{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:52:40Z","timestamp":1781585560838,"version":"3.54.5"},"reference-count":95,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>In heart failure, impairment of cardiac muscle function leads to numerous neurohormonal and metabolic disorders, including an imbalance between anabolic and catabolic processes, in favour of the latter. These disorders cause loss of muscle mass with structural and functional changes within the skeletal muscles, known as skeletal myopathy. This phenomenon constitutes an important mechanism that participates in the pathogenesis of chronic heart failure. both its clinical symptoms and the progression of the disease. Attempts to reverse the above\u2010mentioned pathologic processes by exploiting the anabolic action of androgenic hormones could provide a potentially attractive treatment option. The current concepts of anabolic androgen deficiency and resultant skeletal myopathy in patients with heart failure are reviewed, and the potential role of anabolic\u2010androgenic hormones as an emerging therapeutic option for targeting heart failure is discussed.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-014-0152-z","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T07:29:04Z","timestamp":1406791744000},"page":"287-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Skeletal myopathy in patients with chronic heart failure: significance of anabolic\u2010androgenic hormones"],"prefix":"10.1002","volume":"5","author":[{"given":"Krystian","family":"Josiak","sequence":"first","affiliation":[{"name":"Clinic for Heart Diseases Wroclaw Medical University  Wroclaw"},{"name":"Centre for Heart Diseases Military Hospital  Wroclaw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa A.","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Clinic for Heart Diseases Wroclaw Medical University  Wroclaw"},{"name":"Centre for Heart Diseases Military Hospital  Wroclaw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo F.","family":"Piepoli","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Cardiac Department G. da Saliceto Hospital, AUSL Piacenza  Piacenza"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Banasiak","sequence":"additional","affiliation":[{"name":"Centre for Heart Diseases Military Hospital  Wroclaw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Clinic for Heart Diseases Wroclaw Medical University  Wroclaw"},{"name":"Centre for Heart Diseases Military Hospital  Wroclaw"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00323-3"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70361-3"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2003.12.009"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.059"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.55.5.439"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66163-6"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.5.574"},{"key":"e_1_2_14_9_1","first-page":"536","article-title":"Symptoms and quality of life in heart failure: the muscle hypothesis","volume":"72","author":"Coats AJS","year":"1994","journal-title":"Br Heart J"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0218"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs463"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.526"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.4.775"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(75)90010-9"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015229"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00381-1"},{"key":"e_1_2_14_17_1","first-page":"59","article-title":"Relations between strength and endurance of leg skeletal muscle and cardiopulmonary exercise testing parameters in patients with chronic heart failure","volume":"43","author":"Suzuki K","year":"2004","journal-title":"J Cardiol"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.4.431"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0807"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00626-3"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2001.00832.x"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000134374.24181.5b"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000232902.97286.35"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3283244436"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.76.4.337"},{"key":"e_1_2_14_26_1","first-page":"1","article-title":"Histological abnormalities of diaphragmatic muscle may contribute to dyspnea in heart failure","volume":"86","author":"Lindsay DC","year":"1992","journal-title":"Circulation"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.2.518"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80472-1"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4401.098491"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000042704.37387.29"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.07.018"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.3.461"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.605980"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.04.025"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607043350101"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.05.006"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.118"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00938.x"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200305-617OC"},{"issue":"6","key":"e_1_2_14_40_1","first-page":"1521","article-title":"Hormonal determinants of pubertal growth","volume":"14","author":"Delenmarre\u2010van de Waal HA","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2005.00553.x"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031719"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0401"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.649426"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00233-4"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfn004"},{"key":"e_1_2_14_47_1","unstructured":"Jankowska EA. Znaczenie kliniczne i prognostyczne niedoboru hormon\u00f3w anabolicznych u m\u0119\u017cczyzn z niewydolno\u015bci\u0105 serca [dissertation]. Akademia Medyczna we Wroc\u0142awiu 2008."},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.12.011"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00367.2006"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(98)00007-5"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00362.2001"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.269.5.E820"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200405000-00006"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-5215.2002.51018.x"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02339.x"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.1.19"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199902010-00005"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2596"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0120"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.12.M1103"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.07.023"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00490.2009"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1653"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.6.1886"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.08.002"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.02.002"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00054.2002"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-003-0411-1"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06779"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2060"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02166"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.1.41"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.12.2149"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.093"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0251"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.06.009"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.04.004"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-006-9095-9"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200111000-00012"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602004000400018"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510029"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-06-0607"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.11.008"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.2003.00393.x"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00420-8"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(03)00059-1"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199711000-00008"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000071562.12637.3E"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.014639"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi443"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.04.006"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.078"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.090"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199705000-00005"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434080-00003"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(98)80019-4"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1007%2Fs13539-014-0152-z","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s13539-014-0152-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T02:01:44Z","timestamp":1700618504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s13539-014-0152-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":95,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1007\/s13539-014-0152-z"],"URL":"https:\/\/doi.org\/10.1007\/s13539-014-0152-z","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"2013-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}