{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:42:42Z","timestamp":1789929762311,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high\u2010intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialysis patients. A second aim was to compare any anabolic response to that of healthy participants completing the same program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a single blind controlled study, 23 haemodialysis patients and 9 healthy individuals were randomly allocated to PRET or an attention control (SHAM) group. PRET completed high\u2010intensity exercise leg extensions using novel equipment. SHAM completed low\u2010intensity lower body stretching activities using ultra light resistance bands. Exercises were completed thrice weekly for 12\u00a0weeks, during dialysis in the haemodialysis patients. Outcomes included knee extensor muscle volume by magnetic resonance imaging, knee extensor strength by isometric dynamometer and lower body tests of physical function. Data were analysed by a per protocol method using between\u2010group comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PRET elicited a statistically and clinically significant anabolic response in haemodialysis patients (PRET\u2014SHAM, mean difference [95\u00a0% CI]: 193[63 to 324]\u2009cm<jats:sup>3<\/jats:sup>) that was very similar to the response in healthy participants (PRET\u2014SHAM, 169[\u221241 to 379]\u2009cm<jats:sup>3<\/jats:sup>). PRET increased strength in both haemodialysis patients and healthy participants. In contrast, PRET only enhanced lower body functional capacity in the healthy participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intradialytic PRET elicited a normal anabolic and strength response in haemodialysis patients. The lack of a change in functional capacity was surprising and warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-014-0140-3","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T20:02:30Z","timestamp":1396900950000},"page":"199-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Anabolic exercise in haemodialysis patients: a randomised controlled pilot study"],"prefix":"10.1002","volume":"5","author":[{"given":"Danielle L.","family":"Kirkman","sequence":"first","affiliation":[{"name":"School of Sport, Health and Exercise Sciences Bangor University  Bangor Wales"},{"name":"Department of Nephrology, Gwynedd Hospital Betsi Cadwaladr University Health Board  Bangor Wales"},{"name":"College of Health Sciences, Department of Kinesiology and Applied Physiology University of Delaware  504 S College Ave 19716 Newark DE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mullins","sequence":"additional","affiliation":[{"name":"Bangor Imaging Centre, School of Psychology Bangor University  Bangor Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naushad A.","family":"Junglee","sequence":"additional","affiliation":[{"name":"School of Sport, Health and Exercise Sciences Bangor University  Bangor Wales"},{"name":"Department of Nephrology, Gwynedd Hospital Betsi Cadwaladr University Health Board  Bangor Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick","family":"Kumwenda","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Glan Clywd Hospital Betsi Cadwaladr University Health Board  Bangor Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi M.","family":"Jibani","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Gwynedd Hospital Betsi Cadwaladr University Health Board  Bangor Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie H.","family":"Macdonald","sequence":"additional","affiliation":[{"name":"School of Sport, Health and Exercise Sciences Bangor University  Bangor Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","unstructured":"Sakkas GK Ball D Mercer TH Sargeant AJ Tolfrey K Naish PF. 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