{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:02:59Z","timestamp":1781877779234,"version":"3.54.5"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["STA1159\/4-1"],"award-info":[{"award-number":["STA1159\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s13555-019-00321-6","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T07:14:07Z","timestamp":1568186047000},"page":"613-622","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Neuromodulatory Effect of Antipruritic Treatment of Chronic Prurigo"],"prefix":"10.1007","volume":"9","author":[{"given":"Claudia","family":"Zeidler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"St\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"issue":"7","key":"321_CR1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1111\/jdv.14570","volume":"32","author":"MP Pereira","year":"2018","unstructured":"Pereira MP, Steinke S, Zeidler C, et al. European academy of dermatology and venereology European prurigo project. Expert consensus on the definition, classification and terminology of chronic prurigo. J Eur Acad Dermatol Venereol. 2018;32(7):1059\u201365. https:\/\/doi.org\/10.1111\/jdv.14570.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"2","key":"321_CR2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2340\/00015555-2774","volume":"98","author":"C Zeidler","year":"2018","unstructured":"Zeidler C, Tsianakas A, Pereira M, Stander H, Yosipovitch G, Stander S. Chronic prurigo of nodular type. A review. Acta Derm Venereol. 2018;98(2):173\u20139. https:\/\/doi.org\/10.2340\/00015555-2774.","journal-title":"Acta Derm Venereol"},{"key":"321_CR3","unstructured":"Ringkamp M, Meyer R. Pruriceptors. In: Carstens E, AkiyamaItch A, editors. Itch: mechanisms and treatment. Boca Raton (FL): CRC Press\/Taylor & Francis; 2014. Chapter 9."},{"issue":"1","key":"321_CR4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/0190-9622(92)70006-2","volume":"26","author":"B Harris","year":"1992","unstructured":"Harris B, Harris K, Penneys NS. Demonstration by S-100 protein staining of increased numbers of nerves in the papillary dermis of patients with prurigo nodularis. J Am Acad Dermatol. 1992;26(1):56\u20138.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"321_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1365-2133.2011.10306.x","volume":"165","author":"B Schuhknecht","year":"2011","unstructured":"Schuhknecht B, Marziniak M, Wissel A, et al. Reduced intraepidermal nerve fibre density in lesional and nonlesional prurigo nodularis skin as a potential sign of subclinical cutaneous neuropathy. Br J Dermatol. 2011;165(1):85\u201391. https:\/\/doi.org\/10.1111\/j.1365-2133.2011.10306.x.","journal-title":"Br J Dermatol"},{"issue":"10","key":"321_CR6","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/exd.13343","volume":"26","author":"MP Pereira","year":"2017","unstructured":"Pereira MP, Pogatzki-Zahn E, Snels C, et al. There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations. Exp Dermatol. 2017;26(10):969\u201371. https:\/\/doi.org\/10.1111\/exd.13343.","journal-title":"Exp Dermatol"},{"issue":"6","key":"321_CR7","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1038\/jid.2012.464","volume":"133","author":"D Roggenkamp","year":"2013","unstructured":"Roggenkamp D, Kopnick S, Stab F, Wenck H, Schmelz M, Neufang G. Epidermal nerve fibers modulate keratinocyte growth via neuropeptide signaling in an innervated skin model. J Invest Dermatol. 2013;133(6):1620\u20138. https:\/\/doi.org\/10.1038\/jid.2012.464.","journal-title":"J Invest Dermatol"},{"key":"321_CR8","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.regpep.2013.08.001","volume":"186","author":"X Shi","year":"2013","unstructured":"Shi X, Wang L, Clark JD, Kingery WS. Keratinocytes express cytokines and nerve growth factor in response to neuropeptide activation of the ERK1\/2 and JNK MAPK transcription pathways. Regul Pept. 2013;186:92\u2013103. https:\/\/doi.org\/10.1016\/j.regpep.2013.08.001.","journal-title":"Regul Pept"},{"issue":"2","key":"321_CR9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jaci.2016.12.980","volume":"140","author":"E Azimi","year":"2017","unstructured":"Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA. Substance P activates Mas-related G protein-coupled receptors to induce itch. J Allergy Clin Immunol. 