{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:51:20Z","timestamp":1790387480451,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Radiation\u2010esophagitis and weight loss are fre.uently observed toxicities in patients treated with concurrent chemo\u2010radiotherapy (CT\u2010RT) for non\u2010small cell lung cancer (NSCLC) and might be related. The purpose was to investigate whether weight loss already starts early after initiation of CT\u2010RT and precedes radiation\u2010esophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In a retrospective cohort, weight and esophagitis grade \u22652 were assessed during the first weeks of (CT\u2010)RT in patients treated with concurrent (<jats:italic>n<\/jats:italic>\u2009=\u2009102) or sequential (<jats:italic>n<\/jats:italic>\u2009=\u200992) therapy. In a prospective validation study, data on body weight, esophagitis grade \u22652, nutritional intake and muscle strength were obtained before, during and following CT\u2010RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the retrospective cohort, early weight loss was observed in concurrently treated patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), independent of esophagitis\u2009\u2265\u2009grade 2. Early weight loss was also observed in the prospective cohort (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and was not accompanied by decreases in nutritional intake. In addition lower limb muscle strength rapidly declined (<jats:italic>p<\/jats:italic>\u2009=\u20090.042). In the later weeks of treatment, further body weight loss occurred (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) despite increased nutritional supplementation and body weight was only partly recovered after 4\u00a0weeks post CT\u2010RT (<jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weight loss during concurrent CT\u2010RT for NSCLC starts early and prior to onset of esophagitis, re.uiring timely and intense nutritional rehabilitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Electronic supplementary material<\/jats:title><jats:p>The online version of this article (doi:10.1007\/s13539\u2010013\u20100127\u20105) contains supplementary material.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-013-0127-5","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T11:46:11Z","timestamp":1390391171000},"page":"127-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Early body weight loss during concurrent chemo\u2010radiotherapy for non\u2010small cell lung cancer"],"prefix":"10.1002","volume":"5","author":[{"given":"C\u00e9line M. H.","family":"Op den Kamp","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology &amp; Metabolism Maastricht University Medical Centre+  P.O. Box 5800 6202 AZ Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk K. M.","family":"De Ruysscher","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Maastro Clinic) Maastricht University Medical Centre, GROW Research Institute  Maastricht"},{"name":"Radiation Oncology University Hospitals Leuven\/KU Leuven  Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology &amp; Metabolism Maastricht University Medical Centre+  P.O. Box 5800 6202 AZ Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Elferink","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology &amp; Metabolism Maastricht University Medical Centre+  P.O. Box 5800 6202 AZ Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud M. A.","family":"Houben","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Maastro Clinic) Maastricht University Medical Centre, GROW Research Institute  Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary J. G.","family":"Oberije","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Maastro Clinic) Maastricht University Medical Centre, GROW Research Institute  Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben P.","family":"Bootsma","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Atrium Medical Centre  Heerlen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiel H.","family":"Geraedts","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Orbis Medical Centre  Sittard"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula C. M.","family":"Pitz","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Laurentius Hospital  Roermond"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon C.","family":"Langen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology &amp; Metabolism Maastricht University Medical Centre+  P.O. Box 5800 6202 AZ Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiel F. M.","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology &amp; Metabolism Maastricht University Medical Centre+  P.O. Box 5800 6202 AZ Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemie M. W. J.","family":"Schols","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology &amp; Metabolism Maastricht University Medical Centre+  P.O. Box 5800 6202 AZ Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie C.","family":"Dingemans","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology &amp; Metabolism Maastricht University Medical Centre+  P.O. 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