{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:59:00Z","timestamp":1791269940036,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cognitive dysfunction and changes in body composition share common pathophysiological pathways. The aim of the present paper was to evaluate whether changes in appendicular muscle mass (AMM) and fat mass (FM) are associated factors with an increased risk of cognitive dysfunction in community\u2010dwelling older women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nested case\u2013control study was performed in 181 women aged 75\u00a0years and older from a subsample of the <jats:italic>Epidemiologie de l'Osteoporose<\/jats:italic> participants from Toulouse. Body composition parameters at inclusion and 7\u00a0years later (assessed by dual energy X\u2010ray absorptiometry), and the presence of cognitive dysfunction (dementia and mild cognitive impairment) at 7\u00a0years of follow\u2010up, assured by two memory experts based on best clinical practice and validated criteria, were obtained. Multivariate logistic regression models assessed the association of percent change in AMM and FM with risk of cognitive dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 7\u00a0years of follow\u2010up, 15 participants suffered from dementia, 6 suffered from mild cognitive impairment, and 160 were cognitively normal. Neither body composition changes nor gait speed was found to be statistically associated with cognitive dysfunction after controlling for potential confounders. Only age, over 85\u00a0years, was associated with an increased risk of subsequent cognitive impairment (odds ratio 3.10; 95\u00a0% confidence interval 1.07\u20138.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No significant association could be evidenced between changes in body composition and cognitive dysfunction. Due to the small sample size, statistical power could be an issue. The study could also suggest the possibility that the risk of cognitive dysfunction is not mediated by changes in body composition.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-013-0112-z","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T17:41:29Z","timestamp":1374774089000},"page":"225-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Association of a 7\u2010year percent change in fat mass and muscle mass with subsequent cognitive dysfunction: the EPIDOS\u2010Toulouse cohort"],"prefix":"10.1002","volume":"4","author":[{"given":"Gabor","family":"Abellan van Kan","sequence":"first","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Department of Geriatric Medicine Toulouse University Hospital  170, Avenue de Casselardit 31059 Toulouse"},{"name":"INSERM Unit 1027 University Toulouse III  31059 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cesari","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Department of Geriatric Medicine Toulouse University Hospital  170, Avenue de Casselardit 31059 Toulouse"},{"name":"INSERM Unit 1027 University Toulouse III  31059 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gillette-Guyonnet","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Department of Geriatric Medicine Toulouse University Hospital  170, Avenue de Casselardit 31059 Toulouse"},{"name":"INSERM Unit 1027 University Toulouse III  31059 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Dupuy","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Department of Geriatric Medicine Toulouse University Hospital  170, Avenue de Casselardit 31059 Toulouse"},{"name":"INSERM Unit 1027 University Toulouse III  31059 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Department of Geriatric Medicine Toulouse University Hospital  170, Avenue de Casselardit 31059 Toulouse"},{"name":"INSERM Unit 1027 University Toulouse III  31059 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Department of Geriatric Medicine Toulouse University Hospital  170, Avenue de Casselardit 31059 Toulouse"},{"name":"INSERM Unit 1027 University Toulouse III  31059 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.38"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50507.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000154929"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr177"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-011-0089-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs173"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.10.049"},{"key":"e_1_2_7_9_1","first-page":"38","article-title":"IANA (International Academy on Nutrition and Aging) expert group: weight loss and Alzheimer's disease","volume":"11","author":"Gillette Guyonet S","year":"2007","journal-title":"J Nutr Health Aging"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)01440-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.4.M372"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(02)00198-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","unstructured":"Kelly TL Wilson KE Heymsfield SB. 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