2017;140(2):447\u2013453.e3. https:\/\/doi.org\/10.1016\/j.jaci.2016.12.980.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"321_CR10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","volume":"155","author":"SR Wilson","year":"2013","unstructured":"Wilson SR, Th\u00e9 L, Batia LM, et al. The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell. 2013;155(2):285\u201395. https:\/\/doi.org\/10.1016\/j.cell.2013.08.057.","journal-title":"Cell"},{"key":"321_CR11","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/j.biopha.2017.11.124","volume":"96","author":"P Patowary","year":"2017","unstructured":"Patowary P, Pathak MP, Zaman K, Raju PS, Chattopadhyay P. Research progress of capsaicin responses to various pharmacological challenges. Biomed Pharmacother. 2017;96:1501\u201312. https:\/\/doi.org\/10.1016\/j.biopha.2017.11.124.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"321_CR12","doi-asserted-by":"publisher","first-page":"82","DOI":"10.2340\/00015555-2789","volume":"98","author":"MP Pereira","year":"2018","unstructured":"Pereira MP, L\u00fcling H, Dieckh\u00f6fer A, Steinke S, Zeidler C, St\u00e4nder S. Brachioradial pruritus and notalgia paraesthetica. A comparative observational study of clinical presentation and morphological pathologies. Acta Derm Venereol. 2018;98(1):82\u20138. https:\/\/doi.org\/10.2340\/00015555-2789.","journal-title":"Acta Derm Venereol"},{"key":"321_CR13","first-page":"293","volume":"68","author":"K Boyd","year":"2014","unstructured":"Boyd K, Shea SM, Patterson JW. The role of capsaicin in dermatology. Prog Drug Res. 2014;68:293\u2013306.","journal-title":"Prog Drug Res"},{"issue":"4","key":"321_CR14","first-page":"304","volume":"7","author":"JE Bernstein","year":"1988","unstructured":"Bernstein JE. Capsaicin in dermatologic disease. Semin Dermatol. 1988;7(4):304\u20139.","journal-title":"Semin Dermatol"},{"key":"321_CR15","doi-asserted-by":"publisher","unstructured":"Derry S, Rice AS, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017;13;1:CD007393. https:\/\/doi.org\/10.1002\/14651858.CD007393.pub4.2017.","DOI":"10.1002\/14651858.CD007393.pub4.2017"},{"issue":"3","key":"321_CR16","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1067\/mjd.2001.110059","volume":"44","author":"S St\u00e4nder","year":"2001","unstructured":"St\u00e4nder S, Luger T, Metze D. Treatment of prurigo nodularis with topical capsaicin. J Am Acad Dermatol. 2001;44(3):471\u20138. https:\/\/doi.org\/10.1067\/mjd.2001.110059.","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"321_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.0906-6705.2004.0178.x","volume":"13","author":"S Stander","year":"2004","unstructured":"Stander S, Moormann C, Schumacher M, et al. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004;13(3):129\u201339. https:\/\/doi.org\/10.1111\/j.0906-6705.2004.0178.x.","journal-title":"Exp Dermatol"},{"issue":"12","key":"321_CR18","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1080\/13543784.2018.1548606","volume":"27","author":"MP Pereira","year":"2018","unstructured":"Pereira MP, Stander S. Novel drugs for the treatment of chronic pruritus. Expert Opin Investig Drugs. 2018;27(12):981\u20138. https:\/\/doi.org\/10.1080\/13543784.2018.1548606.","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"321_CR19","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.neuron.2014.02.046","volume":"82","author":"AP Kardon","year":"2014","unstructured":"Kardon AP, Polgar E, Hachisuka J, et al.. