.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1250_CR146","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1080\/21556660.2020.1782414","volume":"9","author":"I. Stavropoulos","year":"2020","unstructured":"I. Stavropoulos, A. Sarantopoulos, A. Liverezas, Does sympathetic nervous system modulate tumor progression? A narrative review of the literature. J. Drug. Assess. 9(1), 106\u2013116 (2020). https:\/\/doi.org\/10.1080\/21556660.2020.1782414.","journal-title":"J. Drug. Assess."},{"issue":"18","key":"1250_CR147","doi-asserted-by":"publisher","first-page":"9257","DOI":"10.3390\/ijms26189257","volume":"26","author":"Z.Z. Ji","year":"2025","unstructured":"Z.Z. Ji, M.-K.-K. Chan, P.C.-T. Tang, C.S.-H. Ng, C. Li, D. Zhang, D.J. Nikolic-Paterson, K.-F. To, X. Jiang, P.M.-K. Tang, Tumor innervation: from bystander to emerging therapeutic target for cancer. IJMS 26(18), 9257 (2025). https:\/\/doi.org\/10.3390\/ijms26189257.","journal-title":"IJMS"},{"issue":"19","key":"1250_CR148","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.1016\/j.neuron.2025.09.005","volume":"113","author":"C. Cao","year":"2025","unstructured":"C. Cao, Targeting tumor-associated nerves enhances cancer immunotherapy. Neuron 113(19), 3076\u20133078 (2025). https:\/\/doi.org\/10.1016\/j.neuron.2025.09.005.","journal-title":"Neuron"},{"issue":"17","key":"1250_CR149","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1016\/j.neuron.2025.07.012","volume":"113","author":"M. Monje","year":"2025","unstructured":"M. Monje, The neuroscience of brain cancers. Neuron 113(17), 2734\u20132739 (2025). https:\/\/doi.org\/10.1016\/j.neuron.2025.07.012.","journal-title":"Neuron"},{"issue":"3","key":"1250_CR150","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.ccell.2023.02.012","volume":"41","author":"D. Hanahan","year":"2023","unstructured":"D. Hanahan, M. Monje, Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell. 41(3), 573\u2013580 (2023). https:\/\/doi.org\/10.1016\/j.ccell.2023.02.012.","journal-title":"Cancer Cell."},{"issue":"12","key":"1250_CR151","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1038\/s41591-020-1073-3","volume":"26","author":"D. Cerezo-Wallis","year":"2020","unstructured":"D. Cerezo-Wallis, M. Contreras-Alcalde, K. Troul\u00e9, X. Catena, C. Mucientes, T.G. Calvo, E. Ca\u00f1\u00f3n, C. Tejedo, P.C. Pennacchi, S. Hogan, P. K\u00f6lblinger, H. Tejero, A.X. Chen, N. Ibarz, O. Gra\u00f1a-Castro, L. Martinez, J. Mu\u00f1oz, P. Ortiz-Romero, J.L. Rodriguez-Peralto, G. G\u00f3mez-L\u00f3pez, F. Al-Shahrour, R. Rabad\u00e1n, M.P. Levesque, D. Olmeda, M.S. Soengas, Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nat. Med. 26(12), 1865\u20131877 (2020). https:\/\/doi.org\/10.1038\/s41591-020-1073-3.","journal-title":"Nat Med."},{"issue":"1","key":"1250_CR152","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/biomedicines11010008","volume":"11","author":"Q. Liu","year":"2022","unstructured":"Q. Liu, J. Tan, Z. Zhao, R. Li, L. Zheng, X. Chen, L. Li, X. Dong, T. Wen, J. Liu, Combined usage of MDK inhibitor augments interferon-\u03b3 anti-tumor activity in the SKOV3 human ovarian cancer cell Line. Biomedicines 11(1), 8 (2022). https:\/\/doi.org\/10.3390\/biomedicines11010008.","journal-title":"Biomedicines"},{"issue":"15","key":"1250_CR153","doi-asserted-by":"publisher","first-page":"7326","DOI":"10.3390\/ijms26157326","volume":"26","author":"E. Cecerska-Hery\u0107","year":"2025","unstructured":"E. Cecerska-Hery\u0107, A. Jerzyk, M. Goszka, A. Polikowska, J. Rachwalska, N. Serwin, B. Wojciuk, B. Do\u0142\u0119gowska, TGF-\u03b2 signaling in cancer: mechanisms of progression and therapeutic targets. IJMS 26(15), 7326 (2025). https:\/\/doi.org\/10.3390\/ijms26157326.","journal-title":"IJMS"},{"issue":"1","key":"1250_CR154","doi-asserted-by":"publisher","first-page":"4770","DOI":"10.1038\/s41467-025-60074-z","volume":"16","author":"T. Nejo","year":"2025","unstructured":"T. Nejo, S. Krishna, A. Yamamichi, S. Lakshmanachetty, C. Jimenez, K.Y. Lee, D.L. Baker, J.S. Young, T. Chen, S.S.S. Phyu, L. Phung, M. Gallus, G.C. Maldonado, K. Okada, H. Ogino, P.B. Watchmaker, D. Diebold, A. Choudhury, A.G.S. Daniel, C.R. Cadwell, D.R. Raleigh, S.L. Hervey-Jumper, H. Okada, Glioma-neuronal circuit remodeling induces regional immunosuppression. Nat. Commun. 