{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T10:01:22Z","timestamp":1777197682165,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s13555-019-0299-9","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T13:40:58Z","timestamp":1556631658000},"page":"271-280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Itraconazole in the Treatment of Nonfungal Cutaneous Diseases: A Review"],"prefix":"10.1007","volume":"9","author":[{"given":"Ya-Chu","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-1474","authenticated-orcid":false,"given":"Tsen-Fang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,30]]},"reference":[{"key":"299_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2165\/11533190-000000000-00000","volume":"11","author":"TF Tsai","year":"2010","unstructured":"Tsai TF, Yeh TY. Allopurinol in dermatology. Am J Clin Dermatol. 2010;11:225\u201332.","journal-title":"Am J Clin Dermatol"},{"key":"299_CR2","doi-asserted-by":"publisher","first-page":"6686","DOI":"10.1167\/iovs.15-17045","volume":"56","author":"J Huang","year":"2015","unstructured":"Huang J, Su W, Chen X, et al. Doxycycline attenuates endotoxin-induced uveitis by prostaglandin E2-EP4 signaling. Investig Ophthalmol Vis Sci. 2015;56:6686\u201393.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"299_CR3","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.2174\/1567205013666160819124206","volume":"13","author":"J Budni","year":"2016","unstructured":"Budni J, Garcez ML, de Medeiros J, et al. The anti-inflammatory role of minocycline in Alzheimer\u00b4s disease. Curr Alzheimer Res. 2016;13:1319\u201329.","journal-title":"Curr Alzheimer Res"},{"key":"299_CR4","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1007\/s11064-011-0522-2","volume":"36","author":"C Yi","year":"2011","unstructured":"Yi C, Zhang Z, Wang W, et al. Doxycycline attenuates peripheral inflammation in rat experimental autoimmune neuritis. Neurochem Res. 2011;36:1984\u201390.","journal-title":"Neurochem Res"},{"key":"299_CR5","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.ccr.2010.02.027","volume":"17","author":"J Kim","year":"2010","unstructured":"Kim J, Tang JY, Gong R, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010;17:388\u201399.","journal-title":"Cancer Cell"},{"key":"299_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ccr.2012.11.017","volume":"23","author":"J Kim","year":"2013","unstructured":"Kim J, Aftab BT, Tang JY, et al. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell. 2013;23:23\u201334.","journal-title":"Cancer Cell"},{"key":"299_CR7","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3332\/ecancer.2015.521","volume":"9","author":"P Pantziarka","year":"2015","unstructured":"Pantziarka P, Sukhatme V, Bouche G, et al. Repurposing drugs in oncology (ReDO)\u2014itraconazole as an anti-cancer agent. Ecancermedicalscience. 2015;9:521. https:\/\/doi.org\/10.3332\/ecancer.2015.521","journal-title":"Ecancermedicalscience"},{"key":"299_CR8","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1200\/JCO.2013.49.9525","volume":"32","author":"DJ Kim","year":"2014","unstructured":"Kim DJ, Kim J, Spaunhurst K, et al. Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma. J Clin Oncol. 2014;32:745\u201351.","journal-title":"J Clin Oncol"},{"key":"299_CR9","doi-asserted-by":"publisher","first-page":"6764","DOI":"10.1158\/0008-5472.CAN-11-0691","volume":"71","author":"BT Aftab","year":"2011","unstructured":"Aftab BT, Dobromilskaya I, Liu JO, et al. Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. Cancer Res. 2011;71:6764\u201372.","journal-title":"Cancer Res"},{"key":"299_CR10","doi-asserted-by":"publisher","first-page":"44045","DOI":"10.1074\/jbc.M111.278754","volume":"286","author":"BA Nacev","year":"2011","unstructured":"Nacev BA, Grassi P, Dell A, et al. The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem. 2011;286:44045\u201356.","journal-title":"J Biol Chem"},{"key":"299_CR11","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/1346-8138.12724","volume":"42","author":"Y Ran","year":"2015","unstructured":"Ran Y, Chen S, Dai Y, et al. Successful treatment of oral itraconazole for infantile hemangiomas: a case series. J Dermatol. 