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014;82(3):573\u201386. https:\/\/doi.org\/10.1016\/j.neuron.2014.02.046.","journal-title":"Neuron"},{"issue":"5\u20136","key":"321_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/BF02530092","volume":"288","author":"G Yosipovitch","year":"1996","unstructured":"Yosipovitch G, Szolar C, Hui XY, Maibach H. Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. Arch Dermatol Res. 1996;288(5\u20136):245\u20138.","journal-title":"Arch Dermatol Res"},{"issue":"6","key":"321_CR21","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1111\/jdv.14041","volume":"31","author":"S Stander","year":"2017","unstructured":"Stander S, Augustin M, Roggenkamp D, et al. Novel TRPM8 agonist cooling compound against chronic itch. Results from a randomized, double-blind, controlled, pilot study in dry skin. J Eur Acad Dermatol Venereol. 2017;31(6):1064\u20138. https:\/\/doi.org\/10.1111\/jdv.14041.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"321_CR22","doi-asserted-by":"publisher","unstructured":"Broeders JA, Ahmed Ali U, Fischer G. Systematic review and meta-analysis of randomized clinical trials (RCTs) comparing topical calcineurin inhibitors with topical corticosteroids for atopic dermatitis. A 15-year experience. J Am Acad Dermatol. 2016;75(2):410\u201319.e3. https:\/\/doi.org\/10.1016\/j.jaad.2016.02.12282016.","DOI":"10.1016\/j.jaad.2016.02.12282016"},{"issue":"4","key":"321_CR23","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1159\/000355671","volume":"227","author":"D Siepmann","year":"2013","unstructured":"Siepmann D, Lotts T, Blome C, et al. Evaluation of the antipruritic effects of topical pimecrolimus in non-atopic prurigo nodularis: results of a randomized, hydrocortisone-controlled, double-blind phase II trial. Dermatology. 2013;227(4):353\u201360. https:\/\/doi.org\/10.1159\/000355671.","journal-title":"Dermatology"},{"issue":"1","key":"321_CR24","first-page":"8","volume":"21","author":"E Wong","year":"2016","unstructured":"Wong E, Kurian A. Off-label uses of topical calcineurin inhibitors. Skin Ther Lett. 2016;21(1):8\u201310.","journal-title":"Skin Ther Lett"},{"issue":"3","key":"321_CR25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neures.2004.07.005","volume":"50","author":"E Senba","year":"2004","unstructured":"Senba E, Katanosaka K, Yajima H, Mizumura K. The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers. Neurosci Res. 2004;50(3):257\u201362. https:\/\/doi.org\/10.1016\/j.neures.2004.07.005.","journal-title":"Neurosci Res"},{"issue":"2","key":"321_CR26","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2147\/tcrm.2006.2.2.213","volume":"2","author":"S Stander","year":"2006","unstructured":"Stander S, Schurmeyer-Horst F, Luger TA, Weisshaar E. Treatment of pruritic diseases with topical calcineurin inhibitors. Ther Clin Risk Manag. 2006;2(2):213\u20138.","journal-title":"Ther Clin Risk Manag"},{"issue":"2","key":"321_CR27","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jdermsci.2010.03.007","volume":"58","author":"M Kido","year":"2010","unstructured":"Kido M, Takeuchi S, Esaki H, Hayashida S, Furue M. Scratching behavior does not necessarily correlate with epidermal nerve fiber sprouting or inflammatory cell infiltration. J Dermatol Sci. 2010;58(2):130\u20135. https:\/\/doi.org\/10.1016\/j.jdermsci.2010.03.007.","journal-title":"J Dermatol Sci"},{"issue":"3","key":"321_CR28","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1254\/jphs.11182FP","volume":"118","author":"K Samukawa","year":"2012","unstructured":"Samukawa K, Izumi Y, Shiota M, et al. Red ginseng inhibits scratching behavior associated with atopic dermatitis in experimental animal models. J Pharmacol Sci. 2012;118(3):391\u2013400.","journal-title":"J Pharmacol Sci"},{"issue":"4","key":"321_CR29","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.1365-4632.2009.03968.x","volume":"48","author":"H-O Kim","year":"2009","unstructured":"Kim H-O, Lee C-H, Ahn H-K, Park C-W. Effects of tacrolimus ointment on the expression of substance P, nerve growth factor, and neurotrophin-3 in atopic dermatitis. Int J Dermatol. 