{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:33Z","timestamp":1791216393774,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>The syndrome of cachexia, i.e., involuntary weight loss in patients with underlying diseases, sarcopenia, i.e., loss of muscle mass due to aging, and general muscle atrophy from disuse and\/or prolonged bed rest have received more attention over the last decades. All lead to a higher morbidity and mortality in patients, and therefore, they represent a major socio\u2010economic burden for the society today. This mini\u2010review looks at recent developments in basic research that are relevant to the loss of skeletal muscle. It aims to cover the most significant publication of last 3\u00a0years on the causes and effects of muscle wasting, new targets for therapy development, and potential biomarkers for assessing skeletal muscle mass. The targets include the following: (1) E\u20103 ligases TRIM32, SOCS1, and SOCS3 by involving the elongin BC ubiquitin\u2010ligase, Cbl\u2010b, culling 7, Fbxo40, MG53 (TRIM72), and the mitochondrial Mul1; (2) the kinase MST1; and (3) the G\u2010protein G\u03b1i<jats:sub>2<\/jats:sub>. D(3)\u2010creatine has the potential to be used as a novel biomarker that allows to monitor actual change in skeletal muscle mass over time. In conclusion, significant development efforts are being made by academic groups as well as numerous pharmaceutical companies to identify new target and biomarker muscles, as muscle wasting represents a great medical need, but no therapies have been approved in the last decades.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13539-014-0157-7","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T20:15:54Z","timestamp":1409170554000},"page":"193-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Muscle wasting: an overview of recent developments in basic research"],"prefix":"10.1002","volume":"5","author":[{"given":"Sandra","family":"Palus","sequence":"first","affiliation":[{"name":"Department of Innovative Clinical Trials University Medical Centre G\u00f6ttingen  G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Innovative Clinical Trials University Medical Centre G\u00f6ttingen  G\u00f6ttingen"},{"name":"Applied Cachexia Research, Department of Cardiology Charit\u00e9 Medical School  Campus Virchow-Klinikum, Augustenburger Platz 1 13353 Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Springer","sequence":"additional","affiliation":[{"name":"Department of Innovative Clinical Trials University Medical Centre G\u00f6ttingen  G\u00f6ttingen"},{"name":"Department of Cardiology and Pneumology University Medical Centre G\u00f6ttingen  Robert-Koch-Str. 40 37075 G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-013-0111-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0089-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-013-0124-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-013-0105-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0002-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0014-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.12.M772"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00099"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.06.024"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0068-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","unstructured":"Abstracts of the 7th cachexia conference Japan december 9-11 2013. J Cachexia Sarcopenia Muscle. 2013;4:295-343.","DOI":"10.1007\/s13539-013-0123-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","unstructured":"Abstracts of the 7th cachexia conference kobe\/osaka Japan december 9-11 2013 (part 2). J Cachexia Sarcopenia Muscle. 2014;5:35-78.","DOI":"10.1007\/s13539-014-0129-y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0087-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0043-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2387"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.442"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0011-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-1-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0065-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0034-6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht302"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0062-x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0047-1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030276"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.10.022"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys238"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0035-5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.857291"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.011"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0049-z"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-2-2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.001"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0101-7"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0052-4"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-2-3"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32833862df"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.52"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004973"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200901052"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201110067"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-3-11"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-222844"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200444200"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01347-08"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.03.009"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.20.6922"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.09.011"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11834"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0051-5"},{"key":"e_1_2_7_52_1","doi-asserted-by":"crossref","unstructured":"Fogelman DR Holmes H Mohammed K Katz MH Prado CM Lieffers J et al. Does IGFR1 inhibition result in increased muscle mass loss in patients undergoing treatment for pancreatic cancer? J Cachexia Sarcopenia Muscle. 2014. doi:10.1007\/s13539-014-0145-y.","DOI":"10.1007\/s13539-014-0145-y"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0029-3"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-013-0113-y"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.05.019"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.60"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.10.005"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0073-7"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0071-9"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-11-12"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0082-6"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.01.263"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0085-3"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199508000-00003"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0018-6"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2081-3"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00555.2011"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2404"},{"key":"e_1_2_7_69_1","doi-asserted-by":"crossref","unstructured":"Minetti GC Feige JN Rosenstiel A Bombard F Meier V Werner A et al. Galphai2 signaling promotes skeletal muscle hypertrophy myoblast differentiation and muscle regeneration. Sci Signal. 2011;4:ra80.","DOI":"10.1126\/scisignal.2002038"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0081-7"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0078-2"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0086-2"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1434"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0021-y"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-013-0114-x"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9836-3"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo3040931"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0079-1"},{"key":"e_1_2_7_79_1","doi-asserted-by":"crossref","unstructured":"Stimpson SA Turner SM Clifton LG Poole JC Mohammed HA Shearer TW et al. Total\u2010body creatine pool size and skeletal muscle mass determination by creatine-(methyl-D3) dilution in rats. J Appl Physiol (1985). 2012;112:1940-8.","DOI":"10.1152\/japplphysiol.00122.2012"},{"key":"e_1_2_7_80_1","first-page":"1605","article-title":"Total body skeletal muscle mass: estimation by creatine (methyl\u2010d3) dilution in humans","volume":"2014","author":"Clark RV","year":"1985","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_81_1","doi-asserted-by":"crossref","unstructured":"Stimpson SA Leonard MS Clifton LG Poole JC Turner SM Shearer TW et al. Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D-creatine dilution method. J Cachex Sarcopenia Muscle. 2013;4:217\u201323.","DOI":"10.1007\/s13539-013-0110-1"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1007%2Fs13539-014-0157-7","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s13539-014-0157-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T01:53:56Z","timestamp":1698458036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s13539-014-0157-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,28]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1007\/s13539-014-0157-7"],"URL":"https:\/\/doi.org\/10.1007\/s13539-014-0157-7","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,28]]},"assertion":[{"value":"2014-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}