{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:32:08Z","timestamp":1786357928159,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2025M772163"],"award-info":[{"award-number":["2025M772163"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018546","name":"Postdoctoral Innovation Project of Shandong Province","doi-asserted-by":"crossref","award":["SDCX-ZG-202501040"],"award-info":[{"award-number":["SDCX-ZG-202501040"]}],"id":[{"id":"10.13039\/501100018546","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82030082"],"award-info":[{"award-number":["82030082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82303560"],"award-info":[{"award-number":["82303560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172676"],"award-info":[{"award-number":["82172676"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the foundation of Natural Science Foundation of Shandong","award":["ZR2023ZD26"],"award-info":[{"award-number":["ZR2023ZD26"]}]},{"name":"the foundation of Natural Science Foundation of Shandong","award":["ZR2024MH315"],"award-info":[{"award-number":["ZR2024MH315"]}]},{"name":"the foundation of Natural Science Foundation of Shandong","award":["ZR2024JQ032"],"award-info":[{"award-number":["ZR2024JQ032"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0519900"],"award-info":[{"award-number":["2024ZD0519900"]}]},{"name":"the Innovation and Development Joint Fund Program of the Shandong Provincial Natural Science Foundation","award":["ZR2025LZL010"],"award-info":[{"award-number":["ZR2025LZL010"]}]},{"name":"the Youth Innovation Team Program of Shandong Universities and Colleges","award":["2024KJJ022"],"award-info":[{"award-number":["2024KJJ022"]}]},{"name":"Collaborative Academic Innovation Project of Shandong Cancer Hospital","award":["GF001"],"award-info":[{"award-number":["GF001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Oncol."],"DOI":"10.1007\/s13402-026-01267-6","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:05:00Z","timestamp":1785416700000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TFAP2A enhances radioresistance of non-small cell lung cancer by transcriptionally activating BRCA1"],"prefix":"10.1007","volume":"49","author":[{"given":"Jiachun","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunshun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jupeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-7997","authenticated-orcid":false,"given":"Dawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"1267_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL 1 Siegel","year":"2025","unstructured":"R.L. Siegel, T.B. Kratzer, A.N. Giaquinto, H. Sung, A. Jemal, Cancer statistics, 2025. Cancer J. Clin. 75, 10\u201345 (2025). https:\/\/doi.org\/10.3322\/caac.21871","journal-title":"Cancer J. Clin."},{"key":"1267_CR2","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1056\/NEJMra1703413","volume":"377","author":"M 2 Reck","year":"2017","unstructured":"M. Reck, K.F. Rabe, Precision Diagnosis and Treatment for Advanced Non-Small-Cell Lung Cancer. N. Engl. J. Med. 377, 849\u2013861 (2017). https:\/\/doi.org\/10.1056\/NEJMra1703413","journal-title":"N. Engl. J. Med."},{"key":"1267_CR3","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/s2213-2600(20)30391-x","volume":"9","author":"W 3 Theelen","year":"2021","unstructured":"W. Theelen et al., Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Respiratory Med. 9, 467\u2013475 (2021). https:\/\/doi.org\/10.1016\/s2213-2600(20)30391-x","journal-title":"Lancet Respiratory Med."},{"key":"1267_CR4","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1016\/j.jtho.2016.09.124","volume":"11","author":"VW 4 Rusch","year":"2016","unstructured":"V.W. Rusch et al., The IASLC Mesothelioma Staging Project: Proposals for the M Descriptors and for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Mesothelioma. J. Thorac. Oncol. 11, 2112\u20132119 (2016). https:\/\/doi.org\/10.1016\/j.jtho.2016.09.124","journal-title":"J. Thorac. Oncol."