{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:52:01Z","timestamp":1793350321846,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Involuntary weight loss (IWL) is frequent in advanced cancer patients causing compromised anticancer treatment outcomes and function. Cancer cachexia is influenced by nutrition impact symptoms (NIS). The aim of this study was to explore the frequency of NIS in advanced patients and to assess specific interventions guided by a 12\u2010item NIS checklist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients from an outpatient nutrition\u2010fatigue clinic completed the NIS checklist. The NIS checklist was developed based on literature review and multiprofessional clinical expert consensus. Chart review was performed to detect defined NIS typical interventions. Oncology outpatients not seen in the nutrition\u2010fatigue clinic were matched for age, sex, and tumor to serve as controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 52 nutrition\u2010fatigue clinic patients, a mixed cancer population [IWL in 2\u00a0months 5.96\u00a0% (mean)], the five most frequent NIS were taste and smell alterations 27\u00a0%, constipation 19\u00a0%, abdominal pain 14\u00a0%, dysphagia 12\u00a0%, and epigastric pain 10\u00a0%. A statistically significant difference for NIS typical interventions in patients with taste and smell alterations (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04), constipation (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), pain (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0001), and fatigue (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0004) were found compared to the control population [mixed cancer, 3.53\u00a0% IWL in 2\u00a0months (mean)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NIS are common in advanced cancer patients. The NIS checklist can guide therapeutic nutrition\u2010targeted interventions. The awareness for NIS will likely evoke more research in assessment, impact, and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13539-012-0099-x","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T11:48:03Z","timestamp":1357818483000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Nutrition impact symptoms in advanced cancer patients: frequency and specific interventions, a case\u2013control study"],"prefix":"10.1002","volume":"4","author":[{"given":"Aurelius","family":"Omlin","sequence":"first","affiliation":[{"name":"From the Section Oncological Palliative Medicine, Division of Oncology\/Hematology, Department Internal Medicine and Palliative Care Center Cantonal Hospital  St. Gallen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blum","sequence":"additional","affiliation":[{"name":"From the Section Oncological Palliative Medicine, Division of Oncology\/Hematology, Department Internal Medicine and Palliative Care Center Cantonal Hospital  St. Gallen"},{"name":"Department of Cancer Research and Molecular Medicine, Faculty of Medicine Norwegian University of Science and Technology (NTNU)  7491 Trondheim"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wierecky","sequence":"additional","affiliation":[{"name":"Onkologische Gemeinschaftspraxis  Ballindamm 3 20095 Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R.","family":"Haile","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit Cantonal Hospital St. Gallen  St. Gallen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith D.","family":"Ottery","sequence":"additional","affiliation":[{"name":"Ottery and Associates Oncology Care Consultants  Pier 5 Suite 139, 7N Columbus Blvd 19106 Philadelphia 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