2015;42:202\u20136.","journal-title":"J Dermatol"},{"key":"299_CR12","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1097\/01.prs.0000278813.23244.3f","volume":"120","author":"E Okada","year":"2007","unstructured":"Okada E, Maruyama Y. Are keloids and hypertrophic scars caused by fungal infection? Plast Reconstr Surg. 2007;120:814\u20135.","journal-title":"Plast Reconstr Surg"},{"key":"299_CR13","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1097\/PRS.0b013e31817d6179","volume":"122","author":"CH Chui","year":"2008","unstructured":"Chui CH. Treatment of keloids with itraconazole. Plast Reconstr Surg. 2008;122:681\u20132.","journal-title":"Plast Reconstr Surg"},{"key":"299_CR14","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1001\/archderm.134.5.639","volume":"134","author":"M Mihara","year":"1998","unstructured":"Mihara M, Hagari Y, Morimura T, et al. Itraconazole as a new treatment for pustulosis palmaris et plantaris. Arch Dermatol. 1998;134:639\u201340.","journal-title":"Arch Dermatol"},{"key":"299_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1529-8019.2008.01219.x","volume":"22","author":"MT V\u2019lckova-Laskoska","year":"2009","unstructured":"V\u2019lckova-Laskoska MT, Caca-Biljanovska NG, Laskoski DS, et al. Palmoplantar pustulosis treated with itraconazole: a single, active-arm pilot study. Dermatol Ther. 2009;22:85\u20139.","journal-title":"Dermatol Ther"},{"key":"299_CR16","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1001\/archderm.131.3.358","volume":"131","author":"TG Berger","year":"1995","unstructured":"Berger TG, Heon V, King C, Schulze K, et al. Itraconazole therapy for human immunodeficiency virus-associated eosinophilic folliculitis. Arch Dermatol. 1995;131:358\u201360.","journal-title":"Arch Dermatol"},{"key":"299_CR17","first-page":"247","volume":"62","author":"LF Libow","year":"1998","unstructured":"Libow LF, Coots NV. Treatment of lichen planus and lichen nitidus with itraconazole: reports of six cases. Cutis. 1998;62:247\u20138.","journal-title":"Cutis"},{"key":"299_CR18","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/j.1468-3083.2008.02743.x","volume":"23","author":"S Khandpur","year":"2009","unstructured":"Khandpur S, Sugandhan S, Sharma VK. Pulsed itraconazole therapy in eruptive lichen planus. J Eur Acad Dermatol Venereol. 2009;23:98\u2013101.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"299_CR19","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.rmed.2006.08.005","volume":"101","author":"M Tercelj","year":"2007","unstructured":"Tercelj M, Rott T, Rylander R. Antifungal treatment in sarcoidosis\u2013a pilot intervention trial. Respir Med. 2007;101:774\u20138.","journal-title":"Respir Med"},{"key":"299_CR20","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1046\/j.1468-3083.2003.00763.x","volume":"17","author":"SM Cooper","year":"2003","unstructured":"Cooper SM, Sheridan A, Burge S. Mycosis fungoides responding to systemic itraconazole. J Eur Acad Dermatol Venereol. 2003;17:588\u201390.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"299_CR21","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0192-0561(91)90111-J","volume":"13","author":"G Pawelec","year":"1991","unstructured":"Pawelec G, Ehninger G, Rehbein A, et al. Comparison of the immunosuppressive activities of the antimycotic agents itraconazole, fluconazole, ketoconazole and miconazole on human T-cells. Int J Immunopharmacol. 1991;13:299\u2013304.","journal-title":"Int J Immunopharmacol"},{"key":"299_CR22","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1046\/j.1365-4362.1997.00309.x","volume":"36","author":"T Rosen","year":"1997","unstructured":"Rosen T, Schell BJ, Orengo I. Anti-inflammatory activity of antifungal preparations. Int J Dermatol. 1997;36:788\u201392.","journal-title":"Int J Dermatol"},{"key":"299_CR23","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/0192-0561(90)90101-R","volume":"12","author":"V Vuddhakul","year":"1990","unstructured":"Vuddhakul V, Mai GT, McCormack JG, et al. Suppression of neutrophil and lymphoproliferative responses in vitro by itraconazole but not fluconazole. Int J Immunopharmacol. 