16(1), 4770 (2025). https:\/\/doi.org\/10.1038\/s41467-025-60074-z.","journal-title":"Nat Commun."},{"issue":"10","key":"1250_CR155","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1038\/s41590-025-02259-8","volume":"26","author":"J. Sawada","year":"2025","unstructured":"J. Sawada, Y. Kikuchi, M. Duah, J.L. Herrera, F. Kanamori, K. Csomos, T. Stansel, N. Hiraoka, M. Yoshida, J. Walter, C.F. Ware, M. Komatsu, Simultaneous STING and lymphotoxin-\u03b2 receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity. Nat. Immunol. 26(10), 1766\u20131780 (2025). https:\/\/doi.org\/10.1038\/s41590-025-02259-8.","journal-title":"Nat. Immunol."},{"issue":"6","key":"1250_CR156","doi-asserted-by":"publisher","first-page":"117496","DOI":"10.1016\/j.celrep.2026.117496","volume":"45","author":"S. Cai","year":"2026","unstructured":"S. Cai, M.W. Yang, L. Jiang, Z. Weng, X. Wang, X. Ma, Y.-M. Huo, W. Liu, S. Zhang, S.-H. Jiang, Nerve-proximal tertiary lymphoid structures predict chemotherapy sensitivity in pancreatic cancer. Cell. Rep. 45(6), 117496 (2026). https:\/\/doi.org\/10.1016\/j.celrep.2026.117496.","journal-title":"Cell. Rep."},{"issue":"1","key":"1250_CR157","doi-asserted-by":"publisher","first-page":"4241","DOI":"10.1038\/s41467-024-48606-5","volume":"15","author":"Y. Zhang","year":"2024","unstructured":"Y. Zhang, K. Xi, Z. Fu, Y. Zhang, B. Cheng, F. Feng, Y. Dong, Z. Fang, Y. Zhang, J. Shen, M. Wang, X. Han, H. Geng, L. Sun, X. Li, C. Chen, X. Jiang, S. Ni, Stimulation of tumoricidal immunity via bacteriotherapy inhibits glioblastoma relapse. Nat. Commun. 15(1), 4241 (2024). https:\/\/doi.org\/10.1038\/s41467-024-48606-5.","journal-title":"Nat Commun."},{"key":"1250_CR158","doi-asserted-by":"publisher","unstructured":"Y. Ma, M. Li, X. Fu, D. Li, C. Gao, Z. Li, Y. Zhang, Z. Gao, H. Geng, G. Li, S. Ni, J. Cui, Engineering of nanofibers embedded with targeted Nanoparticles breaks redox levers for glioblastoma therapy. Adv. Funct. Mater. 35(3. 2025). https:\/\/doi.org\/10.1002\/adfm.202413518.","DOI":"10.1002\/adfm.202413518"},{"issue":"2","key":"1250_CR159","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41565-024-01803-1","volume":"20","author":"J. Qin","year":"2025","unstructured":"J. Qin, J. Liu, Z. Wei, X. Li, Z. Chen, J. Li, W. Zheng, H. Liu, S. Xu, T. Yong, B. Zhao, S. Gou, S. Ju, G.-J. Teng, X. Yang, L. Gan, Targeted intervention in nerve\u2013cancer crosstalk enhances pancreatic cancer chemotherapy. Nat. Nanotechnol. 20(2), 311\u2013324 (2025). https:\/\/doi.org\/10.1038\/s41565-024-01803-1.","journal-title":"Nat Nanotechnol."},{"issue":"3","key":"1250_CR160","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/ph18030384","volume":"18","author":"D.P. Radin","year":"2025","unstructured":"D.P. Radin, Glutamatergic synaptic input to glioma cells drives brain tumour progressionAMPA receptor modulation in the treatment of high-grade glioma: translating Good Science into Better outcomes. Pharmaceuticals (Basel) 18(3), 384 (2025). https:\/\/doi.org\/10.3390\/ph18030384.","journal-title":"Pharmaceuticals (Basel)"}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-026-01250-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-026-01250-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-026-01250-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:06:11Z","timestamp":1790773571000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-026-01250-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":160,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["1250"],"URL":"https:\/\/doi.org\/10.1007\/s13402-026-01250-1","relation":{},"ISSN":["2211-3436"],"issn-type":[{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"9 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"126"}}