},{"key":"1267_CR5","doi-asserted-by":"publisher","first-page":"5792","DOI":"10.1158\/1078-0432.Ccr-17-3620","volume":"24","author":"EC 5 Ko","year":"2018","unstructured":"E.C. Ko, D. Raben, S.C. Formenti, The Integration of Radiotherapy with Immunotherapy for the Treatment of Non-Small Cell Lung Cancer. Clin. Cancer Res. 24, 5792\u20135806 (2018). https:\/\/doi.org\/10.1158\/1078-0432.Ccr-17-3620","journal-title":"Clin. Cancer Res."},{"key":"1267_CR6","doi-asserted-by":"publisher","first-page":"11144","DOI":"10.7150\/thno.42578","volume":"10","author":"G 6 Yao","year":"2020","unstructured":"G. Yao et al., Cyclin K interacts with \u03b2-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer. Theranostics. 10, 11144\u201311158 (2020). https:\/\/doi.org\/10.7150\/thno.42578","journal-title":"Theranostics"},{"key":"1267_CR7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/pro6.1220","volume":"8","author":"D 7 Nakamura","year":"2024","unstructured":"D. Nakamura et al., Stereotactic body radiation therapy for clinically diagnosed early-stage non-small cell lung cancer: Importance of accurate CT interpretation by experts. Precision Radiation Oncol. 8, 30\u201336 (2024). https:\/\/doi.org\/10.1002\/pro6.1220","journal-title":"Precision Radiation Oncol."},{"key":"1267_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12943-016-0577-4","volume":"16","author":"SY Lee","year":"2017","unstructured":"S.Y. Lee et al., Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation. Mol. Cancer. 16, 10 (2017). https:\/\/doi.org\/10.1186\/s12943-016-0577-4","journal-title":"Mol. Cancer"},{"key":"1267_CR9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cllc.2015.09.006","volume":"17","author":"DE 9 Spratt","year":"2016","unstructured":"D.E. Spratt et al., Recurrence Patterns and Second Primary Lung Cancers After Stereotactic Body Radiation Therapy for Early-Stage Non-Small-Cell Lung Cancer: Implications for Surveillance. Clin. Lung Cancer. 17, 177\u2013183e172 (2016). https:\/\/doi.org\/10.1016\/j.cllc.2015.09.006","journal-title":"Clin. Lung Cancer"},{"key":"1267_CR10","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/s0140-6736(16)30958-8","volume":"389","author":"FR 10 Hirsch","year":"2017","unstructured":"F.R. Hirsch et al., Lung cancer: current therapies and new targeted treatments. Lancet (London England). 389, 299\u2013311 (2017). https:\/\/doi.org\/10.1016\/s0140-6736(16)30958-8","journal-title":"Lancet (London England)"},{"key":"1267_CR11","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nrc3958","volume":"15","author":"HE 11 Barker","year":"2015","unstructured":"H.E. Barker, J.T. Paget, A.A. Khan, K.J. Harrington, The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat. Rev. Cancer.15, 409\u2013425 (2015). https:\/\/doi.org\/10.1038\/nrc3958","journal-title":"Nat. Rev. Cancer"},{"key":"1267_CR12","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.trecan.2022.05.005","volume":"8","author":"A 12 Mittal","year":"2022","unstructured":"A. Mittal et al., Radiotherapy-induced metabolic hallmarks in the tumor microenvironment. Trends cancer. 8, 855\u2013869 (2022). https:\/\/doi.org\/10.1016\/j.trecan.2022.05.005","journal-title":"Trends cancer"},{"key":"1267_CR13","doi-asserted-by":"publisher","unstructured":"A. Salem et al., Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome. J. Natl Cancer Inst. 110 (2018). https:\/\/doi.org\/10.1093\/jnci\/djx160","DOI":"10.1093\/jnci\/djx160"},{"key":"1267_CR14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41392-021-00648-7","volume":"6","author":"R 14 Huang","year":"2021","unstructured":"R. Huang, P.K. Zhou, DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy. Signal. Transduct. Target. therapy. 