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Over the past several decades, the scientific and medical communities have recognized that skeletal muscle dysfunction (e.g., muscle weakness, poor muscle coordination, etc.) is a debilitating and life\u2010threatening condition in the elderly. For example, the age\u2010associated loss of muscle strength is highly associated with both mortality and physical disability. It is well\u2010accepted that voluntary muscle force production is not solely dependent upon muscle size, but rather results from a combination of neurologic and skeletal muscle factors, and that biologic properties of both of these systems are altered with aging. Accordingly, numerous scientists and clinicians have used the term \u201cmuscle quality\u201d to describe the relationship between voluntary muscle strength and muscle size. In this review article, we discuss the age\u2010associated changes in the neuromuscular system\u2014starting at the level of the brain and proceeding down to the subcellular level of individual muscle fibers\u2014that are potentially influential in the etiology of dynapenia (age\u2010related loss of muscle strength and power).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13539-011-0054-2","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T13:32:55Z","timestamp":1328621575000},"page":"95-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Evolving concepts on the age\u2010related changes in \u201cmuscle quality\u201d"],"prefix":"10.1002","volume":"3","author":[{"given":"David W.","family":"Russ","sequence":"first","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute (OMNI) Ohio University  236 Irvine Hall 45701 Athens OH"},{"name":"Division of 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