{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:57:06Z","timestamp":1762459026703},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Postmenopausal women typically experience accelerated muscle loss which has a negative effect on strength. The maximum daily recommended dosage of ibuprofen (1,200\u00a0mg) following resistance exercise has been shown to increase muscle hypertrophy and strength in older adults. This study aimed to determine the effects of low\u2010dose ibuprofen (400\u00a0mg) immediately following resistance exercise sessions on muscle mass and strength in postmenopausal women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were randomized to ingest ibuprofen (IBU: <jats:italic>n<\/jats:italic>\u2009=\u200915, 57.8\u2009\u00b1\u20095.1\u00a0years, 75.9\u2009\u00b1\u20099.0\u00a0kg, 165.9\u2009\u00b1\u20096.2\u00a0cm, BMI\u2009=\u200928\u2009\u00b1\u20094\u00a0kg\/m<jats:sup>2<\/jats:sup>) or placebo (PLA: <jats:italic>n<\/jats:italic>\u2009=\u200913, 56.5\u2009\u00b1\u20094.4\u00a0years, 73.0\u2009\u00b1\u200910.4\u00a0kg, 163.1\u2009\u00b1\u20095.9\u00a0cm, BMI\u2009=\u200926\u2009\u00b1\u20099\u00a0kg\/m<jats:sup>2<\/jats:sup>) immediately following resistance exercise (11 whole\u2010body exercises), which was performed 3\u00a0days\/week, on nonconsecutive days, for 9\u00a0weeks. Prior to and following training, measures were taken for lean tissue mass (dual\u2010energy X\u2010ray absorptiometry), muscle size of the elbow and knee flexors and extensors and ankle dorsiflexors and plantar flexors (ultrasound), and strength (one\u2010repetition maximum leg press and chest press).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the 9\u00a0weeks of training, there were significant changes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in lean tissue mass (IBU, \u22121.1\u2009\u00b1\u20091.0\u00a0kg; PLA, \u22120.7\u2009\u00b1\u20091.4\u00a0kg), muscle size of the knee extensors (IBU, 0.3\u2009\u00b1\u20090.6\u00a0cm; PLA, 0.2\u2009\u00b1\u20090.7\u00a0cm), ankle dorsiflexors (IBU, 0.5\u2009\u00b1\u20090.8\u00a0cm; PLA, 0.1\u2009\u00b1\u20090.5\u00a0cm), and ankle plantar flexors (IBU, 0.3\u2009\u00b1\u20090.9\u00a0cm; PLA, 0.5\u2009\u00b1\u20090.9\u00a0cm), leg press strength (IBU, 20.6\u2009\u00b1\u200918.0\u00a0kg; PLA, 20.0\u2009\u00b1\u200920.0\u00a0kg), and chest press strength (IBU, 5.1\u2009\u00b1\u20099.5\u00a0kg; PLA, 8.1\u2009\u00b1\u20097.6\u00a0kg), with no differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose ibuprofen following resistance exercise has no greater effect on muscle mass or strength over exercise alone in postmenopausal women.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-012-0077-3","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T13:01:07Z","timestamp":1341838867000},"page":"41-46","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ingestion of low\u2010dose ibuprofen following resistance exercise in postmenopausal women"],"prefix":"10.1002","volume":"4","author":[{"given":"Darren G.","family":"Candow","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology and Health Studies, Centre on Aging and Health University of Regina  S4S 0A2 Regina SK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip D.","family":"Chilibeck","sequence":"additional","affiliation":[{"name":"College of Kinesiology University of Saskatchewan  Saskatoon SK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krissy","family":"Weisgarber","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Health Studies, Centre on Aging and Health University of Regina  S4S 0A2 Regina SK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emelie","family":"Vogt","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Health Studies, Centre on Aging and Health University of Regina  S4S 0A2 Regina SK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam D. 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