6, 254 (2021). https:\/\/doi.org\/10.1038\/s41392-021-00648-7","journal-title":"Signal. Transduct. Target. therapy"},{"key":"1267_CR15","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","volume":"172","author":"SA Lambert","year":"2018","unstructured":"S.A. Lambert et al., Hum. Transcription Factors Cell. 172, 650\u2013665 (2018). https:\/\/doi.org\/10.1016\/j.cell.2018.01.029","journal-title":"Hum. Transcription Factors Cell."},{"key":"1267_CR16","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/ncb3013","volume":"16","author":"P 16 Zhang","year":"2014","unstructured":"P. Zhang et al., ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat. Cell Biol. 16, 864\u2013875 (2014). https:\/\/doi.org\/10.1038\/ncb3013","journal-title":"Nat. Cell Biol."},{"key":"1267_CR17","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.62347\/vsju7227","volume":"14","author":"L 17 Guo","year":"2024","unstructured":"L. Guo et al., Transcription factor STAT4 counteracts radiotherapy resistance in breast carcinoma cells by activating the MALAT1\/miR-21-5p\/THRB regulatory network. Am. J. cancer Res. 14, 1501\u20131522 (2024). https:\/\/doi.org\/10.62347\/vsju7227","journal-title":"Am. J. cancer Res."},{"key":"1267_CR18","doi-asserted-by":"publisher","first-page":"681","DOI":"10.7150\/thno.88899","volume":"14","author":"X 18 Sun","year":"2024","unstructured":"X. Sun et al., NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway. Theranostics. 14, 681\u2013698 (2024) https:\/\/doi.org\/10.7150\/thno.88899","journal-title":"Theranostics"},{"key":"1267_CR19","doi-asserted-by":"publisher","unstructured":"J. Yuan, J. Liu, R. Fai, Z. Liu, TFAP2A facilitates the metastasis and radioresistance of esophageal cancer by promoting EGFR transcription. Naunyn-Schmiedeberg\u2019s archives of pharmacology (2025). https:\/\/doi.org\/10.1007\/s00210-025-03848-y","DOI":"10.1007\/s00210-025-03848-y"},{"key":"1267_CR20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/gb-2005-6-13-246","volume":"6","author":"D 20 Eckert","year":"2005","unstructured":"D. Eckert, S. Buhl, S. Weber, R. J\u00e4ger, H. Schorle, The AP-2 family of transcription factors. Genome Biol. 6, 246 (2005). https:\/\/doi.org\/10.1186\/gb-2005-6-13-246","journal-title":"Genome Biol."},{"key":"1267_CR21","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1111\/j.1742-4658.2009.07509.x","volume":"277","author":"AK 21 Wenke","year":"2010","unstructured":"A.K. Wenke, A.K. Bosserhoff, Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development. FEBS J. 277, 894\u2013902 (2010). https:\/\/doi.org\/10.1111\/j.1742-4658.2009.07509.x","journal-title":"FEBS J."},{"key":"1267_CR22","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41419-021-03606-x","volume":"12","author":"Y 22 Xiong","year":"2021","unstructured":"Y. Xiong et al., TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family\/TFAP2A\/PSG9\/TGF-\u03b2 signaling pathway. Cell Death Dis. 12, 352 (2021). https:\/\/doi.org\/10.1038\/s41419-021-03606-x","journal-title":"Cell Death Dis."},{"key":"1267_CR23","doi-asserted-by":"publisher","unstructured":"M.C. King, The race to clone BRCA1. Science (New York, N.Y.) 343, 1462\u20131465 (2014). https:\/\/doi.org\/10.1126\/science.1251900","DOI":"10.1126\/science.1251900"},{"key":"1267_CR24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-biochem-013118-111058","volume":"88","author":"W 24 Zhao","year":"2019","unstructured":"W. Zhao, C. Wiese, Y. Kwon, R. Hromas, P. Sung, The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination. Annu. Rev. Biochem. 88, 221\u2013245 (2019). https:\/\/doi.org\/10.1146\/annurev-biochem-013118-111058","journal-title":"Annu. Rev. Biochem."},{"key":"1267_CR25","doi-asserted-by":"publisher","first-page":"e2711","DOI":"10.1038\/cddis.2017.136","volume":"8","author":"NK 25 Karanam","year":"2017","unstructured":"N.K. Karanam et al., Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines. Cell Death Dis. 8, e2711 (2017). https:\/\/doi.org\/10.1038\/cddis.2017.136","journal-title":"Cell Death Dis."