2009;48(4):431\u20138. https:\/\/doi.org\/10.1111\/j.1365-4632.2009.03968.x.","journal-title":"Int J Dermatol"},{"issue":"1","key":"321_CR30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.1365-2133.2010.09757.x","volume":"163","author":"U Pereira","year":"2010","unstructured":"Pereira U, Boulais N, Lebonvallet N, Pennec JP, Dorange G, Misery L. Mechanisms of the sensory effects of tacrolimus on the skin. Br J Dermatol. 2010;163(1):70\u20137. https:\/\/doi.org\/10.1111\/j.1365-2133.2010.09757.x.","journal-title":"Br J Dermatol"},{"issue":"1","key":"321_CR31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.2340\/00015555-1648","volume":"94","author":"H Murota","year":"2014","unstructured":"Murota H, El-latif MA, Tamura T, Katayama I. Olopatadine hydrochloride decreases tissue interleukin-31 levels in an atopic dermatitis mouse model. Acta Derm Venereol. 2014;94(1):78\u20139. https:\/\/doi.org\/10.2340\/00015555-1648.","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"321_CR32","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1080\/09546634.2016.1243787","volume":"28","author":"A He","year":"2017","unstructured":"He A, Kwatra SG, Sharma D, Matsuda KM. The role of topical anesthetics in the management of chronic pruritus. J Dermatolog Treat. 2017;28(4):338\u201341. https:\/\/doi.org\/10.1080\/09546634.2016.1243787.","journal-title":"J Dermatolog Treat"},{"issue":"10","key":"321_CR33","first-page":"1129","volume":"8","author":"G Yosipovitch","year":"1993","unstructured":"Yosipovitch G, Tur E, Morduchowicz G, Boner G. Skin surface pH, moisture, and pruritus in haemodialysis patients. Nephrol Dial Transplant. 1993;8(10):1129\u201332.","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"321_CR34","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/BF00290302","volume":"8","author":"CF Allenby","year":"1993","unstructured":"Allenby CF, Johnstone RS, Chatfield S, Pike LC, Tidy G. PERINAL\u2014a new no-touch spray to relieve the symptoms of pruritus ani. Int J Colorectal Dis. 1993;8(4):184\u20137.","journal-title":"Int J Colorectal Dis"},{"issue":"2","key":"321_CR35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1080\/09546630802441218","volume":"20","author":"TA Young","year":"2009","unstructured":"Young TA, Patel TS, Camacho F et al. A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients. J Dermatolog Treat. 2009;20(2):76\u201381. https:\/\/doi.org\/10.1080\/09546630802441218.","journal-title":"J Dermatolog Treat"},{"issue":"2","key":"321_CR36","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1001\/2013.jamadermatol.646","volume":"149","author":"TJ Poterucha","year":"2013","unstructured":"Poterucha TJ, Murphy SL, Davis MDP, et al Topical amitriptyline-ketamine for the treatment of brachioradial pruritus. JAMA Dermatol. 2013;149(2):148\u201350. https:\/\/doi.org\/10.1001\/2013.jamadermatol.646.","journal-title":"JAMA Dermatol"},{"issue":"2","key":"321_CR37","first-page":"115","volume":"14","author":"JR Griffin","year":"2015","unstructured":"Griffin JR, Davis MDP. Amitriptyline\/ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster. J Drugs Dermatol. 2015;14(2):115\u20138.","journal-title":"J Drugs Dermatol"},{"issue":"1","key":"321_CR38","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1124\/jpet.110.178384","volume":"338","author":"JE Quintero","year":"2011","unstructured":"Quintero JE, Dooley DJ, Pomerleau F, Huettl P, Gerhardt GA. Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices. Role of voltage-sensitive Ca2+ alpha2delta-1 subunit. J Pharmacol Exp Ther. 2011;338(1):240\u20135. https:\/\/doi.org\/10.1124\/jpet.110.178384.","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"321_CR39","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1213\/ANE.0b013e31820f2a16","volume":"112","author":"T Takasusuki","year":"2011","unstructured":"Takasusuki T, Yaksh TL. The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg. 2011;112(4):971\u20136. https:\/\/doi.org\/10.1213\/ANE.0b013e31820f2a16.","journal-title":"Anesth Analg"},{"issue":"3","key":"321_CR40","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.jaad.2016.02.1237","volume":"75","author":"KM Matsuda","year":"2016","unstructured":"Matsuda KM, Sharma D, Schonfeld AR, Kwatra SG. Gabapentin and pregabalin for the treatment of chronic pruritus. J Am Acad Dermatol. 2016;75(3):619\u2013625.e6. https:\/\/doi.org\/10.1016\/j.jaad.2016.02.1237.","journal-title":"J Am Acad Dermatol"},{"key":"321_CR41","unstructured":"Bergasa NV. Pruritus of cholestasis. In: Carstens E, AkiyamaItch A, editors. Itch: mechanisms and treatment. Boca Raton: CRC Press; 2014. Chapter 6."},{"issue":"1","key":"321_CR42","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/jcpt.12005","volume":"38","author":"M Mazza","year":"2013","unstructured":"Mazza M, Guerriero G, Marano G, Janiri L, Bria P, Mazza S. Treatment of prurigo nodularis with pregabalin. J Clin Pharm Ther. 2013;38(1):16\u20138. https:\/\/doi.org\/10.1111\/jcpt.12005.","journal-title":"J Clin Pharm Ther"},{"issue":"8","key":"321_CR43","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/ddg.13304","volume":"15","author":"S Stander","year":"2017","unstructured":"Stander S, Zeidler C, Augustin M et al. S2k guidelines for the diagnosis and treatment of chronic pruritus\u2014update-short version. J Dtsch Dermatol Ges. 2017;15(8):860\u201372. https:\/\/doi.org\/10.1111\/ddg.13304.","journal-title":"J Dtsch Dermatol Ges"},{"key":"321_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics9030031","author":"CJ Martin","year":"2017","unstructured":"Martin CJ, Alcock N, Hiom S, Birchall JC. Development and evaluation of topical gabapentin formulations. Pharmaceutics. 2017. https:\/\/doi.org\/10.3390\/pharmaceutics9030031.","journal-title":"Pharmaceutics"},{"issue":"5","key":"321_CR45","doi-asserted-by":"publisher","first-page":"624","DOI":"10.2340\/00015555-2318","volume":"96","author":"KC Ko","year":"2016","unstructured":"Ko KC, Tominaga M, Kamata Y, et al. Possible antipruritic mechanism of cyclosporine A in atopic dermatitis. Acta Derm Venereol. 2016;96(5):624\u20139. https:\/\/doi.org\/10.2340\/00015555-2318.","journal-title":"Acta Derm Venereol"},{"issue":"8","key":"321_CR46","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00105-016-3838-7","volume":"67","author":"U Raap","year":"2016","unstructured":"Raap U, Papakonstantinou E, Metz M, Lippert U, Schmelz M. Update on the cutaneous neurobiology of pruritus. Hautarzt. 2016;67(8):595\u2013600. https:\/\/doi.org\/10.1007\/s00105-016-3838-7.","journal-title":"Hautarzt"},{"issue":"3 Pt 2","key":"321_CR47","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1006\/clin.1996.0140","volume":"80","author":"S Ho","year":"1996","unstructured":"Ho S, Clipstone N, Timmermann L, et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol. 1996;80(3 Pt 2):S40\u20135.","journal-title":"Clin Immunol Immunopathol"},{"issue":"2","key":"321_CR48","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","volume":"133","author":"F Cevikbas","year":"2014","unstructured":"Cevikbas F, Wang X, Akiyama T et al. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch. Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol. 2014;133(2):448\u201360. https:\/\/doi.org\/10.1016\/j.jaci.2013.10.048.","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"321_CR49","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1684\/ejd.2011.1470","volume":"21","author":"A Otsuka","year":"2011","unstructured":"Otsuka A, Tanioka M, Nakagawa Y et al. Effects of cyclosporine on pruritus and serum IL-31 levels in patients with atopic dermatitis. Eur J Dermatol. 