{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:01:44Z","timestamp":1760781704014},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T00:00:00Z","timestamp":1337040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Standard\u2010of\u2010care (SOC) cancer treatments are primarily aimed at reducing size and progression of a tumor. There is a need for successful supplemental anabolic therapies to combat cancer cachexia in addition to these SOC treatment modalities. Anabolic interventions, including testosterone and amino acid supplements, may be beneficial in reducing and\/or reversing muscle wasting in these patient populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 48\u2010year\u2010old Caucasian female with recurrent cervical cancer was scheduled to receive three 21\u2010day cycles of cisplatin and topetecan chemotherapy. She qualified, consented, and enrolled into a blinded interventional pilot study where she received daily whey protein (10\u00a0g, three times per day with meals) and a weekly injection of testosterone enanthate (100\u00a0mg intramuscular) before and during the SOC chemotherapy treatment period. Body composition, serum inflammatory markers, mixed muscle protein synthesis and breakdown rates, physical function, fatigue, and quality of life were assessed before and after the intervention period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body composition, as assessed by an increase in body weight and lean body mass and reduction in fat mass; physical function; fatigue; and quality of life each improved across the entire intervention period despite general increases in inflammatory markers and no improvements in muscle protein turnover towards the end of the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Concomitant treatment of oral amino acids and testosterone may be a viable therapeutic option for fighting cachexia and improving body composition and quality of life during chemotherapeutic treatment of recurrent cervical cancer. These positive outcomes may be attainable over time despite overall poor inflammatory status.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-012-0066-6","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T13:37:18Z","timestamp":1337002638000},"page":"253-263","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cancer cachexia and anabolic interventions: a case report"],"prefix":"10.1002","volume":"3","author":[{"given":"Edgar L.","family":"Dillon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurjot","family":"Basra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid M.","family":"Horstman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanon L.","family":"Casperson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Randolph","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Durham","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall J.","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepcion","family":"Diaz-Arrastia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyuba","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra S.","family":"Hatch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Willis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwyn","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Sheffield-Moore","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas Medical Branch at Galveston  77555-0569 Galveston TX"},{"name":"Department of Internal Medicine Division of Endocrinology and Metabolism  301 University Blvd 77555-0264 Galveston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19920036"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.07.026"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.03.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hci127"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2005.09.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2005.02.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.10.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr042889"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000165004.93707.88"},{"key":"e_1_2_7_11_1","first-page":"257","article-title":"Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia","volume":"14","author":"DeJong CH","year":"2005","journal-title":"Oncol Rep"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0185"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00019.2005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.1.243S"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6445.584"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.07.004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.8.550"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00362.2001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8397"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031069"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1210\/jcem.85.1.6226","article-title":"The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism","volume":"85","author":"Yesilova Z","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2060"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4049\/jimmunol.162.1.35","article-title":"Androgens alter the cytokine profile and reduce encephalitogenicity of myelin\u2010reactive T cells","volume":"162","author":"Bebo BF","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.10.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860701)58:1<183::AID-CNCR2820580131>3.0.CO;2-3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.2.M165"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.2.378"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00053.2002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.264S"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00041.2007"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01970.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00818.2005"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000227542.43669.45"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.2.628"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.570"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00647843"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.1.80"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20753"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.136"},{"key":"e_1_2_7_41_1","doi-asserted-by":"crossref","unstructured":"Noble M Russell C Kraemer L Sharratt M. UW WELL\u2010FIT: the impact of supervised exercise programs on physical capacity and quality of life in individuals receiving treatment for cancer. Support Care Cancer. 2011;20:865\u201373.","DOI":"10.1007\/s00520-011-1175-z"},{"key":"e_1_2_7_42_1","doi-asserted-by":"crossref","unstructured":"Ohnishi N Kataoka T Okamura H. Relationships between roles and mental states and role functional QOL in breast cancer outpatients. Jpn J Clin Oncol. 2011;41:1112\u20138.","DOI":"10.1093\/jjco\/hyr104"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0830-7"},{"key":"e_1_2_7_44_1","first-page":"7106","article-title":"Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12\u2010O\u2010tetradecanoylphorbolacetate\u2010induced apoptosis in androgen\u2010sensitive prostate cancer LNCaP cells","volume":"63","author":"Altuwaijri S","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2006.12.012"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.42.26267"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","unstructured":"Bakkar N Guttridge DC. NF\u2010kappaB signaling: a tale of two pathways in skeletal myogenesis. Physiol Rev 2010;90:495\u2013511.","DOI":"10.1152\/physrev.00040.2009"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602402"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207129200"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328339fdd2"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2009.02.001"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.11.043"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2009"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E03-08-0585"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1139\/H07-054"},{"key":"e_1_2_7_56_1","first-page":"312","article-title":"Steep elevation of blood interleukin\u20106 (IL\u20106) associated only with late stages of cachexia in cancer patients","volume":"15","author":"Iwase S","year":"2004","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357900600705359"},{"key":"e_1_2_7_58_1","doi-asserted-by":"crossref","unstructured":"Helaly GF Hussein NG Refai W Ibrahim M. Relation of serum insulin\u2010like growth factor\u20101 (IGF\u20101) levels with hepatitis C virus infection and insulin resistance. Transl Res. 2011;158:155\u201362.","DOI":"10.1016\/j.trsl.2011.04.005"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318160c599"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.10.021"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0003-5"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1007%2Fs13539-012-0066-6","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s13539-012-0066-6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s13539-012-0066-6","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s13539-012-0066-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:50:08Z","timestamp":1700571008000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s13539-012-0066-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,15]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1007\/s13539-012-0066-6"],"URL":"https:\/\/doi.org\/10.1007\/s13539-012-0066-6","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,15]]},"assertion":[{"value":"2011-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}