},{"key":"1267_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1471-2407-8-97","volume":"8","author":"L 26 Wang","year":"2008","unstructured":"L. Wang et al., ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and\/or docetaxel. BMC cancer. 8, 97 (2008). https:\/\/doi.org\/10.1186\/1471-2407-8-97","journal-title":"BMC cancer"},{"key":"1267_CR27","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1158\/0008-5472.Can-14-0735","volume":"74","author":"E 27 Kim","year":"2014","unstructured":"E. Kim et al., PAK1 tyrosine phosphorylation is required to induce epithelial-mesenchymal transition and radioresistance in lung cancer cells. Cancer Res. 74, 5520\u20135531 (2014). https:\/\/doi.org\/10.1158\/0008-5472.Can-14-0735","journal-title":"Cancer Res."},{"key":"1267_CR28","doi-asserted-by":"publisher","first-page":"5506","DOI":"10.1200\/jco.2007.14.1226","volume":"25","author":"KM 28 Pisters","year":"2007","unstructured":"K.M. Pisters et al., Cancer Care Ontario and American Society of Clinical Oncology adjuvant chemotherapy and adjuvant radiation therapy for stages I-IIIA resectable non small-cell lung cancer guideline. J. Clin. Oncol. 25, 5506\u20135518 (2007). https:\/\/doi.org\/10.1200\/jco.2007.14.1226","journal-title":"J. Clin. Oncol."},{"key":"1267_CR29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H 29 Sung","year":"2021","unstructured":"H. Sung et al., Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Cancer J. Clin. 71, 209\u2013249 (2021). https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"Cancer J. Clin."},{"key":"1267_CR30","doi-asserted-by":"publisher","unstructured":"D. Ko\u0142at, \u017b. Ka\u0142uzi\u0144ska, A.K. Bednarek, E. P\u0142uciennik, The biological characteristics of transcription factors AP-2\u03b1 and AP-2\u03b3 and their importance in various types of cancers. Biosci. Rep. 39 (2019). https:\/\/doi.org\/10.1042\/bsr20181928","DOI":"10.1042\/bsr20181928"},{"key":"1267_CR31","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s12967-023-04189-1","volume":"21","author":"C 31 Jin","year":"2023","unstructured":"C. Jin et al., Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views. J. translational Med. 21, 371 (2023). https:\/\/doi.org\/10.1186\/s12967-023-04189-1","journal-title":"J. translational Med."},{"key":"1267_CR32","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.18632\/aging.205225","volume":"16","author":"C 32 Niu","year":"2024","unstructured":"C. Niu et al., Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer. Aging. 16, 1021\u20131048 (2024). https:\/\/doi.org\/10.18632\/aging.205225","journal-title":"Aging"},{"key":"1267_CR33","doi-asserted-by":"publisher","first-page":"154759","DOI":"10.1016\/j.prp.2023.154759","volume":"249","author":"J 33 Zhao","year":"2023","unstructured":"J. Zhao, G. Lan, TFAP2A activates HMGA1 to promote glycolysis and lung adenocarcinoma progression. Pathol. Res. Pract. 249, 154759 (2023). https:\/\/doi.org\/10.1016\/j.prp.2023.154759","journal-title":"Pathol. Res. Pract."},{"key":"1267_CR34","doi-asserted-by":"publisher","unstructured":"J. Yang, Y. Gao, S. Yao, S. Wan, H. Cai, TFAP2A promotes cervical cancer via a positive feedback pathway with PD\u2013L1. Oncol. Rep. 49 (2023). https:\/\/doi.org\/10.3892\/or.2023.8551","DOI":"10.3892\/or.2023.8551"},{"key":"1267_CR35","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13046-021-02011-8","volume":"40","author":"G 35 Chen","year":"2021","unstructured":"G. Chen et al., A positive feedback loop between Periostin and TGF\u03b21 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2\u03b1 activation. J. experimental Clin. cancer research: CR. 40, 218 (2021). https:\/\/doi.org\/10.1186\/s13046-021-02011-8","journal-title":"J. experimental Clin. cancer research: CR"},{"key":"1267_CR36","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1158\/0008-5472.Can-21-0772","volume":"81","author":"JR 36 White","year":"2021","unstructured":"J.R. White et al., AP-2\u03b1-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis. Cancer Res. 81, 4455\u20134470 (2021). https:\/\/doi.org\/10.1158\/0008-5472.Can-21-0772","journal-title":"Cancer Res."