2011;21(5):816\u20137. https:\/\/doi.org\/10.1684\/ejd.2011.1470.","journal-title":"Eur J Dermatol"},{"issue":"11","key":"321_CR50","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1111\/j.1610-0387.2008.06745.x","volume":"6","author":"D Siepmann","year":"2008","unstructured":"Siepmann D, Luger TA, Stander S. Antipruritic effect of cyclosporine microemulsion in prurigo nodularis. Results of a case series. J Dtsch Dermatol Ges. 2008;6(11):941\u20136. https:\/\/doi.org\/10.1111\/j.1610-0387.2008.06745.x.","journal-title":"J Dtsch Dermatol Ges"},{"issue":"3","key":"321_CR51","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jaad.2016.04.054","volume":"75","author":"EL Simpson","year":"2016","unstructured":"Simpson EL, Gadkari A, Worm M et al. Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs). A phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD). J Am Acad Dermatol. 2016;75(3):506\u201315. https:\/\/doi.org\/10.1016\/j.jaad.2016.04.054.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"321_CR52","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","volume":"171","author":"LK Oetjen","year":"2017","unstructured":"Oetjen LK, Mack MR, Feng J et al. Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch. Cell. 2017;171(1):217\u2013228.e13. https:\/\/doi.org\/10.1016\/j.cell.2017.08.006.","journal-title":"Cell"},{"issue":"1","key":"321_CR53","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1001\/jamadermatol.2018.3912","volume":"155","author":"KM Beck","year":"2019","unstructured":"Beck KM, Yang EJ, Sekhon S, Bhutani T, Liao W. Dupilumab treatment for generalized prurigo nodularis. JAMA Dermatol. 2019;155(1):118\u201320. https:\/\/doi.org\/10.1001\/jamadermatol.2018.3912.","journal-title":"JAMA Dermatol"},{"key":"321_CR54","doi-asserted-by":"publisher","unstructured":"Mollanazar NK, Elgash M, Weaver L, Valdes-Rodriguez R, Hsu S. Reduced itch associated with dupilumab treatment in 4 patients with prurigo nodularis. JAMA Dermatol. 2019;155(1):121\u20132. https:\/\/doi.org\/10.1001\/jamadermatol.2018.3906.","DOI":"10.1001\/jamadermatol.2018.3906"},{"issue":"1","key":"321_CR55","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jaci.2016.12.960","volume":"140","author":"T Fukuyama","year":"2017","unstructured":"Fukuyama T, Ganchingco JR, Mishra SK et al. Janus kinase inhibitors display broad anti-itch properties. A possible link through the TRPV1 receptor. J Allergy Clin Immunol. 2017;140(1):306\u2013309.e3. https:\/\/doi.org\/10.1016\/j.jaci.2016.12.960.","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"321_CR56","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1111\/bjd.14871","volume":"175","author":"R Bissonnette","year":"2016","unstructured":"Bissonnette R, Papp KA, Poulin Y et al. Topical tofacitinib for atopic dermatitis. A phase IIa randomized trial. Br J Dermatol. 2016;175(5):902\u201311. https:\/\/doi.org\/10.1111\/bjd.14871.","journal-title":"Br J Dermatol"},{"issue":"6","key":"321_CR57","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.jaad.2016.07.040","volume":"75","author":"SR Feldman","year":"2016","unstructured":"Feldman SR, Thaci D, Gooderham M et al. Tofacitinib improves pruritus and health-related quality of life up to 52\u00a0weeks. Results from 2 randomized phase III trials in patients with moderate to severe plaque psoriasis. J Am Acad Dermatol. 2016;75(6):1162\u20131170.e3. https:\/\/doi.org\/10.1016\/j.jaad.2016.07.040.","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"321_CR58","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1007\/s00105-004-0802-8","volume":"55","author":"A Brune","year":"2004","unstructured":"Brune A, Metze D, Luger TA, Stander S. Antipruritic therapy with the oral opioid receptor antagonist naltrexone. Open, non-placebo controlled administration in 133 patients. Hautarzt. 2004;55(12):1130\u20136. https:\/\/doi.org\/10.1007\/s00105-004-0802-8.","journal-title":"Hautarzt"},{"issue":"4","key":"321_CR59","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.jaad.2009.08.052","volume":"63","author":"NQ Phan","year":"2010","unstructured":"Phan NQ, Bernhard JD, Luger TA, Stander S. Antipruritic treatment with systemic mu-opioid receptor antagonists. A review. J Am Acad Dermatol. 