1990;12:639\u201345.","journal-title":"Int J Immunopharmacol"},{"key":"299_CR24","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1747-0285.2008.00694.x","volume":"72","author":"HC Steel","year":"2008","unstructured":"Steel HC, Tintinger GR, Anderson R. Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure. Chem Biol Drug. 2008;72:225\u20138.","journal-title":"Chem Biol Drug."},{"key":"299_CR25","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1159\/000246433","volume":"192","author":"C Luyten","year":"1996","unstructured":"Luyten C, Andr\u00e9 J, Walraevens C, et al. Yellow nail syndrome and onychomycosis. Experience with itraconazole pulse therapy combined with vitamin E. Dermatology. 1996;192:406\u20138.","journal-title":"Dermatology."},{"key":"299_CR26","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1365-2230.1994.tb02693.x","volume":"19","author":"P De Donker","year":"1994","unstructured":"De Donker P, Pierard GE. Acquired nail beading in patients receiving itraconazole\u2014an indicator of faster nail growth? A study using optical profilometry. Clin Exp Dermatol. 1994;19:404\u20136.","journal-title":"Clin Exp Dermatol"},{"key":"299_CR27","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1046\/j.1365-2133.2002.04671.x","volume":"146","author":"A Tosti","year":"2002","unstructured":"Tosti A, Piraccini BM, Iorizzo M. Systemic itraconazole in the yellow nail syndrome. Br J Dermatol. 2002;146:1064\u20137.","journal-title":"Br J Dermatol"},{"key":"299_CR28","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.jaad.2014.04.045","volume":"71","author":"BH Kaffenberger","year":"2014","unstructured":"Kaffenberger BH, Mathis J, Zirwas MJ. A retrospective descriptive study of oral azole antifungal agents in patients with patch test-negative head and neck predominant atopic dermatitis. J Am Acad Dermatol. 2014;71:480\u20133.","journal-title":"J Am Acad Dermatol"},{"key":"299_CR29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1468-3083.2004.00963.x","volume":"18","author":"Svejgaard El","year":"2004","unstructured":"El Svejgaard, Larsen P\u00d8, Deleuran M, et al. Treatment of head and neck dermatitis comparing itraconazole 200\u00a0mg and 400\u00a0mg daily for 1\u00a0week with placebo. J Eur Acad Dermatol Venereol. 2004;18:445\u20139.","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"299_CR30","first-page":"400","volume":"14","author":"Z Ikezawa","year":"2004","unstructured":"Ikezawa Z, Kondo M, Okajima M, et al. Clinical usefulness of oral itraconazole, an antimycotic drug, for refractory atopic dermatitis. Eur J Dermatol. 2004;14:400\u20136.","journal-title":"Eur J Dermatol"},{"key":"299_CR31","doi-asserted-by":"crossref","unstructured":"Sugita T, Nishikawa A, Zhang E, et al. Atopic dermatitis and skin fungal microorganisms. INTECH Open Access Publishers. 2012; pp 123\u201339. https:\/\/www.intechopen.com\/books\/atopic-dermatitis-disease-etiology-and-clinical-management\/atopic-dermatitis-and-skin-fungal-microorganisms","DOI":"10.5772\/25630"},{"key":"299_CR32","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1080\/00015550310014807","volume":"83","author":"J Faergemann","year":"2003","unstructured":"Faergemann J, Diehl U, Bergfelt L, et al. Scalp psoriasis: synergy between the Malassezia yeasts and skin irritation due to calcipotriol. Acta Derm Venereol. 2003;83:438\u201341.","journal-title":"Acta Derm Venereol"}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-019-0299-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-019-0299-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-019-0299-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:37:36Z","timestamp":1724413056000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-019-0299-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,30]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["299"],"URL":"https:\/\/doi.org\/10.1007\/s13555-019-0299-9","relation":{},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,30]]},"assertion":[{"value":"10 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}