{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:37:29Z","timestamp":1768815449081,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Appetite loss has a major impact on cancer patients. It is exceedingly prevalent, is a prognostic indicator and is associated with inferior quality of life. Cachexia is a multi\u2010factorial syndrome defined by a negative protein and energy balance, driven by a variable combination of reduced food intake and abnormal metabolism. Not all cancer patients that experience weight loss have appetite loss, and the pathophysiology between cachexia and appetite loss may thus be different. Knowledge of pathophysiology of appetite loss in cancer patients is still limited. The primary object of this study was to explore the association with 93 predefined candidate single\u2010nucleotide polymorphisms (SNPs) and appetite loss in cancer patients to possibly generate new theories of the pathophysiology of the condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1,853 cancer patients were phenotyped according to appetite loss and then genotyped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After allowing for multiple testing, there was no statistically significant association between any of the SNPs analysed and appetite loss. The ten most significant SNPs in the co\u2010dominant model had observed odds ratios varying from 0.72 to 1.28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This large exploratory study could not find any associations with loss of appetite and 93 SNPs with a potential to be involved in appetite loss in cancer patients. This does not however rule out genes putative role in the development of the symptom, but the observed odds ratios are close to one which makes it unlikely that any of the individual SNPs explored in the present study have great importance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Electronic supplementary material<\/jats:title><jats:p>The online version of this article (doi:10.1007\/s13539\u2010012\u20100064\u20108) contains supplementary material, which is available to authorized users.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-012-0064-8","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T15:44:48Z","timestamp":1335368688000},"page":"191-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Is there a genetic cause of appetite loss?\u2014an explorative study in 1,853 cancer patients"],"prefix":"10.1002","volume":"3","author":[{"given":"Tora S.","family":"Solheim","sequence":"first","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Faculty of Medicine Norwegian University of Science and Technology (NTNU)  7030 Trondheim"},{"name":"Department of Oncology St. Olavs University Hospital  Olav Kyrres gt 13 7006 Trondheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Fayers","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Faculty of Medicine Norwegian University of Science and Technology (NTNU)  7030 Trondheim"},{"name":"Institute of Applied Health Sciences University of Aberdeen  Foresterhill AB25 2ZD Aberdeen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torill","family":"Fladvad","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine Norwegian University of Science and Technology (NTNU)  7030 Trondheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Tan","sequence":"additional","affiliation":[{"name":"Clinical and Surgical Sciences (Surgery) University of Edinburgh  Royal Infirmary, 51 Little France Crescent EH16 4SA Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Skorpen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine Norwegian University of Science and Technology (NTNU)  7030 Trondheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Fearon","sequence":"additional","affiliation":[{"name":"Clinical and Surgical Sciences (Surgery) University of Edinburgh  Royal Infirmary, 51 Little France Crescent EH16 4SA Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vickie E.","family":"Baracos","sequence":"additional","affiliation":[{"name":"Department of Oncology (Division of Palliative Care Medicine) University of Alberta  T6G 1Z2 Edmonton AB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l","family":"Klepstad","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Emergency Medicine St. Olav University Hospital  7006 Trondheim"},{"name":"Department of Circulation and Medical Imaging Norwegian University of Science and Technology  Trondheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Strasser","sequence":"additional","affiliation":[{"name":"Oncological Palliative Medicine, Division of Oncology, Department of Internal Medicine and Palliative Care Center Cantonal Hospital  St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stein","family":"Kaasa","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Faculty of Medicine Norwegian University of Science and Technology (NTNU)  7030 Trondheim"},{"name":"Department of Oncology St. Olavs University Hospital  Olav Kyrres gt 13 7006 Trondheim"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc927"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.02.033"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","unstructured":"Fearon K Strasser F Anker SD Bosaeus I Bruera E Fainsinger RL et al. 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