2010;63(4):680\u20138. https:\/\/doi.org\/10.1016\/j.jaad.2009.08.052.","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"321_CR60","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nrn1950","volume":"7","author":"A Ikoma","year":"2006","unstructured":"Ikoma A, Steinhoff M, Stander S, Yosipovitch G, Schmelz M. The neurobiology of itch. Nat Rev Neurosci. 2006;7(7):535\u201347. https:\/\/doi.org\/10.1038\/nrn1950.","journal-title":"Nat Rev Neurosci"},{"issue":"12","key":"321_CR61","doi-asserted-by":"publisher","first-page":"3742","DOI":"10.1681\/asn.2005020152","volume":"16","author":"B Wikstrom","year":"2005","unstructured":"Wikstrom B, Gellert R, Ladefoged SD et al. Kappa-opioid system in uremic pruritus. Multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol. 2005;16(12):3742\u20137. https:\/\/doi.org\/10.1681\/asn.2005020152.","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"321_CR62","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/hepr.12830","volume":"47","author":"H Kumada","year":"2017","unstructured":"Kumada H, Miyakawa H, Muramatsu T et al. Efficacy of nalfurafine hydrochloride in patients with chronic liver disease with refractory pruritus. A randomized, double-blind trial. Hepatol Res. 2017;47(10):972\u201382. https:\/\/doi.org\/10.1111\/hepr.12830.","journal-title":"Hepatol Res"},{"issue":"5","key":"321_CR63","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1111\/ced.13398","volume":"43","author":"KA Bilir","year":"2018","unstructured":"Bilir KA, Anli G, Ozkan E, Gunduz O, Ulugol A. Involvement of spinal cannabinoid receptors in the antipruritic effects of WIN 55,212-2, a cannabinoid receptor agonist. Clin Exp Dermatol. 2018;43(5):553\u20138. https:\/\/doi.org\/10.1111\/ced.13398.","journal-title":"Clin Exp Dermatol"},{"issue":"2\u20133","key":"321_CR64","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1600-0625.1998.tb00307.x","volume":"7","author":"T Scholzen","year":"1998","unstructured":"Scholzen T, Armstrong CA, Bunnett NW, Luger TA, Olerud JE, Ansel JC. Neuropeptides in the skin Interactions between the neuroendocrine and the skin immune systems. Exp Dermatol. 1998;7(2\u20133):81\u201396.","journal-title":"Exp Dermatol"},{"key":"321_CR65","doi-asserted-by":"publisher","first-page":"495704","DOI":"10.1155\/2015\/495704","volume":"2015","author":"S Garcia-Recio","year":"2015","unstructured":"Garcia-Recio S, Gascon P. Biological and pharmacological aspects of the NK1-receptor. Biomed Res Int. 2015;2015:495704. https:\/\/doi.org\/10.1155\/2015\/495704.","journal-title":"Biomed Res Int"},{"issue":"12","key":"321_CR66","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s00424-013-1284-2","volume":"465","author":"T Liu","year":"2013","unstructured":"Liu T, Ji R-R. New insights into the mechanisms of itch. Are pain and itch controlled by distinct mechanisms? Pflugers Arch. 2013;465(12):1671\u201385. https:\/\/doi.org\/10.1007\/s00424-013-1284-2.","journal-title":"Pflugers Arch"},{"issue":"4","key":"321_CR67","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1097\/ALN.0b013e31824bb303","volume":"116","author":"W-W Li","year":"2012","unstructured":"Li W-W, Guo T-Z, Liang D-y, Sun Y, Kingery WS, Clark JD. Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndrome. Anesthesiology. 