},{"key":"1267_CR37","doi-asserted-by":"publisher","first-page":"9478","DOI":"10.1128\/mcb.24.21.9478-9486.2004","volume":"24","author":"X 37 Yu","year":"2004","unstructured":"X. Yu, J. Chen, DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol. Cell. Biol. 24, 9478\u20139486 (2004). https:\/\/doi.org\/10.1128\/mcb.24.21.9478-9486.2004","journal-title":"Mol. Cell. Biol."},{"key":"1267_CR38","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.4161\/cc.25073","volume":"12","author":"Z 38 Shen","year":"2013","unstructured":"Z. Shen, S.C. Huhn, B.G. Haffty, Escaping death to quiescence: avoiding mitotic catastrophe after DNA damage. Cell. cycle (Georgetown Tex). 12, 1664 (2013). https:\/\/doi.org\/10.4161\/cc.25073","journal-title":"Cell. cycle (Georgetown Tex)"},{"key":"1267_CR39","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.molcel.2016.10.017","volume":"64","author":"R 39 Anand","year":"2016","unstructured":"R. Anand, L. Ranjha, E. Cannavo, P. Cejka, Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection. Mol. Cell. 64, 940\u2013950 (2016). https:\/\/doi.org\/10.1016\/j.molcel.2016.10.017","journal-title":"Mol. Cell"},{"key":"1267_CR40","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nature24060","volume":"550","author":"W 40 Zhao","year":"2017","unstructured":"W. Zhao et al., BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. Nature. 550, 360\u2013365 (2017). https:\/\/doi.org\/10.1038\/nature24060","journal-title":"Nature"},{"key":"1267_CR41","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13046-022-02469-0","volume":"41","author":"C 41 Shi","year":"2022","unstructured":"C. Shi et al., The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy. J. Exp. Clin. Cancer Res. 41, 268 (2022). https:\/\/doi.org\/10.1186\/s13046-022-02469-0","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"1267_CR42","doi-asserted-by":"publisher","unstructured":"J. Jiricny, Postreplicative mismatch repair. Cold Spring Harbor perspectives in biology 5, a012633 (2013). https:\/\/doi.org\/10.1101\/cshperspect.a012633","DOI":"10.1101\/cshperspect.a012633"},{"key":"1267_CR43","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/pro6.70012","volume":"9","author":"P 43 Wu","year":"2025","unstructured":"P. Wu, C. Li, Z. Wei, X. Meng, Radiotherapy after Neoadjuvant Immunochemotherapy in Unresectable Stage III Non-Small Cell Lung Carcinoma: A Novel Therapeutic Approach? Precision Radiation Oncol. 9, 143\u2013144 (2025). https:\/\/doi.org\/10.1002\/pro6.70012","journal-title":"Precision Radiation Oncol."}],"container-title":["Cellular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13402-026-01267-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-026-01267-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13402-026-01267-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:57:26Z","timestamp":1786355846000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13402-026-01267-6"}},"subtitle":["TFAP2A promotes NSCLC radioresistance"],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["1267"],"URL":"https:\/\/doi.org\/10.1007\/s13402-026-01267-6","relation":{},"ISSN":["2211-3436"],"issn-type":[{"value":"2211-3436","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"6 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This research involved the collection of formalin-fixed paraffin-embedded (FFPE) sections from resection tissues. All related protocols were approved by the Ethics Committee of the Cancer Hospital Affiliated to Shandong First Medical University (SDTHEC2024006060) and were conducted according to the Ethical Principles of the Declaration of Helsinki. All mice experiments were performed following institutional guidelines and approved by the Ethics Committee of the Cancer Hospital Affiliated to Shandong First Medical University (SDTHEC2024003059).","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"106"}}