{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:15:33Z","timestamp":1768781733274,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Formoterol is a highly potent \u03b22\u2010adrenoceptor\u2010selective agonist, which is a muscle growth promoter in many animal species, resulting in skeletal muscle hypertrophy. Previous studies carried out in our laboratory have shown that formoterol treatment in tumour\u2010bearing animals resulted in an amelioration of muscle loss through different mechanisms that include muscle apoptosis and proteolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study presented involved rats bearing the Yoshida AH\u2010130 ascites tumour model\u2014which induces a high degree of cachexia\u2014treated with the beta\u20102 agonist formoterol (0.3\u00a0mg\/kg BW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The administration of formoterol to cachectic tumour\u2010bearing rats resulted in a significant reduction of muscle weight loss. The treatment also increased lean body mass and body water. The treatment, however, did not influence heart weight, which was much decreased as a result of tumour burden. Untreated tumour\u2010bearing rats showed important changes in parameters related with heart function:, left ventricle (LV) ejection fraction, fractional shortening, LV diameter and volume (diastolic) and LV stroke volume, LV mass and posterior wall thickness (PWT) (both systolic and diastolic). The administration of formoterol affected LV diameter and volume, LV stroke volume and LV mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that formoterol treatment, in addition to reducing muscle wasting, does not negatively alter heart function\u2014in fact, some cardiac parameters are improved\u2014in animals affected by cancer cachexia.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-014-0153-y","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T08:05:18Z","timestamp":1409213118000},"page":"315-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Formoterol in the treatment of experimental cancer cachexia: effects on heart function"],"prefix":"10.1002","volume":"5","author":[{"given":"M\u00edriam","family":"Toledo","sequence":"first","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona  Diagonal 643 08028 Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Springer","sequence":"additional","affiliation":[{"name":"Applied Cachexia Research, Department of Cardiology Charit\u00e9 Medical School  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edlvia","family":"Busquets","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona  Diagonal 643 08028 Barcelona"},{"name":"Institut de Biomedicina de la Universitat de Barcelona (IBUB)  Barcelona"},{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona  Diagonal 643 08028 Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Tschirner","sequence":"additional","affiliation":[{"name":"Applied Cachexia Research, Department of Cardiology Charit\u00e9 Medical School  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"L\u00f3pez-Soriano","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona  Diagonal 643 08028 Barcelona"},{"name":"Institut de Biomedicina de la Universitat de Barcelona (IBUB)  Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Applied Cachexia Research, Department of Cardiology Charit\u00e9 Medical School  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep M.","family":"Argil\u00e9s","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona  Diagonal 643 08028 Barcelona"},{"name":"Institut de Biomedicina de la Universitat de Barcelona (IBUB)  Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193211000-00002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00251-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","unstructured":"Argiles JM Alvarez B Lopez-Soriano FJ. 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