2012;116(4):882\u201395. https:\/\/doi.org\/10.1097\/ALN.0b013e31824bb303.","journal-title":"Anesthesiology"},{"issue":"3","key":"321_CR68","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jdermsci.2010.03.020","volume":"58","author":"S Haas","year":"2010","unstructured":"Haas S, Capellino S, Phan NQ et al Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis. J Dermatol Sci. 2010;58(3):193\u20137. https:\/\/doi.org\/10.1016\/j.jdermsci.2010.03.020.","journal-title":"J Dermatol Sci"},{"issue":"7","key":"321_CR69","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1097\/j.pain.0000000000000172","volume":"156","author":"T Akiyama","year":"2015","unstructured":"Akiyama T, Nguyen T, Curtis E et al. A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch. Pain. 2015;156(7):1240\u20136. https:\/\/doi.org\/10.1097\/j.pain.0000000000000172.","journal-title":"Pain"},{"key":"321_CR70","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-0305-2","author":"M Pojawa-Golab","year":"2019","unstructured":"Pojawa-Golab M, Jaworecka K, Reich A. NK-1 receptor antagonists and pruritus: review of current literature. Dermatol Ther (Heidelb). 2019. https:\/\/doi.org\/10.1007\/s13555-019-0305-2.","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"1","key":"321_CR71","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2340\/00015555-2780","volume":"98","author":"T Ohanyan","year":"2018","unstructured":"Ohanyan T, Schoepke N, Eirefelt S et al. Role of substance P and its receptor neurokinin 1 in chronic prurigo. A randomized, proof-of-concept, controlled trial with topical aprepitant. Acta Derm Venereol. 2018;98(1):26\u201331. https:\/\/doi.org\/10.2340\/00015555-2780.","journal-title":"Acta Derm Venereol"},{"key":"321_CR72","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3120","author":"A Tsianakas","year":"2019","unstructured":"Tsianakas A, Zeidler C, Riepe C et al. Aprepitant in anti-histamine-refractory chronic nodular prurigo. A multicentre, randomized, double-blind, placebo-controlled, cross-over, phase-II trial (APREPRU). Acta Derm Venereol. 2019. https:\/\/doi.org\/10.2340\/00015555-3120.","journal-title":"Acta Derm Venereol"},{"issue":"2","key":"321_CR73","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jaci.2005.10.033","volume":"117","author":"E Sonkoly","year":"2006","unstructured":"Sonkoly E, Muller A, Lauerma AI et al. A new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol. 2006;117(2):411\u20137. https:\/\/doi.org\/10.1016\/j.jaci.2005.10.033.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"321_CR74","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/bjd.14207","volume":"174","author":"O Nemoto","year":"2016","unstructured":"Nemoto O, Furue M, Nakagawa H et al. The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study. Br J Dermatol. 2016;174(2):296\u2013304. https:\/\/doi.org\/10.1111\/bjd.14207.","journal-title":"Br J Dermatol"},{"issue":"9","key":"321_CR75","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1056\/NEJMoa1606490","volume":"376","author":"T Ruzicka","year":"2017","unstructured":"Ruzicka T, Hanifin JM, Furue M, et al. Anti-interleukin-31 receptor A antibody for atopic dermatitis. N Engl J Med. 2017;376(9):826\u201335. https:\/\/doi.org\/10.1056\/NEJMoa1606490.","journal-title":"N Engl J Med"},{"issue":"4","key":"321_CR76","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.jaci.2018.03.018","volume":"142","author":"K Kabashima","year":"2018","unstructured":"Kabashima K, Furue M, Hanifin JM et al. Nemolizumab in patients with moderate-to-severe atopic dermatitis Randomized, phase II, long-term extension study. J Allergy Clin Immunol. 2018;142(4):1121\u20131130.e7. https:\/\/doi.org\/10.1016\/j.jaci.2018.03.018.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-019-00321-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-019-00321-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-019-00321-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T12:03:07Z","timestamp":1710331387000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-019-00321-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,11]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["321"],"URL":"https:\/\/doi.org\/10.1007\/s13555-019-00321-6","relation":{},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,11]]},"assertion":[{"value":"12 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}