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The present document reports the results of a recent meeting of the International Working Group on Sarcopenia (a task force consisting of geriatricians and scientists from academia and industry) held on June 7\u20138, 2011 in Toulouse (France). The meeting was specifically focused at gaining knowledge on the currently available biomarkers (functional, biological, or imaging\u2010related) that could be utilized in clinical trials of sarcopenia and considered the most reliable and promising to evaluate age\u2010related modifications of skeletal muscle. Specific recommendations about the assessment of aging skeletal muscle in older people and the optimal methodological design of studies on sarcopenia were also discussed and finalized. Although the study of skeletal muscle decline is still in a very preliminary phase, the potential great benefits derived from a better understanding and treatment of this condition should encourage research on sarcopenia. However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-012-0078-2","type":"journal-article","created":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T14:08:21Z","timestamp":1343916501000},"page":"181-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":257,"title":["Biomarkers of sarcopenia in clinical trials\u2014recommendations from the International Working Group on Sarcopenia"],"prefix":"10.1002","volume":"3","author":[{"given":"Matteo","family":"Cesari","sequence":"first","affiliation":[{"name":"Gerontop\u00f4le and INSERM Unit 1027 Universit\u00e9 de Toulouse  Toulouse"},{"name":"Institut du Vieillissement, Gerontop\u00f4le Universit\u00e9 de Toulouse  37 All\u00e9es Jules Guesde 31000 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University  711 Washington Street 02111 Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pahor","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research, Institute on Aging University of Florida  Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret","family":"Goodpaster","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism University of Pittsburgh  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hellerstein","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Toxicology University of California at Berkeley  San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor A.","family":"Van Kan","sequence":"additional","affiliation":[{"name":"Gerontop\u00f4le and INSERM Unit 1027 Universit\u00e9 de Toulouse  Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Virchow-Klinikum Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin"},{"name":"Centre for Clinical and Basic Research IRCCS San Raffaele  Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seward","family":"Rutkove","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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